ID   DISP2_HUMAN             Reviewed;        1401 AA.
AC   A7MBM2; Q6AHW3; Q9C0C1;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 2.
DT   27-MAR-2024, entry version 106.
DE   RecName: Full=Protein dispatched homolog 2;
GN   Name=DISP2 {ECO:0000312|HGNC:HGNC:19712};
GN   Synonyms=C15orf36 {ECO:0000312|HGNC:HGNC:19712}, DISPB, KIAA1742,
GN   LINC00594 {ECO:0000312|HGNC:HGNC:19712};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ALA-47 AND SER-56.
RC   TISSUE=Brain;
RX   PubMed=11214970; DOI=10.1093/dnares/7.6.347;
RA   Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XIX. The
RT   complete sequences of 100 new cDNA clones from brain which code for large
RT   proteins in vitro.";
RL   DNA Res. 7:347-355(2000).
RN   [2]
RP   SEQUENCE REVISION.
RX   PubMed=12168954; DOI=10.1093/dnares/9.3.99;
RA   Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.;
RT   "Construction of expression-ready cDNA clones for KIAA genes: manual
RT   curation of 330 KIAA cDNA clones.";
RL   DNA Res. 9:99-106(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA   Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA   Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA   Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA   O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA   Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA   Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human chromosome
RT   15.";
RL   Nature 440:671-675(2006).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-665, AND VARIANTS ALA-47 AND
RP   SER-56.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1279-1401.
RC   TISSUE=Brain;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the dispatched family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB21833.2; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AB051529; BAB21833.2; ALT_SEQ; mRNA.
DR   EMBL; AC013356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC151833; AAI51834.1; -; mRNA.
DR   EMBL; CR627480; CAH10680.1; -; mRNA.
DR   CCDS; CCDS10056.1; -.
DR   RefSeq; NP_277045.1; NM_033510.2.
DR   RefSeq; XP_011520427.1; XM_011522125.2.
DR   RefSeq; XP_016878176.1; XM_017022687.1.
DR   AlphaFoldDB; A7MBM2; -.
DR   SMR; A7MBM2; -.
DR   BioGRID; 124539; 4.
DR   STRING; 9606.ENSP00000267889; -.
DR   GlyCosmos; A7MBM2; 3 sites, No reported glycans.
DR   GlyGen; A7MBM2; 4 sites.
DR   iPTMnet; A7MBM2; -.
DR   PhosphoSitePlus; A7MBM2; -.
DR   SwissPalm; A7MBM2; -.
DR   BioMuta; DISP2; -.
DR   jPOST; A7MBM2; -.
DR   MassIVE; A7MBM2; -.
DR   MaxQB; A7MBM2; -.
DR   PaxDb; 9606-ENSP00000267889; -.
DR   PeptideAtlas; A7MBM2; -.
DR   ProteomicsDB; 1809; -.
DR   Antibodypedia; 23061; 100 antibodies from 24 providers.
DR   DNASU; 85455; -.
DR   Ensembl; ENST00000267889.5; ENSP00000267889.3; ENSG00000140323.6.
DR   GeneID; 85455; -.
DR   KEGG; hsa:85455; -.
DR   MANE-Select; ENST00000267889.5; ENSP00000267889.3; NM_033510.3; NP_277045.1.
DR   UCSC; uc001zlk.2; human.
DR   AGR; HGNC:19712; -.
DR   DisGeNET; 85455; -.
DR   GeneCards; DISP2; -.
DR   HGNC; HGNC:19712; DISP2.
DR   HPA; ENSG00000140323; Tissue enriched (brain).
DR   MIM; 607503; gene.
DR   neXtProt; NX_A7MBM2; -.
DR   OpenTargets; ENSG00000140323; -.
DR   PharmGKB; PA134876083; -.
DR   VEuPathDB; HostDB:ENSG00000140323; -.
DR   eggNOG; KOG3664; Eukaryota.
DR   GeneTree; ENSGT00940000159551; -.
DR   HOGENOM; CLU_004076_1_1_1; -.
DR   InParanoid; A7MBM2; -.
DR   OMA; MPVTIVW; -.
DR   OrthoDB; 2875706at2759; -.
DR   PhylomeDB; A7MBM2; -.
DR   TreeFam; TF324144; -.
DR   PathwayCommons; A7MBM2; -.
DR   Reactome; R-HSA-5362798; Release of Hh-Np from the secreting cell.
DR   SignaLink; A7MBM2; -.
DR   BioGRID-ORCS; 85455; 18 hits in 1148 CRISPR screens.
DR   ChiTaRS; DISP2; human.
DR   GenomeRNAi; 85455; -.
DR   Pharos; A7MBM2; Tbio.
DR   PRO; PR:A7MBM2; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   RNAct; A7MBM2; Protein.
DR   Bgee; ENSG00000140323; Expressed in cerebellar cortex and 123 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0007224; P:smoothened signaling pathway; IBA:GO_Central.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR45951:SF2; PROTEIN DISPATCHED HOMOLOG 2; 1.
