Reviewed, UniProtKB/Swiss-Prot A7MBI3 (L2HDH_BOVIN)

Names and origin

Protein names

Recommended name:
    L-2-hydroxyglutarate dehydrogenase, mitochondrial
      Short name=Duranin
    EC=1.1.99.2

Gene names

Name:

L2HGDH

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	463 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	(S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor.
Cofactor	FAD By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the L2HGDH family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	2-hydroxyglutarate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 52	52	Mitochondrion Potential
	Chain	53 – 463	411	L-2-hydroxyglutarate dehydrogenase, mitochondrial		PRO_0000331213

Sequences

	Sequence		Length	Mass (Da)
	A7MBI3-1 [UniParc]. Last modified October 2, 2007. Version 1. Checksum: 682632966A525F92	FASTA	463	51,022
	10 20 30 40 50 60 MVPALRYLGS VCGRARGIFP GGFSAAHTPA SGKSRLLCQG GRRASTSSFD IVIIGGGIVG 70 80 90 100 110 120 LASARALILR HPALSIGVLE KEKNLAVHQT GHNSGVIHSG IYYKPESLKA KLCVQGAALI 130 140 150 160 170 180 YEYCNQKGIS YKQCGKLIVA VEQEEIPRLQ ALYERGLQNG VQGLRLIQQE DIKKKEPYCR 190 200 210 220 230 240 GLMAIDCPYT GIVDYRQVAF SFAKDFQEAG GSVLTNFEVE DIEMARESPS RSKDGMKYPI 250 260 270 280 290 300 VIRNTKGEEV RCQYVVTCAG LYSDRISELS GCNPNPRIVP FRGDYLVLKP EKRYLVKGNI 310 320 330 340 350 360 YPVPDSRFPF LGVHFTPRMD GNIWLGPNAI LAFKREGYRP FDFSARDIMD IIIKSGLIKL 370 380 390 400 410 420 VFQNFSYGVN EMYKACFLSA TVKHLQKFIP EITISDVLRG PAGVRAQALD RDGNLIEDFV 430 440 450 460 FDGGVGDIGN RILHVRNAPS PAATSSLAIS GMIADEVQQR FKL

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Ascending colon.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC151577 mRNA. Translation: AAI51578.1.
IPI	IPI00691649.
RefSeq	NP_001094560.1.
UniGene	Bt.58900
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAG00000015200. Bos taurus. [Contig view]
GeneID	514230.
KEGG	bta:514230.
Phylogenomic databases
OMA	A7MBI3. KIVPFRG.
Family and domain databases
InterPro	IPR006076. FAD-dep_OxRdtase. [Graphical view]
Pfam	PF01266. DAO. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

L2HDH_BOVIN

Accession

Primary (citable) accession number: A7MBI3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	October 2, 2007
Last modified:	June 16, 2009
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)