Dihydroorotase - Enterobacter sakazakii (strain ATCC BAA-894)

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Reviewed, UniProtKB/Swiss-Prot A7MG30 (PYRC_ENTS8)

Last modified June 16, 2009. Version 12. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
    Dihydroorotase
      Short name=DHOase
    EC=3.5.2.3

Gene names

Name:	pyrC
Ordered Locus Names:	ESA_02286

Organism

Enterobacter sakazakii (strain ATCC BAA-894) [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Cronobacter

Protein attributes

Sequence length	348 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(S)-dihydroorotate + H₂O = N-carbamoyl-L-aspartate. HAMAP MF_00219
Cofactor	Binds 2 zinc ions per subunit By similarity.
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 3/6. HAMAP MF_00219
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the DHOase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	dihydroorotase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

348

Dihydroorotase HAMAP MF_00219

PRO_1000024012

Sites

Metal binding

1

Zinc 1 By similarity

Metal binding

1

Zinc 1 By similarity

Metal binding

1

Zinc 1; via carbamate group By similarity

Metal binding

1

Zinc 2; via carbamate group By similarity

Metal binding

1

Zinc 2 By similarity

Metal binding

1

Zinc 2 By similarity

Metal binding

1

Zinc 1 By similarity

Amino acid modifications

Modified residue

1

N6-carboxylysine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

A7MG30-1 [UniParc].

Last modified October 2, 2007. Version 1.
Checksum: 7E2E81788657B6B2
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348

38,591

        10         20         30         40         50         60 
MTAQPQVLTI RRPDDWHVHL RDGDMLKTVV PYTSETYGRA IVMPNLAPPV TTVEAAIAYR 

        70         80         90        100        110        120 
QRILDAVPEH HAFEPLMTCY LTDTLDADEL ERGFQQGVFT AAKLYPANAT TNSSHGVTSV 

       130        140        150        160        170        180 
DNIMTVLERM EKLGMPLLVH GEVTHSEVDI FDREARFIET VMEPLRKRLQ GLKVVFEHIT 

       190        200        210        220        230        240 
TKDAADYVRE GNSLLGATIT PQHLMFNRNH MLAGGIRPHL YCLPILKRNV HQQALRELVA 

       250        260        270        280        290        300 
SGCERVFLGT DSAPHARHRK ETSCGCAGCF NAPSALGAYA TVFEEMNALA HFEAFASLNG 

       310        320        330        340 
PGFYGLPVNE GTVTLVREES VMPETIAIAD DTLVPFLAGE AVRWTVKR

References

[1]	McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S., Fulton B., Wollam A., Shah N., Pepin K., Bhonagiri V., Nash W., Johnson M., Thiruvilangam P., Wilson R. Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
	CP000783 Genomic DNA. Translation: ABU77535.1.
RefSeq	YP_001438371.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5551627.
GenomeReviews	Gene locus ESA_02286 in contig CP000783_GR.
KEGG	esa:ESA_02286.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A7MG30. IMPNLVP.
Family and domain databases
HAMAP	MF_00219. [Tree]
InterPro	IPR006680. Amidohydro_1. IPR004721. DHOdimr. IPR002195. Dihydroorotase_CS. [Graphical view]
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
PIRSF	PIRSF001237. DHOdimr. 1 hit.
TIGRFAMs	TIGR00856. pyrC_dimer. 1 hit.
PROSITE	PS00482. DIHYDROOROTASE_1. 1 hit. PS00483. DIHYDROOROTASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRC_ENTS8

Accession

Primary (citable) accession number: A7MG30

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	October 2, 2007
Last modified:	June 16, 2009
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents