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A7MBJ4

- PTPRF_BOVIN

UniProt

A7MBJ4 - PTPRF_BOVIN

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Protein

Receptor-type tyrosine-protein phosphatase F

Gene

PTPRF

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity (By similarity).By similarity
The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1507 – 15071SubstrateBy similarity
Active sitei1539 – 15391Phosphocysteine intermediateBy similarity
Binding sitei1583 – 15831SubstrateBy similarity
Active sitei1830 – 18301Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. heparin binding Source: UniProtKB-KW
  2. protein tyrosine phosphatase activity Source: UniProtKB

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. cell migration Source: UniProtKB
  3. negative regulation of receptor binding Source: UniProtKB
  4. peptidyl-tyrosine dephosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Heparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase F (EC:3.1.3.48)
Gene namesi
Name:PTPRF
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 3

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Chaini30 – 18981869Receptor-type tyrosine-protein phosphatase FPRO_0000370192Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 107PROSITE-ProRule annotation
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi156 ↔ 207PROSITE-ProRule annotation
Glycosylationi250 – 2501N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi253 ↔ 298PROSITE-ProRule annotation
Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi721 – 7211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi941 – 9411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi957 – 9571N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiA7MBJ4.

Interactioni

Subunit structurei

Interacts with GRIP1. Interacts with PPFIA1, PPFIA2 and PPFIA3. Interacts with INSR.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024046.

Structurei

3D structure databases

ProteinModelPortaliA7MBJ4.
SMRiA7MBJ4. Positions 319-415, 596-719, 814-905, 909-1001, 1325-1893.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini30 – 12541225ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1276 – 1898623CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1255 – 127521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 12391Ig-like C2-type 1Add
BLAST
Domaini135 – 22490Ig-like C2-type 2Add
BLAST
Domaini232 – 31483Ig-like C2-type 3Add
BLAST
Domaini321 – 41191Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini416 – 51095Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini514 – 60491Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini609 – 70698Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini711 – 810100Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST
Domaini811 – 90595Fibronectin type-III 6PROSITE-ProRule annotationAdd
BLAST
Domaini909 – 100193Fibronectin type-III 7PROSITE-ProRule annotationAdd
BLAST
Domaini1005 – 108985Fibronectin type-III 8PROSITE-ProRule annotationAdd
BLAST
Domaini1343 – 1598256Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
BLAST
Domaini1630 – 1889260Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni68 – 7710Heparin-bindingBy similarity
Regioni1539 – 15457Substrate bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1164 – 11696Poly-Arg

Sequence similaritiesi

Contains 8 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00760000118900.
HOGENOMiHOG000010250.
InParanoidiA7MBJ4.
KOiK05695.
OMAiVFTPTIE.
OrthoDBiEOG7M98FB.
TreeFamiTF312900.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 7 hits.
PF07679. I-set. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 8 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 5 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7MBJ4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTPEPAPGRT MVPLVPALVM LGLVAGAHGD SKPVFVKVPE DQTGLSGGVA
60 70 80 90 100
SFVCQATGEP KPRITWMKKG KKVSSQRFEV IEFDDGAGSV LRIQPLRVQR
110 120 130 140 150
DEAIYECTAT NSLGEINTSA KLSVLEEEQL PLGFPSIDMG PQLKVVEKAR
160 170 180 190 200
TATMLCAAGG NPDPEISWFK DFLPVDPAAS NGRIKQLRSG ALQIESSEES
210 220 230 240 250
DQGKYECVAT NSAGTRYSAP ANLYVRVRRV APRFSIPPSS QEVMPGGSVN
260 270 280 290 300
LTCVAVGAPM PYVKWMMGAE ELTKEDEMPV GRNVLELSNV VRSANYTCVA
310 320 330 340 350
ISSLGMIEAT AQVTVKALPK PPIDLVVTET TATSVTLTWD SGNSEPVSYY
360 370 380 390 400
GIQYRPAGAE GPFQEVDGVA TTRYSIGGLS PFSEYAFRVL AVNSIGRGPP
410 420 430 440 450
SEAVRARTGE QAPSSPPRRV QARMLSASTM LVQWEPPEEP NGLVRGYRVY
460 470 480 490 500
YTPDSRRPLS AWHKHNTDAG LLTTVGSLLP GITYSLRVLA FTAVGDGPPS
510 520 530 540 550
PTIQVKTQQG VPAQPADFQA EVDSDTRIQL SWLLPPQERI VKYELVYWAA
560 570 580 590 600
EDEGQQHKVT FDPTSSYTVE DLKPDTLYRF QLAARSELGV GVFTPTIEAR
610 620 630 640 650
TAQSTPSAPP QKVTCVSVGS TTVRVSWVPP PADSRNGVIT QYSVAYEAVD
660 670 680 690 700
GEDRGRHVVD GIGREHSSWD LVGLEKWTEY RVWVRAHTDV GPGPESSPVL
710 720 730 740 750
VRTDEDVPSG PPRKVEVEPL NSTAVRVSWK LPVPSKQHGQ IRGYQVTYVR
760 770 780 790 800
LENGEPRGAP IIQDVMLAEA QETTISGLTP ETTYSITVAA YTTKGDGARS
810 820 830 840 850
KPKIVTTTGA VPGRPTMMVS TTAMNTALLQ WHPPKELPGE LLGYRLQYRR
860 870 880 890 900
ADEARPSTID FGKDDQHFTV TGLHKGATYI FRLTAKNRAG LGEEFEKEIT
910 920 930 940 950
TPEDVPSGFP QNLRVIGLTT STTELIWDPP VLAERNGRIT NYTVVYRDIN
960 970 980 990 1000
SQQELQNVTA DTHLTLSGLK PDTTYDIKVR ARTSKGAGPL SPSIQSRTMP
1010 1020 1030 1040 1050
VEQVFAKNFR VEAAMKTSVL LSWEVPDSYK SAVPFRILYN GQSVEVDGHS
1060 1070 1080 1090 1100
MRKLIADLQP NTEYSFVLMN RGSSAGGLQH LVSIRTAPDL LPHKPLPASA
1110 1120 1130 1140 1150
YIEDGRFTLT MPRVQEPALV RWFYIMVVPI DRMGGSMLAP QWSTPEELEL
1160 1170 1180 1190 1200
DELLEAIEQG GGERLRRRRQ TERLKPYVAA QVDVLPETFT LGDKKNYQGF
1210 1220 1230 1240 1250
YNRPLSPDLS YQCFVLASLK EPVDQKRYAC SPYSDEIVVQ VTPAQQQEEP
1260 1270 1280 1290 1300
ELLWVTGPVL AVILIVLIVI AILLFKRKRT HSPSSKDEQS IGLKDSLLAH
1310 1320 1330 1340 1350
SSDPVEMRRL NYQTPGMRDH PPIPITDLAD NIERLKANDG LKFSQEYESI
1360 1370 1380 1390 1400
DPGQQFTWEN SNLEVNKPKN RYANVIAYDH SRVILTSIDG VPGSDYINAN
1410 1420 1430 1440 1450
YIDGYRKQNA YIATQGPLPE TMGDFWRMVW EQRTATVVMM TRLEEKSRVK
1460 1470 1480 1490 1500
CDQYWPARGT ETYGLIQVTL LDTVELATYT VRTFALYKSG SSEKRELRQF
1510 1520 1530 1540 1550
QFMAWPDHGV PEYPTPILAF LRRVKACNPL DAGPMVVHCS AGVGRTGCFI
1560 1570 1580 1590 1600
VIDAMLERMK HEKTVDIYGH VTCMRAQRNY MVQTEDQYVF IHEALLEAAM
1610 1620 1630 1640 1650
CGHTEVPARN LYAHIQKLGQ VPPGESVTAM ELEFKLLANS KAHTSRFISA
1660 1670 1680 1690 1700
NLPCNKFKNR LVNIMPYELT RVCLQPIRGV EGSDYINASF LDGYRQQKAY
1710 1720 1730 1740 1750
IATQGPLAES TEDFWRMLWE HNSTIIVMLT RLREMGREKC HQYWPAERSA
1760 1770 1780 1790 1800
RYQYFVVDPM AEYNMPQYIL REFKVTDARD GQSRTIRQFQ FTDWPEQGVP
1810 1820 1830 1840 1850
KTGEGFIDFI GQVHKTKEQF GQDGPITVHC SAGVGRTGVF ITLSIVLERM
1860 1870 1880 1890
RYEGVVDMFQ TVKTLRTQRP AMVQTEDQYQ LCYRAALEYL GSFDHYAT
Length:1,898
Mass (Da):211,382
Last modified:October 2, 2007 - v1
Checksum:i863570011A8BF6F1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC151592 mRNA. Translation: AAI51593.1.
RefSeqiNP_001094549.1. NM_001101079.1.
UniGeneiBt.5379.

Genome annotation databases

EnsembliENSBTAT00000024046; ENSBTAP00000024046; ENSBTAG00000000253.
GeneIDi512072.
KEGGibta:512072.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC151592 mRNA. Translation: AAI51593.1 .
RefSeqi NP_001094549.1. NM_001101079.1.
UniGenei Bt.5379.

3D structure databases

ProteinModelPortali A7MBJ4.
SMRi A7MBJ4. Positions 319-415, 596-719, 814-905, 909-1001, 1325-1893.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000024046.

Proteomic databases

PRIDEi A7MBJ4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000024046 ; ENSBTAP00000024046 ; ENSBTAG00000000253 .
GeneIDi 512072.
KEGGi bta:512072.

Organism-specific databases

CTDi 5792.

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00760000118900.
HOGENOMi HOG000010250.
InParanoidi A7MBJ4.
KOi K05695.
OMAi VFTPTIE.
OrthoDBi EOG7M98FB.
TreeFami TF312900.

Miscellaneous databases

NextBioi 20870237.

Family and domain databases

Gene3Di 2.60.40.10. 10 hits.
3.90.190.10. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 7 hits.
PF07679. I-set. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 8 hits.
SM00408. IGc2. 3 hits.
SM00194. PTPc. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 5 hits.
SSF52799. SSF52799. 2 hits.
PROSITEi PS50853. FN3. 8 hits.
PS50835. IG_LIKE. 3 hits.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal skin.

Entry informationi

Entry nameiPTPRF_BOVIN
AccessioniPrimary (citable) accession number: A7MBJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 2, 2007
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3