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Protein

TANK-binding kinase 1-binding protein 1

Gene

TBKBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity, Innate immunity

Enzyme and pathway databases

BioCyciZFISH:G66-30956-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
TANK-binding kinase 1-binding protein 1
Short name:
TBK1-binding protein 1
Gene namesi
Name:TBKBP1Imported
Synonyms:KIAA0775Imported, SINTBAD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:30140. TBKBP1.

Pathology & Biotechi

Organism-specific databases

DisGeNETi9755.
OpenTargetsiENSG00000198933.
PharmGKBiPA142670830.

Polymorphism and mutation databases

BioMutaiTBKBP1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003246541 – 615TANK-binding kinase 1-binding protein 1Add BLAST615

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei184PhosphoserineCombined sources1
Modified residuei365PhosphoserineCombined sources1
Modified residuei372PhosphoserineCombined sources1
Modified residuei379PhosphoserineCombined sources1
Modified residuei385PhosphoserineCombined sources1
Modified residuei400PhosphoserineCombined sources1
Modified residuei415PhosphoserineCombined sources1
Modified residuei504PhosphoserineCombined sources1
Modified residuei534PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA7MCY6.
MaxQBiA7MCY6.
PaxDbiA7MCY6.
PRIDEiA7MCY6.

PTM databases

iPTMnetiA7MCY6.
PhosphoSitePlusiA7MCY6.

Expressioni

Tissue specificityi

Detected in leukocytes, lung, placenta, small intestine, liver, kidney, spleen, muscle, heart, brain and at low levels in thymus.1 Publication

Gene expression databases

BgeeiENSG00000198933.
CleanExiHS_TBKBP1.
ExpressionAtlasiA7MCY6. baseline and differential.
GenevisibleiA7MCY6. HS.

Organism-specific databases

HPAiHPA062347.
HPA064856.

Interactioni

Subunit structurei

Homodimer. May form a heterodimer with NAP1. Interacts with TKB1 and IKBKE.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AGO2Q9UKV82EBI-359969,EBI-528269
APBA3O960182EBI-359969,EBI-6115839
IKBKEQ141644EBI-359969,EBI-307369
RB1CC1Q8TDY22EBI-359969,EBI-1047793
TBK1Q9UHD28EBI-359969,EBI-356402
VACWR022P173622EBI-359969,EBI-9519257From a different organism.

Protein-protein interaction databases

BioGridi115103. 16 interactors.
DIPiDIP-27604N.
IntActiA7MCY6. 14 interactors.
MINTiMINT-1141660.
STRINGi9606.ENSP00000354777.

Structurei

3D structure databases

ProteinModelPortaliA7MCY6.
SMRiA7MCY6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 279HomodimerizationBy similarityAdd BLAST279
Regioni280 – 329Interaction with TBK1 and IKBKEBy similarityAdd BLAST50

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili48 – 162Sequence analysisAdd BLAST115
Coiled coili221 – 276Sequence analysisAdd BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi343 – 434Pro-richSequence analysisAdd BLAST92

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGJJ. Eukaryota.
ENOG410ZK7E. LUCA.
GeneTreeiENSGT00390000008865.
HOGENOMiHOG000154514.
HOVERGENiHBG108550.
InParanoidiA7MCY6.
KOiK12652.
OMAiYGGELYG.
OrthoDBiEOG091G06LV.
PhylomeDBiA7MCY6.
TreeFamiTF331289.

Family and domain databases

InterProiIPR024581. TBD.
[Graphical view]
PfamiPF12845. TBD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 12 Publications (identifier: A7MCY6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESMFEDDIS ILTQEALGPS EVWLDSPGDP SLGGDMCSAS HFALITAYGD
60 70 80 90 100
IKERLGGLER ENATLRRRLK VYEIKYPLIS DFGEEHGFSL YEIKDGSLLE
110 120 130 140 150
VEKVSLQQRL NQFQHELQKN KEQEEQLGEM IQAYEKLCVE KSDLETELRE
160 170 180 190 200
MRALVETHLR QICGLEQQLR QQQGLQDAAF SNLSPPPAPA PPCTDLDLHY
210 220 230 240 250
LALRGGSGLS HAGWPGSTPS VSDLERRRLE EALEAAQGEA RGAQLREEQL
260 270 280 290 300
QAECERLQGE LKQLQETRAQ DLASNQSERD MAWVKRVGDD QVNLALAYTE
310 320 330 340 350
LTEELGRLRE LSSLQGRILR TLLQEQARSG GQRHSPLSQR HSPAPQCPSP
360 370 380 390 400
SPPARAAPPC PPCQSPVPQR RSPVPPCPSP QQRRSPASPS CPSPVPQRRS
410 420 430 440 450
PVPPSCQSPS PQRRSPVPPS CPAPQPRPPP PPPPGERTLA ERAYAKPPSH
460 470 480 490 500
HVKAGFQGRR SYSELAEGAA YAGASPPWLQ AEAATLPKPR AYGSELYGPG
510 520 530 540 550
RPLSPRRAFE GIRLRFEKQP SEEDEWAVPT SPPSPEVGTI RCASFCAGFP
560 570 580 590 600
IPESPAATAY AHAEHAQSWP SINLLMETVG SDIRSCPLCQ LGFPVGYPDD
610
ALIKHIDSHL ENSKI
Length:615
Mass (Da):67,702
Last modified:October 2, 2007 - v1
Checksum:iC8F42919164A554E
GO
Isoform 21 Publication (identifier: A7MCY6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     186-222: PPAPAPPCTDLDLHYLALRGGSGLSHAGWPGSTPSVS → RRARAVLAVHQLADGDGGLRHPQLPPLPAGFPCRVPG
     223-615: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:222
Mass (Da):25,043
Checksum:iE52578DA01C2B322
GO

