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A7MBE4 (MIOX_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inositol oxygenase

EC=1.13.99.1
Alternative name(s):
Myo-inositol oxygenase
Short name=MI oxygenase
Gene names
Name:MIOX
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length285 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Myo-inositol + O2 = D-glucuronate + H2O.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the myo-inositol oxygenase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processinositol catabolic process

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionferric iron binding

Inferred from sequence or structural similarity. Source: UniProtKB

inositol oxygenase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 285285Inositol oxygenase
PRO_0000328412

Regions

Region85 – 873Substrate binding By similarity
Region141 – 1422Substrate binding By similarity
Region220 – 2212Substrate binding By similarity

Sites

Metal binding981Iron 1 By similarity
Metal binding1231Iron 1 By similarity
Metal binding1241Iron 1 By similarity
Metal binding1241Iron 2 By similarity
Metal binding1941Iron 2 By similarity
Metal binding2201Iron 2 By similarity
Metal binding2531Iron 1 By similarity
Binding site291Substrate By similarity
Binding site1271Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
A7MBE4 [UniParc].

Last modified October 2, 2007. Version 1.
Checksum: CC9C772AF56DD5D6

FASTA28532,973
        10         20         30         40         50         60 
MKVAADPDPS LVSQRDMEPE AAKDKDSFRN YTSGPLLDRV FATYKLMHTW QTVDFVRRKH 

        70         80         90        100        110        120 
AQFGGFSYKR MTVMEAVDML DGLVDESDPD VDFPNSFHAF QTAEGIRKAH PDKDWFHLVG 

       130        140        150        160        170        180 
LLHDLGKVLA LAGEPQWAVV GDTFPVGCRP QASVVFRDCT FQDNPDLQDP LYSTELGMYQ 

       190        200        210        220        230        240 
PHCGLENVLM SWGHDEYMYR MMKFNKFALP PEAFYIIRFH SFYPWHKFGD YQQLCNEQDL 

       250        260        270        280 
AMLPWVQEFN KFDLYTKSSS LPDVAALRPY YQGLVDKYCP GILCW 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC151511 mRNA. Translation: AAI51512.1.
RefSeqNP_001094535.1. NM_001101065.1.
UniGeneBt.27866.

3D structure databases

ProteinModelPortalA7MBE4.
SMRA7MBE4. Positions 28-285.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000003315.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID508591.
KEGGbta:508591.

Organism-specific databases

CTD55586.

Phylogenomic databases

eggNOGNOG135479.
HOGENOMHOG000163182.
HOVERGENHBG039556.
InParanoidA7MBE4.
KOK00469.

Enzyme and pathway databases

UniPathwayUPA00111; UER00527.

Family and domain databases

InterProIPR007828. Inositol_oxygenase.
[Graphical view]
PANTHERPTHR12588. PTHR12588. 1 hit.
PfamPF05153. DUF706. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20868588.

Entry information

Entry nameMIOX_BOVIN
AccessionPrimary (citable) accession number: A7MBE4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 2, 2007
Last modified: January 22, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways