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A7ML85

- ASSY_CROS8

UniProt

A7ML85 - ASSY_CROS8

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Protein
Argininosuccinate synthase
Gene
argG, ESA_03807
Organism
Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei92 – 921Citrulline By similarity
Binding sitei97 – 971Citrulline By similarity
Binding sitei122 – 1221ATP; via amide nitrogen By similarity
Binding sitei124 – 1241Aspartate By similarity
Binding sitei128 – 1281Aspartate By similarity
Binding sitei128 – 1281Citrulline By similarity
Binding sitei129 – 1291Aspartate By similarity
Binding sitei132 – 1321Citrulline By similarity
Binding sitei181 – 1811Citrulline By similarity
Binding sitei190 – 1901Citrulline By similarity
Binding sitei266 – 2661Citrulline By similarity
Binding sitei278 – 2781Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 209ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. argininosuccinate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCSAK290339:GJ80-3796-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:ESA_03807
OrganismiCronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Taxonomic identifieri290339 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCronobacter
ProteomesiUP000000260: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405Argininosuccinate synthaseUniRule annotation
PRO_1000000395Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi290339.ESA_03807.

Structurei

3D structure databases

ProteinModelPortaliA7ML85.
SMRiA7ML85. Positions 8-401.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiPWNEPTK.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7ML85-1 [UniParc]FASTAAdd to Basket

« Hide

MQNHGIKKVV LAYSGGLDTS AIIPWLKENY EGCDVVACVV DIGQDRDDLK    50
GVEQKALRSG ASECYVVDAR EEFIKDYVYP VLQTGALYEG SYLLGTSMAR 100
PLIAKALVDV AKKVGADALC HGATGKGNDQ VRFESAWAAL APHLKVIAPW 150
REWNLRSREA LLDYLKARDI PTTASLEKIY SRDENAWHIS TEGGVLESPW 200
NAPNQDCWVW TVDPKDAPDE AEQVTVTVEK GNVVAVNGEQ LTPFGCLEVL 250
NKIGAKHGVG RIDIVENRLV GIKSRGCYET PGGTIMMAAL RGVEQLVLDR 300
DSFKWREQVG LEMSYVVYDG RWFAPLRQSL QAAAQSLAEQ VSGEVVLELY 350
KGRVTAIQKK STNSLYNEEF ATFGEDEVYD HSHAGGFIRL FSLSSRIRAL 400
NELKK 405
Length:405
Mass (Da):44,801
Last modified:October 2, 2007 - v1
Checksum:i25FFA84908623256
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000783 Genomic DNA. Translation: ABU78993.1.
RefSeqiWP_012126069.1. NC_009778.1.
YP_001439829.1. NC_009778.1.

Genome annotation databases

EnsemblBacteriaiABU78993; ABU78993; ESA_03807.
GeneIDi5548188.
KEGGiesa:ESA_03807.
PATRICi20399295. VBICroSak107175_3381.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000783 Genomic DNA. Translation: ABU78993.1 .
RefSeqi WP_012126069.1. NC_009778.1.
YP_001439829.1. NC_009778.1.

3D structure databases

ProteinModelPortali A7ML85.
SMRi A7ML85. Positions 8-401.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290339.ESA_03807.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABU78993 ; ABU78993 ; ESA_03807 .
GeneIDi 5548188.
KEGGi esa:ESA_03807.
PATRICi 20399295. VBICroSak107175_3381.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi PWNEPTK.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci CSAK290339:GJ80-3796-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic hybridization analysis with other Cronobacter species."
    Kucerova E., Clifton S.W., Xia X.Q., Long F., Porwollik S., Fulton L., Fronick C., Minx P., Kyung K., Warren W., Fulton R., Feng D., Wollam A., Shah N., Bhonagiri V., Nash W.E., Hallsworth-Pepin K., Wilson R.K., McClelland M., Forsythe S.J.
    PLoS ONE 5:E9556-E9556(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-894.

Entry informationi

Entry nameiASSY_CROS8
AccessioniPrimary (citable) accession number: A7ML85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: September 3, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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