A7MBI3 (L2HDH_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-2-hydroxyglutarate dehydrogenase, mitochondrial
EC=1.1.99.2

Alternative name(s):
Duranin

Gene names

Name:

L2HGDH

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	463 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	(S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor.
Cofactor	FAD By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the L2HGDH family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	2-hydroxyglutarate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 52	52	Mitochondrion Potential
	Chain	53 – 463	411	L-2-hydroxyglutarate dehydrogenase, mitochondrial		PRO_0000331213

Sequences

	Sequence		Length	Mass (Da)
	A7MBI3 [UniParc]. Last modified October 2, 2007. Version 1. Checksum: 682632966A525F92	FASTA	463	51,022
	10 20 30 40 50 60 MVPALRYLGS VCGRARGIFP GGFSAAHTPA SGKSRLLCQG GRRASTSSFD IVIIGGGIVG 70 80 90 100 110 120 LASARALILR HPALSIGVLE KEKNLAVHQT GHNSGVIHSG IYYKPESLKA KLCVQGAALI 130 140 150 160 170 180 YEYCNQKGIS YKQCGKLIVA VEQEEIPRLQ ALYERGLQNG VQGLRLIQQE DIKKKEPYCR 190 200 210 220 230 240 GLMAIDCPYT GIVDYRQVAF SFAKDFQEAG GSVLTNFEVE DIEMARESPS RSKDGMKYPI 250 260 270 280 290 300 VIRNTKGEEV RCQYVVTCAG LYSDRISELS GCNPNPRIVP FRGDYLVLKP EKRYLVKGNI 310 320 330 340 350 360 YPVPDSRFPF LGVHFTPRMD GNIWLGPNAI LAFKREGYRP FDFSARDIMD IIIKSGLIKL 370 380 390 400 410 420 VFQNFSYGVN EMYKACFLSA TVKHLQKFIP EITISDVLRG PAGVRAQALD RDGNLIEDFV 430 440 450 460 FDGGVGDIGN RILHVRNAPS PAATSSLAIS GMIADEVQQR FKL

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Ascending colon.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC151577 mRNA. Translation: AAI51578.1.
IPI	IPI00691649.
RefSeq	NP_001094560.1. NM_001101090.1.
UniGene	Bt.58900.
3D structure databases
ProteinModelPortal	A7MBI3.
ModBase	Search...
Protein-protein interaction databases
STRING	A7MBI3.
Proteomic databases
PRIDE	A7MBI3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000020226; ENSBTAP00000020226; ENSBTAG00000015200.
GeneID	514230.
KEGG	bta:514230.
Organism-specific databases
CTD	79944.
Phylogenomic databases
eggNOG	maNOG11390.
GeneTree	ENSGT00490000043421.
HOVERGEN	HBG081883.
InParanoid	A7MBI3.
OMA	GVHFTRM.
OrthoDB	EOG4QNMWB.
PhylomeDB	A7MBI3.
Family and domain databases
InterPro	IPR006076. FAD-dep_OxRdtase. [Graphical view]
KO	K00109.
Pfam	PF01266. DAO. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

L2HDH_BOVIN

Accession

Primary (citable) accession number: A7MBI3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	October 2, 2007
Last modified:	November 16, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program