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A7MBJ4

- PTPRF_BOVIN

UniProt

A7MBJ4 - PTPRF_BOVIN

Protein

Receptor-type tyrosine-protein phosphatase F

Gene

PTPRF

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity By similarity.By similarity
    The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei1507 – 15071SubstrateBy similarity
    Active sitei1539 – 15391Phosphocysteine intermediateBy similarity
    Binding sitei1583 – 15831SubstrateBy similarity
    Active sitei1830 – 18301Phosphocysteine intermediateBy similarity

    GO - Molecular functioni

    1. heparin binding Source: UniProtKB-KW
    2. protein tyrosine phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. cell migration Source: UniProtKB
    3. negative regulation of receptor binding Source: UniProtKB
    4. peptidyl-tyrosine dephosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase, Receptor

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Heparin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Receptor-type tyrosine-protein phosphatase F (EC:3.1.3.48)
    Gene namesi
    Name:PTPRF
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 3

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Chaini30 – 18981869Receptor-type tyrosine-protein phosphatase FPRO_0000370192Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi54 ↔ 107PROSITE-ProRule annotation
    Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi156 ↔ 207PROSITE-ProRule annotation
    Glycosylationi250 – 2501N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi253 ↔ 298PROSITE-ProRule annotation
    Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi721 – 7211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi941 – 9411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi957 – 9571N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiA7MBJ4.

    Interactioni

    Subunit structurei

    Interacts with GRIP1. Interacts with PPFIA1, PPFIA2 and PPFIA3. Interacts with INSR.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000024046.

    Structurei

    3D structure databases

    ProteinModelPortaliA7MBJ4.
    SMRiA7MBJ4. Positions 319-415, 596-719, 814-905, 909-1001, 1325-1893.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 12541225ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1276 – 1898623CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1255 – 127521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini33 – 12391Ig-like C2-type 1Add
    BLAST
    Domaini135 – 22490Ig-like C2-type 2Add
    BLAST
    Domaini232 – 31483Ig-like C2-type 3Add
    BLAST
    Domaini321 – 41191Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini416 – 51095Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini514 – 60491Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini609 – 70698Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini711 – 810100Fibronectin type-III 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini811 – 90595Fibronectin type-III 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini909 – 100193Fibronectin type-III 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini1005 – 108985Fibronectin type-III 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini1343 – 1598256Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1630 – 1889260Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni68 – 7710Heparin-bindingBy similarity
    Regioni1539 – 15457Substrate bindingBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1164 – 11696Poly-Arg

    Sequence similaritiesi

    Contains 8 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5599.
    GeneTreeiENSGT00590000082937.
    HOGENOMiHOG000010250.
    InParanoidiA7MBJ4.
    KOiK05695.
    OMAiVFTPTIE.
    OrthoDBiEOG7M98FB.
    TreeFamiTF312900.

    Family and domain databases

    Gene3Di2.60.40.10. 10 hits.
    3.90.190.10. 2 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00041. fn3. 7 hits.
    PF07679. I-set. 3 hits.
    PF00102. Y_phosphatase. 2 hits.
    [Graphical view]
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM00060. FN3. 8 hits.
    SM00408. IGc2. 3 hits.
    SM00194. PTPc. 2 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 5 hits.
    SSF52799. SSF52799. 2 hits.
    PROSITEiPS50853. FN3. 8 hits.
    PS50835. IG_LIKE. 3 hits.
    PS00383. TYR_PHOSPHATASE_1. 2 hits.
    PS50056. TYR_PHOSPHATASE_2. 2 hits.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A7MBJ4-1 [UniParc]FASTAAdd to Basket

