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A7MFC3 (MDTK_CROS8) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Multidrug resistance protein MdtK
Alternative name(s):
Multidrug-efflux transporter
Gene names
Name:mdtK
Ordered Locus Names:ESA_02027
OrganismCronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii) [Complete proteome] [HAMAP]
Taxonomic identifier290339 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCronobacter

Protein attributes

Sequence length457 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Multidrug efflux pump that functions probably as a Na+/drug antiporter By similarity. HAMAP-Rule MF_00400

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00400.

Sequence similarities

Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily. [View classification]

Ontologies

Keywords
   Biological processAntiport
Ion transport
Sodium transport
Transport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandSodium
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processsodium ion transport

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionantiporter activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

drug transmembrane transporter activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 457457Multidrug resistance protein MdtK HAMAP-Rule MF_00400
PRO_1000049613

Regions

Transmembrane11 – 3121Helical; Potential
Transmembrane53 – 7321Helical; Potential
Transmembrane93 – 11321Helical; Potential
Transmembrane127 – 14721Helical; Potential
Transmembrane160 – 18021Helical; Potential
Transmembrane188 – 20821Helical; Potential
Transmembrane243 – 26321Helical; Potential
Transmembrane276 – 29621Helical; Potential
Transmembrane316 – 33621Helical; Potential
Transmembrane357 – 37721Helical; Potential
Transmembrane387 – 40721Helical; Potential
Transmembrane418 – 43821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A7MFC3 [UniParc].

Last modified October 2, 2007. Version 1.
Checksum: 09AA5D7782CEFD1A

FASTA45749,941
        10         20         30         40         50         60 
MQKYFVEARQ LLALAIPVIF AQIAQTSMGV VDTVMAGGYS ATDMAAVAIG TSIWLPAILF 

        70         80         90        100        110        120 
GHGLLLALTP VIAQLNGSGR RDRIAHQVQQ GFVLAGLVSV LIMLVLWNAG YIIHAMHNID 

       130        140        150        160        170        180 
PVLANKAVNY LRALLWGAPG YLFFQVMRNQ CEGLAKTTPG MAMGFIGLLV NIPVNYIFIY 

       190        200        210        220        230        240 
GHFGMPELGG VGCGVATASV YWVMFFCMRF WVKRAGSMRD IRPEPASRRF DWPVIRRLAQ 

       250        260        270        280        290        300 
IGMPVALALF FEVTLFAVVA LLVSPLGIVD VAGHQIALNF SSLMFVLPMS MSAAVTIRVG 

       310        320        330        340        350        360 
FRLGQGSTLE AQTSARTGII VGICLAVLTA LFTVVFREPI ALLYNDNPEV VTLASHLMLL 

       370        380        390        400        410        420 
AAIYQISDSI QVIGSGVLRG YKDTRSIFFI TFIAYWVLGL PSGYILGLTD WVVEPMGPAG 

       430        440        450 
FWFGFILGLT SAAIMMMWRM RYLQRQPSET ILARAAR 

« Hide

References

[1]"Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic hybridization analysis with other Cronobacter species."
Kucerova E., Clifton S.W., Xia X.Q., Long F., Porwollik S., Fulton L., Fronick C., Minx P., Kyung K., Warren W., Fulton R., Feng D., Wollam A., Shah N., Bhonagiri V., Nash W.E., Hallsworth-Pepin K., Wilson R.K., McClelland M., Forsythe S.J.
PLoS ONE 5:E9556-E9556(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-894.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000783 Genomic DNA. Translation: ABU77280.1.
RefSeqYP_001438116.1. NC_009778.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING290339.ESA_02027.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABU77280; ABU77280; ESA_02027.
GeneID5549796.
KEGGesa:ESA_02027.
PATRIC20396041. VBICroSak107175_1810.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0534.
HOGENOMHOG000038538.
KOK03327.
OMAGGVGCGW.
OrthoDBEOG6423C5.

Enzyme and pathway databases

BioCycCSAK290339:GJ80-2022-MONOMER.

Family and domain databases

HAMAPMF_00400. MdtK.
InterProIPR002528. MATE.
IPR022913. Multidrug-R_MdtK.
[Graphical view]
PfamPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsTIGR00797. matE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMDTK_CROS8
AccessionPrimary (citable) accession number: A7MFC3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: May 14, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families