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A7MBJ4 (PTPRF_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Receptor-type tyrosine-protein phosphatase F
EC=3.1.3.48
Gene names
Name:PTPRF
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length1898 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) By similarity.

The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subunit structure

Interacts with GRIP1 By similarity. Interacts with PPFIA1, PPFIA2 and PPFIA3 By similarity. Interacts with INSR By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.

Contains 8 fibronectin type-III domains.

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Contains 2 tyrosine-protein phosphatase domains.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentMembrane
   DomainImmunoglobulin domain
Repeat
Signal
Transmembrane
Transmembrane helix
   LigandHeparin-binding
   Molecular functionHydrolase
Protein phosphatase
Receptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionheparin binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein tyrosine phosphatase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 18981869Receptor-type tyrosine-protein phosphatase F
PRO_0000370192

Regions

Topological domain30 – 12541225Extracellular Potential
Transmembrane1255 – 127521Helical; Potential
Topological domain1276 – 1898623Cytoplasmic Potential
Domain33 – 12391Ig-like C2-type 1
Domain135 – 22490Ig-like C2-type 2
Domain232 – 31483Ig-like C2-type 3
Domain319 – 40789Fibronectin type-III 1
Domain413 – 50694Fibronectin type-III 2
Domain512 – 60291Fibronectin type-III 3
Domain606 – 70398Fibronectin type-III 4
Domain708 – 80699Fibronectin type-III 5
Domain808 – 90194Fibronectin type-III 6
Domain906 – 99994Fibronectin type-III 7
Domain1002 – 108685Fibronectin type-III 8
Domain1343 – 1598256Tyrosine-protein phosphatase 1
Domain1630 – 1889260Tyrosine-protein phosphatase 2
Region68 – 7710Heparin-binding By similarity
Region1539 – 15457Substrate binding By similarity
Compositional bias1164 – 11696Poly-Arg

Sites

Active site15391Phosphocysteine intermediate By similarity
Active site18301Phosphocysteine intermediate By similarity
Binding site15071Substrate By similarity
Binding site15831Substrate By similarity

Amino acid modifications

Glycosylation1171N-linked (GlcNAc...) Potential
Glycosylation2501N-linked (GlcNAc...) Potential
Glycosylation2951N-linked (GlcNAc...) Potential
Glycosylation7211N-linked (GlcNAc...) Potential
Glycosylation9411N-linked (GlcNAc...) Potential
Glycosylation9571N-linked (GlcNAc...) Potential
Disulfide bond54 ↔ 107 By similarity
Disulfide bond156 ↔ 207 By similarity
Disulfide bond253 ↔ 298 By similarity

Sequences

Sequence LengthMass (Da)Tools
A7MBJ4 [UniParc].

Last modified October 2, 2007. Version 1.
Checksum: 863570011A8BF6F1

FASTA1,898211,382
        10         20         30         40         50         60 
MTPEPAPGRT MVPLVPALVM LGLVAGAHGD SKPVFVKVPE DQTGLSGGVA SFVCQATGEP 

        70         80         90        100        110        120 
KPRITWMKKG KKVSSQRFEV IEFDDGAGSV LRIQPLRVQR DEAIYECTAT NSLGEINTSA 

       130        140        150        160        170        180 
KLSVLEEEQL PLGFPSIDMG PQLKVVEKAR TATMLCAAGG NPDPEISWFK DFLPVDPAAS 

       190        200        210        220        230        240 
NGRIKQLRSG ALQIESSEES DQGKYECVAT NSAGTRYSAP ANLYVRVRRV APRFSIPPSS 

       250        260        270        280        290        300 
QEVMPGGSVN LTCVAVGAPM PYVKWMMGAE ELTKEDEMPV GRNVLELSNV VRSANYTCVA 

       310        320        330        340        350        360 
ISSLGMIEAT AQVTVKALPK PPIDLVVTET TATSVTLTWD SGNSEPVSYY GIQYRPAGAE 

       370        380        390        400        410        420 
GPFQEVDGVA TTRYSIGGLS PFSEYAFRVL AVNSIGRGPP SEAVRARTGE QAPSSPPRRV 

       430        440        450        460        470        480 
QARMLSASTM LVQWEPPEEP NGLVRGYRVY YTPDSRRPLS AWHKHNTDAG LLTTVGSLLP 

       490        500        510        520        530        540 
GITYSLRVLA FTAVGDGPPS PTIQVKTQQG VPAQPADFQA EVDSDTRIQL SWLLPPQERI 

       550        560        570        580        590        600 
VKYELVYWAA EDEGQQHKVT FDPTSSYTVE DLKPDTLYRF QLAARSELGV GVFTPTIEAR 

       610        620        630        640        650        660 
TAQSTPSAPP QKVTCVSVGS TTVRVSWVPP PADSRNGVIT QYSVAYEAVD GEDRGRHVVD 

       670        680        690        700        710        720 
GIGREHSSWD LVGLEKWTEY RVWVRAHTDV GPGPESSPVL VRTDEDVPSG PPRKVEVEPL 

