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A7MBM2

- DISP2_HUMAN

UniProt

A7MBM2 - DISP2_HUMAN

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Protein
Protein dispatched homolog 2
Gene
DISP2, DISPB, KIAA1742
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. smoothened signaling pathway Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiA7MBM2.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein dispatched homolog 2
Gene namesi
Name:DISP2
Synonyms:DISPB, KIAA1742
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:19712. DISP2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei170 – 19021Helical; Reviewed prediction
Add
BLAST
Transmembranei484 – 50421Helical; Reviewed prediction
Add
BLAST
Transmembranei510 – 53021Helical; Reviewed prediction
Add
BLAST
Transmembranei542 – 56221Helical; Reviewed prediction
Add
BLAST
Transmembranei589 – 60921Helical; Reviewed prediction
Add
BLAST
Transmembranei617 – 63721Helical; Reviewed prediction
Add
BLAST
Transmembranei704 – 72421Helical; Reviewed prediction
Add
BLAST
Transmembranei964 – 98421Helical; Reviewed prediction
Add
BLAST
Transmembranei990 – 101021Helical; Reviewed prediction
Add
BLAST
Transmembranei1019 – 103921Helical; Reviewed prediction
Add
BLAST
Transmembranei1064 – 108421Helical; Reviewed prediction
Add
BLAST
Transmembranei1088 – 110821Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134876083.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14011401Protein dispatched homolog 2
PRO_0000310696Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi239 – 2391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi349 – 3491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi465 – 4651N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiA7MBM2.
PaxDbiA7MBM2.
PRIDEiA7MBM2.

PTM databases

PhosphoSiteiA7MBM2.

Expressioni

Gene expression databases

BgeeiA7MBM2.
CleanExiHS_DISP2.
GenevestigatoriA7MBM2.

Organism-specific databases

HPAiHPA059903.

Interactioni

Protein-protein interaction databases

BioGridi124539. 1 interaction.
STRINGi9606.ENSP00000267889.

Structurei

3D structure databases

ProteinModelPortaliA7MBM2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini471 – 643173SSD
Add
BLAST

Sequence similaritiesi

Belongs to the dispatched family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG296314.
HOGENOMiHOG000112218.
HOVERGENiHBG094891.
InParanoidiA7MBM2.
OMAiLIAEWPV.
OrthoDBiEOG7DRJ26.
PhylomeDBiA7MBM2.
TreeFamiTF324144.

Family and domain databases

InterProiIPR000731. SSD.
[Graphical view]
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7MBM2-1 [UniParc]FASTAAdd to Basket

« Hide

MDGDSSSSSG GSGPAPGPGP EGEQRPEGEP LAPDGGSPDS TQTKAVPPEA     50
SPERSCSLHS CPLEDPSSSS GPPPTTSTLQ PVGPSSPLAP AHFTYPRALQ 100
EYQGGSSLPG LGDRAALCSH GSSLSPSPAP SQRDGTWKPP AVQHHVVSVR 150
QERAFQMPKS YSQLIAEWPV AVLMLCLAVI FLCTLAGLLG ARLPDFSKPL 200
LGFEPRDTDI GSKLVVWRAL QALTGPRKLL FLSPDLELNS SSSHNTLRPA 250
PRGSAQESAV RPRRMVEPLE DRRQENFFCG PPEKSYAKLV FMSTSSGSLW 300
NLHAIHSMCR MEQDQIRSHT SFGALCQRTA ANQCCPSWSL GNYLAVLSNR 350
SSCLDTTQAD AARTLALLRT CALYYHSGAL VPSCLGPGQN KSPRCAQVPT 400
KCSQSSAIYQ LLHFLLDRDF LSPQTTDYQV PSLKYSLLFL PTPKGASLMD 450
IYLDRLATPW GLADNYTSVT GMDLGLKQEL LRHFLVQDTV YPLLALVAIF 500
FGMALYLRSL FLTLMVLLGV LGSLLVAFFL YQVAFRMAYF PFVNLAALLL 550
LSSVCANHTL IFFDLWRLSK SQLPSGGLAQ RVGRTMHHFG YLLLVSGLTT 600
SAAFYASYLS RLPAVRCLAL FMGTAVLVHL ALTLVWLPAS AVLHERYLAR 650
GCARRARGRW EGSAPRRLLL ALHRRLRGLR RAAAGTSRLL FQRLLPCGVI 700
KFRYIWICWF AALAAGGAYI AGVSPRLRLP TLPPPGGQVF RPSHPFERFD 750
AEYRQLFLFE QLPQGEGGHM PVVLVWGVLP VDTGDPLDPR SNSSLVRDPA 800
FSASGPEAQR WLLALCHRAR NQSFFDTLQE GWPTLCFVET LQRWMESPSC 850
ARLGPDLCCG HSDFPWAPQF FLHCLKMMAL EQGPDGTQDL GLRFDAHGSL 900
AALVLQFQTN FRNSPDYNQT QLFYNEVSHW LAAELGMAPP GLRRGWFTSR 950
LELYSLQHSL STEPAVVLGL ALALAFATLL LGTWNVPLSL FSVAAVAGTV 1000
LLTVGLLVLL EWQLNTAEAL FLSASVGLSV DFTVNYCISY HLCPHPDRLS 1050
RVAFSLRQTS CATAVGAAAL FAAGVLMLPA TVLLYRKLGI ILMMVKCVSC 1100
GFASFFFQSL CCFFGPEKNC GQILWPCAHL PWDAGTGDPG GEKAGRPRPG 1150
SVGGMPGSCS EQYELQPLAR RRSPSFDTST ATSKLSHRPS VLSEDLQLHD 1200
GPCCSRPPPA PASPRELLLD HQAVFSQCPA LQTSSPYKQA GPSPKTRARQ 1250
DSQGEEAEPL PASPEAPAHS PKAKAADPPD GFCSSASTLE GLSVSDETCL 1300
STSEPSARVP DSVGVSPDDL DDTGQPVLER GQLNGKRDTL WLALRETVYD 1350
PSLPASHHSS LSWKGRGGPG DGSPVVLPNS QPDLPDVWLR RPSTHTSGYS 1400
S 1401
Length:1,401
Mass (Da):152,003
Last modified:November 13, 2007 - v2
Checksum:i67BD27DC491C72CE
GO