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    MTPEPAPGRT MVPLVPALVM LGLVAGAHGD SKPVFVKVPE DQTGLSGGVA     50
    SFVCQATGEP KPRITWMKKG KKVSSQRFEV IEFDDGAGSV LRIQPLRVQR 100
    DEAIYECTAT NSLGEINTSA KLSVLEEEQL PLGFPSIDMG PQLKVVEKAR 150
    TATMLCAAGG NPDPEISWFK DFLPVDPAAS NGRIKQLRSG ALQIESSEES 200
    DQGKYECVAT NSAGTRYSAP ANLYVRVRRV APRFSIPPSS QEVMPGGSVN 250
    LTCVAVGAPM PYVKWMMGAE ELTKEDEMPV GRNVLELSNV VRSANYTCVA 300
    ISSLGMIEAT AQVTVKALPK PPIDLVVTET TATSVTLTWD SGNSEPVSYY 350
    GIQYRPAGAE GPFQEVDGVA TTRYSIGGLS PFSEYAFRVL AVNSIGRGPP 400
    SEAVRARTGE QAPSSPPRRV QARMLSASTM LVQWEPPEEP NGLVRGYRVY 450
    YTPDSRRPLS AWHKHNTDAG LLTTVGSLLP GITYSLRVLA FTAVGDGPPS 500
    PTIQVKTQQG VPAQPADFQA EVDSDTRIQL SWLLPPQERI VKYELVYWAA 550
    EDEGQQHKVT FDPTSSYTVE DLKPDTLYRF QLAARSELGV GVFTPTIEAR 600
    TAQSTPSAPP QKVTCVSVGS TTVRVSWVPP PADSRNGVIT QYSVAYEAVD 650
    GEDRGRHVVD GIGREHSSWD LVGLEKWTEY RVWVRAHTDV GPGPESSPVL 700
    VRTDEDVPSG PPRKVEVEPL NSTAVRVSWK LPVPSKQHGQ IRGYQVTYVR 750
    LENGEPRGAP IIQDVMLAEA QETTISGLTP ETTYSITVAA YTTKGDGARS 800
    KPKIVTTTGA VPGRPTMMVS TTAMNTALLQ WHPPKELPGE LLGYRLQYRR 850
    ADEARPSTID FGKDDQHFTV TGLHKGATYI FRLTAKNRAG LGEEFEKEIT 900
    TPEDVPSGFP QNLRVIGLTT STTELIWDPP VLAERNGRIT NYTVVYRDIN 950
    SQQELQNVTA DTHLTLSGLK PDTTYDIKVR ARTSKGAGPL SPSIQSRTMP 1000
    VEQVFAKNFR VEAAMKTSVL LSWEVPDSYK SAVPFRILYN GQSVEVDGHS 1050
    MRKLIADLQP NTEYSFVLMN RGSSAGGLQH LVSIRTAPDL LPHKPLPASA 1100
    YIEDGRFTLT MPRVQEPALV RWFYIMVVPI DRMGGSMLAP QWSTPEELEL 1150
    DELLEAIEQG GGERLRRRRQ TERLKPYVAA QVDVLPETFT LGDKKNYQGF 1200
    YNRPLSPDLS YQCFVLASLK EPVDQKRYAC SPYSDEIVVQ VTPAQQQEEP 1250
    ELLWVTGPVL AVILIVLIVI AILLFKRKRT HSPSSKDEQS IGLKDSLLAH 1300
    SSDPVEMRRL NYQTPGMRDH PPIPITDLAD NIERLKANDG LKFSQEYESI 1350
    DPGQQFTWEN SNLEVNKPKN RYANVIAYDH SRVILTSIDG VPGSDYINAN 1400
    YIDGYRKQNA YIATQGPLPE TMGDFWRMVW EQRTATVVMM TRLEEKSRVK 1450
    CDQYWPARGT ETYGLIQVTL LDTVELATYT VRTFALYKSG SSEKRELRQF 1500
    QFMAWPDHGV PEYPTPILAF LRRVKACNPL DAGPMVVHCS AGVGRTGCFI 1550
    VIDAMLERMK HEKTVDIYGH VTCMRAQRNY MVQTEDQYVF IHEALLEAAM 1600
    CGHTEVPARN LYAHIQKLGQ VPPGESVTAM ELEFKLLANS KAHTSRFISA 1650
    NLPCNKFKNR LVNIMPYELT RVCLQPIRGV EGSDYINASF LDGYRQQKAY 1700
    IATQGPLAES TEDFWRMLWE HNSTIIVMLT RLREMGREKC HQYWPAERSA 1750
    RYQYFVVDPM AEYNMPQYIL REFKVTDARD GQSRTIRQFQ FTDWPEQGVP 1800
    KTGEGFIDFI GQVHKTKEQF GQDGPITVHC SAGVGRTGVF ITLSIVLERM 1850
    RYEGVVDMFQ TVKTLRTQRP AMVQTEDQYQ LCYRAALEYL GSFDHYAT 1898
    Length:1,898
    Mass (Da):211,382
    Last modified:October 2, 2007 - v1
    Checksum:i863570011A8BF6F1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC151592 mRNA. Translation: AAI51593.1.
    RefSeqiNP_001094549.1. NM_001101079.1.
    UniGeneiBt.5379.

    Genome annotation databases

    EnsembliENSBTAT00000024046; ENSBTAP00000024046; ENSBTAG00000000253.
    GeneIDi512072.
    KEGGibta:512072.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC151592 mRNA. Translation: AAI51593.1 .
    RefSeqi NP_001094549.1. NM_001101079.1.
    UniGenei Bt.5379.

    3D structure databases

    ProteinModelPortali A7MBJ4.
    SMRi A7MBJ4. Positions 319-415, 596-719, 814-905, 909-1001, 1325-1893.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000024046.

    Proteomic databases

    PRIDEi A7MBJ4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000024046 ; ENSBTAP00000024046 ; ENSBTAG00000000253 .
    GeneIDi 512072.
    KEGGi bta:512072.

    Organism-specific databases

    CTDi 5792.

    Phylogenomic databases

    eggNOGi COG5599.
    GeneTreei ENSGT00590000082937.
    HOGENOMi HOG000010250.
    InParanoidi A7MBJ4.
    KOi K05695.
    OMAi VFTPTIE.
    OrthoDBi EOG7M98FB.
    TreeFami TF312900.

    Miscellaneous databases

    NextBioi 20870237.

    Family and domain databases

    Gene3Di 2.60.40.10. 10 hits.
    3.90.190.10. 2 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00041. fn3. 7 hits.
    PF07679. I-set. 3 hits.
    PF00102. Y_phosphatase. 2 hits.
    [Graphical view ]
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM00060. FN3. 8 hits.
    SM00408. IGc2. 3 hits.
    SM00194. PTPc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 5 hits.
    SSF52799. SSF52799. 2 hits.
    PROSITEi PS50853. FN3. 8 hits.
    PS50835. IG_LIKE. 3 hits.
    PS00383. TYR_PHOSPHATASE_1. 2 hits.
    PS50056. TYR_PHOSPHATASE_2. 2 hits.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal skin.

    Entry informationi

    Entry nameiPTPRF_BOVIN
    AccessioniPrimary (citable) accession number: A7MBJ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3