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Protein

Inositol oxygenase

Gene

MIOX

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Myo-inositol + O2 = D-glucuronate + H2O.

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei29 – 291SubstrateBy similarity
Metal bindingi98 – 981Iron 1By similarity
Metal bindingi123 – 1231Iron 1By similarity
Metal bindingi124 – 1241Iron 1By similarity
Metal bindingi124 – 1241Iron 2By similarity
Binding sitei127 – 1271SubstrateBy similarity
Metal bindingi194 – 1941Iron 2By similarity
Metal bindingi220 – 2201Iron 2By similarity
Metal bindingi253 – 2531Iron 1By similarity

GO - Molecular functioni

  1. ferric iron binding Source: UniProtKB
  2. inositol oxygenase activity Source: UniProtKB

GO - Biological processi

  1. inositol catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00111; UER00527.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol oxygenase (EC:1.13.99.1)
Alternative name(s):
Myo-inositol oxygenase
Short name:
MI oxygenase
Gene namesi
Name:MIOX
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Unplaced

Subcellular locationi

  1. Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 285285Inositol oxygenasePRO_0000328412Add
BLAST

Expressioni

Gene expression databases

ExpressionAtlasiA7MBE4. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003315.

Structurei

3D structure databases

ProteinModelPortaliA7MBE4.
SMRiA7MBE4. Positions 28-285.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni85 – 873Substrate bindingBy similarity
Regioni141 – 1422Substrate bindingBy similarity
Regioni220 – 2212Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the myo-inositol oxygenase family.Curated

Phylogenomic databases

eggNOGiNOG135479.
HOGENOMiHOG000163182.
HOVERGENiHBG039556.
InParanoidiA7MBE4.
KOiK00469.

Family and domain databases

InterProiIPR007828. Inositol_oxygenase.
[Graphical view]
PANTHERiPTHR12588. PTHR12588. 1 hit.
PfamiPF05153. DUF706. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7MBE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVAADPDPS LVSQRDMEPE AAKDKDSFRN YTSGPLLDRV FATYKLMHTW
60 70 80 90 100
QTVDFVRRKH AQFGGFSYKR MTVMEAVDML DGLVDESDPD VDFPNSFHAF
110 120 130 140 150
QTAEGIRKAH PDKDWFHLVG LLHDLGKVLA LAGEPQWAVV GDTFPVGCRP
160 170 180 190 200
QASVVFRDCT FQDNPDLQDP LYSTELGMYQ PHCGLENVLM SWGHDEYMYR
210 220 230 240 250
MMKFNKFALP PEAFYIIRFH SFYPWHKFGD YQQLCNEQDL AMLPWVQEFN
260 270 280
KFDLYTKSSS LPDVAALRPY YQGLVDKYCP GILCW
Length:285
Mass (Da):32,973
Last modified:October 2, 2007 - v1
Checksum:iCC9C772AF56DD5D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151511 mRNA. Translation: AAI51512.1.
RefSeqiNP_001094535.1. NM_001101065.1.
XP_010804139.1. XM_010805837.1.
UniGeneiBt.27866.

Genome annotation databases

GeneIDi508591.
KEGGibta:508591.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151511 mRNA. Translation: AAI51512.1.
RefSeqiNP_001094535.1. NM_001101065.1.
XP_010804139.1. XM_010805837.1.
UniGeneiBt.27866.

3D structure databases

ProteinModelPortaliA7MBE4.
SMRiA7MBE4. Positions 28-285.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000003315.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi508591.
KEGGibta:508591.

Organism-specific databases

CTDi55586.

Phylogenomic databases

eggNOGiNOG135479.
HOGENOMiHOG000163182.
HOVERGENiHBG039556.
InParanoidiA7MBE4.
KOiK00469.

Enzyme and pathway databases

UniPathwayiUPA00111; UER00527.

Miscellaneous databases

NextBioi20868588.

Gene expression databases

ExpressionAtlasiA7MBE4. baseline.

Family and domain databases

InterProiIPR007828. Inositol_oxygenase.
[Graphical view]
PANTHERiPTHR12588. PTHR12588. 1 hit.
PfamiPF05153. DUF706. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Kidney.

Entry informationi

Entry nameiMIOX_BOVIN
AccessioniPrimary (citable) accession number: A7MBE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 2, 2007
Last modified: March 4, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.