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Protein

Putative sialic acid transporter

Gene

nanT

Organism
Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

May be a sugar-cation symporter involved in sialic acid uptake.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Putative sialic acid transporterUniRule annotation
Alternative name(s):
Sialic acid permeaseUniRule annotation
Gene namesi
Name:nanTUniRule annotation
Ordered Locus Names:ESA_03611
OrganismiCronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Taxonomic identifieri290339 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeCronobacter
Proteomesi
  • UP000000260 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalUniRule annotationAdd BLAST21
Transmembranei58 – 78HelicalUniRule annotationAdd BLAST21
Transmembranei86 – 106HelicalUniRule annotationAdd BLAST21
Transmembranei116 – 136HelicalUniRule annotationAdd BLAST21
Transmembranei148 – 168HelicalUniRule annotationAdd BLAST21
Transmembranei170 – 190HelicalUniRule annotationAdd BLAST21
Transmembranei224 – 244HelicalUniRule annotationAdd BLAST21
Transmembranei247 – 267HelicalUniRule annotationAdd BLAST21
Transmembranei278 – 298HelicalUniRule annotationAdd BLAST21
Transmembranei316 – 336HelicalUniRule annotationAdd BLAST21
Transmembranei355 – 375HelicalUniRule annotationAdd BLAST21
Transmembranei406 – 426HelicalUniRule annotationAdd BLAST21
Transmembranei431 – 451HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002140531 – 496Putative sialic acid transporterAdd BLAST496

Expressioni

Inductioni

By N-acetylneuraminate.UniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi290339.ESA_03611.

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily. Sugar transporter family. Sialic acid transporter (TC 2.A.1.12.1) subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105JHE. Bacteria.
ENOG410XSSD. LUCA.
HOGENOMiHOG000074791.
KOiK03290.
OMAiIGYLLDG.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01238. MFS_NanT. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004742. SA_transporter.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00891. 2A0112. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7MJD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKTTQLIPW YRHLNRAQWR AFSAAWLGYL LDGFDFVLIA LVLTEIQDEF
60 70 80 90 100
GLTTIQAASL ISAAFISRWF GGLMLGAMGD RYGRRLAMIS SIVLFSVGTL
110 120 130 140 150
ACGLAPGYTT LFIARLVIGI GMAGEYGASA TYVIESWPKA LRNKASGFLI
160 170 180 190 200
SGFSVGAVVA AFVYSLVVPV WGWRALFFIG ILPIVFALWL RKNIPEAHDW
210 220 230 240 250
EARRSEKTPV RTMVDILYRG EHRVINIVLT LLASVSLWLC FTGELNSAVI
260 270 280 290 300
VAALGLVCAA IFISFMVQSS GPRWPTGVTL MVIVLFAFLY SWPIQALLPT
310 320 330 340 350
YLKTELAYEP ATVARVLFFS GFGAAVGCCV GGFLGDWLGT RRAYVYSLLA
360 370 380 390 400
SQVLIIPVFA IGGANVWVLG LLLFFQQMLG QGISGILPKL IGGYFDTDQR
410 420 430 440 450
AAGLGFTYNV GALGGALAPV LGALIAERLH LGAALCSLSF GLTFVVVLLI
460 470 480 490
GLDMPSRVQR WLRPEALRTH DATDGKPLSG AQAVSGRKRG LVKSKS
Length:496
Mass (Da):53,695
Last modified:October 2, 2007 - v1
Checksum:i23D4778468AA4F25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000783 Genomic DNA. Translation: ABU78821.1.
RefSeqiWP_012125979.1. NC_009778.1.

Genome annotation databases

EnsemblBacteriaiABU78821; ABU78821; ESA_03611.
GeneIDi5550624.
KEGGiesa:ESA_03611.
PATRICi20398912. VBICroSak107175_3215.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000783 Genomic DNA. Translation: ABU78821.1.
RefSeqiWP_012125979.1. NC_009778.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290339.ESA_03611.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABU78821; ABU78821; ESA_03611.
GeneIDi5550624.
KEGGiesa:ESA_03611.
PATRICi20398912. VBICroSak107175_3215.

Phylogenomic databases

eggNOGiENOG4105JHE. Bacteria.
ENOG410XSSD. LUCA.
HOGENOMiHOG000074791.
KOiK03290.
OMAiIGYLLDG.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01238. MFS_NanT. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004742. SA_transporter.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00891. 2A0112. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNANT_CROS8
AccessioniPrimary (citable) accession number: A7MJD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: October 2, 2007
Last modified: November 2, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.