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Protein

L-2-hydroxyglutarate dehydrogenase, mitochondrial

Gene

L2HGDH

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor.

Cofactori

FADBy similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-BTA-880009 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate

Names & Taxonomyi

Protein namesi
Recommended name:
L-2-hydroxyglutarate dehydrogenase, mitochondrial (EC:1.1.99.2)
Alternative name(s):
Duranin
Gene namesi
Name:L2HGDH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi

Organism-specific databases

VGNCiVGNC:30761 L2HGDH

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 52MitochondrionSequence analysisAdd BLAST52
ChainiPRO_000033121353 – 463L-2-hydroxyglutarate dehydrogenase, mitochondrialAdd BLAST411

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei104N6-acetyllysineBy similarity1
Modified residuei173N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiA7MBI3
PRIDEiA7MBI3

Expressioni

Gene expression databases

BgeeiENSBTAG00000015200

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020226

Structurei

3D structure databases

ProteinModelPortaliA7MBI3
SMRiA7MBI3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L2HGDH family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2665 Eukaryota
COG0579 LUCA
GeneTreeiENSGT00490000043421
HOGENOMiHOG000245180
HOVERGENiHBG081883
InParanoidiA7MBI3
KOiK00109
OMAiGVHFTRM
OrthoDBiEOG091G06OM
TreeFamiTF105922

Family and domain databases

InterProiView protein in InterPro
IPR006076 FAD-dep_OxRdtase
IPR036188 FAD/NAD-bd_sf
PfamiView protein in Pfam
PF01266 DAO, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7MBI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPALRYLGS VCGRARGIFP GGFSAAHTPA SGKSRLLCQG GRRASTSSFD
60 70 80 90 100
IVIIGGGIVG LASARALILR HPALSIGVLE KEKNLAVHQT GHNSGVIHSG
110 120 130 140 150
IYYKPESLKA KLCVQGAALI YEYCNQKGIS YKQCGKLIVA VEQEEIPRLQ
160 170 180 190 200
ALYERGLQNG VQGLRLIQQE DIKKKEPYCR GLMAIDCPYT GIVDYRQVAF
210 220 230 240 250
SFAKDFQEAG GSVLTNFEVE DIEMARESPS RSKDGMKYPI VIRNTKGEEV
260 270 280 290 300
RCQYVVTCAG LYSDRISELS GCNPNPRIVP FRGDYLVLKP EKRYLVKGNI
310 320 330 340 350
YPVPDSRFPF LGVHFTPRMD GNIWLGPNAI LAFKREGYRP FDFSARDIMD
360 370 380 390 400
IIIKSGLIKL VFQNFSYGVN EMYKACFLSA TVKHLQKFIP EITISDVLRG
410 420 430 440 450
PAGVRAQALD RDGNLIEDFV FDGGVGDIGN RILHVRNAPS PAATSSLAIS
460
GMIADEVQQR FKL
Length:463
Mass (Da):51,022
Last modified:October 2, 2007 - v1
Checksum:i682632966A525F92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151577 mRNA Translation: AAI51578.1
RefSeqiNP_001094560.1, NM_001101090.1
UniGeneiBt.58900

Genome annotation databases

EnsembliENSBTAT00000020226; ENSBTAP00000020226; ENSBTAG00000015200
GeneIDi514230
KEGGibta:514230

Entry informationi

Entry nameiL2HDH_BOVIN
AccessioniPrimary (citable) accession number: A7MBI3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 2, 2007
Last modified: March 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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