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A7MCY6

- TBKB1_HUMAN

UniProt

A7MCY6 - TBKB1_HUMAN

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Protein

TANK-binding kinase 1-binding protein 1

Gene
TBKBP1, KIAA0775, SINTBAD
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity.By similarity1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. innate immune response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
TANK-binding kinase 1-binding protein 1
Short name:
TBK1-binding protein 1
Gene namesi
Name:TBKBP1
Synonyms:KIAA0775, SINTBAD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:30140. TBKBP1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670830.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 615615TANK-binding kinase 1-binding protein 1PRO_0000324654Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei184 – 1841Phosphoserine1 Publication
Modified residuei365 – 3651Phosphoserine1 Publication
Modified residuei372 – 3721Phosphoserine1 Publication
Modified residuei379 – 3791Phosphoserine1 Publication
Modified residuei385 – 3851Phosphoserine1 Publication
Modified residuei400 – 4001Phosphoserine1 Publication
Modified residuei415 – 4151Phosphoserine1 Publication
Modified residuei504 – 5041Phosphoserine1 Publication
Modified residuei534 – 5341Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiA7MCY6.
PaxDbiA7MCY6.
PRIDEiA7MCY6.

PTM databases

PhosphoSiteiA7MCY6.

Expressioni

Tissue specificityi

Detected in leukocytes, lung, placenta, small intestine, liver, kidney, spleen, muscle, heart, brain and at low levels in thymus.1 Publication

Gene expression databases

ArrayExpressiA7MCY6.
BgeeiA7MCY6.
CleanExiHS_TBKBP1.
GenevestigatoriA7MCY6.

Interactioni

Subunit structurei

Homodimer. May form a heterodimer with NAP1. Interacts with TKB1 and IKBKE.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AGO2Q9UKV82EBI-359969,EBI-528269
APBA3O960182EBI-359969,EBI-6115839
IKBKEQ141643EBI-359969,EBI-307369
RB1CC1Q8TDY22EBI-359969,EBI-1047793
TBK1Q9UHD27EBI-359969,EBI-356402

Protein-protein interaction databases

BioGridi115103. 16 interactions.
DIPiDIP-27604N.
IntActiA7MCY6. 12 interactions.
MINTiMINT-1141660.
STRINGi9606.ENSP00000354777.

Structurei

3D structure databases

ProteinModelPortaliA7MCY6.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 279279Homodimerization By similarityAdd
BLAST
Regioni280 – 32950Interaction with TBK1 and IKBKE By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili48 – 162115 Reviewed predictionAdd
BLAST
Coiled coili221 – 27656 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi343 – 43492Pro-richAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG85276.
HOGENOMiHOG000154514.
HOVERGENiHBG108550.
InParanoidiA7MCY6.
KOiK12652.
OMAiYGGELYG.
OrthoDBiEOG7KQ21K.
PhylomeDBiA7MCY6.
TreeFamiTF331289.

Family and domain databases

InterProiIPR024581. TBD.
[Graphical view]
PfamiPF12845. TBD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 12 Publications (identifier: A7MCY6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MESMFEDDIS ILTQEALGPS EVWLDSPGDP SLGGDMCSAS HFALITAYGD    50
IKERLGGLER ENATLRRRLK VYEIKYPLIS DFGEEHGFSL YEIKDGSLLE 100
VEKVSLQQRL NQFQHELQKN KEQEEQLGEM IQAYEKLCVE KSDLETELRE 150
MRALVETHLR QICGLEQQLR QQQGLQDAAF SNLSPPPAPA PPCTDLDLHY 200
LALRGGSGLS HAGWPGSTPS VSDLERRRLE EALEAAQGEA RGAQLREEQL 250
QAECERLQGE LKQLQETRAQ DLASNQSERD MAWVKRVGDD QVNLALAYTE 300
LTEELGRLRE LSSLQGRILR TLLQEQARSG GQRHSPLSQR HSPAPQCPSP 350
SPPARAAPPC PPCQSPVPQR RSPVPPCPSP QQRRSPASPS CPSPVPQRRS 400
PVPPSCQSPS PQRRSPVPPS CPAPQPRPPP PPPPGERTLA ERAYAKPPSH 450
HVKAGFQGRR SYSELAEGAA YAGASPPWLQ AEAATLPKPR AYGSELYGPG 500
RPLSPRRAFE GIRLRFEKQP SEEDEWAVPT SPPSPEVGTI RCASFCAGFP 550
IPESPAATAY AHAEHAQSWP SINLLMETVG SDIRSCPLCQ LGFPVGYPDD 600
ALIKHIDSHL ENSKI 615
Length:615
Mass (Da):67,702
Last modified:October 2, 2007 - v1
Checksum:iC8F42919164A554E
GO
Isoform 21 Publication (identifier: A7MCY6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     186-222: PPAPAPPCTDLDLHYLALRGGSGLSHAGWPGSTPSVS → RRARAVLAVHQLADGDGGLRHPQLPPLPAGFPCRVPG
     223-615: Missing.

