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A7MBJ4

- PTPRF_BOVIN

UniProt

A7MBJ4 - PTPRF_BOVIN

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Protein

Receptor-type tyrosine-protein phosphatase F

Gene
PTPRF
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity By similarity.
The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one By similarity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1507 – 15071Substrate By similarity
Active sitei1539 – 15391Phosphocysteine intermediate By similarity
Binding sitei1583 – 15831Substrate By similarity
Active sitei1830 – 18301Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. heparin binding Source: UniProtKB-KW
  2. protein tyrosine phosphatase activity Source: UniProtKB

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. cell migration Source: UniProtKB
  3. negative regulation of receptor binding Source: UniProtKB
  4. peptidyl-tyrosine dephosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase F (EC:3.1.3.48)
Gene namesi
Name:PTPRF
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 3

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 12541225Extracellular Reviewed predictionAdd
BLAST
Transmembranei1255 – 127521Helical; Reviewed predictionAdd
BLAST
Topological domaini1276 – 1898623Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 Reviewed predictionAdd
BLAST
Chaini30 – 18981869Receptor-type tyrosine-protein phosphatase FPRO_0000370192Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 107 By similarity
Glycosylationi117 – 1171N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi156 ↔ 207 By similarity
Glycosylationi250 – 2501N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi253 ↔ 298 By similarity
Glycosylationi295 – 2951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi721 – 7211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi941 – 9411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi957 – 9571N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiA7MBJ4.

Interactioni

Subunit structurei

Interacts with GRIP1 By similarity. Interacts with PPFIA1, PPFIA2 and PPFIA3 By similarity. Interacts with INSR By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024046.

Structurei

3D structure databases

ProteinModelPortaliA7MBJ4.
SMRiA7MBJ4. Positions 319-415, 596-719, 814-905, 909-1001, 1325-1893.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 12391Ig-like C2-type 1Add
BLAST
Domaini135 – 22490Ig-like C2-type 2Add
BLAST
Domaini232 – 31483Ig-like C2-type 3Add
BLAST
Domaini321 – 41191Fibronectin type-III 1Add
BLAST
Domaini416 – 51095Fibronectin type-III 2Add
BLAST
Domaini514 – 60491Fibronectin type-III 3Add
BLAST
Domaini609 – 70698Fibronectin type-III 4Add
BLAST
Domaini711 – 810100Fibronectin type-III 5Add
BLAST
Domaini811 – 90595Fibronectin type-III 6Add
BLAST
Domaini909 – 100193Fibronectin type-III 7Add
BLAST
Domaini1005 – 108985Fibronectin type-III 8Add
BLAST
Domaini1343 – 1598256Tyrosine-protein phosphatase 1Add
BLAST
Domaini1630 – 1889260Tyrosine-protein phosphatase 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni68 – 7710Heparin-binding By similarity
Regioni1539 – 15457Substrate binding By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1164 – 11696Poly-Arg

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00590000082937.
HOGENOMiHOG000010250.
InParanoidiA7MBJ4.
KOiK05695.
OMAiVFTPTIE.
OrthoDBiEOG7M98FB.
TreeFamiTF312900.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 7 hits.
PF07679. I-set. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 8 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 5 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7MBJ4-1 [UniParc]FASTAAdd to Basket

