Reviewed, UniProtKB/Swiss-Prot A7MLJ4 (CDD_ENTS8)

Names and origin

Protein names

Recommended name:
    Cytidine deaminase
    EC=3.5.4.5
Alternative name(s):
    Cytidine aminohydrolase
      Short name=CDA

Gene names

Name:	cdd
Ordered Locus Names:	ESA_01092

Organism

Enterobacter sakazakii (strain ATCC BAA-894) [Complete proteome] [HAMAP]

Taxonomic identifier

290339 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Cronobacter

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity.
Catalytic activity	Cytidine + H2O = uridine + NH3. HAMAP MF_01558
Cofactor	Binds 1 zinc ion By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cytidine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	cytidine deaminase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 294	294	Cytidine deaminase HAMAP MF_01558		PRO_1000068954
Regions
	Region	89 – 91	3	Substrate binding By similarity
Sites
	Active site	104	1	Proton donor By similarity
	Metal binding	102	1	Zinc; catalytic By similarity
	Metal binding	129	1	Zinc; catalytic By similarity
	Metal binding	132	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7MLJ4-1 [UniParc]. Last modified October 2, 2007. Version 1. Checksum: 520A7878C6141D03	FASTA	294	31,350
	10 20 30 40 50 60 MHPRFETAFA QLPAALQAAL APLIADTYFP AMLSAEQVAD VRRQSGLDDD ALAFALLPLA 70 80 90 100 110 120 AACAQTEISH FNVGAVARGL SGNLYFGGNM EFRGAAMQQT IHAEQSAITH AWMRGETGLA 130 140 150 160 170 180 AITVNYTPCG HCRQFMNELN SGLTLRINLP GRAPSQLGDY LPDAFGPRDL DIKTLIFDTE 190 200 210 220 230 240 NHGYALKGDA LTQAAIAAAN RSHAPYSQSP SGLAIETRDG EIFTGSYAEN AAFNPSLPPL 250 260 270 280 290 QAALNLMSLN GYAWADIKRV ALAERDDATI VQRDATAATL KALGFTNLEL VTLA

References

[1]	McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S., Fulton B., Wollam A., Shah N., Pepin K., Bhonagiri V., Nash W., Johnson M., Thiruvilangam P., Wilson R. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000783 Genomic DNA. Translation: ABU76360.1.
RefSeq	YP_001437196.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A7MLJ4.
Genome annotation databases
GeneID	5548445.
GenomeReviews	Gene locus ESA_01092 in contig CP000783_GR.
KEGG	esa:ESA_01092.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	FSPCGHC.
Family and domain databases
HAMAP	MF_01558. [Tree]
InterPro	IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR002125. CMP_dCMP_Zn_bd. IPR013171. Cyd/dCyd_deaminase_Zn_bd. IPR006263. Cyt_deam_dimer. [Graphical view]
Pfam	PF00383. dCMP_cyt_deam_1. 1 hit. PF08211. dCMP_cyt_deam_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01355. cyt_deam_dimer. 1 hit.
PROSITE	PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDD_ENTS8

Accession

Primary (citable) accession number: A7MLJ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 2, 2007
Last modified:	November 3, 2009
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)