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A7MGS7

- A7MGS7_CROS8

UniProt

A7MGS7 - A7MGS7_CROS8

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Protein

Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)

Gene
uppS, ESA_03168
Organism
Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide By similarity.UniRule annotation

Catalytic activityi

(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = 8 diphosphate + di-trans,octa-cis-undecaprenyl diphosphate.UniRule annotation

Cofactori

Binds 2 magnesium ions per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi25 – 251Magnesium By similarityUniRule annotation
Binding sitei30 – 301Substrate By similarityUniRule annotation
Binding sitei38 – 381Substrate By similarityUniRule annotation
Binding sitei42 – 421Substrate By similarityUniRule annotation
Active sitei73 – 731Proton acceptor By similarityUniRule annotation
Binding sitei74 – 741Substrate By similarityUniRule annotation
Binding sitei76 – 761Substrate By similarityUniRule annotation
Binding sitei193 – 1931Substrate By similarityUniRule annotation
Metal bindingi198 – 1981Magnesium By similarityUniRule annotation
Metal bindingi212 – 2121Magnesium By similarityUniRule annotation

GO - Molecular functioni

  1. di-trans,poly-cis-decaprenylcistransferase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  2. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciCSAK290339:GJ80-3158-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)UniRule annotation (EC:2.5.1.31UniRule annotation)
Alternative name(s):
Ditrans,polycis-undecaprenylcistransferase
Undecaprenyl diphosphate synthase
Undecaprenyl pyrophosphate synthase
Gene namesi
Name:uppSUniRule annotation
Ordered Locus Names:ESA_03168Imported
OrganismiCronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)Imported
Taxonomic identifieri290339 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCronobacter
ProteomesiUP000000260: Chromosome

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi290339.ESA_03168.

Structurei

3D structure databases

ProteinModelPortaliA7MGS7.
SMRiA7MGS7. Positions 9-239.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0020.
HOGENOMiHOG000006054.
KOiK00806.
OMAiNRPEQEV.
OrthoDBiEOG68H89T.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7MGS7-1 [UniParc]FASTAAdd to Basket

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MLSVNLPLSE NLPAHGARHV AIIMDGNGRW AKRQGKIRAF GHKAGAKSVR    50
RAVSFAANNG IEALTLYAFS SENWNRPAQE VSALMELFVW ALDSEVKSLH 100
RHNVRLRVIG DISRFNTRLQ DRIHKAEALT SQNTGLTLNI AANYGGRWDI 150
IQGVQQLAAQ VQEGLLRPDQ IDEEMLSKQI CMHELAPVDL VIRTGGEHRI 200
SNFLLWQIAY AELYFTDVLW PDFDEQDFEG ALNAFANRER RFGGTAPGGI 250
DA 252
Length:252
Mass (Da):28,187
Last modified:October 2, 2007 - v1
Checksum:i0434C816186E1178
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000783 Genomic DNA. Translation: ABU78391.1.
RefSeqiYP_001439227.1. NC_009778.1.

Genome annotation databases

EnsemblBacteriaiABU78391; ABU78391; ESA_03168.
GeneIDi5549566.
KEGGiesa:ESA_03168.
PATRICi20398069. VBICroSak107175_2799.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000783 Genomic DNA. Translation: ABU78391.1 .
RefSeqi YP_001439227.1. NC_009778.1.

3D structure databases

ProteinModelPortali A7MGS7.
SMRi A7MGS7. Positions 9-239.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290339.ESA_03168.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABU78391 ; ABU78391 ; ESA_03168 .
GeneIDi 5549566.
KEGGi esa:ESA_03168.
PATRICi 20398069. VBICroSak107175_2799.

Phylogenomic databases

eggNOGi COG0020.
HOGENOMi HOG000006054.
KOi K00806.
OMAi NRPEQEV.
OrthoDBi EOG68H89T.

Enzyme and pathway databases

BioCyci CSAK290339:GJ80-3158-MONOMER.

Family and domain databases

Gene3Di 3.40.1180.10. 1 hit.
HAMAPi MF_01139. ISPT.
InterProi IPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view ]
PANTHERi PTHR10291. PTHR10291. 1 hit.
Pfami PF01255. Prenyltransf. 1 hit.
[Graphical view ]
SUPFAMi SSF64005. SSF64005. 1 hit.
TIGRFAMsi TIGR00055. uppS. 1 hit.
PROSITEi PS01066. UPP_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic hybridization analysis with other Cronobacter species."
    Kucerova E., Clifton S.W., Xia X.Q., Long F., Porwollik S., Fulton L., Fronick C., Minx P., Kyung K., Warren W., Fulton R., Feng D., Wollam A., Shah N., Bhonagiri V., Nash W.E., Hallsworth-Pepin K., Wilson R.K., McClelland M., Forsythe S.J.
    PLoS ONE 5:E9556-E9556(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-894Imported.

Entry informationi

Entry nameiA7MGS7_CROS8
AccessioniPrimary (citable) accession number: A7MGS7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: June 11, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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