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Protein
Submitted name:

Neuroendocrine convertase 2

Gene

PCSK2

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Neuroendocrine convertase 2Imported
Submitted name:
PCSK2 proteinImported
Gene namesi
Name:PCSK2Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Organism-specific databases

VGNCiVGNC:32648 PCSK2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_501408407026 – 638Sequence analysisAdd BLAST613

Expressioni

Gene expression databases

BgeeiENSBTAG00000008687

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini461 – 597P/Homo BInterPro annotationAdd BLAST137

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili609 – 629Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3525 Eukaryota
KOG3526 Eukaryota
COG1404 LUCA
COG4935 LUCA
GeneTreeiENSGT00750000117358
HOVERGENiHBG008705
OMAiPQRGVLK
OrthoDBiEOG091G05HI
TreeFamiTF314277

Family and domain databases

CDDicd04059 Peptidases_S8_Protein_converta, 1 hit
Gene3Di2.60.120.260, 1 hit
3.30.70.850, 1 hit
3.40.50.200, 1 hit
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR034182 Kexin/furin
IPR002884 P_dom
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR023827 Peptidase_S8_Asp-AS
IPR022398 Peptidase_S8_His-AS
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
IPR032815 S8_pro-domain
IPR038466 S8_pro-domain_sf
PfamiView protein in Pfam
PF01483 P_proprotein, 1 hit
PF00082 Peptidase_S8, 1 hit
PF16470 S8_pro-domain, 1 hit
PRINTSiPR00723 SUBTILISIN
SUPFAMiSSF49785 SSF49785, 1 hit
SSF52743 SSF52743, 1 hit
PROSITEiView protein in PROSITE
PS51829 P_HOMO_B, 1 hit
PS00136 SUBTILASE_ASP, 1 hit
PS00137 SUBTILASE_HIS, 1 hit
PS00138 SUBTILASE_SER, 1 hit

Sequencei

Sequence statusi: Complete.

A7MBJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGGCISQGK AAAGLLFCVM VFASAERPVF TNHFLVELHR GGEEEARQVA
60 70 80 90 100
AEHGFGVRKL PFAEGLYQFY HNGLAKAKRR RSLQHQQQLE RDPRVKRALQ
110 120 130 140 150
QEGFNRKKRG YRDINEIDIN VNDPLFTKQW YLINTGQADG TPGLDLNVAE
160 170 180 190 200
AWELGYTGKG VTIGIMDDGI DYLHPDLASN YNAEASYDFS SNDPYPYPRY
210 220 230 240 250
TDDWFNSHGT RCAGEVSAAA NNNICGVGVA YGSKVAGIRM LDQPFMTDII
260 270 280 290 300
EASSISHMPQ LIDIYSASWG PTDNGKTVDG PRELTLQAMA DGVNKGRGGK
310 320 330 340 350
GSIYVWASGD GGSYDDCNCD GYASSMWTIS INSAINDGRT ALYDESCSST
360 370 380 390 400
LASTFSNGRK RNPEAGVATT DLYGNCTLRH SGTSAAAPEA AGVFALALEA
410 420 430 440 450
NLGLTWRDMQ HLTVLTSKRN QLHDEVHQWR RNGVGLEFNH LFGYGVLDAG
460 470 480 490 500
AMVKMAKDWK TVPERFHCVG GSVQNPEKIP TTGKLVLTLT TDACEGKENF
510 520 530 540 550
VRYLEHVQAV VTVNATRRGD LNINMTSPMG TKSILLSRRP RDDDAKVGFD
560 570 580 590 600
KWPFMTTHTW GEDARGTWIL ELGFVGSAPQ KGVLKEWTLM LHGTQSAPYI
610 620 630
DQVVRDYQSK LAMSKKEELE EELDEAVQRS LKSILGKD
Length:638
Mass (Da):70,342
Last modified:October 2, 2007 - v1
Checksum:i76F8316DC143F2E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02035697 Genomic DNA No translation available.
DAAA02035698 Genomic DNA No translation available.
DAAA02035699 Genomic DNA No translation available.
DAAA02035700 Genomic DNA No translation available.
DAAA02035701 Genomic DNA No translation available.
DAAA02035702 Genomic DNA No translation available.
DAAA02035703 Genomic DNA No translation available.
DAAA02035704 Genomic DNA No translation available.
BC151600 mRNA Translation: AAI51601.1
RefSeqiXP_005214382.1, XM_005214325.3
UniGeneiBt.5563

Genome annotation databases

EnsembliENSBTAT00000011451; ENSBTAP00000011451; ENSBTAG00000008687
ENSBTAT00000052049; ENSBTAP00000050841; ENSBTAG00000008687
GeneIDi281968

Similar proteinsi

Entry informationi

Entry nameiA7MBJ9_BOVIN
AccessioniPrimary (citable) accession number: A7MBJ9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: March 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health