A7MGA7 (RSMC_CROS8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribosomal RNA small subunit methyltransferase C
EC=2.1.1.172

Alternative name(s):
16S rRNA m2G1207 methyltransferase
rRNA (guanine-N(2)-)-methyltransferase RsmC

Gene names

Name:	rsmC
Ordered Locus Names:	ESA_03381

Organism

Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii) [Complete proteome] [HAMAP]

Taxonomic identifier

290339 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Cronobacter

Protein attributes

Sequence length	342 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Specifically methylates the guanosine in position 1207 of 16S rRNA in the 30S particle By similarity. HAMAP MF_01862
Catalytic activity	S-adenosyl-L-methionine + guanosine(1207) in 16S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanosine(1207) in 16S rRNA. HAMAP MF_01862
Subunit structure	Monomer By similarity. HAMAP MF_01862
Subcellular location	Cytoplasm Potential HAMAP MF_01862.
Sequence similarities	Belongs to the methyltransferase superfamily. RsmC family.

Ontologies

Keywords
Biological process	rRNA processing
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nucleic acid binding Inferred from electronic annotation. Source: InterPro rRNA (guanine-N2-)-methyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 342	342	Ribosomal RNA small subunit methyltransferase C HAMAP MF_01862		PRO_0000369694

Sequences

	Sequence		Length	Mass (Da)
	A7MGA7 [UniParc]. Last modified October 2, 2007. Version 1. Checksum: 355B55CC26C33362	FASTA	342	37,460
	10 20 30 40 50 60 MSGFSPASEV LLRHSDDFTE SRVLFAGDMQ DDLPARFDTA QSRAHTQQFH HWQVLSKPMG 70 80 90 100 110 120 DNARYGLVAD AEIVADSDTL IYYWPKNKPE AQFQLMNLLS LLPVGTDVFV VGENRSGVRS 130 140 150 160 170 180 AEAMLEAHCP LNKVDSARRC GLYHGRLEKQ PEFNADGWWG EYQVDDLTIK TLPGVFSRDG 190 200 210 220 230 240 LDVGSDLLLS TLSPHTKGKV LDVGCGAGVL AAVLASHSPK VRLTLCDVSA PAVEASRATL 250 260 270 280 290 300 AANGFEGEVV ASNVFSEIKG RFDMIISNPP FHDGMETSFE AAQTLIRSAV RHLNIGGELR 310 320 330 340 IVANAFLPYP NVLDETFGNH EVLAQTGRFK VYRAVMGRNA KR

References

[1]

"Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic hybridization analysis with other Cronobacter species." Kucerova E., Clifton S.W., Xia X.Q., Long F., Porwollik S., Fulton L., Fronick C., Minx P., Kyung K., Warren W., Fulton R., Feng D., Wollam A., Shah N., Bhonagiri V., Nash W.E., Hallsworth-Pepin K., Wilson R.K., McClelland M., Forsythe S.J. PLoS ONE 5:E9556-E9556(2010) [PubMed: 20221447] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-894.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000783 Genomic DNA. Translation: ABU78602.1.
RefSeq	YP_001439438.1. NC_009778.1.
3D structure databases
ProteinModelPortal	A7MGA7.
SMR	A7MGA7. Positions 3-336.
ModBase	Search...
Protein-protein interaction databases
STRING	A7MGA7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5550963.
GenomeReviews	Gene locus ESA_03381 in contig CP000783_GR.
KEGG	esa:ESA_03381.
PATRIC	20398478. VBICroSak107175_3004.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2813.
HOGENOM	HBG296757.
OMA	TGKFKVY.
ProtClustDB	PRK09489.
Family and domain databases
HAMAP	MF_01862. 16SrRNA_methyltr_C. [Tree]
InterPro	IPR002052. DNA_methylase_N6_adenine_CS. IPR013675. Mtase_sm_N. IPR023543. rRNA_ssu_MeTfrase_C. IPR007848. Small_mtfrase. [Graphical view]
KO	K00564.
Pfam	PF05175. MTS. 1 hit. PF08468. MTS_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RSMC_CROS8

Accession

Primary (citable) accession number: A7MGA7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	October 2, 2007
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program