DR   PANTHER; PTHR45951; PROTEIN DISPATCHED-RELATED; 1.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
DR   Genevisible; A7MBM2; HS.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Methylation; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..1401
FT                   /note="Protein dispatched homolog 2"
FT                   /id="PRO_0000310696"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        484..504
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        510..530
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        542..562
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        589..609
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        617..637
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        704..724
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        964..984
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        990..1010
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1019..1039
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1064..1084
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1088..1108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          471..643
FT                   /note="SSD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00199"
FT   REGION          1..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          113..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          241..264
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1169..1192
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1229..1337
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1352..1401
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..84
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1172..1190
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1229..1248
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1286..1309
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1366
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8CIP5"
FT   CARBOHYD        239
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        349
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        465
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         47
FT                   /note="P -> A (in dbSNP:rs1898883)"
FT                   /evidence="ECO:0000269|PubMed:11214970,
FT                   ECO:0000269|PubMed:15489334"
FT                   /id="VAR_037078"
FT   VARIANT         56
FT                   /note="C -> S (in dbSNP:rs1898882)"
FT                   /evidence="ECO:0000269|PubMed:11214970,
FT                   ECO:0000269|PubMed:15489334"
FT                   /id="VAR_037079"
FT   VARIANT         388
FT                   /note="G -> E (in dbSNP:rs35043215)"
FT                   /id="VAR_037080"
FT   VARIANT         1145
FT                   /note="G -> S (in dbSNP:rs2412512)"
FT                   /id="VAR_037081"
FT   VARIANT         1247
FT                   /note="R -> W (in dbSNP:rs3743142)"
FT                   /id="VAR_037082"
FT   CONFLICT        67
FT                   /note="S -> F (in Ref. 1; BAB21833)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        70
FT                   /note="S -> L (in Ref. 1; BAB21833)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        77
FT                   /note="S -> F (in Ref. 1; BAB21833)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        96
FT                   /note="P -> T (in Ref. 1; BAB21833)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1401 AA;  152003 MW;  67BD27DC491C72CE CRC64;
     MDGDSSSSSG GSGPAPGPGP EGEQRPEGEP LAPDGGSPDS TQTKAVPPEA SPERSCSLHS
     CPLEDPSSSS GPPPTTSTLQ PVGPSSPLAP AHFTYPRALQ EYQGGSSLPG LGDRAALCSH
     GSSLSPSPAP SQRDGTWKPP AVQHHVVSVR QERAFQMPKS YSQLIAEWPV AVLMLCLAVI
     FLCTLAGLLG ARLPDFSKPL LGFEPRDTDI GSKLVVWRAL QALTGPRKLL FLSPDLELNS
     SSSHNTLRPA PRGSAQESAV RPRRMVEPLE DRRQENFFCG PPEKSYAKLV FMSTSSGSLW
     NLHAIHSMCR MEQDQIRSHT SFGALCQRTA ANQCCPSWSL GNYLAVLSNR SSCLDTTQAD
     AARTLALLRT CALYYHSGAL VPSCLGPGQN KSPRCAQVPT KCSQSSAIYQ LLHFLLDRDF
     LSPQTTDYQV PSLKYSLLFL PTPKGASLMD IYLDRLATPW GLADNYTSVT GMDLGLKQEL
     LRHFLVQDTV YPLLALVAIF FGMALYLRSL FLTLMVLLGV LGSLLVAFFL YQVAFRMAYF
     PFVNLAALLL LSSVCANHTL IFFDLWRLSK SQLPSGGLAQ RVGRTMHHFG YLLLVSGLTT
     SAAFYASYLS RLPAVRCLAL FMGTAVLVHL ALTLVWLPAS AVLHERYLAR GCARRARGRW
     EGSAPRRLLL ALHRRLRGLR RAAAGTSRLL FQRLLPCGVI KFRYIWICWF AALAAGGAYI
     AGVSPRLRLP TLPPPGGQVF RPSHPFERFD AEYRQLFLFE QLPQGEGGHM PVVLVWGVLP
     VDTGDPLDPR SNSSLVRDPA FSASGPEAQR WLLALCHRAR NQSFFDTLQE GWPTLCFVET
     LQRWMESPSC ARLGPDLCCG HSDFPWAPQF FLHCLKMMAL EQGPDGTQDL GLRFDAHGSL
     AALVLQFQTN FRNSPDYNQT QLFYNEVSHW LAAELGMAPP GLRRGWFTSR LELYSLQHSL
     STEPAVVLGL ALALAFATLL LGTWNVPLSL FSVAAVAGTV LLTVGLLVLL EWQLNTAEAL
     FLSASVGLSV DFTVNYCISY HLCPHPDRLS RVAFSLRQTS CATAVGAAAL FAAGVLMLPA
     TVLLYRKLGI ILMMVKCVSC GFASFFFQSL CCFFGPEKNC GQILWPCAHL PWDAGTGDPG
     GEKAGRPRPG SVGGMPGSCS EQYELQPLAR RRSPSFDTST ATSKLSHRPS VLSEDLQLHD
     GPCCSRPPPA PASPRELLLD HQAVFSQCPA LQTSSPYKQA GPSPKTRARQ DSQGEEAEPL
     PASPEAPAHS PKAKAADPPD GFCSSASTLE GLSVSDETCL STSEPSARVP DSVGVSPDDL
     DDTGQPVLER GQLNGKRDTL WLALRETVYD PSLPASHHSS LSWKGRGGPG DGSPVVLPNS
     QPDLPDVWLR RPSTHTSGYS S
//