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A7MBJ9

- A7MBJ9_BOVIN

UniProt

A7MBJ9 - A7MBJ9_BOVIN

Protein
Submitted name:

Neuroendocrine convertase 2

Gene

PCSK2

Organism
Bos taurus (Bovine)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: Ensembl

    GO - Biological processi

    1. enkephalin processing Source: Ensembl
    2. insulin processing Source: Ensembl
    3. nervous system development Source: Ensembl
    4. protein autoprocessing Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Neuroendocrine convertase 2Imported
    Submitted name:
    PCSK2 proteinImported
    Gene namesi
    Name:PCSK2Imported
    OrganismiBos taurus (Bovine)Imported
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 13

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl
    2. membrane Source: Ensembl

    Structurei

    3D structure databases

    ProteinModelPortaliA7MBJ9.
    SMRiA7MBJ9. Positions 119-597.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S8 family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117358.
    HOVERGENiHBG008705.
    InParanoidiA7MBJ9.
    KOiK01360.
    OMAiWLLEATF.
    OrthoDBiEOG7BW0JD.
    TreeFamiTF314277.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    3.40.50.200. 1 hit.
    InterProiIPR008979. Galactose-bd-like.
    IPR000209. Peptidase_S8/S53_dom.
    IPR023827. Peptidase_S8_Asp-AS.
    IPR022398. Peptidase_S8_His-AS.
    IPR023828. Peptidase_S8_Ser-AS.
    IPR015500. Peptidase_S8_subtilisin-rel.
    IPR009020. Prot_inh_propept.
    IPR002884. PrprotnconvertsP.
    [Graphical view]
    PANTHERiPTHR10795. PTHR10795. 1 hit.
    PfamiPF01483. P_proprotein. 1 hit.
    PF00082. Peptidase_S8. 1 hit.
    [Graphical view]
    PRINTSiPR00723. SUBTILISIN.
    SUPFAMiSSF49785. SSF49785. 1 hit.
    SSF52743. SSF52743. 1 hit.
    SSF54897. SSF54897. 1 hit.
    PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
    PS00137. SUBTILASE_HIS. 1 hit.
    PS00138. SUBTILASE_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7MBJ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRGGCISQGK AAAGLLFCVM VFASAERPVF TNHFLVELHR GGEEEARQVA    50
    AEHGFGVRKL PFAEGLYQFY HNGLAKAKRR RSLQHQQQLE RDPRVKRALQ 100
    QEGFNRKKRG YRDINEIDIN VNDPLFTKQW YLINTGQADG TPGLDLNVAE 150
    AWELGYTGKG VTIGIMDDGI DYLHPDLASN YNAEASYDFS SNDPYPYPRY 200
    TDDWFNSHGT RCAGEVSAAA NNNICGVGVA YGSKVAGIRM LDQPFMTDII 250
    EASSISHMPQ LIDIYSASWG PTDNGKTVDG PRELTLQAMA DGVNKGRGGK 300
    GSIYVWASGD GGSYDDCNCD GYASSMWTIS INSAINDGRT ALYDESCSST 350
    LASTFSNGRK RNPEAGVATT DLYGNCTLRH SGTSAAAPEA AGVFALALEA 400
    NLGLTWRDMQ HLTVLTSKRN QLHDEVHQWR RNGVGLEFNH LFGYGVLDAG 450
    AMVKMAKDWK TVPERFHCVG GSVQNPEKIP TTGKLVLTLT TDACEGKENF 500
    VRYLEHVQAV VTVNATRRGD LNINMTSPMG TKSILLSRRP RDDDAKVGFD 550
    KWPFMTTHTW GEDARGTWIL ELGFVGSAPQ KGVLKEWTLM LHGTQSAPYI 600
    DQVVRDYQSK LAMSKKEELE EELDEAVQRS LKSILGKD 638
    Length:638
    Mass (Da):70,342
    Last modified:October 2, 2007 - v1
    Checksum:i76F8316DC143F2E9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DAAA02035697 Genomic DNA. No translation available.
    DAAA02035698 Genomic DNA. No translation available.
    DAAA02035699 Genomic DNA. No translation available.
    DAAA02035700 Genomic DNA. No translation available.
    DAAA02035701 Genomic DNA. No translation available.
    DAAA02035702 Genomic DNA. No translation available.
    DAAA02035703 Genomic DNA. No translation available.
    DAAA02035704 Genomic DNA. No translation available.
    BC151600 mRNA. Translation: AAI51601.1.
    RefSeqiXP_005214382.1. XM_005214325.1.
    UniGeneiBt.5563.

    Genome annotation databases

    EnsembliENSBTAT00000011451; ENSBTAP00000011451; ENSBTAG00000008687.
    ENSBTAT00000052049; ENSBTAP00000050841; ENSBTAG00000008687.
    GeneIDi281968.
    KEGGibta:281968.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DAAA02035697 Genomic DNA. No translation available.
    DAAA02035698 Genomic DNA. No translation available.
    DAAA02035699 Genomic DNA. No translation available.
    DAAA02035700 Genomic DNA. No translation available.
    DAAA02035701 Genomic DNA. No translation available.
    DAAA02035702 Genomic DNA. No translation available.
    DAAA02035703 Genomic DNA. No translation available.
    DAAA02035704 Genomic DNA. No translation available.
    BC151600 mRNA. Translation: AAI51601.1 .
    RefSeqi XP_005214382.1. XM_005214325.1.
    UniGenei Bt.5563.

    3D structure databases

    ProteinModelPortali A7MBJ9.
    SMRi A7MBJ9. Positions 119-597.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000011451 ; ENSBTAP00000011451 ; ENSBTAG00000008687 .
    ENSBTAT00000052049 ; ENSBTAP00000050841 ; ENSBTAG00000008687 .
    GeneIDi 281968.
    KEGGi bta:281968.

    Organism-specific databases

    CTDi 5126.

    Phylogenomic databases

    GeneTreei ENSGT00750000117358.
    HOVERGENi HBG008705.
    InParanoidi A7MBJ9.
    KOi K01360.
    OMAi WLLEATF.
    OrthoDBi EOG7BW0JD.
    TreeFami TF314277.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    3.40.50.200. 1 hit.
    InterProi IPR008979. Galactose-bd-like.
    IPR000209. Peptidase_S8/S53_dom.
    IPR023827. Peptidase_S8_Asp-AS.
    IPR022398. Peptidase_S8_His-AS.
    IPR023828. Peptidase_S8_Ser-AS.
    IPR015500. Peptidase_S8_subtilisin-rel.
    IPR009020. Prot_inh_propept.
    IPR002884. PrprotnconvertsP.
    [Graphical view ]
    PANTHERi PTHR10795. PTHR10795. 1 hit.
    Pfami PF01483. P_proprotein. 1 hit.
    PF00082. Peptidase_S8. 1 hit.
    [Graphical view ]
    PRINTSi PR00723. SUBTILISIN.
    SUPFAMi SSF49785. SSF49785. 1 hit.
    SSF52743. SSF52743. 1 hit.
    SSF54897. SSF54897. 1 hit.
    PROSITEi PS00136. SUBTILASE_ASP. 1 hit.
    PS00137. SUBTILASE_HIS. 1 hit.
    PS00138. SUBTILASE_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: HerefordImported.
      Tissue: Fetal ponsImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HerefordImported.
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: HerefordImported.

    Entry informationi

    Entry nameiA7MBJ9_BOVIN
    AccessioniPrimary (citable) accession number: A7MBJ9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 2, 2007
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3