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Protein

Protein dispatched homolog 2

Gene

DISP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • smoothened signaling pathway Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-5362798. Release of Hh-Np from the secreting cell.
SignaLinkiA7MBM2.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein dispatched homolog 2
Gene namesi
Name:DISP2
Synonyms:DISPB, KIAA1742
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:19712. DISP2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Transmembranei484 – 504HelicalSequence analysisAdd BLAST21
Transmembranei510 – 530HelicalSequence analysisAdd BLAST21
Transmembranei542 – 562HelicalSequence analysisAdd BLAST21
Transmembranei589 – 609HelicalSequence analysisAdd BLAST21
Transmembranei617 – 637HelicalSequence analysisAdd BLAST21
Transmembranei704 – 724HelicalSequence analysisAdd BLAST21
Transmembranei964 – 984HelicalSequence analysisAdd BLAST21
Transmembranei990 – 1010HelicalSequence analysisAdd BLAST21
Transmembranei1019 – 1039HelicalSequence analysisAdd BLAST21
Transmembranei1064 – 1084HelicalSequence analysisAdd BLAST21
Transmembranei1088 – 1108HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000140323.
PharmGKBiPA134876083.

Polymorphism and mutation databases

BioMutaiDISP2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003106961 – 1401Protein dispatched homolog 2Add BLAST1401

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi239N-linked (GlcNAc...)Sequence analysis1
Glycosylationi349N-linked (GlcNAc...)Sequence analysis1
Glycosylationi465N-linked (GlcNAc...)Sequence analysis1
Modified residuei1366Omega-N-methylarginineBy similarity1

Keywords - PTMi

Glycoprotein, Methylation

Proteomic databases

MaxQBiA7MBM2.
PaxDbiA7MBM2.
PRIDEiA7MBM2.

PTM databases

iPTMnetiA7MBM2.
PhosphoSitePlusiA7MBM2.

Expressioni

Gene expression databases

BgeeiENSG00000140323.
CleanExiHS_DISP2.
GenevisibleiA7MBM2. HS.

Organism-specific databases

HPAiHPA059903.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000267889.

Structurei

3D structure databases

ProteinModelPortaliA7MBM2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini471 – 643SSDPROSITE-ProRule annotationAdd BLAST173

Sequence similaritiesi

Belongs to the dispatched family.Curated
Contains 1 SSD (sterol-sensing) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3664. Eukaryota.
ENOG410XT7M. LUCA.
GeneTreeiENSGT00530000063208.
HOGENOMiHOG000112218.
HOVERGENiHBG094891.
InParanoidiA7MBM2.
OMAiHSMCRME.
OrthoDBiEOG091G00FX.
PhylomeDBiA7MBM2.
TreeFamiTF324144.

Family and domain databases

InterProiIPR000731. SSD.
[Graphical view]
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7MBM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGDSSSSSG GSGPAPGPGP EGEQRPEGEP LAPDGGSPDS TQTKAVPPEA
60 70 80 90 100
SPERSCSLHS CPLEDPSSSS GPPPTTSTLQ PVGPSSPLAP AHFTYPRALQ
110 120 130 140 150
EYQGGSSLPG LGDRAALCSH GSSLSPSPAP SQRDGTWKPP AVQHHVVSVR
160 170 180 190 200
QERAFQMPKS YSQLIAEWPV AVLMLCLAVI FLCTLAGLLG ARLPDFSKPL
210 220 230 240 250
LGFEPRDTDI GSKLVVWRAL QALTGPRKLL FLSPDLELNS SSSHNTLRPA
260 270 280 290 300
PRGSAQESAV RPRRMVEPLE DRRQENFFCG PPEKSYAKLV FMSTSSGSLW
310 320 330 340 350
NLHAIHSMCR MEQDQIRSHT SFGALCQRTA ANQCCPSWSL GNYLAVLSNR
360 370 380 390 400
SSCLDTTQAD AARTLALLRT CALYYHSGAL VPSCLGPGQN KSPRCAQVPT
410 420 430 440 450
KCSQSSAIYQ LLHFLLDRDF LSPQTTDYQV PSLKYSLLFL PTPKGASLMD
460 470 480 490 500
IYLDRLATPW GLADNYTSVT GMDLGLKQEL LRHFLVQDTV YPLLALVAIF
510 520 530 540 550
FGMALYLRSL FLTLMVLLGV LGSLLVAFFL YQVAFRMAYF PFVNLAALLL
560 570 580 590 600
LSSVCANHTL IFFDLWRLSK SQLPSGGLAQ RVGRTMHHFG YLLLVSGLTT
610 620 630 640 650
SAAFYASYLS RLPAVRCLAL FMGTAVLVHL ALTLVWLPAS AVLHERYLAR
660 670 680 690 700
GCARRARGRW EGSAPRRLLL ALHRRLRGLR RAAAGTSRLL FQRLLPCGVI
710 720 730 740 750
KFRYIWICWF AALAAGGAYI AGVSPRLRLP TLPPPGGQVF RPSHPFERFD
760 770 780 790 800
AEYRQLFLFE QLPQGEGGHM PVVLVWGVLP VDTGDPLDPR SNSSLVRDPA
810 820 830 840 850
FSASGPEAQR WLLALCHRAR NQSFFDTLQE GWPTLCFVET LQRWMESPSC
860 870 880 890 900
ARLGPDLCCG HSDFPWAPQF FLHCLKMMAL EQGPDGTQDL GLRFDAHGSL
910 920 930 940 950
AALVLQFQTN FRNSPDYNQT QLFYNEVSHW LAAELGMAPP GLRRGWFTSR
960 970 980 990 1000
LELYSLQHSL STEPAVVLGL ALALAFATLL LGTWNVPLSL FSVAAVAGTV
1010 1020 1030 1040 1050
LLTVGLLVLL EWQLNTAEAL FLSASVGLSV DFTVNYCISY HLCPHPDRLS
1060 1070 1080 1090 1100
RVAFSLRQTS CATAVGAAAL FAAGVLMLPA TVLLYRKLGI ILMMVKCVSC
1110 1120 1130 1140 1150
GFASFFFQSL CCFFGPEKNC GQILWPCAHL PWDAGTGDPG GEKAGRPRPG
1160 1170 1180 1190 1200
SVGGMPGSCS EQYELQPLAR RRSPSFDTST ATSKLSHRPS VLSEDLQLHD
1210 1220 1230 1240 1250
GPCCSRPPPA PASPRELLLD HQAVFSQCPA LQTSSPYKQA GPSPKTRARQ
1260 1270 1280 1290 1300
DSQGEEAEPL PASPEAPAHS PKAKAADPPD GFCSSASTLE GLSVSDETCL
1310 1320 1330 1340 1350
STSEPSARVP DSVGVSPDDL DDTGQPVLER GQLNGKRDTL WLALRETVYD
1360 1370 1380 1390 1400
PSLPASHHSS LSWKGRGGPG DGSPVVLPNS QPDLPDVWLR RPSTHTSGYS

