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A7MCY6

- TBKB1_HUMAN

UniProt

A7MCY6 - TBKB1_HUMAN

Protein

TANK-binding kinase 1-binding protein 1

Gene

TBKBP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. innate immune response Source: UniProtKB-KW

    Keywords - Biological processi

    Immunity, Innate immunity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TANK-binding kinase 1-binding protein 1
    Short name:
    TBK1-binding protein 1
    Gene namesi
    Name:TBKBP1Imported
    Synonyms:KIAA0775Imported, SINTBAD
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:30140. TBKBP1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670830.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 615615TANK-binding kinase 1-binding protein 1PRO_0000324654Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei184 – 1841Phosphoserine1 Publication
    Modified residuei365 – 3651Phosphoserine1 Publication
    Modified residuei372 – 3721Phosphoserine1 Publication
    Modified residuei379 – 3791Phosphoserine1 Publication
    Modified residuei385 – 3851Phosphoserine1 Publication
    Modified residuei400 – 4001Phosphoserine1 Publication
    Modified residuei415 – 4151Phosphoserine1 Publication
    Modified residuei504 – 5041Phosphoserine1 Publication
    Modified residuei534 – 5341Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiA7MCY6.
    PaxDbiA7MCY6.
    PRIDEiA7MCY6.

    PTM databases

    PhosphoSiteiA7MCY6.

    Expressioni

    Tissue specificityi

    Detected in leukocytes, lung, placenta, small intestine, liver, kidney, spleen, muscle, heart, brain and at low levels in thymus.1 Publication

    Gene expression databases

    ArrayExpressiA7MCY6.
    BgeeiA7MCY6.
    CleanExiHS_TBKBP1.
    GenevestigatoriA7MCY6.

    Interactioni

    Subunit structurei

    Homodimer. May form a heterodimer with NAP1. Interacts with TKB1 and IKBKE.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AGO2Q9UKV82EBI-359969,EBI-528269
    APBA3O960182EBI-359969,EBI-6115839
    IKBKEQ141643EBI-359969,EBI-307369
    RB1CC1Q8TDY22EBI-359969,EBI-1047793
    TBK1Q9UHD27EBI-359969,EBI-356402

    Protein-protein interaction databases

    BioGridi115103. 16 interactions.
    DIPiDIP-27604N.
    IntActiA7MCY6. 12 interactions.
    MINTiMINT-1141660.
    STRINGi9606.ENSP00000354777.

    Structurei

    3D structure databases

    ProteinModelPortaliA7MCY6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 279279HomodimerizationBy similarityAdd
    BLAST
    Regioni280 – 32950Interaction with TBK1 and IKBKEBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili48 – 162115Sequence AnalysisAdd
    BLAST
    Coiled coili221 – 27656Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi343 – 43492Pro-richSequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG85276.
    HOGENOMiHOG000154514.
    HOVERGENiHBG108550.
    InParanoidiA7MCY6.
    KOiK12652.
    OMAiYGGELYG.
    OrthoDBiEOG7KQ21K.
    PhylomeDBiA7MCY6.
    TreeFamiTF331289.

    Family and domain databases

    InterProiIPR024581. TBD.
    [Graphical view]
    PfamiPF12845. TBD. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 12 Publications (identifier: A7MCY6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MESMFEDDIS ILTQEALGPS EVWLDSPGDP SLGGDMCSAS HFALITAYGD    50
    IKERLGGLER ENATLRRRLK VYEIKYPLIS DFGEEHGFSL YEIKDGSLLE 100
    VEKVSLQQRL NQFQHELQKN KEQEEQLGEM IQAYEKLCVE KSDLETELRE 150
    MRALVETHLR QICGLEQQLR QQQGLQDAAF SNLSPPPAPA PPCTDLDLHY 200
    LALRGGSGLS HAGWPGSTPS VSDLERRRLE EALEAAQGEA RGAQLREEQL 250
    QAECERLQGE LKQLQETRAQ DLASNQSERD MAWVKRVGDD QVNLALAYTE 300
    LTEELGRLRE LSSLQGRILR TLLQEQARSG GQRHSPLSQR HSPAPQCPSP 350
    SPPARAAPPC PPCQSPVPQR RSPVPPCPSP QQRRSPASPS CPSPVPQRRS 400
    PVPPSCQSPS PQRRSPVPPS CPAPQPRPPP PPPPGERTLA ERAYAKPPSH 450
    HVKAGFQGRR SYSELAEGAA YAGASPPWLQ AEAATLPKPR AYGSELYGPG 500
    RPLSPRRAFE GIRLRFEKQP SEEDEWAVPT SPPSPEVGTI RCASFCAGFP 550
    IPESPAATAY AHAEHAQSWP SINLLMETVG SDIRSCPLCQ LGFPVGYPDD 600
    ALIKHIDSHL ENSKI 615
    Length:615
    Mass (Da):67,702
    Last modified:October 2, 2007 - v1
    Checksum:iC8F42919164A554E
    GO
    Isoform 21 Publication (identifier: A7MCY6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         186-222: PPAPAPPCTDLDLHYLALRGGSGLSHAGWPGSTPSVS → RRARAVLAVHQLADGDGGLRHPQLPPLPAGFPCRVPG
         223-615: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:222
    Mass (Da):25,043
    Checksum:iE52578DA01C2B322
    GO

