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Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.UniRule annotation

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (ESA_01189)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism, Glucose metabolism

Enzyme and pathway databases

UniPathwayiUPA00115; UER00409

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonaseUniRule annotation (EC:3.1.1.31UniRule annotation)
Short name:
6-P-gluconolactonaseUniRule annotation
Gene namesi
Name:pglUniRule annotation
Ordered Locus Names:ESA_02577
OrganismiCronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Taxonomic identifieri290339 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeCronobacter
Proteomesi
  • UP000000260 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000694111 – 3336-phosphogluconolactonaseAdd BLAST333

Interactioni

Protein-protein interaction databases

STRINGi290339.ESA_02577

Structurei

3D structure databases

ProteinModelPortaliA7MIZ2
SMRiA7MIZ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cycloisomerase 2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105HHQ Bacteria
COG2706 LUCA
HOGENOMiHOG000257418
KOiK07404
OMAiEGNWPRD

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_01605 6P_gluconolactonase, 1 hit
InterProiView protein in InterPro
IPR022528 6-phosphogluconolactonase_YbhE
IPR019405 Lactonase_7-beta_prop
IPR011045 N2O_reductase_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF10282 Lactonase, 1 hit
SUPFAMiSSF50974 SSF50974, 1 hit

Sequencei

Sequence statusi: Complete.

A7MIZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQTVYTASP ESQQIHVWRL EPQGTLTLLQ VVDAPGQVQP MVISPDKRFL
60 70 80 90 100
YVGVRPEFRV IAYRIAAHDG TLSEAGEAPL PGSPTHISTD HTGRFLFSGS
110 120 130 140 150
YNAGSVSVVR LNDGLPGETV TVVEGLEGCH SANISPDNRT LWVPALKQDR
160 170 180 190 200
ICLFTLTDDG HLEPQTPAEV TTVAGAGPRH MVFHPSKPFA YCVNELNSSV
210 220 230 240 250
DVWALSDPHG NIECVQTLDM MPADFSDTRW AADIHITPDG RHLYACDRTA
260 270 280 290 300
SVITVFTVSE DGSVLAVQGH QPTETQPRGF NIDNSGQYLI AAGQKSHHIA
310 320 330
VYGIEGEQGL LAEKGRYAVG QGPMWVVINA FDA
Length:333
Mass (Da):36,107
Last modified:October 2, 2007 - v1
Checksum:i1E0B2C3A4D87178D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000783 Genomic DNA Translation: ABU77822.1
RefSeqiWP_007888520.1, NC_009778.1

Genome annotation databases

EnsemblBacteriaiABU77822; ABU77822; ESA_02577
GeneIDi29460448
KEGGiesa:ESA_02577

Similar proteinsi

Entry informationi

Entry namei6PGL_CROS8
AccessioniPrimary (citable) accession number: A7MIZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 2, 2007
Last modified: March 28, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health