Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Exoribonuclease 2

Gene

rnb

Organism
Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction.UniRule annotation

Catalytic activityi

Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

  1. exoribonuclease II activity Source: UniProtKB-HAMAP
  2. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciCSAK290339:GJ80-1584-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Exoribonuclease 2UniRule annotation (EC:3.1.13.1UniRule annotation)
Alternative name(s):
Exoribonuclease IIUniRule annotation
Short name:
RNase IIUniRule annotation
Short name:
Ribonuclease IIUniRule annotation
Gene namesi
Name:rnbUniRule annotation
Ordered Locus Names:ESA_01589
OrganismiCronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Taxonomic identifieri290339 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCronobacter
ProteomesiUP000000260: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 644644Exoribonuclease 2PRO_1000063889Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290339.ESA_01589.

Structurei

3D structure databases

ProteinModelPortaliA7MMD8.
SMRiA7MMD8. Positions 5-644.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini561 – 64383S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the RNR ribonuclease family. RNase II subfamily.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG4776.
HOGENOMiHOG000271427.
KOiK01147.
OMAiTEFITTA.
OrthoDBiEOG6Q5NRD.

Family and domain databases

HAMAPiMF_01036. RNase_II.
InterProiIPR011129. Cold_shock_prot.
IPR012340. NA-bd_OB-fold.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR013223. RNase_B_OB_dom.
IPR011804. RNase_II.
IPR022966. RNase_II/R_CS.
IPR004476. RNase_II/RNase_R.
IPR022967. S1_dom.
[Graphical view]
PfamiPF08206. OB_RNB. 1 hit.
PF00575. S1. 1 hit.
[Graphical view]
SMARTiSM00357. CSP. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 4 hits.
TIGRFAMsiTIGR00358. 3_prime_RNase. 1 hit.
TIGR02062. RNase_B. 1 hit.
PROSITEiPS01175. RIBONUCLEASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7MMD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQDNPLLAQ LKQQLHSQTP RAEGVVKATE KGFGFLEVDA QKSYFIPPPQ
60 70 80 90 100
MKKVMHGDRV IAVIHTEKEK ESAEPEELIE PFLTRFVGRV QKKDDRLSIV
110 120 130 140 150
PDHPLLKDAI PCRAERGVSH DFQNGDWAVA EMRRHPLKGD RGFYAELTQF
160 170 180 190 200
ITFGEDHFVP WWVTLARHNL EREAPDGVAT EMLDENLTRE DLTALDFVTI
210 220 230 240 250
DSASTEDMDD ALYVEALDGD RLQLTVAIAD PTAWIAEGSK LDNIAKVRAF
260 270 280 290 300
TNYLPGFNIP MLPRELSDDL CSLREGVQRP ALVCRMIIEA DGAISDDIHF
310 320 330 340 350
FAAIIESKAK LAYDDVSDWL EEKGDWQPGS EAIAAQIRLL QQICQRRSAW
360 370 380 390 400
RTEHALVFKD RPDYRFVLGE KGEVLDIVAE PRRIANRIVE ESMIAANICA
410 420 430 440 450
ARVLRDKLGF GVYNVHAGFD PASTEQLATL LQSHGMHVDA NDVLTLPGFC
460 470 480 490 500
KLRRELDAQP SGFLDSRIRR FQSFAEISTE PGPHFGLGLE AYATWTSPIR
510 520 530 540 550
KYGDMVNHRL LKAIIKGESA TRPQDEATVQ MAERRRLNRM AERDVGDWLY
560 570 580 590 600
ARFLKDKAGT DSRFAAEIID VSRGGMRVRL VDNGAVAFIP APFLHAVRDE
610 620 630 640
LVCSQENGTV QIKGETVYKV TDVIDVTIAE VRMETRSVIA RPVA
Length:644
Mass (Da):72,443
Last modified:October 2, 2007 - v1
Checksum:i925299EE474D4CCB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000783 Genomic DNA. Translation: ABU76843.1.
RefSeqiWP_012124582.1. NC_009778.1.
YP_001437679.1. NC_009778.1.

Genome annotation databases

EnsemblBacteriaiABU76843; ABU76843; ESA_01589.
GeneIDi5549705.
KEGGiesa:ESA_01589.
PATRICi20395255. VBICroSak107175_1417.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000783 Genomic DNA. Translation: ABU76843.1.
RefSeqiWP_012124582.1. NC_009778.1.
YP_001437679.1. NC_009778.1.

3D structure databases

ProteinModelPortaliA7MMD8.
SMRiA7MMD8. Positions 5-644.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290339.ESA_01589.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABU76843; ABU76843; ESA_01589.
GeneIDi5549705.
KEGGiesa:ESA_01589.
PATRICi20395255. VBICroSak107175_1417.

Phylogenomic databases

eggNOGiCOG4776.
HOGENOMiHOG000271427.
KOiK01147.
OMAiTEFITTA.
OrthoDBiEOG6Q5NRD.

Enzyme and pathway databases

BioCyciCSAK290339:GJ80-1584-MONOMER.

Family and domain databases

HAMAPiMF_01036. RNase_II.
InterProiIPR011129. Cold_shock_prot.
IPR012340. NA-bd_OB-fold.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR013223. RNase_B_OB_dom.
IPR011804. RNase_II.
IPR022966. RNase_II/R_CS.
IPR004476. RNase_II/RNase_R.
IPR022967. S1_dom.
[Graphical view]
PfamiPF08206. OB_RNB. 1 hit.
PF00575. S1. 1 hit.
[Graphical view]
SMARTiSM00357. CSP. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 4 hits.
TIGRFAMsiTIGR00358. 3_prime_RNase. 1 hit.
TIGR02062. RNase_B. 1 hit.
PROSITEiPS01175. RIBONUCLEASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic hybridization analysis with other Cronobacter species."
    Kucerova E., Clifton S.W., Xia X.Q., Long F., Porwollik S., Fulton L., Fronick C., Minx P., Kyung K., Warren W., Fulton R., Feng D., Wollam A., Shah N., Bhonagiri V., Nash W.E., Hallsworth-Pepin K., Wilson R.K., McClelland M., Forsythe S.J.
    PLoS ONE 5:E9556-E9556(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-894.

Entry informationi

Entry nameiRNB_CROS8
AccessioniPrimary (citable) accession number: A7MMD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 2, 2007
Last modified: March 4, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.