« Hide

MTPEPAPGRT MVPLVPALVM LGLVAGAHGD SKPVFVKVPE DQTGLSGGVA     50
SFVCQATGEP KPRITWMKKG KKVSSQRFEV IEFDDGAGSV LRIQPLRVQR 100
DEAIYECTAT NSLGEINTSA KLSVLEEEQL PLGFPSIDMG PQLKVVEKAR 150
TATMLCAAGG NPDPEISWFK DFLPVDPAAS NGRIKQLRSG ALQIESSEES 200
DQGKYECVAT NSAGTRYSAP ANLYVRVRRV APRFSIPPSS QEVMPGGSVN 250
LTCVAVGAPM PYVKWMMGAE ELTKEDEMPV GRNVLELSNV VRSANYTCVA 300
ISSLGMIEAT AQVTVKALPK PPIDLVVTET TATSVTLTWD SGNSEPVSYY 350
GIQYRPAGAE GPFQEVDGVA TTRYSIGGLS PFSEYAFRVL AVNSIGRGPP 400
SEAVRARTGE QAPSSPPRRV QARMLSASTM LVQWEPPEEP NGLVRGYRVY 450
YTPDSRRPLS AWHKHNTDAG LLTTVGSLLP GITYSLRVLA FTAVGDGPPS 500
PTIQVKTQQG VPAQPADFQA EVDSDTRIQL SWLLPPQERI VKYELVYWAA 550
EDEGQQHKVT FDPTSSYTVE DLKPDTLYRF QLAARSELGV GVFTPTIEAR 600
TAQSTPSAPP QKVTCVSVGS TTVRVSWVPP PADSRNGVIT QYSVAYEAVD 650
GEDRGRHVVD GIGREHSSWD LVGLEKWTEY RVWVRAHTDV GPGPESSPVL 700
VRTDEDVPSG PPRKVEVEPL NSTAVRVSWK LPVPSKQHGQ IRGYQVTYVR 750
LENGEPRGAP IIQDVMLAEA QETTISGLTP ETTYSITVAA YTTKGDGARS 800
KPKIVTTTGA VPGRPTMMVS TTAMNTALLQ WHPPKELPGE LLGYRLQYRR 850
ADEARPSTID FGKDDQHFTV TGLHKGATYI FRLTAKNRAG LGEEFEKEIT 900
TPEDVPSGFP QNLRVIGLTT STTELIWDPP VLAERNGRIT NYTVVYRDIN 950
SQQELQNVTA DTHLTLSGLK PDTTYDIKVR ARTSKGAGPL SPSIQSRTMP 1000
VEQVFAKNFR VEAAMKTSVL LSWEVPDSYK SAVPFRILYN GQSVEVDGHS 1050
MRKLIADLQP NTEYSFVLMN RGSSAGGLQH LVSIRTAPDL LPHKPLPASA 1100
YIEDGRFTLT MPRVQEPALV RWFYIMVVPI DRMGGSMLAP QWSTPEELEL 1150
DELLEAIEQG GGERLRRRRQ TERLKPYVAA QVDVLPETFT LGDKKNYQGF 1200
YNRPLSPDLS YQCFVLASLK EPVDQKRYAC SPYSDEIVVQ VTPAQQQEEP 1250
ELLWVTGPVL AVILIVLIVI AILLFKRKRT HSPSSKDEQS IGLKDSLLAH 1300
SSDPVEMRRL NYQTPGMRDH PPIPITDLAD NIERLKANDG LKFSQEYESI 1350
DPGQQFTWEN SNLEVNKPKN RYANVIAYDH SRVILTSIDG VPGSDYINAN 1400
YIDGYRKQNA YIATQGPLPE TMGDFWRMVW EQRTATVVMM TRLEEKSRVK 1450
CDQYWPARGT ETYGLIQVTL LDTVELATYT VRTFALYKSG SSEKRELRQF 1500
QFMAWPDHGV PEYPTPILAF LRRVKACNPL DAGPMVVHCS AGVGRTGCFI 1550
VIDAMLERMK HEKTVDIYGH VTCMRAQRNY MVQTEDQYVF IHEALLEAAM 1600
CGHTEVPARN LYAHIQKLGQ VPPGESVTAM ELEFKLLANS KAHTSRFISA 1650
NLPCNKFKNR LVNIMPYELT RVCLQPIRGV EGSDYINASF LDGYRQQKAY 1700
IATQGPLAES TEDFWRMLWE HNSTIIVMLT RLREMGREKC HQYWPAERSA 1750
RYQYFVVDPM AEYNMPQYIL REFKVTDARD GQSRTIRQFQ FTDWPEQGVP 1800
KTGEGFIDFI GQVHKTKEQF GQDGPITVHC SAGVGRTGVF ITLSIVLERM 1850
RYEGVVDMFQ TVKTLRTQRP AMVQTEDQYQ LCYRAALEYL GSFDHYAT 1898
Length:1,898
Mass (Da):211,382
Last modified:October 2, 2007 - v1
Checksum:i863570011A8BF6F1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC151592 mRNA. Translation: AAI51593.1.
RefSeqiNP_001094549.1. NM_001101079.1.
UniGeneiBt.5379.

Genome annotation databases

EnsembliENSBTAT00000024046; ENSBTAP00000024046; ENSBTAG00000000253.
GeneIDi512072.
KEGGibta:512072.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC151592 mRNA. Translation: AAI51593.1 .
RefSeqi NP_001094549.1. NM_001101079.1.
UniGenei Bt.5379.

3D structure databases

ProteinModelPortali A7MBJ4.
SMRi A7MBJ4. Positions 319-415, 596-719, 814-905, 909-1001, 1325-1893.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000024046.

Proteomic databases

PRIDEi A7MBJ4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000024046 ; ENSBTAP00000024046 ; ENSBTAG00000000253 .
GeneIDi 512072.
KEGGi bta:512072.

Organism-specific databases

CTDi 5792.

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00590000082937.
HOGENOMi HOG000010250.
InParanoidi A7MBJ4.
KOi K05695.
OMAi VFTPTIE.
OrthoDBi EOG7M98FB.
TreeFami TF312900.

Miscellaneous databases

NextBioi 20870237.

Family and domain databases

Gene3Di 2.60.40.10. 10 hits.
3.90.190.10. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 7 hits.
PF07679. I-set. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 8 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 5 hits.
SSF52799. SSF52799. 2 hits.
PROSITEi PS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal skin.

Entry informationi

Entry nameiPTPRF_BOVIN
AccessioniPrimary (citable) accession number: A7MBJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 2, 2007
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi