Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

L-2-hydroxyglutarate dehydrogenase, mitochondrial

Gene

L2HGDH

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor.

Cofactori

FADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-BTA-880009. Interconversion of 2-oxoglutarate and 2-hydroxyglutarate.

Names & Taxonomyi

Protein namesi
Recommended name:
L-2-hydroxyglutarate dehydrogenase, mitochondrial (EC:1.1.99.2)
Alternative name(s):
Duranin
Gene namesi
Name:L2HGDH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5252MitochondrionSequence analysisAdd
BLAST
Chaini53 – 463411L-2-hydroxyglutarate dehydrogenase, mitochondrialPRO_0000331213Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei104 – 1041N6-acetyllysineBy similarity
Modified residuei173 – 1731N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiA7MBI3.
PRIDEiA7MBI3.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020226.

Structurei

3D structure databases

ProteinModelPortaliA7MBI3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L2HGDH family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2665. Eukaryota.
COG0579. LUCA.
GeneTreeiENSGT00490000043421.
HOGENOMiHOG000245180.
HOVERGENiHBG081883.
InParanoidiA7MBI3.
KOiK00109.
OMAiGVHFTRM.
OrthoDBiEOG7MPRDR.
TreeFamiTF105922.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR006076. FAD-dep_OxRdtase.
IPR023753. FAD/NAD-binding_dom.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7MBI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPALRYLGS VCGRARGIFP GGFSAAHTPA SGKSRLLCQG GRRASTSSFD
60 70 80 90 100
IVIIGGGIVG LASARALILR HPALSIGVLE KEKNLAVHQT GHNSGVIHSG
110 120 130 140 150
IYYKPESLKA KLCVQGAALI YEYCNQKGIS YKQCGKLIVA VEQEEIPRLQ
160 170 180 190 200
ALYERGLQNG VQGLRLIQQE DIKKKEPYCR GLMAIDCPYT GIVDYRQVAF
210 220 230 240 250
SFAKDFQEAG GSVLTNFEVE DIEMARESPS RSKDGMKYPI VIRNTKGEEV
260 270 280 290 300
RCQYVVTCAG LYSDRISELS GCNPNPRIVP FRGDYLVLKP EKRYLVKGNI
310 320 330 340 350
YPVPDSRFPF LGVHFTPRMD GNIWLGPNAI LAFKREGYRP FDFSARDIMD
360 370 380 390 400
IIIKSGLIKL VFQNFSYGVN EMYKACFLSA TVKHLQKFIP EITISDVLRG
410 420 430 440 450
PAGVRAQALD RDGNLIEDFV FDGGVGDIGN RILHVRNAPS PAATSSLAIS
460
GMIADEVQQR FKL
Length:463
Mass (Da):51,022
Last modified:October 2, 2007 - v1
Checksum:i682632966A525F92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151577 mRNA. Translation: AAI51578.1.
RefSeqiNP_001094560.1. NM_001101090.1.
UniGeneiBt.58900.

Genome annotation databases

EnsembliENSBTAT00000020226; ENSBTAP00000020226; ENSBTAG00000015200.
GeneIDi514230.
KEGGibta:514230.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151577 mRNA. Translation: AAI51578.1.
RefSeqiNP_001094560.1. NM_001101090.1.
UniGeneiBt.58900.

3D structure databases

ProteinModelPortaliA7MBI3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020226.

Proteomic databases

PaxDbiA7MBI3.
PRIDEiA7MBI3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000020226; ENSBTAP00000020226; ENSBTAG00000015200.
GeneIDi514230.
KEGGibta:514230.

Organism-specific databases

CTDi79944.

Phylogenomic databases

eggNOGiKOG2665. Eukaryota.
COG0579. LUCA.
GeneTreeiENSGT00490000043421.
HOGENOMiHOG000245180.
HOVERGENiHBG081883.
InParanoidiA7MBI3.
KOiK00109.
OMAiGVHFTRM.
OrthoDBiEOG7MPRDR.
TreeFamiTF105922.

Enzyme and pathway databases

ReactomeiR-BTA-880009. Interconversion of 2-oxoglutarate and 2-hydroxyglutarate.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR006076. FAD-dep_OxRdtase.
IPR023753. FAD/NAD-binding_dom.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Ascending colon.

Entry informationi

Entry nameiL2HDH_BOVIN
AccessioniPrimary (citable) accession number: A7MBI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 2, 2007
Last modified: June 8, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.