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A7MBM2 (DISP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein dispatched homolog 2
Gene names
Name:DISP2
Synonyms:DISPB, KIAA1742
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1401 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the dispatched family.

Contains 1 SSD (sterol-sensing) domain.

Sequence caution

The sequence BAB21833.2 differs from that shown. Reason: Erroneous termination at position 100. Translated as Gln.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsmoothened signaling pathway

Non-traceable author statement PubMed 16258256. Source: UniProtKB

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14011401Protein dispatched homolog 2
PRO_0000310696

Regions

Transmembrane170 – 19021Helical; Potential
Transmembrane484 – 50421Helical; Potential
Transmembrane510 – 53021Helical; Potential
Transmembrane542 – 56221Helical; Potential
Transmembrane589 – 60921Helical; Potential
Transmembrane617 – 63721Helical; Potential
Transmembrane704 – 72421Helical; Potential
Transmembrane964 – 98421Helical; Potential
Transmembrane990 – 101021Helical; Potential
Transmembrane1019 – 103921Helical; Potential
Transmembrane1064 – 108421Helical; Potential
Transmembrane1088 – 110821Helical; Potential
Domain471 – 643173SSD

Amino acid modifications

Glycosylation2391N-linked (GlcNAc...) Potential
Glycosylation3491N-linked (GlcNAc...) Potential
Glycosylation4651N-linked (GlcNAc...) Potential

Natural variations

Natural variant471P → A. Ref.1 Ref.4
Corresponds to variant rs1898883 [ dbSNP | Ensembl ].
VAR_037078
Natural variant561C → S. Ref.1 Ref.4
Corresponds to variant rs1898882 [ dbSNP | Ensembl ].
VAR_037079
Natural variant3881G → E.
Corresponds to variant rs35043215 [ dbSNP | Ensembl ].
VAR_037080
Natural variant11451G → S.
Corresponds to variant rs2412512 [ dbSNP | Ensembl ].
VAR_037081
Natural variant12471R → W.
Corresponds to variant rs3743142 [ dbSNP | Ensembl ].
VAR_037082

Experimental info

Sequence conflict671S → F in BAB21833. Ref.1
Sequence conflict701S → L in BAB21833. Ref.1
Sequence conflict771S → F in BAB21833. Ref.1
Sequence conflict961P → T in BAB21833. Ref.1

Sequences

Sequence LengthMass (Da)Tools
A7MBM2 [UniParc].

Last modified November 13, 2007. Version 2.
Checksum: 67BD27DC491C72CE

FASTA1,401152,003
        10         20         30         40         50         60 
MDGDSSSSSG GSGPAPGPGP EGEQRPEGEP LAPDGGSPDS TQTKAVPPEA SPERSCSLHS 

        70         80         90        100        110        120 
CPLEDPSSSS GPPPTTSTLQ PVGPSSPLAP AHFTYPRALQ EYQGGSSLPG LGDRAALCSH 

       130        140        150        160        170        180 
GSSLSPSPAP SQRDGTWKPP AVQHHVVSVR QERAFQMPKS YSQLIAEWPV AVLMLCLAVI 

       190        200        210        220        230        240 
FLCTLAGLLG ARLPDFSKPL LGFEPRDTDI GSKLVVWRAL QALTGPRKLL FLSPDLELNS 

       250        260        270        280        290        300 
SSSHNTLRPA PRGSAQESAV RPRRMVEPLE DRRQENFFCG PPEKSYAKLV FMSTSSGSLW 

       310        320        330        340        350        360 
NLHAIHSMCR MEQDQIRSHT SFGALCQRTA ANQCCPSWSL GNYLAVLSNR SSCLDTTQAD 

       370        380        390        400        410        420 
AARTLALLRT CALYYHSGAL VPSCLGPGQN KSPRCAQVPT KCSQSSAIYQ LLHFLLDRDF 

       430        440        450        460        470        480 
LSPQTTDYQV PSLKYSLLFL PTPKGASLMD IYLDRLATPW GLADNYTSVT GMDLGLKQEL 

       490        500        510        520        530        540 
LRHFLVQDTV YPLLALVAIF FGMALYLRSL FLTLMVLLGV LGSLLVAFFL YQVAFRMAYF 

       550        560        570        580        590        600 
PFVNLAALLL LSSVCANHTL IFFDLWRLSK SQLPSGGLAQ RVGRTMHHFG YLLLVSGLTT 

       610        620        630        640        650        660 
SAAFYASYLS RLPAVRCLAL FMGTAVLVHL ALTLVWLPAS AVLHERYLAR GCARRARGRW 

