Reviewed, UniProtKB/Swiss-Prot A7MLL8 (UXUA_ENTS8)

Names and origin

Protein names

Recommended name:
    Mannonate dehydratase
    EC=4.2.1.8
Alternative name(s):
    D-mannonate hydrolase

Gene names

Name:	uxuA
Ordered Locus Names:	ESA_01068

Organism

Enterobacter sakazakii (strain ATCC BAA-894) [Complete proteome] [HAMAP]

Taxonomic identifier

290339 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Cronobacter

Protein attributes

Sequence length	396 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 396	396	Mannonate dehydratase HAMAP MF_00106		PRO_1000034327

Sequences

	Sequence		Length	Mass (Da)
	A7MLL8-1 [UniParc]. Last modified October 2, 2007. Version 1. Checksum: B39F2669DE98DBBB	FASTA	396	44,961
	10 20 30 40 50 60 MEQTWRWYGP NDPVSLDDIR QAGATGIVTA LHHIPNGEVW PVEEIKKRQA ELAQKGLTWS 70 80 90 100 110 120 VVESIPVHED IKTHTGQYDR YIASYQQSIR NLAACGIDTV CYNFMPILDW TRTDLEYTLP 130 140 150 160 170 180 DGSKALRFDH IAFAAFELHI LKRDGARHDY TDDEQRQAQD YFSAMSEAQI ETLTRNIIAG 190 200 210 220 230 240 LPGAEEGYTL DQFRARLSEY DHIDKTALRD NMAYFLKAIV PVAEEAGVRL AVHPDDPPRP 250 260 270 280 290 300 ILGLPRIVST IEDMQWLKET VDSIHNGFTM CTGSYGVRAD NDLVRMVETF ADRIHFTHLR 310 320 330 340 350 360 STCREANPKT FHEAAHLYGD VDMVAVVKAI LTEEQRRKKA GDLRPIPFRP DHGHQMLDDL 370 380 390 RKKTNPGYSA IGRLKGLAEV RGVELALKKV LFPDLL

References

[1]	McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S., Fulton B., Wollam A., Shah N., Pepin K., Bhonagiri V., Nash W., Johnson M., Thiruvilangam P., Wilson R. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000783 Genomic DNA. Translation: ABU76336.1.
RefSeq	YP_001437172.1.
3D structure databases
SMR	A7MLL8. Positions 1-389.
ModBase	Search...
Protein-protein interaction databases
STRING	A7MLL8.
Genome annotation databases
GeneID	5551948.
GenomeReviews	Gene locus ESA_01068 in contig CP000783_GR.
KEGG	esa:ESA_01068.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1312.
HOGENOM	HBG585927.
OMA	VHEEIKT.
Family and domain databases
HAMAP	MF_00106. UxuA. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
TIGRFAMs	TIGR00695. uxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA_ENTS8

Accession

Primary (citable) accession number: A7MLL8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 2, 2007
Last modified:	February 9, 2010
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)