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A7MBM2

- DISP2_HUMAN

UniProt

A7MBM2 - DISP2_HUMAN

Protein

Protein dispatched homolog 2

Gene

DISP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 2 (13 Nov 2007)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. smoothened signaling pathway Source: UniProtKB

    Enzyme and pathway databases

    SignaLinkiA7MBM2.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein dispatched homolog 2
    Gene namesi
    Name:DISP2
    Synonyms:DISPB, KIAA1742
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:19712. DISP2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134876083.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14011401Protein dispatched homolog 2PRO_0000310696Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi349 – 3491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi465 – 4651N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiA7MBM2.
    PaxDbiA7MBM2.
    PRIDEiA7MBM2.

    PTM databases

    PhosphoSiteiA7MBM2.

    Expressioni

    Gene expression databases

    BgeeiA7MBM2.
    CleanExiHS_DISP2.
    GenevestigatoriA7MBM2.

    Organism-specific databases

    HPAiHPA059903.

    Interactioni

    Protein-protein interaction databases

    BioGridi124539. 1 interaction.
    STRINGi9606.ENSP00000267889.

    Structurei

    3D structure databases

    ProteinModelPortaliA7MBM2.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei170 – 19021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei484 – 50421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei510 – 53021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei542 – 56221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei589 – 60921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei617 – 63721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei704 – 72421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei964 – 98421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei990 – 101021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1019 – 103921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1064 – 108421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1088 – 110821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini471 – 643173SSDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the dispatched family.Curated
    Contains 1 SSD (sterol-sensing) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG296314.
    HOGENOMiHOG000112218.
    HOVERGENiHBG094891.
    InParanoidiA7MBM2.
    OMAiLIAEWPV.
    OrthoDBiEOG7DRJ26.
    PhylomeDBiA7MBM2.
    TreeFamiTF324144.

    Family and domain databases

    InterProiIPR000731. SSD.
    [Graphical view]
    PROSITEiPS50156. SSD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7MBM2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDGDSSSSSG GSGPAPGPGP EGEQRPEGEP LAPDGGSPDS TQTKAVPPEA     50
    SPERSCSLHS CPLEDPSSSS GPPPTTSTLQ PVGPSSPLAP AHFTYPRALQ 100
    EYQGGSSLPG LGDRAALCSH GSSLSPSPAP SQRDGTWKPP AVQHHVVSVR 150
    QERAFQMPKS YSQLIAEWPV AVLMLCLAVI FLCTLAGLLG ARLPDFSKPL 200
    LGFEPRDTDI GSKLVVWRAL QALTGPRKLL FLSPDLELNS SSSHNTLRPA 250
    PRGSAQESAV RPRRMVEPLE DRRQENFFCG PPEKSYAKLV FMSTSSGSLW 300
    NLHAIHSMCR MEQDQIRSHT SFGALCQRTA ANQCCPSWSL GNYLAVLSNR 350
    SSCLDTTQAD AARTLALLRT CALYYHSGAL VPSCLGPGQN KSPRCAQVPT 400
    KCSQSSAIYQ LLHFLLDRDF LSPQTTDYQV PSLKYSLLFL PTPKGASLMD 450
    IYLDRLATPW GLADNYTSVT GMDLGLKQEL LRHFLVQDTV YPLLALVAIF 500
    FGMALYLRSL FLTLMVLLGV LGSLLVAFFL YQVAFRMAYF PFVNLAALLL 550
    LSSVCANHTL IFFDLWRLSK SQLPSGGLAQ RVGRTMHHFG YLLLVSGLTT 600
    SAAFYASYLS RLPAVRCLAL FMGTAVLVHL ALTLVWLPAS AVLHERYLAR 650
    GCARRARGRW EGSAPRRLLL ALHRRLRGLR RAAAGTSRLL FQRLLPCGVI 700
    KFRYIWICWF AALAAGGAYI AGVSPRLRLP TLPPPGGQVF RPSHPFERFD 750
    AEYRQLFLFE QLPQGEGGHM PVVLVWGVLP VDTGDPLDPR SNSSLVRDPA 800
    FSASGPEAQR WLLALCHRAR NQSFFDTLQE GWPTLCFVET LQRWMESPSC 850
    ARLGPDLCCG HSDFPWAPQF FLHCLKMMAL EQGPDGTQDL GLRFDAHGSL 900
    AALVLQFQTN FRNSPDYNQT QLFYNEVSHW LAAELGMAPP GLRRGWFTSR 950
    LELYSLQHSL STEPAVVLGL ALALAFATLL LGTWNVPLSL FSVAAVAGTV 1000
    LLTVGLLVLL EWQLNTAEAL FLSASVGLSV DFTVNYCISY HLCPHPDRLS 1050
    RVAFSLRQTS CATAVGAAAL FAAGVLMLPA TVLLYRKLGI ILMMVKCVSC 1100
    GFASFFFQSL CCFFGPEKNC GQILWPCAHL PWDAGTGDPG GEKAGRPRPG 1150
    SVGGMPGSCS EQYELQPLAR RRSPSFDTST ATSKLSHRPS VLSEDLQLHD 1200
    GPCCSRPPPA PASPRELLLD HQAVFSQCPA LQTSSPYKQA GPSPKTRARQ 1250
    DSQGEEAEPL PASPEAPAHS PKAKAADPPD GFCSSASTLE GLSVSDETCL 1300
    STSEPSARVP DSVGVSPDDL DDTGQPVLER GQLNGKRDTL WLALRETVYD 1350
    PSLPASHHSS LSWKGRGGPG DGSPVVLPNS QPDLPDVWLR RPSTHTSGYS 1400
    S 1401
    Length:1,401
    Mass (Da):152,003
    Last modified:November 13, 2007 - v2
    Checksum:i67BD27DC491C72CE
    GO

    Sequence cautioni

    The sequence BAB21833.2 differs from that shown. Reason: Erroneous termination at position 100. Translated as Gln.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti67 – 671S → F in BAB21833. (PubMed:11214970)Curated
    Sequence conflicti70 – 701S → L in BAB21833. (PubMed:11214970)Curated
    Sequence conflicti77 – 771S → F in BAB21833. (PubMed:11214970)Curated
    Sequence conflicti96 – 961P → T in BAB21833. (PubMed:11214970)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti47 – 471P → A.2 Publications
    Corresponds to variant rs1898883 [ dbSNP | Ensembl ].
    VAR_037078
    Natural varianti56 – 561C → S.2 Publications
    Corresponds to variant rs1898882 [ dbSNP | Ensembl ].
    VAR_037079
    Natural varianti388 – 3881G → E.
    Corresponds to variant rs35043215 [ dbSNP | Ensembl ].
    VAR_037080
    Natural varianti1145 – 11451G → S.
    Corresponds to variant rs2412512 [ dbSNP | Ensembl ].
    VAR_037081
    Natural varianti1247 – 12471R → W.
    Corresponds to variant rs3743142 [ dbSNP | Ensembl ].
    VAR_037082

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB051529 mRNA. Translation: BAB21833.2. Sequence problems.
    AC013356 Genomic DNA. No translation available.
    BC151833 mRNA. Translation: AAI51834.1.
    CR627480 mRNA. Translation: CAH10680.1.
    CCDSiCCDS10056.1.
    RefSeqiNP_277045.1. NM_033510.1.
    UniGeneiHs.355645.

    Genome annotation databases

    EnsembliENST00000267889; ENSP00000267889; ENSG00000140323.
    GeneIDi85455.
    KEGGihsa:85455.
    UCSCiuc001zlk.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB051529 mRNA. Translation: BAB21833.2 . Sequence problems.
    AC013356 Genomic DNA. No translation available.
    BC151833 mRNA. Translation: AAI51834.1 .
    CR627480 mRNA. Translation: CAH10680.1 .
    CCDSi CCDS10056.1.
    RefSeqi NP_277045.1. NM_033510.1.
    UniGenei Hs.355645.

    3D structure databases

    ProteinModelPortali A7MBM2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124539. 1 interaction.
    STRINGi 9606.ENSP00000267889.

    PTM databases

    PhosphoSitei A7MBM2.

    Proteomic databases

    MaxQBi A7MBM2.
    PaxDbi A7MBM2.
    PRIDEi A7MBM2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000267889 ; ENSP00000267889 ; ENSG00000140323 .
    GeneIDi 85455.
    KEGGi hsa:85455.
    UCSCi uc001zlk.1. human.

    Organism-specific databases

    CTDi 85455.
    GeneCardsi GC15P040650.
    H-InvDB HIX0202137.
    HGNCi HGNC:19712. DISP2.
    HPAi HPA059903.
    MIMi 607503. gene.
    neXtProti NX_A7MBM2.
    PharmGKBi PA134876083.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG296314.
    HOGENOMi HOG000112218.
    HOVERGENi HBG094891.
    InParanoidi A7MBM2.
    OMAi LIAEWPV.
    OrthoDBi EOG7DRJ26.
    PhylomeDBi A7MBM2.
    TreeFami TF324144.

    Enzyme and pathway databases

    SignaLinki A7MBM2.

    Miscellaneous databases

    GenomeRNAii 85455.
    NextBioi 76081.
    PROi A7MBM2.
    SOURCEi Search...

    Gene expression databases

    Bgeei A7MBM2.
    CleanExi HS_DISP2.
    Genevestigatori A7MBM2.

    Family and domain databases

    InterProi IPR000731. SSD.
    [Graphical view ]
    PROSITEi PS50156. SSD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
      DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ALA-47 AND SER-56.
      Tissue: Brain.
    2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
      Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
      , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
      Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-665, VARIANTS ALA-47 AND SER-56.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1279-1401.
      Tissue: Brain.

    Entry informationi

    Entry nameiDISP2_HUMAN
    AccessioniPrimary (citable) accession number: A7MBM2
    Secondary accession number(s): Q6AHW3, Q9C0C1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: November 13, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3