Note: No experimental confirmation available.

Show »
Length:222
Mass (Da):25,043
Checksum:iE52578DA01C2B322
GO

Sequence cautioni

The sequence BAA34495.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei186 – 22237PPAPA…TPSVS → RRARAVLAVHQLADGDGGLR HPQLPPLPAGFPCRVPG in isoform 2. 1 PublicationVSP_052714Add
BLAST
Alternative sequencei223 – 615393Missing in isoform 2. 1 PublicationVSP_052715Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB018318 mRNA. Translation: BAA34495.2. Different initiation.
BC111418 mRNA. Translation: AAI11419.1.
BC152407 mRNA. Translation: AAI52408.1.
BC167150 mRNA. Translation: AAI67150.1.
CCDSiCCDS45722.1. [A7MCY6-1]
RefSeqiNP_055541.1. NM_014726.2. [A7MCY6-1]
XP_005257916.1. XM_005257859.2. [A7MCY6-1]
XP_005257917.1. XM_005257860.2. [A7MCY6-1]
XP_005257918.1. XM_005257861.2. [A7MCY6-1]
XP_005257919.1. XM_005257862.2. [A7MCY6-1]
UniGeneiHs.94790.

Genome annotation databases

EnsembliENST00000361722; ENSP00000354777; ENSG00000198933. [A7MCY6-1]
GeneIDi9755.
KEGGihsa:9755.
UCSCiuc002ilu.3. human. [A7MCY6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB018318 mRNA. Translation: BAA34495.2 . Different initiation.
BC111418 mRNA. Translation: AAI11419.1 .
BC152407 mRNA. Translation: AAI52408.1 .
BC167150 mRNA. Translation: AAI67150.1 .
CCDSi CCDS45722.1. [A7MCY6-1 ]
RefSeqi NP_055541.1. NM_014726.2. [A7MCY6-1 ]
XP_005257916.1. XM_005257859.2. [A7MCY6-1 ]
XP_005257917.1. XM_005257860.2. [A7MCY6-1 ]
XP_005257918.1. XM_005257861.2. [A7MCY6-1 ]
XP_005257919.1. XM_005257862.2. [A7MCY6-1 ]
UniGenei Hs.94790.

3D structure databases

ProteinModelPortali A7MCY6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115103. 16 interactions.
DIPi DIP-27604N.
IntActi A7MCY6. 12 interactions.
MINTi MINT-1141660.
STRINGi 9606.ENSP00000354777.

PTM databases

PhosphoSitei A7MCY6.

Proteomic databases

MaxQBi A7MCY6.
PaxDbi A7MCY6.
PRIDEi A7MCY6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000361722 ; ENSP00000354777 ; ENSG00000198933 . [A7MCY6-1 ]
GeneIDi 9755.
KEGGi hsa:9755.
UCSCi uc002ilu.3. human. [A7MCY6-1 ]

Organism-specific databases

CTDi 9755.
GeneCardsi GC17P045772.
HGNCi HGNC:30140. TBKBP1.
MIMi 608476. gene.
neXtProti NX_A7MCY6.
PharmGKBi PA142670830.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG85276.
HOGENOMi HOG000154514.
HOVERGENi HBG108550.
InParanoidi A7MCY6.
KOi K12652.
OMAi YGGELYG.
OrthoDBi EOG7KQ21K.
PhylomeDBi A7MCY6.
TreeFami TF331289.

Miscellaneous databases

GenomeRNAii 9755.
NextBioi 36720.
PROi A7MCY6.
SOURCEi Search...

Gene expression databases

ArrayExpressi A7MCY6.
Bgeei A7MCY6.
CleanExi HS_TBKBP1.
Genevestigatori A7MCY6.

Family and domain databases

InterProi IPR024581. TBD.
[Graphical view ]
Pfami PF12845. TBD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. Ohara O., Suyama M., Nagase T., Ishikawa K., Kikuno R.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  4. Cited for: IDENTIFICATION.
  5. "SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK."
    Ryzhakov G., Randow F.
    EMBO J. 26:3180-3190(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH IKBKE, TISSUE SPECIFICITY.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-184; SER-365; SER-372; SER-379; SER-385; SER-400; SER-415; SER-504 AND SER-534, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: FUNCTION, INTERACTION WITH TBK1.

Entry informationi

Entry nameiTBKB1_HUMAN
AccessioniPrimary (citable) accession number: A7MCY6
Secondary accession number(s): B2RZG6, O94873, Q14DW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 2, 2007
Last modified: July 9, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi