<?xml version='1.0' encoding='UTF-8'?>
<uniprot xmlns="http://uniprot.org/uniprot" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/support/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2007-10-02" modified="2013-04-03" version="44">
<accession>A7MCK2</accession>
<name>A7MCK2_DANRE</name>
<protein>
<submittedName>
<fullName evidence="4">Hsd17b12b protein</fullName>
</submittedName>
<submittedName>
<fullName evidence="2">Hydroxysteroid (17-beta) dehydrogenase 12b</fullName>
</submittedName>
</protein>
<gene>
<name type="primary" evidence="2 3">hsd17b12b</name>
</gene>
<organism>
<name type="scientific">Danio rerio</name>
<name type="common">Zebrafish</name>
<name type="synonym">Brachydanio rerio</name>
<dbReference type="NCBI Taxonomy" id="7955"/>
<lineage>
<taxon>Eukaryota</taxon>
<taxon>Metazoa</taxon>
<taxon>Chordata</taxon>
<taxon>Craniata</taxon>
<taxon>Vertebrata</taxon>
<taxon>Euteleostomi</taxon>
<taxon>Actinopterygii</taxon>
<taxon>Neopterygii</taxon>
<taxon>Teleostei</taxon>
<taxon>Ostariophysi</taxon>
<taxon>Cypriniformes</taxon>
<taxon>Cyprinidae</taxon>
<taxon>Danio</taxon>
</lineage>
</organism>
<reference key="1" evidence="4">
<citation type="journal article" date="2002" name="Proc. Natl. Acad. Sci. U.S.A." volume="99" first="16899" last="16903">
<title>Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.</title>
<authorList>
<consortium name="Mammalian Gene Collection Program Team"/>
<person name="Strausberg R.L."/>
<person name="Feingold E.A."/>
<person name="Grouse L.H."/>
<person name="Derge J.G."/>
<person name="Klausner R.D."/>
<person name="Collins F.S."/>
<person name="Wagner L."/>
<person name="Shenmen C.M."/>
<person name="Schuler G.D."/>
<person name="Altschul S.F."/>
<person name="Zeeberg B."/>
<person name="Buetow K.H."/>
<person name="Schaefer C.F."/>
<person name="Bhat N.K."/>
<person name="Hopkins R.F."/>
<person name="Jordan H."/>
<person name="Moore T."/>
<person name="Max S.I."/>
<person name="Wang J."/>
<person name="Hsieh F."/>
<person name="Diatchenko L."/>
<person name="Marusina K."/>
<person name="Farmer A.A."/>
<person name="Rubin G.M."/>
<person name="Hong L."/>
<person name="Stapleton M."/>
<person name="Soares M.B."/>
<person name="Bonaldo M.F."/>
<person name="Casavant T.L."/>
<person name="Scheetz T.E."/>
<person name="Brownstein M.J."/>
<person name="Usdin T.B."/>
<person name="Toshiyuki S."/>
<person name="Carninci P."/>
<person name="Prange C."/>
<person name="Raha S.S."/>
<person name="Loquellano N.A."/>
<person name="Peters G.J."/>
<person name="Abramson R.D."/>
<person name="Mullahy S.J."/>
<person name="Bosak S.A."/>
<person name="McEwan P.J."/>
<person name="McKernan K.J."/>
<person name="Malek J.A."/>
<person name="Gunaratne P.H."/>
<person name="Richards S."/>
<person name="Worley K.C."/>
<person name="Hale S."/>
<person name="Garcia A.M."/>
<person name="Gay L.J."/>
<person name="Hulyk S.W."/>
<person name="Villalon D.K."/>
<person name="Muzny D.M."/>
<person name="Sodergren E.J."/>
<person name="Lu X."/>
<person name="Gibbs R.A."/>
<person name="Fahey J."/>
<person name="Helton E."/>
<person name="Ketteman M."/>
<person name="Madan A."/>
<person name="Rodrigues S."/>
<person name="Sanchez A."/>
<person name="Whiting M."/>
<person name="Madan A."/>
<person name="Young A.C."/>
<person name="Shevchenko Y."/>
<person name="Bouffard G.G."/>
<person name="Blakesley R.W."/>
<person name="Touchman J.W."/>
<person name="Green E.D."/>
<person name="Dickson M.C."/>
<person name="Rodriguez A.C."/>
<person name="Grimwood J."/>
<person name="Schmutz J."/>
<person name="Myers R.M."/>
<person name="Butterfield Y.S."/>
<person name="Krzywinski M.I."/>
<person name="Skalska U."/>
<person name="Smailus D.E."/>
<person name="Schnerch A."/>
<person name="Schein J.E."/>
<person name="Jones S.J."/>
<person name="Marra M.A."/>
</authorList>
<dbReference type="PubMed" id="12477932"/>
<dbReference type="DOI" id="10.1073/pnas.242603899"/>
</citation>
<scope>NUCLEOTIDE SEQUENCE</scope>
<source>
<tissue evidence="4">Ovary</tissue>
</source>
</reference>
<reference key="2" evidence="2">
<citation type="submission" date="2007-08" db="EMBL/GenBank/DDBJ databases">
<authorList>
<consortium name="NIH - Zebrafish Gene Collection (ZGC) project"/>
</authorList>
</citation>
<scope>NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]</scope>
<source>
<tissue evidence="2">Larvae</tissue>
</source>
</reference>
<reference key="3" evidence="4">
<citation type="submission" date="2007-10" db="EMBL/GenBank/DDBJ databases">
<authorList>
<consortium name="NIH MGC Project"/>
</authorList>
</citation>
<scope>NUCLEOTIDE SEQUENCE</scope>
<source>
<tissue evidence="4">Ovary</tissue>
</source>
</reference>
<comment type="similarity">
<text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
</comment>
<dbReference type="EMBL" id="BC152213">
<property type="protein sequence ID" value="AAI52214.1"/>
<property type="molecule type" value="mRNA"/>
</dbReference>
<dbReference type="EMBL" id="BC154318">
<property type="protein sequence ID" value="AAI54319.1"/>
<property type="molecule type" value="mRNA"/>
</dbReference>
<dbReference type="IPI" id="IPI00488184"/>
<dbReference type="RefSeq" id="NP_955907.1">
<property type="nucleotide sequence ID" value="NM_199613.1"/>
</dbReference>
<dbReference type="UniGene" id="Dr.20571"/>
<dbReference type="GeneID" id="322626"/>
<dbReference type="KEGG" id="dre:322626"/>
<dbReference type="CTD" id="322626"/>
<dbReference type="ZFIN" id="ZDB-GENE-030131-1346">
<property type="gene designation" value="hsd17b12b"/>
</dbReference>
<dbReference type="HOVERGEN" id="HBG005478"/>
<dbReference type="KO" id="K10251"/>
<dbReference type="NextBio" id="20807877"/>
<dbReference type="GO" id="GO:0000166">
<property type="term" value="F:nucleotide binding"/>
<property type="evidence" value="IEA:InterPro"/>
</dbReference>
<dbReference type="GO" id="GO:0016491">
<property type="term" value="F:oxidoreductase activity"/>
<property type="evidence" value="IEA:InterPro"/>
</dbReference>
<dbReference type="GO" id="GO:0055114">
<property type="term" value="P:oxidation-reduction process"/>
<property type="evidence" value="IEA:GOC"/>
</dbReference>
<dbReference type="Gene3D" id="3.40.50.720">
<property type="match status" value="1"/>
</dbReference>
<dbReference type="InterPro" id="IPR002198">
<property type="entry name" value="DH_sc/Rdtase_SDR"/>
</dbReference>
<dbReference type="InterPro" id="IPR002347">
<property type="entry name" value="Glc/ribitol_DH"/>
</dbReference>
<dbReference type="InterPro" id="IPR016040">
<property type="entry name" value="NAD(P)-bd_dom"/>
</dbReference>
<dbReference type="Pfam" id="PF00106">
<property type="entry name" value="adh_short"/>
<property type="match status" value="1"/>
</dbReference>
<dbReference type="PIRSF" id="PIRSF000126">
<property type="entry name" value="11-beta-HSD1"/>
<property type="match status" value="1"/>
</dbReference>
<dbReference type="PRINTS" id="PR00081">
<property type="entry name" value="GDHRDH"/>
</dbReference>
<dbReference type="PRINTS" id="PR00080">
<property type="entry name" value="SDRFAMILY"/>
</dbReference>
<proteinExistence type="evidence at transcript level"/>
<evidence key="1" type="ECO:0000203">
<source>
<dbReference type="RuleBase" id="RU000363"/>
</source>
</evidence>
<evidence key="2" type="ECO:0000313">
<source>
<dbReference type="EMBL" id="AAI52214.1"/>
</source>
</evidence>
<evidence key="3" type="ECO:0000313">
<source>
<dbReference type="ZFIN" id="ZDB-GENE-030131-1346"/>
</source>
</evidence>
<evidence key="4" type="ECO:0000313">
<source>
<dbReference type="EMBL" id="AAI54319.1"/>
</source>
</evidence>
<sequence length="311" mass="34279" checksum="995F46371555BFB4" modified="2007-10-02" version="1">
MEPFADALFWVGAVTVLWLSVSSLWSLINGIRVWILGNGNLMRASSLGKWAVVTGATDGI
GKAYAEELARRGFAIVLISRTQEKLDEVSKAIESKYKVETKTISADFGSVDIYPKIESGL
AGLEIGVLVNNVGVSYSYPEFFLNIPDVDSFINNMININIMSVCQMTRLVLPRMVDRSKG
VILNVASASGMYPVPLLTLYSSTKAFVDFFSRGLDAEYKSKGIIIQSVLPFYVTTKLSKI
RKPTLDIPTPERYVKAQLSTIGLQTQSNGYLPHAIMGWVTASLLPAKLLNKYVMGMGLSQ
RARYLKKQKQG
</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
</copyright>
</uniprot>