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Protein

Serine/arginine repetitive matrix protein 4

Gene

SRRM4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Splicing factor specifically required for neural cell differentiation. Acts in conjuction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation, mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/arginine repetitive matrix protein 4
Alternative name(s):
Medulloblastoma antigen MU-MB-2.76
Neural-specific serine/arginine repetitive splicing factor of 100 kDa
Short name:
Neural-specific SR-related protein of 100 kDa
Short name:
nSR100
Gene namesi
Name:SRRM4
Synonyms:KIAA1853
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:29389. SRRM4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165513415.

Polymorphism and mutation databases

BioMutaiSRRM4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 611611Serine/arginine repetitive matrix protein 4PRO_0000311911Add
BLAST

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA7MD48.
PRIDEiA7MD48.

PTM databases

iPTMnetiA7MD48.
PhosphoSiteiA7MD48.

Expressioni

Tissue specificityi

Specifically expressed in neuronal cells (at protein level). Expressed in the cerebellum.2 Publications

Gene expression databases

BgeeiA7MD48.
CleanExiHS_KIAA1853.
ExpressionAtlasiA7MD48. baseline and differential.
GenevisibleiA7MD48. HS.

Organism-specific databases

HPAiHPA052783.

Interactioni

Protein-protein interaction databases

BioGridi124121. 1 interaction.
IntActiA7MD48. 1 interaction.
STRINGi9606.ENSP00000267260.

Structurei

3D structure databases

ProteinModelPortaliA7MD48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi109 – 17163Lys-richAdd
BLAST
Compositional biasi123 – 608486Ser-richAdd
BLAST
Compositional biasi442 – 598157Arg-richAdd
BLAST

Sequence similaritiesi

Belongs to the nSR100 family.Curated

Phylogenomic databases

eggNOGiENOG410IEGN. Eukaryota.
ENOG4112C96. LUCA.
HOGENOMiHOG000013098.
HOVERGENiHBG108046.
InParanoidiA7MD48.
OMAiPCLECAE.
OrthoDBiEOG7BCNCC.
PhylomeDBiA7MD48.

Family and domain databases

InterProiIPR029360. SRRM_C.
[Graphical view]
PfamiPF15230. SRRM_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7MD48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVQQGEKQ LFEKFWRGTF KAVATPRPES IIVASITARK PLPRTEPQNN
60 70 80 90 100
PVVPAQDGPS EKLGQHLATE PLGTNSWERD KTCRELGATR GHSASHDKDL
110 120 130 140 150
TPPPSSRGKK KKKKSTRKKR RRSSSYSPSP VKKKKKKSSK KHKRRRSFSK
160 170 180 190 200
KRRHSSSSPK SKRRDEKRHK KQSRSRPRKS HRHRHHRCPS RSQSSESRPS
210 220 230 240 250
SCESRHRGRS PEEGQKSRRR HSRRCSKTLC KDSPEAQSSR PPSQPLQMLG
260 270 280 290 300
YLSARGVITG SGSAADLFTK TASPLTTSRG RSQEYDSGND TSSPPSTQTS
310 320 330 340 350
SARSRGQEKG SPSGGLSKSR ELNSGNTSDS GNSFTTSSPQ NKGAMLENLS
360 370 380 390 400
PTSRGRESRG FQSPCLECAE VKKSSLVPST ARSSPMKGCS RSSSYASTRS
410 420 430 440 450
SSHSSRSPNP RASPRYTQSR STSSEKRSYS RSPSYSSKSG KRSPPSRSSR
460 470 480 490 500
SRRSPSYSRY SPSRERDPKY SEKDSQQRER ERARRRRRSY SPMRKRRRDS
510 520 530 540 550
PSHLEARRIT SARKRPIPYY RPSPSSSGSL SSTSSWYSSS SSRSASRSYS
560 570 580 590 600
RSRSRSRSRR RSRTRTSSSS SSRSPSPGSR SRSRSRSRSR SRSRSQSRSY
610
SSADSYSSTR R
Length:611
Mass (Da):68,559
Last modified:December 15, 2009 - v2
Checksum:i2D8B551D7C9DE43D
GO