Sequence cautioni

The sequence BAB21833.2 differs from that shown. Reason: Erroneous termination at position 100. Translated as Gln.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti47 – 471P → A.2 Publications
Corresponds to variant rs1898883 [ dbSNP | Ensembl ].
VAR_037078
Natural varianti56 – 561C → S.2 Publications
Corresponds to variant rs1898882 [ dbSNP | Ensembl ].
VAR_037079
Natural varianti388 – 3881G → E.
Corresponds to variant rs35043215 [ dbSNP | Ensembl ].
VAR_037080
Natural varianti1145 – 11451G → S.
Corresponds to variant rs2412512 [ dbSNP | Ensembl ].
VAR_037081
Natural varianti1247 – 12471R → W.
Corresponds to variant rs3743142 [ dbSNP | Ensembl ].
VAR_037082

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 671S → F in BAB21833. 1 Publication
Sequence conflicti70 – 701S → L in BAB21833. 1 Publication
Sequence conflicti77 – 771S → F in BAB21833. 1 Publication
Sequence conflicti96 – 961P → T in BAB21833. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB051529 mRNA. Translation: BAB21833.2. Sequence problems.
AC013356 Genomic DNA. No translation available.
BC151833 mRNA. Translation: AAI51834.1.
CR627480 mRNA. Translation: CAH10680.1.
CCDSiCCDS10056.1.
RefSeqiNP_277045.1. NM_033510.1.
UniGeneiHs.355645.

Genome annotation databases

EnsembliENST00000267889; ENSP00000267889; ENSG00000140323.
GeneIDi85455.
KEGGihsa:85455.
UCSCiuc001zlk.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB051529 mRNA. Translation: BAB21833.2 . Sequence problems.
AC013356 Genomic DNA. No translation available.
BC151833 mRNA. Translation: AAI51834.1 .
CR627480 mRNA. Translation: CAH10680.1 .
CCDSi CCDS10056.1.
RefSeqi NP_277045.1. NM_033510.1.
UniGenei Hs.355645.

3D structure databases

ProteinModelPortali A7MBM2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124539. 1 interaction.
STRINGi 9606.ENSP00000267889.

PTM databases

PhosphoSitei A7MBM2.

Proteomic databases

MaxQBi A7MBM2.
PaxDbi A7MBM2.
PRIDEi A7MBM2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000267889 ; ENSP00000267889 ; ENSG00000140323 .
GeneIDi 85455.
KEGGi hsa:85455.
UCSCi uc001zlk.1. human.

Organism-specific databases

CTDi 85455.
GeneCardsi GC15P040650.
H-InvDB HIX0202137.
HGNCi HGNC:19712. DISP2.
HPAi HPA059903.
MIMi 607503. gene.
neXtProti NX_A7MBM2.
PharmGKBi PA134876083.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG296314.
HOGENOMi HOG000112218.
HOVERGENi HBG094891.
InParanoidi A7MBM2.
OMAi LIAEWPV.
OrthoDBi EOG7DRJ26.
PhylomeDBi A7MBM2.
TreeFami TF324144.

Enzyme and pathway databases

SignaLinki A7MBM2.

Miscellaneous databases

GenomeRNAii 85455.
NextBioi 76081.
PROi A7MBM2.
SOURCEi Search...

Gene expression databases

Bgeei A7MBM2.
CleanExi HS_DISP2.
Genevestigatori A7MBM2.

Family and domain databases

InterProi IPR000731. SSD.
[Graphical view ]
PROSITEi PS50156. SSD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Hattori A., Kondo Y., Okumura K., Ohara O.
    DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ALA-47 AND SER-56.
    Tissue: Brain.
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
    Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
    DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION.
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-665, VARIANTS ALA-47 AND SER-56.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1279-1401.
    Tissue: Brain.

Entry informationi

Entry nameiDISP2_HUMAN
AccessioniPrimary (citable) accession number: A7MBM2
Secondary accession number(s): Q6AHW3, Q9C0C1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: July 9, 2014
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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