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Protein

Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)

Gene

uppS

Organism
Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.UniRule annotation

Catalytic activityi

(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = 8 diphosphate + di-trans,octa-cis-undecaprenyl diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei25UniRule annotation1
Metal bindingi25MagnesiumUniRule annotation1
Binding sitei30SubstrateUniRule annotation1
Binding sitei38SubstrateUniRule annotation1
Binding sitei42SubstrateUniRule annotation1
Active sitei73Proton acceptorUniRule annotation1
Binding sitei74SubstrateUniRule annotation1
Binding sitei76SubstrateUniRule annotation1
Binding sitei193SubstrateUniRule annotation1
Metal bindingi198MagnesiumUniRule annotation1
Metal bindingi212MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotation
Biological processCell shape, Cell wall biogenesis/degradationUniRule annotation, Peptidoglycan synthesisUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)UniRule annotation (EC:2.5.1.31UniRule annotation)
Alternative name(s):
Ditrans,polycis-undecaprenylcistransferaseUniRule annotation
Undecaprenyl diphosphate synthaseUniRule annotation
Short name:
UDSUniRule annotation
Undecaprenyl pyrophosphate synthaseUniRule annotation
Short name:
UPP synthaseUniRule annotation
Gene namesi
Name:uppSUniRule annotation
Ordered Locus Names:ESA_03168Imported
OrganismiCronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)Imported
Taxonomic identifieri290339 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeCronobacter
Proteomesi
  • UP000000260 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi290339.ESA_03168.

Structurei

3D structure databases

ProteinModelPortaliA7MGS7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CR3. Bacteria.
COG0020. LUCA.
HOGENOMiHOG000006054.
KOiK00806.
OMAiWAKLKNK.

Family and domain databases

CDDicd00475. Cis_IPPS. 1 hit.
Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT. 1 hit.
InterProiView protein in InterPro
IPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiView protein in Pfam
PF01255. Prenyltransf. 1 hit.
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiView protein in PROSITE
PS01066. UPP_SYNTHASE. 1 hit.

Sequencei

Sequence statusi: Complete.

A7MGS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSVNLPLSE NLPAHGARHV AIIMDGNGRW AKRQGKIRAF GHKAGAKSVR
60 70 80 90 100
RAVSFAANNG IEALTLYAFS SENWNRPAQE VSALMELFVW ALDSEVKSLH
110 120 130 140 150
RHNVRLRVIG DISRFNTRLQ DRIHKAEALT SQNTGLTLNI AANYGGRWDI
160 170 180 190 200
IQGVQQLAAQ VQEGLLRPDQ IDEEMLSKQI CMHELAPVDL VIRTGGEHRI
210 220 230 240 250
SNFLLWQIAY AELYFTDVLW PDFDEQDFEG ALNAFANRER RFGGTAPGGI

DA
Length:252
Mass (Da):28,187
Last modified:October 2, 2007 - v1
Checksum:i0434C816186E1178
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000783 Genomic DNA. Translation: ABU78391.1.
RefSeqiWP_004386134.1. NC_009778.1.

Genome annotation databases

EnsemblBacteriaiABU78391; ABU78391; ESA_03168.
GeneIDi29459218.
KEGGiesa:ESA_03168.
PATRICi20398069. VBICroSak107175_2799.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000783 Genomic DNA. Translation: ABU78391.1.
RefSeqiWP_004386134.1. NC_009778.1.

3D structure databases

ProteinModelPortaliA7MGS7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290339.ESA_03168.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABU78391; ABU78391; ESA_03168.
GeneIDi29459218.
KEGGiesa:ESA_03168.
PATRICi20398069. VBICroSak107175_2799.

Phylogenomic databases

eggNOGiENOG4105CR3. Bacteria.
COG0020. LUCA.
HOGENOMiHOG000006054.
KOiK00806.
OMAiWAKLKNK.

Family and domain databases

CDDicd00475. Cis_IPPS. 1 hit.
Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT. 1 hit.
InterProiView protein in InterPro
IPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiView protein in Pfam
PF01255. Prenyltransf. 1 hit.
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiView protein in PROSITE
PS01066. UPP_SYNTHASE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA7MGS7_CROS8
AccessioniPrimary (citable) accession number: A7MGS7
Entry historyiIntegrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: May 10, 2017
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.