Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Neuroendocrine convertase 2

Gene

PCSK2

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: Ensembl

GO - Biological processi

  1. enkephalin processing Source: Ensembl
  2. insulin processing Source: Ensembl
  3. nervous system development Source: Ensembl
  4. protein autoprocessing Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiREACT_218634. Insulin processing.

Names & Taxonomyi

Protein namesi
Submitted name:
Neuroendocrine convertase 2Imported
Submitted name:
PCSK2 proteinImported
Gene namesi
Name:PCSK2Imported
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 13

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. membrane Source: Ensembl
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotation
Contains peptidase S8 domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00750000117358.
HOVERGENiHBG008705.
KOiK01360.
OMAiYHCEAGE.
OrthoDBiEOG7BW0JD.
TreeFamiTF314277.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7MBJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGGCISQGK AAAGLLFCVM VFASAERPVF TNHFLVELHR GGEEEARQVA
60 70 80 90 100
AEHGFGVRKL PFAEGLYQFY HNGLAKAKRR RSLQHQQQLE RDPRVKRALQ
110 120 130 140 150
QEGFNRKKRG YRDINEIDIN VNDPLFTKQW YLINTGQADG TPGLDLNVAE
160 170 180 190 200
AWELGYTGKG VTIGIMDDGI DYLHPDLASN YNAEASYDFS SNDPYPYPRY
210 220 230 240 250
TDDWFNSHGT RCAGEVSAAA NNNICGVGVA YGSKVAGIRM LDQPFMTDII
260 270 280 290 300
EASSISHMPQ LIDIYSASWG PTDNGKTVDG PRELTLQAMA DGVNKGRGGK
310 320 330 340 350
GSIYVWASGD GGSYDDCNCD GYASSMWTIS INSAINDGRT ALYDESCSST
360 370 380 390 400
LASTFSNGRK RNPEAGVATT DLYGNCTLRH SGTSAAAPEA AGVFALALEA
410 420 430 440 450
NLGLTWRDMQ HLTVLTSKRN QLHDEVHQWR RNGVGLEFNH LFGYGVLDAG
460 470 480 490 500
AMVKMAKDWK TVPERFHCVG GSVQNPEKIP TTGKLVLTLT TDACEGKENF
510 520 530 540 550
VRYLEHVQAV VTVNATRRGD LNINMTSPMG TKSILLSRRP RDDDAKVGFD
560 570 580 590 600
KWPFMTTHTW GEDARGTWIL ELGFVGSAPQ KGVLKEWTLM LHGTQSAPYI
610 620 630
DQVVRDYQSK LAMSKKEELE EELDEAVQRS LKSILGKD
Length:638
Mass (Da):70,342
Last modified:October 2, 2007 - v1
Checksum:i76F8316DC143F2E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02035697 Genomic DNA. No translation available.
DAAA02035698 Genomic DNA. No translation available.
DAAA02035699 Genomic DNA. No translation available.
DAAA02035700 Genomic DNA. No translation available.
DAAA02035701 Genomic DNA. No translation available.
DAAA02035702 Genomic DNA. No translation available.
DAAA02035703 Genomic DNA. No translation available.
DAAA02035704 Genomic DNA. No translation available.
BC151600 mRNA. Translation: AAI51601.1.
RefSeqiXP_005214382.1. XM_005214325.2.
UniGeneiBt.5563.

Genome annotation databases

EnsembliENSBTAT00000011451; ENSBTAP00000011451; ENSBTAG00000008687.
ENSBTAT00000052049; ENSBTAP00000050841; ENSBTAG00000008687.
GeneIDi281968.
KEGGibta:281968.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02035697 Genomic DNA. No translation available.
DAAA02035698 Genomic DNA. No translation available.
DAAA02035699 Genomic DNA. No translation available.
DAAA02035700 Genomic DNA. No translation available.
DAAA02035701 Genomic DNA. No translation available.
DAAA02035702 Genomic DNA. No translation available.
DAAA02035703 Genomic DNA. No translation available.
DAAA02035704 Genomic DNA. No translation available.
BC151600 mRNA. Translation: AAI51601.1.
RefSeqiXP_005214382.1. XM_005214325.2.
UniGeneiBt.5563.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000011451; ENSBTAP00000011451; ENSBTAG00000008687.
ENSBTAT00000052049; ENSBTAP00000050841; ENSBTAG00000008687.
GeneIDi281968.
KEGGibta:281968.

Organism-specific databases

CTDi5126.

Phylogenomic databases

GeneTreeiENSGT00750000117358.
HOVERGENiHBG008705.
KOiK01360.
OMAiYHCEAGE.
OrthoDBiEOG7BW0JD.
TreeFamiTF314277.

Enzyme and pathway databases

ReactomeiREACT_218634. Insulin processing.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HerefordImported.
    Tissue: Fetal ponsImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HerefordImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: HerefordImported.

Entry informationi

Entry nameiA7MBJ9_BOVIN
AccessioniPrimary (citable) accession number: A7MBJ9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: March 4, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.