       670        680        690        700        710        720 
EGSAPRRLLL ALHRRLRGLR RAAAGTSRLL FQRLLPCGVI KFRYIWICWF AALAAGGAYI 

       730        740        750        760        770        780 
AGVSPRLRLP TLPPPGGQVF RPSHPFERFD AEYRQLFLFE QLPQGEGGHM PVVLVWGVLP 

       790        800        810        820        830        840 
VDTGDPLDPR SNSSLVRDPA FSASGPEAQR WLLALCHRAR NQSFFDTLQE GWPTLCFVET 

       850        860        870        880        890        900 
LQRWMESPSC ARLGPDLCCG HSDFPWAPQF FLHCLKMMAL EQGPDGTQDL GLRFDAHGSL 

       910        920        930        940        950        960 
AALVLQFQTN FRNSPDYNQT QLFYNEVSHW LAAELGMAPP GLRRGWFTSR LELYSLQHSL 

       970        980        990       1000       1010       1020 
STEPAVVLGL ALALAFATLL LGTWNVPLSL FSVAAVAGTV LLTVGLLVLL EWQLNTAEAL 

      1030       1040       1050       1060       1070       1080 
FLSASVGLSV DFTVNYCISY HLCPHPDRLS RVAFSLRQTS CATAVGAAAL FAAGVLMLPA 

      1090       1100       1110       1120       1130       1140 
TVLLYRKLGI ILMMVKCVSC GFASFFFQSL CCFFGPEKNC GQILWPCAHL PWDAGTGDPG 

      1150       1160       1170       1180       1190       1200 
GEKAGRPRPG SVGGMPGSCS EQYELQPLAR RRSPSFDTST ATSKLSHRPS VLSEDLQLHD 

      1210       1220       1230       1240       1250       1260 
GPCCSRPPPA PASPRELLLD HQAVFSQCPA LQTSSPYKQA GPSPKTRARQ DSQGEEAEPL 

      1270       1280       1290       1300       1310       1320 
PASPEAPAHS PKAKAADPPD GFCSSASTLE GLSVSDETCL STSEPSARVP DSVGVSPDDL 

      1330       1340       1350       1360       1370       1380 
DDTGQPVLER GQLNGKRDTL WLALRETVYD PSLPASHHSS LSWKGRGGPG DGSPVVLPNS 

      1390       1400 
QPDLPDVWLR RPSTHTSGYS S 

« Hide

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ALA-47 AND SER-56.
Tissue: Brain.
[2]"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION.
[3]"Analysis of the DNA sequence and duplication history of human chromosome 15."
Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. expand/collapse author list , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-665, VARIANTS ALA-47 AND SER-56.
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1279-1401.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB051529 mRNA. Translation: BAB21833.2. Sequence problems.
AC013356 Genomic DNA. No translation available.
BC151833 mRNA. Translation: AAI51834.1.
CR627480 mRNA. Translation: CAH10680.1.
CCDSCCDS10056.1.
RefSeqNP_277045.1. NM_033510.1.
UniGeneHs.355645.

3D structure databases

ProteinModelPortalA7MBM2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124539. 1 interaction.
STRING9606.ENSP00000267889.

PTM databases

PhosphoSiteA7MBM2.

Proteomic databases

MaxQBA7MBM2.
PaxDbA7MBM2.
PRIDEA7MBM2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000267889; ENSP00000267889; ENSG00000140323.
GeneID85455.
KEGGhsa:85455.
UCSCuc001zlk.1. human.

Organism-specific databases

CTD85455.
GeneCardsGC15P040650.
H-InvDBHIX0202137.
HGNCHGNC:19712. DISP2.
HPAHPA059903.
MIM607503. gene.
neXtProtNX_A7MBM2.
PharmGKBPA134876083.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG296314.
HOGENOMHOG000112218.
HOVERGENHBG094891.
InParanoidA7MBM2.
OMALIAEWPV.
OrthoDBEOG7DRJ26.
PhylomeDBA7MBM2.
TreeFamTF324144.

Enzyme and pathway databases

SignaLinkA7MBM2.

Gene expression databases

BgeeA7MBM2.
CleanExHS_DISP2.
GenevestigatorA7MBM2.

Family and domain databases

InterProIPR000731. SSD.
[Graphical view]
PROSITEPS50156. SSD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi85455.
NextBio76081.
PROA7MBM2.
SOURCESearch...

Entry information

Entry nameDISP2_HUMAN
AccessionPrimary (citable) accession number: A7MBM2
Secondary accession number(s): Q6AHW3, Q9C0C1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: July 9, 2014
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM