A7MIZ2 (6PGL_CROS8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
6-phosphogluconolactonase
Short name=6-P-gluconolactonase
EC=3.1.1.31

Gene names

Name:	pgl
Ordered Locus Names:	ESA_02577

Organism

Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii) [Complete proteome] [HAMAP]

Taxonomic identifier

290339 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Cronobacter

Protein attributes

Sequence length	333 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate By similarity. HAMAP MF_01605
Catalytic activity	6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate. HAMAP MF_01605
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3. HAMAP MF_01605
Sequence similarities	Belongs to the cycloisomerase 2 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Glucose metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pentose-phosphate shunt Inferred from electronic annotation. Source: InterPro
Molecular function	6-phosphogluconolactonase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 333	333	6-phosphogluconolactonase HAMAP MF_01605		PRO_1000069411

Sequences

	Sequence		Length	Mass (Da)
	A7MIZ2 [UniParc]. Last modified October 2, 2007. Version 1. Checksum: 1E0B2C3A4D87178D	FASTA	333	36,107
	10 20 30 40 50 60 MKQTVYTASP ESQQIHVWRL EPQGTLTLLQ VVDAPGQVQP MVISPDKRFL YVGVRPEFRV 70 80 90 100 110 120 IAYRIAAHDG TLSEAGEAPL PGSPTHISTD HTGRFLFSGS YNAGSVSVVR LNDGLPGETV 130 140 150 160 170 180 TVVEGLEGCH SANISPDNRT LWVPALKQDR ICLFTLTDDG HLEPQTPAEV TTVAGAGPRH 190 200 210 220 230 240 MVFHPSKPFA YCVNELNSSV DVWALSDPHG NIECVQTLDM MPADFSDTRW AADIHITPDG 250 260 270 280 290 300 RHLYACDRTA SVITVFTVSE DGSVLAVQGH QPTETQPRGF NIDNSGQYLI AAGQKSHHIA 310 320 330 VYGIEGEQGL LAEKGRYAVG QGPMWVVINA FDA

References

[1]

"Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic hybridization analysis with other Cronobacter species." Kucerova E., Clifton S.W., Xia X.Q., Long F., Porwollik S., Fulton L., Fronick C., Minx P., Kyung K., Warren W., Fulton R., Feng D., Wollam A., Shah N., Bhonagiri V., Nash W.E., Hallsworth-Pepin K., Wilson R.K., McClelland M., Forsythe S.J. PLoS ONE 5:E9556-E9556(2010) [PubMed: 20221447] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-894.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000783 Genomic DNA. Translation: ABU77822.1.
RefSeq	YP_001438658.1. NC_009778.1.
3D structure databases
ProteinModelPortal	A7MIZ2.
SMR	A7MIZ2. Positions 1-332.
ModBase	Search...
Protein-protein interaction databases
STRING	A7MIZ2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5549467.
GenomeReviews	Gene locus ESA_02577 in contig CP000783_GR.
KEGG	esa:ESA_02577.
PATRIC	20397027. VBICroSak107175_2298.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2706.
HOGENOM	HBG741123.
OMA	CINELNS.
ProtClustDB	PRK11028.
Family and domain databases
HAMAP	MF_01605. 6P-gluconolactonase. [Tree]
InterPro	IPR022528. 6-phosphogluconolactonase_YbhE. IPR019405. Lactonase_7-beta_prop. IPR011045. N2O_reductase_N. IPR015943. WD40/YVTN_repeat-like_dom. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
KO	K07404.
Pfam	PF10282. Lactonase. 1 hit. [Graphical view]
SUPFAM	SSF50974. N2O_reductase_N. 1 hit.
ProtoNet	Search...

Entry information

Entry name

6PGL_CROS8

Accession

Primary (citable) accession number: A7MIZ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 2, 2007
Last modified:	January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program