S
Length:1,401
Mass (Da):152,003
Last modified:November 13, 2007 - v2
Checksum:i67BD27DC491C72CE
GO

Sequence cautioni

The sequence BAB21833 differs from that shown. Reason: Erroneous termination at position 100. Translated as Gln.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67S → F in BAB21833 (PubMed:11214970).Curated1
Sequence conflicti70S → L in BAB21833 (PubMed:11214970).Curated1
Sequence conflicti77S → F in BAB21833 (PubMed:11214970).Curated1
Sequence conflicti96P → T in BAB21833 (PubMed:11214970).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03707847P → A.2 PublicationsCorresponds to variant rs1898883dbSNPEnsembl.1
Natural variantiVAR_03707956C → S.2 PublicationsCorresponds to variant rs1898882dbSNPEnsembl.1
Natural variantiVAR_037080388G → E.Corresponds to variant rs35043215dbSNPEnsembl.1
Natural variantiVAR_0370811145G → S.Corresponds to variant rs2412512dbSNPEnsembl.1
Natural variantiVAR_0370821247R → W.Corresponds to variant rs3743142dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051529 mRNA. Translation: BAB21833.2. Sequence problems.
AC013356 Genomic DNA. No translation available.
BC151833 mRNA. Translation: AAI51834.1.
CR627480 mRNA. Translation: CAH10680.1.
CCDSiCCDS10056.1.
RefSeqiNP_277045.1. NM_033510.2.
XP_011520427.1. XM_011522125.2.
XP_016878176.1. XM_017022687.1.
UniGeneiHs.355645.

Genome annotation databases

EnsembliENST00000267889; ENSP00000267889; ENSG00000140323.
GeneIDi85455.
KEGGihsa:85455.
UCSCiuc001zlk.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051529 mRNA. Translation: BAB21833.2. Sequence problems.
AC013356 Genomic DNA. No translation available.
BC151833 mRNA. Translation: AAI51834.1.
CR627480 mRNA. Translation: CAH10680.1.
CCDSiCCDS10056.1.
RefSeqiNP_277045.1. NM_033510.2.
XP_011520427.1. XM_011522125.2.
XP_016878176.1. XM_017022687.1.
UniGeneiHs.355645.

3D structure databases

ProteinModelPortaliA7MBM2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000267889.

PTM databases

iPTMnetiA7MBM2.
PhosphoSitePlusiA7MBM2.

Polymorphism and mutation databases

BioMutaiDISP2.

Proteomic databases

MaxQBiA7MBM2.
PaxDbiA7MBM2.
PRIDEiA7MBM2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267889; ENSP00000267889; ENSG00000140323.
GeneIDi85455.
KEGGihsa:85455.
UCSCiuc001zlk.2. human.

Organism-specific databases

CTDi85455.
GeneCardsiDISP2.
H-InvDBHIX0202137.
HGNCiHGNC:19712. DISP2.
HPAiHPA059903.
MIMi607503. gene.
neXtProtiNX_A7MBM2.
OpenTargetsiENSG00000140323.
PharmGKBiPA134876083.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3664. Eukaryota.
ENOG410XT7M. LUCA.
GeneTreeiENSGT00530000063208.
HOGENOMiHOG000112218.
HOVERGENiHBG094891.
InParanoidiA7MBM2.
OMAiHSMCRME.
OrthoDBiEOG091G00FX.
PhylomeDBiA7MBM2.
TreeFamiTF324144.

Enzyme and pathway databases

ReactomeiR-HSA-5362798. Release of Hh-Np from the secreting cell.
SignaLinkiA7MBM2.

Miscellaneous databases

ChiTaRSiDISP2. human.
GenomeRNAii85455.
PROiA7MBM2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140323.
CleanExiHS_DISP2.
GenevisibleiA7MBM2. HS.

Family and domain databases

InterProiIPR000731. SSD.
[Graphical view]
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDISP2_HUMAN
AccessioniPrimary (citable) accession number: A7MBM2
Secondary accession number(s): Q6AHW3, Q9C0C1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: November 2, 2016
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.