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A7MBM2

- DISP2_HUMAN

UniProt

A7MBM2 - DISP2_HUMAN

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Protein

Protein dispatched homolog 2

Gene

DISP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. smoothened signaling pathway Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiA7MBM2.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein dispatched homolog 2
Gene namesi
Name:DISP2
Synonyms:DISPB, KIAA1742
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:19712. DISP2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134876083.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14011401Protein dispatched homolog 2PRO_0000310696Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi349 – 3491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi465 – 4651N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiA7MBM2.
PaxDbiA7MBM2.
PRIDEiA7MBM2.

PTM databases

PhosphoSiteiA7MBM2.

Expressioni

Gene expression databases

BgeeiA7MBM2.
CleanExiHS_DISP2.
GenevestigatoriA7MBM2.

Organism-specific databases

HPAiHPA059903.

Interactioni

Protein-protein interaction databases

BioGridi124539. 1 interaction.
STRINGi9606.ENSP00000267889.

Structurei

3D structure databases

ProteinModelPortaliA7MBM2.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei170 – 19021HelicalSequence AnalysisAdd
BLAST
Transmembranei484 – 50421HelicalSequence AnalysisAdd
BLAST
Transmembranei510 – 53021HelicalSequence AnalysisAdd
BLAST
Transmembranei542 – 56221HelicalSequence AnalysisAdd
BLAST
Transmembranei589 – 60921HelicalSequence AnalysisAdd
BLAST
Transmembranei617 – 63721HelicalSequence AnalysisAdd
BLAST
Transmembranei704 – 72421HelicalSequence AnalysisAdd
BLAST
Transmembranei964 – 98421HelicalSequence AnalysisAdd
BLAST
Transmembranei990 – 101021HelicalSequence AnalysisAdd
BLAST
Transmembranei1019 – 103921HelicalSequence AnalysisAdd
BLAST
Transmembranei1064 – 108421HelicalSequence AnalysisAdd
BLAST
Transmembranei1088 – 110821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini471 – 643173SSDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the dispatched family.Curated
Contains 1 SSD (sterol-sensing) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG296314.
GeneTreeiENSGT00530000063208.
HOGENOMiHOG000112218.
HOVERGENiHBG094891.
InParanoidiA7MBM2.
OMAiLIAEWPV.
OrthoDBiEOG7DRJ26.
PhylomeDBiA7MBM2.
TreeFamiTF324144.

Family and domain databases

InterProiIPR000731. SSD.
[Graphical view]
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7MBM2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDGDSSSSSG GSGPAPGPGP EGEQRPEGEP LAPDGGSPDS TQTKAVPPEA
60 70 80 90 100
SPERSCSLHS CPLEDPSSSS GPPPTTSTLQ PVGPSSPLAP AHFTYPRALQ
110 120 130 140 150
EYQGGSSLPG LGDRAALCSH GSSLSPSPAP SQRDGTWKPP AVQHHVVSVR
160 170 180 190 200
QERAFQMPKS YSQLIAEWPV AVLMLCLAVI FLCTLAGLLG ARLPDFSKPL
210 220 230 240 250
LGFEPRDTDI GSKLVVWRAL QALTGPRKLL FLSPDLELNS SSSHNTLRPA
260 270 280 290 300
PRGSAQESAV RPRRMVEPLE DRRQENFFCG PPEKSYAKLV FMSTSSGSLW
310 320 330 340 350
NLHAIHSMCR MEQDQIRSHT SFGALCQRTA ANQCCPSWSL GNYLAVLSNR
360 370 380 390 400
SSCLDTTQAD AARTLALLRT CALYYHSGAL VPSCLGPGQN KSPRCAQVPT
410 420 430 440 450
KCSQSSAIYQ LLHFLLDRDF LSPQTTDYQV PSLKYSLLFL PTPKGASLMD
460 470 480 490 500
IYLDRLATPW GLADNYTSVT GMDLGLKQEL LRHFLVQDTV YPLLALVAIF
510 520 530 540 550
FGMALYLRSL FLTLMVLLGV LGSLLVAFFL YQVAFRMAYF PFVNLAALLL
560 570 580 590 600
LSSVCANHTL IFFDLWRLSK SQLPSGGLAQ RVGRTMHHFG YLLLVSGLTT
610 620 630 640 650
SAAFYASYLS RLPAVRCLAL FMGTAVLVHL ALTLVWLPAS AVLHERYLAR
660 670 680 690 700
GCARRARGRW EGSAPRRLLL ALHRRLRGLR RAAAGTSRLL FQRLLPCGVI
710 720 730 740 750
KFRYIWICWF AALAAGGAYI AGVSPRLRLP TLPPPGGQVF RPSHPFERFD
760 770 780 790 800
AEYRQLFLFE QLPQGEGGHM PVVLVWGVLP VDTGDPLDPR SNSSLVRDPA
810 820 830 840 850
FSASGPEAQR WLLALCHRAR NQSFFDTLQE GWPTLCFVET LQRWMESPSC
860 870 880 890 900
ARLGPDLCCG HSDFPWAPQF FLHCLKMMAL EQGPDGTQDL GLRFDAHGSL
910 920 930 940 950
AALVLQFQTN FRNSPDYNQT QLFYNEVSHW LAAELGMAPP GLRRGWFTSR
960 970 980 990 1000
LELYSLQHSL STEPAVVLGL ALALAFATLL LGTWNVPLSL FSVAAVAGTV
1010 1020 1030 1040 1050
LLTVGLLVLL EWQLNTAEAL FLSASVGLSV DFTVNYCISY HLCPHPDRLS
1060 1070 1080 1090 1100
RVAFSLRQTS CATAVGAAAL FAAGVLMLPA TVLLYRKLGI ILMMVKCVSC
1110 1120 1130 1140 1150
GFASFFFQSL CCFFGPEKNC GQILWPCAHL PWDAGTGDPG GEKAGRPRPG
1160 1170 1180 1190 1200
SVGGMPGSCS EQYELQPLAR RRSPSFDTST ATSKLSHRPS VLSEDLQLHD
1210 1220 1230 1240 1250
GPCCSRPPPA PASPRELLLD HQAVFSQCPA LQTSSPYKQA GPSPKTRARQ
1260 1270 1280 1290 1300
DSQGEEAEPL PASPEAPAHS PKAKAADPPD GFCSSASTLE GLSVSDETCL
1310 1320 1330 1340 1350
STSEPSARVP DSVGVSPDDL DDTGQPVLER GQLNGKRDTL WLALRETVYD
1360 1370 1380 1390 1400
PSLPASHHSS LSWKGRGGPG DGSPVVLPNS QPDLPDVWLR RPSTHTSGYS

