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Protein

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase

Gene

menH

Organism
Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).UniRule annotation

Catalytic activityi

5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate.UniRule annotation

Pathwayi: 1,4-dihydroxy-2-naphthoate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate.UniRule annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. Isochorismate synthase MenF (menF)
  2. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (menD)
  3. 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (menH)
  4. o-succinylbenzoate synthase (menC)
  5. no protein annotated in this organism
  6. 1,4-dihydroxy-2-naphthoyl-CoA synthase (menB)
  7. 1,4-dihydroxy-2-naphthoyl-CoA hydrolase (menI)
This subpathway is part of the pathway 1,4-dihydroxy-2-naphthoate biosynthesis, which is itself part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate, the pathway 1,4-dihydroxy-2-naphthoate biosynthesis and in Quinol/quinone metabolism.

Pathwayi: menaquinone biosynthesis

This protein is involved in the pathway menaquinone biosynthesis, which is part of Quinol/quinone metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processMenaquinone biosynthesis

Enzyme and pathway databases

BioCyciCSAK290339:G1G9O-898-MONOMER
UniPathwayiUPA00079
UPA01057; UER00900

Protein family/group databases

ESTHERients8-menh MenH_SHCHC

Names & Taxonomyi

Protein namesi
Recommended name:
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthaseUniRule annotation (EC:4.2.99.20UniRule annotation)
Short name:
SHCHC synthaseUniRule annotation
Gene namesi
Name:menHUniRule annotation
Ordered Locus Names:ESA_00950
OrganismiCronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Taxonomic identifieri290339 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeCronobacter
Proteomesi
  • UP000000260 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003419021 – 2542-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthaseAdd BLAST254

Proteomic databases

PRIDEiA7MHU5

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi290339.ESA_00950

Structurei

3D structure databases

ProteinModelPortaliA7MHU5
SMRiA7MHU5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. MenH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107J5P Bacteria
COG0596 LUCA
HOGENOMiHOG000028072
KOiK08680
OMAiLNDWYQQ

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
HAMAPiMF_01660 MenH, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
IPR022485 SHCHC_synthase_MenH
PfamiView protein in Pfam
PF12697 Abhydrolase_6, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
TIGRFAMsiTIGR03695 menH_SHCHC, 1 hit

Sequencei

Sequence statusi: Complete.

A7MHU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLTAYFQPA RAAARGTVVW LHGFLGDHRE WQTVAAACVE HNHLFIDLPG
60 70 80 90 100
HGGSAHLCAV DFAHVNEQLI ATLNSYNILE YWLVGYSLGG RIAMFHATQG
110 120 130 140 150
NTPGLRGLVV EGGHPGLLNA DERDARFVAD KQWAQRFHDE PIETVLDAWY
160 170 180 190 200
RQPVFATLTD AQRQELITLR ACNAPTALAT MLEATSPGRQ PPLYEPLARL
210 220 230 240 250
SVPFHYLCGE RDAKFRALAA TLNVPLHLIT GAGHNAHREN PAAVACCLNA

ILRP
Length:254
Mass (Da):27,893
Last modified:October 2, 2007 - v1
Checksum:i4220CAE49FCB26DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000783 Genomic DNA Translation: ABU76220.1
RefSeqiWP_012124167.1, NC_009778.1

Genome annotation databases

EnsemblBacteriaiABU76220; ABU76220; ESA_00950
KEGGiesa:ESA_00950
PATRICifig|290339.8.peg.848

Similar proteinsi

Entry informationi

Entry nameiMENH_CROS8
AccessioniPrimary (citable) accession number: A7MHU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: October 2, 2007
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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