Sequence cautioni

The sequence BAA34495 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_052714186 – 222PPAPA…TPSVS → RRARAVLAVHQLADGDGGLR HPQLPPLPAGFPCRVPG in isoform 2. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_052715223 – 615Missing in isoform 2. 1 PublicationAdd BLAST393

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018318 mRNA. Translation: BAA34495.2. Different initiation.
BC111418 mRNA. Translation: AAI11419.1.
BC152407 mRNA. Translation: AAI52408.1.
BC167150 mRNA. Translation: AAI67150.1.
CCDSiCCDS45722.1. [A7MCY6-1]
RefSeqiNP_055541.1. NM_014726.2. [A7MCY6-1]
XP_005257916.1. XM_005257859.4. [A7MCY6-1]
XP_005257917.1. XM_005257860.4. [A7MCY6-1]
XP_005257918.1. XM_005257861.4. [A7MCY6-1]
XP_005257919.1. XM_005257862.3. [A7MCY6-1]
UniGeneiHs.94790.

Genome annotation databases

EnsembliENST00000361722; ENSP00000354777; ENSG00000198933. [A7MCY6-1]
ENST00000622396; ENSP00000484395; ENSG00000198933. [A7MCY6-2]
GeneIDi9755.
KEGGihsa:9755.
UCSCiuc002ilu.4. human. [A7MCY6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018318 mRNA. Translation: BAA34495.2. Different initiation.
BC111418 mRNA. Translation: AAI11419.1.
BC152407 mRNA. Translation: AAI52408.1.
BC167150 mRNA. Translation: AAI67150.1.
CCDSiCCDS45722.1. [A7MCY6-1]
RefSeqiNP_055541.1. NM_014726.2. [A7MCY6-1]
XP_005257916.1. XM_005257859.4. [A7MCY6-1]
XP_005257917.1. XM_005257860.4. [A7MCY6-1]
XP_005257918.1. XM_005257861.4. [A7MCY6-1]
XP_005257919.1. XM_005257862.3. [A7MCY6-1]
UniGeneiHs.94790.

3D structure databases

ProteinModelPortaliA7MCY6.
SMRiA7MCY6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115103. 16 interactors.
DIPiDIP-27604N.
IntActiA7MCY6. 14 interactors.
MINTiMINT-1141660.
STRINGi9606.ENSP00000354777.

PTM databases

iPTMnetiA7MCY6.
PhosphoSitePlusiA7MCY6.

Polymorphism and mutation databases

BioMutaiTBKBP1.

Proteomic databases

EPDiA7MCY6.
MaxQBiA7MCY6.
PaxDbiA7MCY6.
PRIDEiA7MCY6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361722; ENSP00000354777; ENSG00000198933. [A7MCY6-1]
ENST00000622396; ENSP00000484395; ENSG00000198933. [A7MCY6-2]
GeneIDi9755.
KEGGihsa:9755.
UCSCiuc002ilu.4. human. [A7MCY6-1]

Organism-specific databases

CTDi9755.
DisGeNETi9755.
GeneCardsiTBKBP1.
HGNCiHGNC:30140. TBKBP1.
HPAiHPA062347.
HPA064856.
MIMi608476. gene.
neXtProtiNX_A7MCY6.
OpenTargetsiENSG00000198933.
PharmGKBiPA142670830.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGJJ. Eukaryota.
ENOG410ZK7E. LUCA.
GeneTreeiENSGT00390000008865.
HOGENOMiHOG000154514.
HOVERGENiHBG108550.
InParanoidiA7MCY6.
KOiK12652.
OMAiYGGELYG.
OrthoDBiEOG091G06LV.
PhylomeDBiA7MCY6.
TreeFamiTF331289.

Enzyme and pathway databases

BioCyciZFISH:G66-30956-MONOMER.

Miscellaneous databases

GenomeRNAii9755.
PROiA7MCY6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198933.
CleanExiHS_TBKBP1.
ExpressionAtlasiA7MCY6. baseline and differential.
GenevisibleiA7MCY6. HS.

Family and domain databases

InterProiIPR024581. TBD.
[Graphical view]
PfamiPF12845. TBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBKB1_HUMAN
AccessioniPrimary (citable) accession number: A7MCY6
Secondary accession number(s): B2RZG6, O94873, Q14DW3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 2, 2007
Last modified: November 30, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.