S
Length:1,401
Mass (Da):152,003
Last modified:November 13, 2007 - v2
Checksum:i67BD27DC491C72CE
GO

Sequence cautioni

The sequence BAB21833.2 differs from that shown. Reason: Erroneous termination at position 100. Translated as Gln.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 671S → F in BAB21833. (PubMed:11214970)Curated
Sequence conflicti70 – 701S → L in BAB21833. (PubMed:11214970)Curated
Sequence conflicti77 – 771S → F in BAB21833. (PubMed:11214970)Curated
Sequence conflicti96 – 961P → T in BAB21833. (PubMed:11214970)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti47 – 471P → A.2 Publications
Corresponds to variant rs1898883 [ dbSNP | Ensembl ].
VAR_037078
Natural varianti56 – 561C → S.2 Publications
Corresponds to variant rs1898882 [ dbSNP | Ensembl ].
VAR_037079
Natural varianti388 – 3881G → E.
Corresponds to variant rs35043215 [ dbSNP | Ensembl ].
VAR_037080
Natural varianti1145 – 11451G → S.
Corresponds to variant rs2412512 [ dbSNP | Ensembl ].
VAR_037081
Natural varianti1247 – 12471R → W.
Corresponds to variant rs3743142 [ dbSNP | Ensembl ].
VAR_037082

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB051529 mRNA. Translation: BAB21833.2. Sequence problems.
AC013356 Genomic DNA. No translation available.
BC151833 mRNA. Translation: AAI51834.1.
CR627480 mRNA. Translation: CAH10680.1.
CCDSiCCDS10056.1.
RefSeqiNP_277045.1. NM_033510.1.
UniGeneiHs.355645.

Genome annotation databases

EnsembliENST00000267889; ENSP00000267889; ENSG00000140323.
GeneIDi85455.
KEGGihsa:85455.
UCSCiuc001zlk.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB051529 mRNA. Translation: BAB21833.2 . Sequence problems.
AC013356 Genomic DNA. No translation available.
BC151833 mRNA. Translation: AAI51834.1 .
CR627480 mRNA. Translation: CAH10680.1 .
CCDSi CCDS10056.1.
RefSeqi NP_277045.1. NM_033510.1.
UniGenei Hs.355645.

3D structure databases

ProteinModelPortali A7MBM2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124539. 1 interaction.
STRINGi 9606.ENSP00000267889.

PTM databases

PhosphoSitei A7MBM2.

Proteomic databases

MaxQBi A7MBM2.
PaxDbi A7MBM2.
PRIDEi A7MBM2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000267889 ; ENSP00000267889 ; ENSG00000140323 .
GeneIDi 85455.
KEGGi hsa:85455.
UCSCi uc001zlk.1. human.

Organism-specific databases

CTDi 85455.
GeneCardsi GC15P040650.
H-InvDB HIX0202137.
HGNCi HGNC:19712. DISP2.
HPAi HPA059903.
MIMi 607503. gene.
neXtProti NX_A7MBM2.
PharmGKBi PA134876083.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG296314.
GeneTreei ENSGT00530000063208.
HOGENOMi HOG000112218.
HOVERGENi HBG094891.
InParanoidi A7MBM2.
OMAi LIAEWPV.
OrthoDBi EOG7DRJ26.
PhylomeDBi A7MBM2.
TreeFami TF324144.

Enzyme and pathway databases

SignaLinki A7MBM2.

Miscellaneous databases

GenomeRNAii 85455.
NextBioi 76081.
PROi A7MBM2.
SOURCEi Search...

Gene expression databases

Bgeei A7MBM2.
CleanExi HS_DISP2.
Genevestigatori A7MBM2.

Family and domain databases

InterProi IPR000731. SSD.
[Graphical view ]
PROSITEi PS50156. SSD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ALA-47 AND SER-56.
    Tissue: Brain.
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-665, VARIANTS ALA-47 AND SER-56.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1279-1401.
    Tissue: Brain.

Entry informationi

Entry nameiDISP2_HUMAN
AccessioniPrimary (citable) accession number: A7MBM2
Secondary accession number(s): Q6AHW3, Q9C0C1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: October 29, 2014
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3