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Protein

G/U mismatch-specific DNA glycosylase

Gene

mug

Organism
Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells.UniRule annotation

Catalytic activityi

Specifically hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Hydrolase
Biological processDNA damage, DNA excision, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
G/U mismatch-specific DNA glycosylaseUniRule annotation (EC:3.2.2.28UniRule annotation)
Alternative name(s):
Double-strand-specific uracil glycosylaseUniRule annotation
Mismatch-specific uracil DNA-glycosylaseUniRule annotation
Short name:
MUGUniRule annotation
Gene namesi
Name:mugUniRule annotation
Ordered Locus Names:ESA_00353
OrganismiCronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Taxonomic identifieri290339 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeCronobacter
Proteomesi
  • UP000000260 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000707931 – 168G/U mismatch-specific DNA glycosylaseAdd BLAST168

Interactioni

Subunit structurei

Binds DNA as a monomer.UniRule annotation

Protein-protein interaction databases

STRINGi290339.ESA_00353.

Structurei

3D structure databases

ProteinModelPortaliA7MJU3.
SMRiA7MJU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase (UDG) superfamily. TDG/mug family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108VCA. Bacteria.
COG3663. LUCA.
HOGENOMiHOG000264684.
KOiK03649.
OMAiTGHHFAR.

Family and domain databases

CDDicd10028. UDG_F2_MUG. 1 hit.
Gene3Di3.40.470.10. 1 hit.
HAMAPiMF_01956. MUG. 1 hit.
InterProiView protein in InterPro
IPR015637. MUG/TDG.
IPR023502. MUG_bact.
IPR005122. Uracil-DNA_glycosylase-like.
PfamiView protein in Pfam
PF03167. UDG. 1 hit.
SUPFAMiSSF52141. SSF52141. 1 hit.

Sequencei

Sequence statusi: Complete.

A7MJU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINDILEPGL RVVFCGINPG KSSAHTGFHF AHPGNRFWKV IHLAGFTDRQ
60 70 80 90 100
LKPEEERHLL DTRCGITKLV ERPTVQANEV DVKELHEGGR NLIKKIEDFQ
110 120 130 140 150
PDALAVLGKK AYEQAFSQRG VKWGKQKLKI GKTEIWVLPN PSGLNRASLD
160
KLVEAYRELD DALVARGR
Length:168
Mass (Da):18,945
Last modified:October 2, 2007 - v1
Checksum:i936D752F05FD6246
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000783 Genomic DNA. Translation: ABU75651.1.
RefSeqiWP_004385589.1. NC_009778.1.

Genome annotation databases

EnsemblBacteriaiABU75651; ABU75651; ESA_00353.
GeneIDi29460173.
KEGGiesa:ESA_00353.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMUG_CROS8
AccessioniPrimary (citable) accession number: A7MJU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 2, 2007
Last modified: June 7, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families