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Protein

Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)

Gene

uppS

Organism
Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.UniRule annotation

Catalytic activityi

(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = 8 diphosphate + di-trans,octa-cis-undecaprenyl diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi25 – 251MagnesiumUniRule annotation
Binding sitei30 – 301SubstrateUniRule annotation
Binding sitei38 – 381SubstrateUniRule annotation
Binding sitei42 – 421SubstrateUniRule annotation
Active sitei73 – 731Proton acceptorUniRule annotation
Binding sitei74 – 741SubstrateUniRule annotation
Binding sitei76 – 761SubstrateUniRule annotation
Binding sitei193 – 1931SubstrateUniRule annotation
Metal bindingi198 – 1981MagnesiumUniRule annotation
Metal bindingi212 – 2121MagnesiumUniRule annotation

GO - Molecular functioni

  1. di-trans,poly-cis-decaprenylcistransferase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  3. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciCSAK290339:GJ80-3158-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)UniRule annotation (EC:2.5.1.31UniRule annotation)
Alternative name(s):
Ditrans,polycis-undecaprenylcistransferaseUniRule annotation
Undecaprenyl diphosphate synthaseUniRule annotation
Undecaprenyl pyrophosphate synthaseUniRule annotation
Gene namesi
Name:uppSUniRule annotation
Ordered Locus Names:ESA_03168Imported
OrganismiCronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)Imported
Taxonomic identifieri290339 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCronobacter
ProteomesiUP000000260: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi290339.ESA_03168.

Structurei

3D structure databases

ProteinModelPortaliA7MGS7.
SMRiA7MGS7. Positions 9-239.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0020.
HOGENOMiHOG000006054.
KOiK00806.
OMAiYQNRERR.
OrthoDBiEOG68H89T.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7MGS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSVNLPLSE NLPAHGARHV AIIMDGNGRW AKRQGKIRAF GHKAGAKSVR
60 70 80 90 100
RAVSFAANNG IEALTLYAFS SENWNRPAQE VSALMELFVW ALDSEVKSLH
110 120 130 140 150
RHNVRLRVIG DISRFNTRLQ DRIHKAEALT SQNTGLTLNI AANYGGRWDI
160 170 180 190 200
IQGVQQLAAQ VQEGLLRPDQ IDEEMLSKQI CMHELAPVDL VIRTGGEHRI
210 220 230 240 250
SNFLLWQIAY AELYFTDVLW PDFDEQDFEG ALNAFANRER RFGGTAPGGI

DA
Length:252
Mass (Da):28,187
Last modified:October 2, 2007 - v1
Checksum:i0434C816186E1178
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000783 Genomic DNA. Translation: ABU78391.1.
RefSeqiYP_001439227.1. NC_009778.1.

Genome annotation databases

EnsemblBacteriaiABU78391; ABU78391; ESA_03168.
GeneIDi5549566.
KEGGiesa:ESA_03168.
PATRICi20398069. VBICroSak107175_2799.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000783 Genomic DNA. Translation: ABU78391.1.
RefSeqiYP_001439227.1. NC_009778.1.

3D structure databases

ProteinModelPortaliA7MGS7.
SMRiA7MGS7. Positions 9-239.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290339.ESA_03168.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABU78391; ABU78391; ESA_03168.
GeneIDi5549566.
KEGGiesa:ESA_03168.
PATRICi20398069. VBICroSak107175_2799.

Phylogenomic databases

eggNOGiCOG0020.
HOGENOMiHOG000006054.
KOiK00806.
OMAiYQNRERR.
OrthoDBiEOG68H89T.

Enzyme and pathway databases

BioCyciCSAK290339:GJ80-3158-MONOMER.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic hybridization analysis with other Cronobacter species."
    Kucerova E., Clifton S.W., Xia X.Q., Long F., Porwollik S., Fulton L., Fronick C., Minx P., Kyung K., Warren W., Fulton R., Feng D., Wollam A., Shah N., Bhonagiri V., Nash W.E., Hallsworth-Pepin K., Wilson R.K., McClelland M., Forsythe S.J.
    PLoS ONE 5:E9556-E9556(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-894Imported.

Entry informationi

Entry nameiA7MGS7_CROS8
AccessioniPrimary (citable) accession number: A7MGS7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: January 7, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.