Sequence cautioni

The sequence BAB47482.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti553 – 5531R → W in BAB47482 (PubMed:11347906).Curated
Sequence conflicti553 – 5531R → W in AAI52472 (PubMed:15489334).Curated
Sequence conflicti553 – 5531R → W in AAI67162 (PubMed:15489334).Curated
Sequence conflicti553 – 5531R → W in AAI67163 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti243 – 2431S → N.
Corresponds to variant rs7297606 [ dbSNP | Ensembl ].
VAR_037339
Natural varianti406 – 4061R → Q.
Corresponds to variant rs2723880 [ dbSNP | Ensembl ].
VAR_037340
Natural varianti547 – 5471R → S.
Corresponds to variant rs2555273 [ dbSNP | Ensembl ].
VAR_037341

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058756 mRNA. Translation: BAB47482.1. Different initiation.
AK291361 mRNA. Translation: BAF84050.1.
AC087885 Genomic DNA. No translation available.
AC084361 Genomic DNA. No translation available.
BC152471 mRNA. Translation: AAI52472.1.
BC167162 mRNA. Translation: AAI67162.1.
BC167163 mRNA. Translation: AAI67163.1.
AY130006 mRNA. Translation: AAN05090.1.
CCDSiCCDS44994.1.
RefSeqiNP_919262.2. NM_194286.3.
UniGeneiHs.744964.

Genome annotation databases

EnsembliENST00000267260; ENSP00000267260; ENSG00000139767.
GeneIDi84530.
KEGGihsa:84530.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058756 mRNA. Translation: BAB47482.1. Different initiation.
AK291361 mRNA. Translation: BAF84050.1.
AC087885 Genomic DNA. No translation available.
AC084361 Genomic DNA. No translation available.
BC152471 mRNA. Translation: AAI52472.1.
BC167162 mRNA. Translation: AAI67162.1.
BC167163 mRNA. Translation: AAI67163.1.
AY130006 mRNA. Translation: AAN05090.1.
CCDSiCCDS44994.1.
RefSeqiNP_919262.2. NM_194286.3.
UniGeneiHs.744964.

3D structure databases

ProteinModelPortaliA7MD48.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124121. 1 interaction.
IntActiA7MD48. 1 interaction.
STRINGi9606.ENSP00000267260.

PTM databases

iPTMnetiA7MD48.
PhosphoSiteiA7MD48.

Polymorphism and mutation databases

BioMutaiSRRM4.

Proteomic databases

PaxDbiA7MD48.
PRIDEiA7MD48.

Protocols and materials databases

DNASUi84530.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267260; ENSP00000267260; ENSG00000139767.
GeneIDi84530.
KEGGihsa:84530.

Organism-specific databases

CTDi84530.
GeneCardsiSRRM4.
H-InvDBHIX0011050.
HGNCiHGNC:29389. SRRM4.
HPAiHPA052783.
MIMi613103. gene.
neXtProtiNX_A7MD48.
PharmGKBiPA165513415.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEGN. Eukaryota.
ENOG4112C96. LUCA.
HOGENOMiHOG000013098.
HOVERGENiHBG108046.
InParanoidiA7MD48.
OMAiPCLECAE.
OrthoDBiEOG7BCNCC.
PhylomeDBiA7MD48.

Miscellaneous databases

ChiTaRSiSRRM4. human.
GenomeRNAii84530.
PROiA7MD48.
SOURCEiSearch...

Gene expression databases

BgeeiA7MD48.
CleanExiHS_KIAA1853.
ExpressionAtlasiA7MD48. baseline and differential.
GenevisibleiA7MD48. HS.

Family and domain databases

InterProiIPR029360. SRRM_C.
[Graphical view]
PfamiPF15230. SRRM_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 522-611, TISSUE SPECIFICITY.
    Tissue: Medulloblastoma.
  5. "Regulation of vertebrate nervous system alternative splicing and development by an SR-related protein."
    Calarco J.A., Superina S., O'Hanlon D., Gabut M., Raj B., Pan Q., Skalska U., Clarke L., Gelinas D., van der Kooy D., Zhen M., Ciruna B., Blencowe B.J.
    Cell 138:898-910(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiSRRM4_HUMAN
AccessioniPrimary (citable) accession number: A7MD48
Secondary accession number(s): A8K5P6
, B2RZH7, Q7Z5F0, Q96JH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 15, 2009
Last modified: June 8, 2016
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.