ID   L2HDH_BOVIN             Reviewed;         463 AA.
AC   A7MBI3;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   16-JUN-2009, entry version 13.
DE   RecName: Full=L-2-hydroxyglutarate dehydrogenase, mitochondrial;
DE            Short=Duranin;
DE            EC=1.1.99.2;
DE   Flags: Precursor;
GN   Name=L2HGDH;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: (S)-2-hydroxyglutarate + acceptor = 2-
CC       oxoglutarate + reduced acceptor.
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion (By similarity).
CC   -!- SIMILARITY: Belongs to the L2HGDH family.
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DR   EMBL; BC151577; AAI51578.1; -; mRNA.
DR   IPI; IPI00691649; -.
DR   RefSeq; NP_001094560.1; -.
DR   UniGene; Bt.58900; -.
DR   Ensembl; ENSBTAG00000015200; Bos taurus.
DR   GeneID; 514230; -.
DR   KEGG; bta:514230; -.
DR   OMA; A7MBI3; KIVPFRG.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0047545; F:2-hydroxyglutarate dehydrogenase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   Pfam; PF01266; DAO; 1.
PE   2: Evidence at transcript level;
KW   FAD; Flavoprotein; Mitochondrion; Oxidoreductase; Transit peptide.
FT   TRANSIT       1     52       Mitochondrion (Potential).
FT   CHAIN        53    463       L-2-hydroxyglutarate dehydrogenase,
FT                                mitochondrial.
FT                                /FTId=PRO_0000331213.
SQ   SEQUENCE   463 AA;  51022 MW;  682632966A525F92 CRC64;
     MVPALRYLGS VCGRARGIFP GGFSAAHTPA SGKSRLLCQG GRRASTSSFD IVIIGGGIVG
     LASARALILR HPALSIGVLE KEKNLAVHQT GHNSGVIHSG IYYKPESLKA KLCVQGAALI
     YEYCNQKGIS YKQCGKLIVA VEQEEIPRLQ ALYERGLQNG VQGLRLIQQE DIKKKEPYCR
     GLMAIDCPYT GIVDYRQVAF SFAKDFQEAG GSVLTNFEVE DIEMARESPS RSKDGMKYPI
     VIRNTKGEEV RCQYVVTCAG LYSDRISELS GCNPNPRIVP FRGDYLVLKP EKRYLVKGNI
     YPVPDSRFPF LGVHFTPRMD GNIWLGPNAI LAFKREGYRP FDFSARDIMD IIIKSGLIKL
     VFQNFSYGVN EMYKACFLSA TVKHLQKFIP EITISDVLRG PAGVRAQALD RDGNLIEDFV
     FDGGVGDIGN RILHVRNAPS PAATSSLAIS GMIADEVQQR FKL
//