    Sequence cautioni

    The sequence BAA34495.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei186 – 22237PPAPA…TPSVS → RRARAVLAVHQLADGDGGLR HPQLPPLPAGFPCRVPG in isoform 2. 1 PublicationVSP_052714Add
    BLAST
    Alternative sequencei223 – 615393Missing in isoform 2. 1 PublicationVSP_052715Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018318 mRNA. Translation: BAA34495.2. Different initiation.
    BC111418 mRNA. Translation: AAI11419.1.
    BC152407 mRNA. Translation: AAI52408.1.
    BC167150 mRNA. Translation: AAI67150.1.
    CCDSiCCDS45722.1. [A7MCY6-1]
    RefSeqiNP_055541.1. NM_014726.2. [A7MCY6-1]
    XP_005257916.1. XM_005257859.2. [A7MCY6-1]
    XP_005257917.1. XM_005257860.2. [A7MCY6-1]
    XP_005257918.1. XM_005257861.2. [A7MCY6-1]
    XP_005257919.1. XM_005257862.2. [A7MCY6-1]
    UniGeneiHs.94790.

    Genome annotation databases

    EnsembliENST00000361722; ENSP00000354777; ENSG00000198933. [A7MCY6-1]
    GeneIDi9755.
    KEGGihsa:9755.
    UCSCiuc002ilu.3. human. [A7MCY6-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB018318 mRNA. Translation: BAA34495.2 . Different initiation.
    BC111418 mRNA. Translation: AAI11419.1 .
    BC152407 mRNA. Translation: AAI52408.1 .
    BC167150 mRNA. Translation: AAI67150.1 .
    CCDSi CCDS45722.1. [A7MCY6-1 ]
    RefSeqi NP_055541.1. NM_014726.2. [A7MCY6-1 ]
    XP_005257916.1. XM_005257859.2. [A7MCY6-1 ]
    XP_005257917.1. XM_005257860.2. [A7MCY6-1 ]
    XP_005257918.1. XM_005257861.2. [A7MCY6-1 ]
    XP_005257919.1. XM_005257862.2. [A7MCY6-1 ]
    UniGenei Hs.94790.

    3D structure databases

    ProteinModelPortali A7MCY6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115103. 16 interactions.
    DIPi DIP-27604N.
    IntActi A7MCY6. 12 interactions.
    MINTi MINT-1141660.
    STRINGi 9606.ENSP00000354777.

    PTM databases

    PhosphoSitei A7MCY6.

    Proteomic databases

    MaxQBi A7MCY6.
    PaxDbi A7MCY6.
    PRIDEi A7MCY6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000361722 ; ENSP00000354777 ; ENSG00000198933 . [A7MCY6-1 ]
    GeneIDi 9755.
    KEGGi hsa:9755.
    UCSCi uc002ilu.3. human. [A7MCY6-1 ]

    Organism-specific databases

    CTDi 9755.
    GeneCardsi GC17P045772.
    HGNCi HGNC:30140. TBKBP1.
    MIMi 608476. gene.
    neXtProti NX_A7MCY6.
    PharmGKBi PA142670830.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG85276.
    HOGENOMi HOG000154514.
    HOVERGENi HBG108550.
    InParanoidi A7MCY6.
    KOi K12652.
    OMAi YGGELYG.
    OrthoDBi EOG7KQ21K.
    PhylomeDBi A7MCY6.
    TreeFami TF331289.

    Miscellaneous databases

    GenomeRNAii 9755.
    NextBioi 36720.
    PROi A7MCY6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi A7MCY6.
    Bgeei A7MCY6.
    CleanExi HS_TBKBP1.
    Genevestigatori A7MCY6.

    Family and domain databases

    InterProi IPR024581. TBD.
    [Graphical view ]
    Pfami PF12845. TBD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: BrainImported.
    2. Ohara O., Suyama M., Nagase T., Ishikawa K., Kikuno R.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    4. Cited for: IDENTIFICATION.
    5. "SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK."
      Ryzhakov G., Randow F.
      EMBO J. 26:3180-3190(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH IKBKE, TISSUE SPECIFICITY.
    6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-184; SER-365; SER-372; SER-379; SER-385; SER-400; SER-415; SER-504 AND SER-534, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: FUNCTION, INTERACTION WITH TBK1.

    Entry informationi

    Entry nameiTBKB1_HUMAN
    AccessioniPrimary (citable) accession number: A7MCY6
    Secondary accession number(s): B2RZG6, O94873, Q14DW3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3