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A7MFA8

- BETA_CROS8

UniProt

A7MFA8 - BETA_CROS8

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Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei473 – 4731UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 3330FADUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciCSAK290339:GJ80-2044-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Ordered Locus Names:ESA_02049
OrganismiCronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Taxonomic identifieri290339 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCronobacter
ProteomesiUP000000260: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Oxygen-dependent choline dehydrogenasePRO_1000046563Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290339.ESA_02049.

Structurei

3D structure databases

ProteinModelPortaliA7MFA8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiYLQYACT.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7MFA8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEFDYIIIGA GSAGNVLATR LTEDSDVTVL LLEAGGPDYR FDFRTQMPAA
60 70 80 90 100
LAYPLQGKRY NWAYETEPEP YMNNRRMECG RGKGLGGSSL INGMCYIRGN
110 120 130 140 150
AMDLDNWAQQ PGLERWTYLD CLPYYRKSET RDIGANDYHG GDGPVSITTC
160 170 180 190 200
KPGNNPLFAA MIEAGVQAGY PRTDDLNGYQ QEGFGPMDRF VTPKGRRSST
210 220 230 240 250
ARGYLDTAKQ RPNLKIITHA TTDRILFENK RAVGVAYLHG ASNTPQEVHA
260 270 280 290 300
RREVLLCAGA IASPQILQRS GVGNAELLKQ FDIPVVHDLP GVGENLQDHL
310 320 330 340 350
EMYLQYECKE PVSLYPALKW WNQPKIGAEW LFNGTGIGAS NHFEGGGFIR
360 370 380 390 400
SREEFAWPNI QYHFLPVAIN YNGSNAVEAH GFQCHVGSMR SPSRGHVRIK
410 420 430 440 450
SRDPHQHPAI LFNYMSHEQD WQEFRDAIRI TRQIINQPAL DKFRGREISP
460 470 480 490 500
GIDCQTDEQL DEFVRNHAET AYHPCGTCKM GSDEMAVVDD EGRVHGLEGL
510 520 530 540 550
RVVDASIMPL IITGNLNATT IMIGEKIADN IRGRTPLPRS TASYFVAGDR

PVRGEPLRP
Length:559
Mass (Da):62,376
Last modified:October 2, 2007 - v1
Checksum:i9429724C56A48C06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000783 Genomic DNA. Translation: ABU77300.1.
RefSeqiWP_012124948.1. NC_009778.1.
YP_001438136.1. NC_009778.1.

Genome annotation databases

EnsemblBacteriaiABU77300; ABU77300; ESA_02049.
GeneIDi5549303.
KEGGiesa:ESA_02049.
PATRICi20396077. VBICroSak107175_1826.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000783 Genomic DNA. Translation: ABU77300.1 .
RefSeqi WP_012124948.1. NC_009778.1.
YP_001438136.1. NC_009778.1.

3D structure databases

ProteinModelPortali A7MFA8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290339.ESA_02049.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABU77300 ; ABU77300 ; ESA_02049 .
GeneIDi 5549303.
KEGGi esa:ESA_02049.
PATRICi 20396077. VBICroSak107175_1826.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi YLQYACT.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci CSAK290339:GJ80-2044-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic hybridization analysis with other Cronobacter species."
    Kucerova E., Clifton S.W., Xia X.Q., Long F., Porwollik S., Fulton L., Fronick C., Minx P., Kyung K., Warren W., Fulton R., Feng D., Wollam A., Shah N., Bhonagiri V., Nash W.E., Hallsworth-Pepin K., Wilson R.K., McClelland M., Forsythe S.J.
    PLoS ONE 5:E9556-E9556(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-894.

Entry informationi

Entry nameiBETA_CROS8
AccessioniPrimary (citable) accession number: A7MFA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: November 26, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3