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A7MGS7

- A7MGS7_CROS8

UniProt

A7MGS7 - A7MGS7_CROS8

Protein

Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)

Gene

uppS

Organism
Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.UniRule annotation

    Catalytic activityi

    (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = 8 diphosphate + di-trans,octa-cis-undecaprenyl diphosphate.UniRule annotation

    Cofactori

    Binds 2 magnesium ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi25 – 251MagnesiumUniRule annotation
    Binding sitei30 – 301SubstrateUniRule annotation
    Binding sitei38 – 381SubstrateUniRule annotation
    Binding sitei42 – 421SubstrateUniRule annotation
    Active sitei73 – 731Proton acceptorUniRule annotation
    Binding sitei74 – 741SubstrateUniRule annotation
    Binding sitei76 – 761SubstrateUniRule annotation
    Binding sitei193 – 1931SubstrateUniRule annotation
    Metal bindingi198 – 1981MagnesiumUniRule annotation
    Metal bindingi212 – 2121MagnesiumUniRule annotation

    GO - Molecular functioni

    1. di-trans,poly-cis-decaprenylcistransferase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
    2. regulation of cell shape Source: UniProtKB-KW

    Keywords - Molecular functioni

    TransferaseUniRule annotation

    Keywords - Biological processi

    Cell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciCSAK290339:GJ80-3158-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)UniRule annotation (EC:2.5.1.31UniRule annotation)
    Alternative name(s):
    Ditrans,polycis-undecaprenylcistransferaseUniRule annotation
    Undecaprenyl diphosphate synthaseUniRule annotation
    Undecaprenyl pyrophosphate synthaseUniRule annotation
    Gene namesi
    Name:uppSUniRule annotation
    Ordered Locus Names:ESA_03168Imported
    OrganismiCronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)Imported
    Taxonomic identifieri290339 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCronobacter
    ProteomesiUP000000260: Chromosome

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi290339.ESA_03168.

    Structurei

    3D structure databases

    ProteinModelPortaliA7MGS7.
    SMRiA7MGS7. Positions 9-239.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UPP synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0020.
    HOGENOMiHOG000006054.
    KOiK00806.
    OMAiNRPEQEV.
    OrthoDBiEOG68H89T.

    Family and domain databases

    Gene3Di3.40.1180.10. 1 hit.
    HAMAPiMF_01139. ISPT.
    InterProiIPR001441. UPP_synth-like.
    IPR018520. UPP_synth-like_CS.
    [Graphical view]
    PANTHERiPTHR10291. PTHR10291. 1 hit.
    PfamiPF01255. Prenyltransf. 1 hit.
    [Graphical view]
    SUPFAMiSSF64005. SSF64005. 1 hit.
    TIGRFAMsiTIGR00055. uppS. 1 hit.
    PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7MGS7-1 [UniParc]FASTAAdd to Basket

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    MLSVNLPLSE NLPAHGARHV AIIMDGNGRW AKRQGKIRAF GHKAGAKSVR    50
    RAVSFAANNG IEALTLYAFS SENWNRPAQE VSALMELFVW ALDSEVKSLH 100
    RHNVRLRVIG DISRFNTRLQ DRIHKAEALT SQNTGLTLNI AANYGGRWDI 150
    IQGVQQLAAQ VQEGLLRPDQ IDEEMLSKQI CMHELAPVDL VIRTGGEHRI 200
    SNFLLWQIAY AELYFTDVLW PDFDEQDFEG ALNAFANRER RFGGTAPGGI 250
    DA 252
    Length:252
    Mass (Da):28,187
    Last modified:October 2, 2007 - v1
    Checksum:i0434C816186E1178
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000783 Genomic DNA. Translation: ABU78391.1.
    RefSeqiYP_001439227.1. NC_009778.1.

    Genome annotation databases

    EnsemblBacteriaiABU78391; ABU78391; ESA_03168.
    GeneIDi5549566.
    KEGGiesa:ESA_03168.
    PATRICi20398069. VBICroSak107175_2799.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000783 Genomic DNA. Translation: ABU78391.1 .
    RefSeqi YP_001439227.1. NC_009778.1.

    3D structure databases

    ProteinModelPortali A7MGS7.
    SMRi A7MGS7. Positions 9-239.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290339.ESA_03168.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABU78391 ; ABU78391 ; ESA_03168 .
    GeneIDi 5549566.
    KEGGi esa:ESA_03168.
    PATRICi 20398069. VBICroSak107175_2799.

    Phylogenomic databases

    eggNOGi COG0020.
    HOGENOMi HOG000006054.
    KOi K00806.
    OMAi NRPEQEV.
    OrthoDBi EOG68H89T.

    Enzyme and pathway databases

    BioCyci CSAK290339:GJ80-3158-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1180.10. 1 hit.
    HAMAPi MF_01139. ISPT.
    InterProi IPR001441. UPP_synth-like.
    IPR018520. UPP_synth-like_CS.
    [Graphical view ]
    PANTHERi PTHR10291. PTHR10291. 1 hit.
    Pfami PF01255. Prenyltransf. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64005. SSF64005. 1 hit.
    TIGRFAMsi TIGR00055. uppS. 1 hit.
    PROSITEi PS01066. UPP_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic hybridization analysis with other Cronobacter species."
      Kucerova E., Clifton S.W., Xia X.Q., Long F., Porwollik S., Fulton L., Fronick C., Minx P., Kyung K., Warren W., Fulton R., Feng D., Wollam A., Shah N., Bhonagiri V., Nash W.E., Hallsworth-Pepin K., Wilson R.K., McClelland M., Forsythe S.J.
      PLoS ONE 5:E9556-E9556(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-894Imported.

    Entry informationi

    Entry nameiA7MGS7_CROS8
    AccessioniPrimary (citable) accession number: A7MGS7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 2, 2007
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3