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Protein

5'/3'-nucleotidase SurE

Gene

surE

Organism
Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.UniRule annotation

Catalytic activityi

A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation
A 3'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation
(Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate.UniRule annotation

Cofactori

a divalent metal cationUniRule annotationNote: Binds 1 divalent metal cation per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8Divalent metal cationUniRule annotation1
Metal bindingi9Divalent metal cationUniRule annotation1
Metal bindingi39Divalent metal cationUniRule annotation1
Metal bindingi92Divalent metal cationUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
5'/3'-nucleotidase SurEUniRule annotation (EC:3.1.3.5UniRule annotation, EC:3.1.3.6UniRule annotation)
Alternative name(s):
ExopolyphosphataseUniRule annotation (EC:3.6.1.11UniRule annotation)
Nucleoside monophosphate phosphohydrolaseUniRule annotation
Gene namesi
Name:surEUniRule annotation
Ordered Locus Names:ESA_00547
OrganismiCronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Taxonomic identifieri290339 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeCronobacter
Proteomesi
  • UP000000260 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000077301 – 2535'/3'-nucleotidase SurEAdd BLAST253

Proteomic databases

PRIDEiA7MJ60

Interactioni

Protein-protein interaction databases

STRINGi290339.ESA_00547

Structurei

3D structure databases

ProteinModelPortaliA7MJ60
SMRiA7MJ60
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SurE nucleotidase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CV2 Bacteria
COG0496 LUCA
HOGENOMiHOG000122500
KOiK03787
OMAiDCVHIAL

Family and domain databases

Gene3Di3.40.1210.10, 1 hit
HAMAPiMF_00060 SurE, 1 hit
InterProiView protein in InterPro
IPR030048 SurE
IPR002828 SurE-like_Pase/nucleotidase
IPR036523 SurE-like_sf
PfamiView protein in Pfam
PF01975 SurE, 1 hit
TIGRFAMsiTIGR00087 surE, 1 hit

Sequencei

Sequence statusi: Complete.

A7MJ60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRILLSNDDG IHAPGIQALA KALREFAEVQ VVAPDRNRSG ASNSLTLESS
60 70 80 90 100
LRTFTYPNGD IAVQMGTPTD CVFLGVNALM RPRPDVVVSG INAGPNLGDD
110 120 130 140 150
VIYSGTVAAA MEGRHLGLPA LAVSLNGHEH YETAAAVTCT LLRALAREPL
160 170 180 190 200
RTGRILNINV PDLPLEEIKG IRVTRCGSRH PADKVIPQDD PRGNTLYWIG
210 220 230 240 250
PPGEKLDAGP DTDFAAVDEG YVSVTPLHVD LTAHSAQDVV TRWLSSAGVN

GQW
Length:253
Mass (Da):26,970
Last modified:October 2, 2007 - v1
Checksum:iD182FF06AC0273B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000783 Genomic DNA Translation: ABU75838.1
RefSeqiWP_007777731.1, NC_009778.1

Genome annotation databases

EnsemblBacteriaiABU75838; ABU75838; ESA_00547
GeneIDi29456481
KEGGiesa:ESA_00547

Similar proteinsi

Entry informationi

Entry nameiSURE_CROS8
AccessioniPrimary (citable) accession number: A7MJ60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: May 23, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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