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A7MJ60

- SURE_CROS8

UniProt

A7MJ60 - SURE_CROS8

Protein

5'/3'-nucleotidase SurE

Gene

surE

Organism
Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.UniRule annotation

    Catalytic activityi

    A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation
    A 3'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation
    (Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate.UniRule annotation

    Cofactori

    Binds 1 divalent metal cation per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi8 – 81Divalent metal cationUniRule annotation
    Metal bindingi9 – 91Divalent metal cationUniRule annotation
    Metal bindingi39 – 391Divalent metal cationUniRule annotation
    Metal bindingi92 – 921Divalent metal cationUniRule annotation

    GO - Molecular functioni

    1. 3'-nucleotidase activity Source: UniProtKB-HAMAP
    2. 5'-nucleotidase activity Source: UniProtKB-HAMAP
    3. exopolyphosphatase activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-HAMAP
    5. nucleotide binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCSAK290339:GJ80-542-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5'/3'-nucleotidase SurEUniRule annotation (EC:3.1.3.5UniRule annotation, EC:3.1.3.6UniRule annotation)
    Alternative name(s):
    ExopolyphosphataseUniRule annotation (EC:3.6.1.11UniRule annotation)
    Nucleoside monophosphate phosphohydrolaseUniRule annotation
    Gene namesi
    Name:surEUniRule annotation
    Ordered Locus Names:ESA_00547
    OrganismiCronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
    Taxonomic identifieri290339 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCronobacter
    ProteomesiUP000000260: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2532535'/3'-nucleotidase SurEPRO_1000007730Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi290339.ESA_00547.

    Structurei

    3D structure databases

    ProteinModelPortaliA7MJ60.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SurE nucleotidase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0496.
    HOGENOMiHOG000122500.
    KOiK03787.
    OMAiVCDLIPK.
    OrthoDBiEOG68WR45.

    Family and domain databases

    Gene3Di3.40.1210.10. 1 hit.
    HAMAPiMF_00060. SurE.
    InterProiIPR002828. SurE-like_Pase/nucleotidase.
    [Graphical view]
    PfamiPF01975. SurE. 1 hit.
    [Graphical view]
    SUPFAMiSSF64167. SSF64167. 1 hit.
    TIGRFAMsiTIGR00087. surE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7MJ60-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRILLSNDDG IHAPGIQALA KALREFAEVQ VVAPDRNRSG ASNSLTLESS    50
    LRTFTYPNGD IAVQMGTPTD CVFLGVNALM RPRPDVVVSG INAGPNLGDD 100
    VIYSGTVAAA MEGRHLGLPA LAVSLNGHEH YETAAAVTCT LLRALAREPL 150
    RTGRILNINV PDLPLEEIKG IRVTRCGSRH PADKVIPQDD PRGNTLYWIG 200
    PPGEKLDAGP DTDFAAVDEG YVSVTPLHVD LTAHSAQDVV TRWLSSAGVN 250
    GQW 253
    Length:253
    Mass (Da):26,970
    Last modified:October 2, 2007 - v1
    Checksum:iD182FF06AC0273B6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000783 Genomic DNA. Translation: ABU75838.1.
    RefSeqiYP_001436674.1. NC_009778.1.

    Genome annotation databases

    EnsemblBacteriaiABU75838; ABU75838; ESA_00547.
    GeneIDi5551718.
    KEGGiesa:ESA_00547.
    PATRICi20393346. VBICroSak107175_0491.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000783 Genomic DNA. Translation: ABU75838.1 .
    RefSeqi YP_001436674.1. NC_009778.1.

    3D structure databases

    ProteinModelPortali A7MJ60.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290339.ESA_00547.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABU75838 ; ABU75838 ; ESA_00547 .
    GeneIDi 5551718.
    KEGGi esa:ESA_00547.
    PATRICi 20393346. VBICroSak107175_0491.

    Phylogenomic databases

    eggNOGi COG0496.
    HOGENOMi HOG000122500.
    KOi K03787.
    OMAi VCDLIPK.
    OrthoDBi EOG68WR45.

    Enzyme and pathway databases

    BioCyci CSAK290339:GJ80-542-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1210.10. 1 hit.
    HAMAPi MF_00060. SurE.
    InterProi IPR002828. SurE-like_Pase/nucleotidase.
    [Graphical view ]
    Pfami PF01975. SurE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64167. SSF64167. 1 hit.
    TIGRFAMsi TIGR00087. surE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic hybridization analysis with other Cronobacter species."
      Kucerova E., Clifton S.W., Xia X.Q., Long F., Porwollik S., Fulton L., Fronick C., Minx P., Kyung K., Warren W., Fulton R., Feng D., Wollam A., Shah N., Bhonagiri V., Nash W.E., Hallsworth-Pepin K., Wilson R.K., McClelland M., Forsythe S.J.
      PLoS ONE 5:E9556-E9556(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-894.

    Entry informationi

    Entry nameiSURE_CROS8
    AccessioniPrimary (citable) accession number: A7MJ60
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3