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Protein

HTH-type transcriptional regulator MalT

Gene

malT

Organism
Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Binds and recognizes a DNA motif (called the malT box): 5'-GGA[TG]GA-3'.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi39 – 468ATPUniRule annotation
DNA bindingi853 – 87220H-T-H motifUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Carbohydrate metabolism, Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCSAK290339:GJ80-4310-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator MalTUniRule annotation
Alternative name(s):
ATP-dependent transcriptional activator MalTUniRule annotation
Gene namesi
Name:malTUniRule annotation
Ordered Locus Names:ESA_04320
OrganismiCronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Taxonomic identifieri290339 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeCronobacter
Proteomesi
  • UP000000260 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 901901HTH-type transcriptional regulator MalTPRO_1000085772Add
BLAST

Interactioni

Subunit structurei

Monomer in solution but oligomerizes to an active state in the presence of the positive effectors ATP and maltotriose.UniRule annotation

Protein-protein interaction databases

STRINGi290339.ESA_04320.

Structurei

3D structure databases

ProteinModelPortaliA7ME76.
SMRiA7ME76. Positions 438-803.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini829 – 89466HTH luxR-typeUniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH luxR-type DNA-binding domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG41061ZR. Bacteria.
COG2909. LUCA.
HOGENOMiHOG000218261.
KOiK03556.
OMAiSDWVSNA.

Family and domain databases

CDDicd06170. LuxR_C_like. 1 hit.
Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 1 hit.
HAMAPiMF_01247. HTH_type_MalT. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR011990. TPR-like_helical_dom.
IPR023768. Tscrpt_reg_HTH_MalT.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00196. GerE. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF48452. SSF48452. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7ME76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIPSKLSRP VRLEHTVVRE RLLAKLSGAS NYRLALITSP AGYGKTTLIS
60 70 80 90 100
QWAAGKTELG WYSLDEGDNQ PERFASYLIA AIQQATGGHC ASSEVMAQKR
110 120 130 140 150
QYASLSSLFA QLFIELAAWP RPLFLVIDDY HLITNPVIHE AMRFFLRHQP
160 170 180 190 200
DHLTLVVLSR NLPQLGIANL RVREQLLEIG SQQLAFTHQE ARQFFDCRLS
210 220 230 240 250
QPIEPAQSNR LCDDVAGWAT ALQLIALSAR QNTGAVHQSA RRLAGINASH
260 270 280 290 300
LSDYLVDEVL NNVDNDTRQF LLKSALLRSM NDALIARVTG EENGQMRLEE
310 320 330 340 350
IERQGLFLQR MDDSGEWFSY HPLFGSFLRQ RCQWELSTEL PDIHRAAAES
360 370 380 390 400
WMAQGFPSEA IHHALAAGDA SMLRDILLNH AWGLFNHSEL TLLEQSLKAL
410 420 430 440 450
PWESLLANPR LVLLQAWLMQ SQHRYSEVNT LLARAEQEMK GEMDDTLHGE
460 470 480 490 500
FNALRAQVAI NDGDPDEAER LAMVALETLP LANFYSRIVA TSVHGEVLHC
510 520 530 540 550
KGDLTKSLSV MQQTELMARR HDVWHYALWS LIQQSEILFA QGFLQAAWET
560 570 580 590 600
QEKAFTLIQE QHLEQLPLHE FLLRIRAQLL WAWARLDEAE ACARTGMTVL
610 620 630 640 650
ANYQPQQQLQ CLALLVQCSL ARGDLDNARS HLNRLENLLG NGHYHSDWVS
660 670 680 690 700
NADKVRVIYW QMTGDKAAAA AWLRQTPKPA FANNHFLQSQ WRNIARVQIL
710 720 730 740 750
LGDYEPAEMV LEELNENARS LRLMSDINRN LLLLNQLYWN AGRKSDAQRV
760 770 780 790 800
LMEALTLANR TGFISHFVIE GEAMAQQLRQ LLQLNTLPEI EQHRAQRILR
810 820 830 840 850
DINQHHRHKF AHFDENFVNK LLNHPEVPEL IRTSPLTQRE WQVLGLIYSG
860 870 880 890 900
YSNDQIAGEL DVAATTIKTH IRNLYQKLGV AHRQDAVQHA QQLLKMMGYG

V
Length:901
Mass (Da):102,610
Last modified:October 2, 2007 - v1
Checksum:i9BDC56FBE85985D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000783 Genomic DNA. Translation: ABU79499.1.
RefSeqiWP_012126376.1. NC_009778.1.

Genome annotation databases

EnsemblBacteriaiABU79499; ABU79499; ESA_04320.
GeneIDi5552379.
KEGGiesa:ESA_04320.
PATRICi20400239. VBICroSak107175_3847.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000783 Genomic DNA. Translation: ABU79499.1.
RefSeqiWP_012126376.1. NC_009778.1.

3D structure databases

ProteinModelPortaliA7ME76.
SMRiA7ME76. Positions 438-803.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290339.ESA_04320.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABU79499; ABU79499; ESA_04320.
GeneIDi5552379.
KEGGiesa:ESA_04320.
PATRICi20400239. VBICroSak107175_3847.

Phylogenomic databases

eggNOGiENOG41061ZR. Bacteria.
COG2909. LUCA.
HOGENOMiHOG000218261.
KOiK03556.
OMAiSDWVSNA.

Enzyme and pathway databases

BioCyciCSAK290339:GJ80-4310-MONOMER.

Family and domain databases

CDDicd06170. LuxR_C_like. 1 hit.
Gene3Di1.10.10.10. 1 hit.
1.25.40.10. 1 hit.
HAMAPiMF_01247. HTH_type_MalT. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR011990. TPR-like_helical_dom.
IPR023768. Tscrpt_reg_HTH_MalT.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00196. GerE. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF48452. SSF48452. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMALT_CROS8
AccessioniPrimary (citable) accession number: A7ME76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 2, 2007
Last modified: September 7, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.