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A7MFC3

- MDTK_CROS8

UniProt

A7MFC3 - MDTK_CROS8

Protein

Multidrug resistance protein MdtK

Gene

mdtK

Organism
Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Multidrug efflux pump that functions probably as a Na+/drug antiporter.UniRule annotation

    GO - Molecular functioni

    1. antiporter activity Source: UniProtKB-HAMAP
    2. drug transmembrane transporter activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. sodium ion transport Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Antiport, Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Sodium

    Enzyme and pathway databases

    BioCyciCSAK290339:GJ80-2022-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Multidrug resistance protein MdtKUniRule annotation
    Alternative name(s):
    Multidrug-efflux transporterUniRule annotation
    Gene namesi
    Name:mdtKUniRule annotation
    Ordered Locus Names:ESA_02027
    OrganismiCronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
    Taxonomic identifieri290339 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCronobacter
    ProteomesiUP000000260: Chromosome

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 457457Multidrug resistance protein MdtKPRO_1000049613Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi290339.ESA_02027.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalUniRule annotationAdd
    BLAST
    Transmembranei53 – 7321HelicalUniRule annotationAdd
    BLAST
    Transmembranei93 – 11321HelicalUniRule annotationAdd
    BLAST
    Transmembranei127 – 14721HelicalUniRule annotationAdd
    BLAST
    Transmembranei160 – 18021HelicalUniRule annotationAdd
    BLAST
    Transmembranei188 – 20821HelicalUniRule annotationAdd
    BLAST
    Transmembranei243 – 26321HelicalUniRule annotationAdd
    BLAST
    Transmembranei276 – 29621HelicalUniRule annotationAdd
    BLAST
    Transmembranei316 – 33621HelicalUniRule annotationAdd
    BLAST
    Transmembranei357 – 37721HelicalUniRule annotationAdd
    BLAST
    Transmembranei387 – 40721HelicalUniRule annotationAdd
    BLAST
    Transmembranei418 – 43821HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily. [View classification]UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0534.
    HOGENOMiHOG000038538.
    KOiK03327.
    OMAiGGVGCGW.
    OrthoDBiEOG6423C5.

    Family and domain databases

    HAMAPiMF_00400. MdtK.
    InterProiIPR002528. MATE.
    IPR022913. Multidrug-R_MdtK.
    [Graphical view]
    PfamiPF01554. MatE. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00797. matE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7MFC3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQKYFVEARQ LLALAIPVIF AQIAQTSMGV VDTVMAGGYS ATDMAAVAIG    50
    TSIWLPAILF GHGLLLALTP VIAQLNGSGR RDRIAHQVQQ GFVLAGLVSV 100
    LIMLVLWNAG YIIHAMHNID PVLANKAVNY LRALLWGAPG YLFFQVMRNQ 150
    CEGLAKTTPG MAMGFIGLLV NIPVNYIFIY GHFGMPELGG VGCGVATASV 200
    YWVMFFCMRF WVKRAGSMRD IRPEPASRRF DWPVIRRLAQ IGMPVALALF 250
    FEVTLFAVVA LLVSPLGIVD VAGHQIALNF SSLMFVLPMS MSAAVTIRVG 300
    FRLGQGSTLE AQTSARTGII VGICLAVLTA LFTVVFREPI ALLYNDNPEV 350
    VTLASHLMLL AAIYQISDSI QVIGSGVLRG YKDTRSIFFI TFIAYWVLGL 400
    PSGYILGLTD WVVEPMGPAG FWFGFILGLT SAAIMMMWRM RYLQRQPSET 450
    ILARAAR 457
    Length:457
    Mass (Da):49,941
    Last modified:October 2, 2007 - v1
    Checksum:i09AA5D7782CEFD1A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000783 Genomic DNA. Translation: ABU77280.1.
    RefSeqiWP_012124929.1. NC_009778.1.
    YP_001438116.1. NC_009778.1.

    Genome annotation databases

    EnsemblBacteriaiABU77280; ABU77280; ESA_02027.
    GeneIDi5549796.
    KEGGiesa:ESA_02027.
    PATRICi20396041. VBICroSak107175_1810.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000783 Genomic DNA. Translation: ABU77280.1 .
    RefSeqi WP_012124929.1. NC_009778.1.
    YP_001438116.1. NC_009778.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290339.ESA_02027.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABU77280 ; ABU77280 ; ESA_02027 .
    GeneIDi 5549796.
    KEGGi esa:ESA_02027.
    PATRICi 20396041. VBICroSak107175_1810.

    Phylogenomic databases

    eggNOGi COG0534.
    HOGENOMi HOG000038538.
    KOi K03327.
    OMAi GGVGCGW.
    OrthoDBi EOG6423C5.

    Enzyme and pathway databases

    BioCyci CSAK290339:GJ80-2022-MONOMER.

    Family and domain databases

    HAMAPi MF_00400. MdtK.
    InterProi IPR002528. MATE.
    IPR022913. Multidrug-R_MdtK.
    [Graphical view ]
    Pfami PF01554. MatE. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00797. matE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic hybridization analysis with other Cronobacter species."
      Kucerova E., Clifton S.W., Xia X.Q., Long F., Porwollik S., Fulton L., Fronick C., Minx P., Kyung K., Warren W., Fulton R., Feng D., Wollam A., Shah N., Bhonagiri V., Nash W.E., Hallsworth-Pepin K., Wilson R.K., McClelland M., Forsythe S.J.
      PLoS ONE 5:E9556-E9556(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-894.

    Entry informationi

    Entry nameiMDTK_CROS8
    AccessioniPrimary (citable) accession number: A7MFC3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3