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A7MBJ9

- A7MBJ9_BOVIN

UniProt

A7MBJ9 - A7MBJ9_BOVIN

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Protein
Submitted name: Neuroendocrine convertase 2
Gene
PCSK2
Organism
Bos taurus (Bovine)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: Ensembl

GO - Biological processi

  1. enkephalin processing Source: Ensembl
  2. insulin processing Source: Ensembl
  3. nervous system development Source: Ensembl
  4. protein autoprocessing Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseUniRule annotationSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
Neuroendocrine convertase 2Imported
Submitted name:
PCSK2 proteinImported
Gene namesi
Name:PCSK2Imported
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 13

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. membrane Source: Ensembl
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliA7MBJ9.
SMRiA7MBJ9. Positions 119-597.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00750000117358.
HOVERGENiHBG008705.
InParanoidiA7MBJ9.
KOiK01360.
OMAiWLLEATF.
OrthoDBiEOG7BW0JD.
TreeFamiTF314277.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7MBJ9-1 [UniParc]FASTAAdd to Basket

« Hide

MRGGCISQGK AAAGLLFCVM VFASAERPVF TNHFLVELHR GGEEEARQVA    50
AEHGFGVRKL PFAEGLYQFY HNGLAKAKRR RSLQHQQQLE RDPRVKRALQ 100
QEGFNRKKRG YRDINEIDIN VNDPLFTKQW YLINTGQADG TPGLDLNVAE 150
AWELGYTGKG VTIGIMDDGI DYLHPDLASN YNAEASYDFS SNDPYPYPRY 200
TDDWFNSHGT RCAGEVSAAA NNNICGVGVA YGSKVAGIRM LDQPFMTDII 250
EASSISHMPQ LIDIYSASWG PTDNGKTVDG PRELTLQAMA DGVNKGRGGK 300
GSIYVWASGD GGSYDDCNCD GYASSMWTIS INSAINDGRT ALYDESCSST 350
LASTFSNGRK RNPEAGVATT DLYGNCTLRH SGTSAAAPEA AGVFALALEA 400
NLGLTWRDMQ HLTVLTSKRN QLHDEVHQWR RNGVGLEFNH LFGYGVLDAG 450
AMVKMAKDWK TVPERFHCVG GSVQNPEKIP TTGKLVLTLT TDACEGKENF 500
VRYLEHVQAV VTVNATRRGD LNINMTSPMG TKSILLSRRP RDDDAKVGFD 550
KWPFMTTHTW GEDARGTWIL ELGFVGSAPQ KGVLKEWTLM LHGTQSAPYI 600
DQVVRDYQSK LAMSKKEELE EELDEAVQRS LKSILGKD 638
Length:638
Mass (Da):70,342
Last modified:October 2, 2007 - v1
Checksum:i76F8316DC143F2E9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DAAA02035697 Genomic DNA. No translation available.
DAAA02035698 Genomic DNA. No translation available.
DAAA02035699 Genomic DNA. No translation available.
DAAA02035700 Genomic DNA. No translation available.
DAAA02035701 Genomic DNA. No translation available.
DAAA02035702 Genomic DNA. No translation available.
DAAA02035703 Genomic DNA. No translation available.
DAAA02035704 Genomic DNA. No translation available.
BC151600 mRNA. Translation: AAI51601.1.
RefSeqiXP_005214382.1. XM_005214325.1.
UniGeneiBt.5563.

Genome annotation databases

EnsembliENSBTAT00000011451; ENSBTAP00000011451; ENSBTAG00000008687.
ENSBTAT00000052049; ENSBTAP00000050841; ENSBTAG00000008687.
GeneIDi281968.
KEGGibta:281968.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DAAA02035697 Genomic DNA. No translation available.
DAAA02035698 Genomic DNA. No translation available.
DAAA02035699 Genomic DNA. No translation available.
DAAA02035700 Genomic DNA. No translation available.
DAAA02035701 Genomic DNA. No translation available.
DAAA02035702 Genomic DNA. No translation available.
DAAA02035703 Genomic DNA. No translation available.
DAAA02035704 Genomic DNA. No translation available.
BC151600 mRNA. Translation: AAI51601.1 .
RefSeqi XP_005214382.1. XM_005214325.1.
UniGenei Bt.5563.

3D structure databases

ProteinModelPortali A7MBJ9.
SMRi A7MBJ9. Positions 119-597.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000011451 ; ENSBTAP00000011451 ; ENSBTAG00000008687 .
ENSBTAT00000052049 ; ENSBTAP00000050841 ; ENSBTAG00000008687 .
GeneIDi 281968.
KEGGi bta:281968.

Organism-specific databases

CTDi 5126.

Phylogenomic databases

GeneTreei ENSGT00750000117358.
HOVERGENi HBG008705.
InParanoidi A7MBJ9.
KOi K01360.
OMAi WLLEATF.
OrthoDBi EOG7BW0JD.
TreeFami TF314277.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProi IPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view ]
PANTHERi PTHR10795. PTHR10795. 1 hit.
Pfami PF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view ]
PRINTSi PR00723. SUBTILISIN.
SUPFAMi SSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEi PS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HerefordImported.
    Tissue: Fetal ponsImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HerefordImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: HerefordImported.

Entry informationi

Entry nameiA7MBJ9_BOVIN
AccessioniPrimary (citable) accession number: A7MBJ9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: July 9, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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