A7MCY6 (TBKB1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
TANK-binding kinase 1-binding protein 1
Short name=TBK1-binding protein 1

Gene names

Name:	TBKBP1
Synonyms:	KIAA0775

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	615 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Adapter protein which constitutively binds TBK1 and IKBKE and may play a role in antiviral innate immunity By similarity. UniProtKB A2A9T0
Subunit structure	Homodimer. May form a heterodimer with NAP1. Interacts with TKB1 and IKBKE By similarity. UniProtKB A2A9T0
Sequence caution	The sequence BAA34495.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Immunity Innate immunity
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	innate immune response Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
APBA3	O96018	2	EBI-359969,EBI-6115839
EIF2C2	Q9UKV8	2	EBI-359969,EBI-528269
RB1CC1	Q8TDY2	2	EBI-359969,EBI-1047793

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 Ref.1 Ref.3 (identifier: A7MCY6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 Ref.3 (identifier: A7MCY6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     186-222: PPAPAPPCTDLDLHYLALRGGSGLSHAGWPGSTPSVS → RRARAVLAVHQLADGDGGLRHPQLPPLPAGFPCRVPG
     223-615: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 615	615	TANK-binding kinase 1-binding protein 1		PRO_0000324654
Regions
	Coiled coil	48 – 162	115	Potential
	Coiled coil	221 – 276	56	Potential
	Compositional bias	343 – 434	92	Pro-rich
Amino acid modifications
	Modified residue	184	1	Phosphoserine Ref.5
	Modified residue	365	1	Phosphoserine Ref.5
	Modified residue	372	1	Phosphoserine Ref.5
	Modified residue	379	1	Phosphoserine Ref.5
	Modified residue	385	1	Phosphoserine Ref.5
	Modified residue	400	1	Phosphoserine Ref.5
	Modified residue	415	1	Phosphoserine Ref.5
	Modified residue	504	1	Phosphoserine Ref.5
	Modified residue	534	1	Phosphoserine Ref.5
Natural variations
	Alternative sequence	186 – 222	37	PPAPA…TPSVS → RRARAVLAVHQLADGDGGLR HPQLPPLPAGFPCRVPG in isoform 2. Ref.3		VSP_052714
	Alternative sequence	223 – 615	393	Missing in isoform 2. Ref.3		VSP_052715

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 2, 2007. Version 1. Checksum: C8F42919164A554E	FASTA	615	67,702
	10 20 30 40 50 60 MESMFEDDIS ILTQEALGPS EVWLDSPGDP SLGGDMCSAS HFALITAYGD IKERLGGLER 70 80 90 100 110 120 ENATLRRRLK VYEIKYPLIS DFGEEHGFSL YEIKDGSLLE VEKVSLQQRL NQFQHELQKN 130 140 150 160 170 180 KEQEEQLGEM IQAYEKLCVE KSDLETELRE MRALVETHLR QICGLEQQLR QQQGLQDAAF 190 200 210 220 230 240 SNLSPPPAPA PPCTDLDLHY LALRGGSGLS HAGWPGSTPS VSDLERRRLE EALEAAQGEA 250 260 270 280 290 300 RGAQLREEQL QAECERLQGE LKQLQETRAQ DLASNQSERD MAWVKRVGDD QVNLALAYTE 310 320 330 340 350 360 LTEELGRLRE LSSLQGRILR TLLQEQARSG GQRHSPLSQR HSPAPQCPSP SPPARAAPPC 370 380 390 400 410 420 PPCQSPVPQR RSPVPPCPSP QQRRSPASPS CPSPVPQRRS PVPPSCQSPS PQRRSPVPPS 430 440 450 460 470 480 CPAPQPRPPP PPPPGERTLA ERAYAKPPSH HVKAGFQGRR SYSELAEGAA YAGASPPWLQ 490 500 510 520 530 540 AEAATLPKPR AYGSELYGPG RPLSPRRAFE GIRLRFEKQP SEEDEWAVPT SPPSPEVGTI 550 560 570 580 590 600 RCASFCAGFP IPESPAATAY AHAEHAQSWP SINLLMETVG SDIRSCPLCQ LGFPVGYPDD 610 ALIKHIDSHL ENSKI
	Isoform 2 [UniParc]. Checksum: E52578DA01C2B322	FASTA	222	25,043
	10 20 30 40 50 60 MESMFEDDIS ILTQEALGPS EVWLDSPGDP SLGGDMCSAS HFALITAYGD IKERLGGLER 70 80 90 100 110 120 ENATLRRRLK VYEIKYPLIS DFGEEHGFSL YEIKDGSLLE VEKVSLQQRL NQFQHELQKN 130 140 150 160 170 180 KEQEEQLGEM IQAYEKLCVE KSDLETELRE MRALVETHLR QICGLEQQLR QQQGLQDAAF 190 200 210 220 SNLSPRRARA VLAVHQLADG DGGLRHPQLP PLPAGFPCRV PG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	Ohara O., Suyama M., Nagase T., Ishikawa K., Kikuno R. Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
[4]	"A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway." Bouwmeester T., Bauch A., Ruffner H., Angrand P.-O., Bergamini G., Croughton K., Cruciat C., Eberhard D., Gagneur J., Ghidelli S., Hopf C., Huhse B., Mangano R., Michon A.-M., Schirle M., Schlegl J., Schwab M., Stein M.A. , Bauer A., Casari G., Drewes G., Gavin A.-C., Jackson D.B., Joberty G., Neubauer G., Rick J., Kuster B., Superti-Furga G. Nat. Cell Biol. 6:97-105(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[5]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-184; SER-365; SER-372; SER-379; SER-385; SER-400; SER-415; SER-504 AND SER-534, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB018318 mRNA. Translation: BAA34495.2. Different initiation. BC111418 mRNA. Translation: AAI11419.1. BC152407 mRNA. Translation: AAI52408.1. BC167150 mRNA. Translation: AAI67150.1.
IPI	IPI00006064. IPI00887117.
RefSeq	NP_055541.1. NM_014726.2.
UniGene	Hs.94790.
3D structure databases
ProteinModelPortal	A7MCY6.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-27604N.
IntAct	A7MCY6. 10 interactions.
MINT	MINT-1141660.
STRING	9606.ENSP00000354777.
PTM databases
PhosphoSite	A7MCY6.
Proteomic databases
PaxDb	A7MCY6.
PRIDE	A7MCY6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000361722; ENSP00000354777; ENSG00000198933.
GeneID	9755.
KEGG	hsa:9755.
UCSC	uc002ilu.3. human.
Organism-specific databases
CTD	9755.
GeneCards	GC17P045772.
HGNC	HGNC:30140. TBKBP1.
MIM	608476. gene.
neXtProt	NX_A7MCY6.
PharmGKB	PA142670830.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG85276.
HOGENOM	HOG000154514.
HOVERGEN	HBG108550.
InParanoid	A7MCY6.
KO	K12652.
OMA	YGGELYG.
OrthoDB	EOG4CRM00.
Gene expression databases
Bgee	A7MCY6.
CleanEx	HS_TBKBP1.
Genevestigator	A7MCY6.
Family and domain databases
InterPro	IPR024581. TBD. [Graphical view]
Pfam	PF12845. TBD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	9755.
NextBio	36720.
SOURCE	Search...

Entry information

Entry name

TBKB1_HUMAN

Accession

Primary (citable) accession number: A7MCY6
Secondary accession number(s): B2RZG6, O94873, Q14DW3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	October 2, 2007
Last modified:	May 1, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.