       730        740        750        760        770        780 
NSTAVRVSWK LPVPSKQHGQ IRGYQVTYVR LENGEPRGAP IIQDVMLAEA QETTISGLTP 

       790        800        810        820        830        840 
ETTYSITVAA YTTKGDGARS KPKIVTTTGA VPGRPTMMVS TTAMNTALLQ WHPPKELPGE 

       850        860        870        880        890        900 
LLGYRLQYRR ADEARPSTID FGKDDQHFTV TGLHKGATYI FRLTAKNRAG LGEEFEKEIT 

       910        920        930        940        950        960 
TPEDVPSGFP QNLRVIGLTT STTELIWDPP VLAERNGRIT NYTVVYRDIN SQQELQNVTA 

       970        980        990       1000       1010       1020 
DTHLTLSGLK PDTTYDIKVR ARTSKGAGPL SPSIQSRTMP VEQVFAKNFR VEAAMKTSVL 

      1030       1040       1050       1060       1070       1080 
LSWEVPDSYK SAVPFRILYN GQSVEVDGHS MRKLIADLQP NTEYSFVLMN RGSSAGGLQH 

      1090       1100       1110       1120       1130       1140 
LVSIRTAPDL LPHKPLPASA YIEDGRFTLT MPRVQEPALV RWFYIMVVPI DRMGGSMLAP 

      1150       1160       1170       1180       1190       1200 
QWSTPEELEL DELLEAIEQG GGERLRRRRQ TERLKPYVAA QVDVLPETFT LGDKKNYQGF 

      1210       1220       1230       1240       1250       1260 
YNRPLSPDLS YQCFVLASLK EPVDQKRYAC SPYSDEIVVQ VTPAQQQEEP ELLWVTGPVL 

      1270       1280       1290       1300       1310       1320 
AVILIVLIVI AILLFKRKRT HSPSSKDEQS IGLKDSLLAH SSDPVEMRRL NYQTPGMRDH 

      1330       1340       1350       1360       1370       1380 
PPIPITDLAD NIERLKANDG LKFSQEYESI DPGQQFTWEN SNLEVNKPKN RYANVIAYDH 

      1390       1400       1410       1420       1430       1440 
SRVILTSIDG VPGSDYINAN YIDGYRKQNA YIATQGPLPE TMGDFWRMVW EQRTATVVMM 

      1450       1460       1470       1480       1490       1500 
TRLEEKSRVK CDQYWPARGT ETYGLIQVTL LDTVELATYT VRTFALYKSG SSEKRELRQF 

      1510       1520       1530       1540       1550       1560 
QFMAWPDHGV PEYPTPILAF LRRVKACNPL DAGPMVVHCS AGVGRTGCFI VIDAMLERMK 

      1570       1580       1590       1600       1610       1620 
HEKTVDIYGH VTCMRAQRNY MVQTEDQYVF IHEALLEAAM CGHTEVPARN LYAHIQKLGQ 

      1630       1640       1650       1660       1670       1680 
VPPGESVTAM ELEFKLLANS KAHTSRFISA NLPCNKFKNR LVNIMPYELT RVCLQPIRGV 

      1690       1700       1710       1720       1730       1740 
EGSDYINASF LDGYRQQKAY IATQGPLAES TEDFWRMLWE HNSTIIVMLT RLREMGREKC 

      1750       1760       1770       1780       1790       1800 
HQYWPAERSA RYQYFVVDPM AEYNMPQYIL REFKVTDARD GQSRTIRQFQ FTDWPEQGVP 

      1810       1820       1830       1840       1850       1860 
KTGEGFIDFI GQVHKTKEQF GQDGPITVHC SAGVGRTGVF ITLSIVLERM RYEGVVDMFQ 

      1870       1880       1890 
TVKTLRTQRP AMVQTEDQYQ LCYRAALEYL GSFDHYAT

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References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal skin.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC151592 mRNA. Translation: AAI51593.1.
IPIIPI00702912.
RefSeqNP_001094549.1. NM_001101079.1.
UniGeneBt.5379.

3D structure databases

ProteinModelPortalA7MBJ4.
SMRA7MBJ4. Positions 319-415, 596-719, 814-905, 909-1001, 1325-1893.
ModBaseSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000024046.

Proteomic databases

PRIDEA7MBJ4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000024046; ENSBTAP00000024046; ENSBTAG00000000253.
GeneID512072.
KEGGbta:512072.

Organism-specific databases

CTD5792.

Phylogenomic databases

eggNOGCOG5599.
GeneTreeENSGT00590000082937.
HOGENOMHOG000010250.
InParanoidA7MBJ4.
KOK05695.
OMAFTPTIEA.
OrthoDBEOG4BG8V3.

Family and domain databases

Gene3D2.60.40.10. 10 hits.
InterProIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00041. fn3. 7 hits.
PF07679. I-set. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSPR00700. PRTYPHPHTASE.
SMARTSM00060. FN3. 8 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMSSF49265. FN_III-like. 8 hits.
PROSITEPS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20870237.

Entry information

Entry namePTPRF_BOVIN
AccessionPrimary (citable) accession number: A7MBJ4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 2, 2007
Last modified: April 3, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents