A7MBE4 (MIOX_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Inositol oxygenase
EC=1.13.99.1

Alternative name(s):
Myo-inositol oxygenase
Short name=MI oxygenase

Gene names

Name:

MIOX

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	285 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Myo-inositol + O2 = D-glucuronate + H2O.
Cofactor	Binds 2 iron ions per subunit By similarity.
Pathway	Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the myo-inositol oxygenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ferric iron binding Inferred from sequence or structural similarity. Source: UniProtKB inositol oxygenase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 285	285	Inositol oxygenase		PRO_0000328412
Regions
	Region	85 – 87	3	Substrate binding By similarity
	Region	141 – 142	2	Substrate binding By similarity
	Region	220 – 221	2	Substrate binding By similarity
Sites
	Metal binding	98	1	Iron 1 By similarity
	Metal binding	123	1	Iron 1 By similarity
	Metal binding	124	1	Iron 1 By similarity
	Metal binding	124	1	Iron 2 By similarity
	Metal binding	194	1	Iron 2 By similarity
	Metal binding	220	1	Iron 2 By similarity
	Metal binding	253	1	Iron 1 By similarity
	Binding site	29	1	Substrate By similarity
	Binding site	127	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7MBE4 [UniParc]. Last modified October 2, 2007. Version 1. Checksum: CC9C772AF56DD5D6	FASTA	285	32,973
	10 20 30 40 50 60 MKVAADPDPS LVSQRDMEPE AAKDKDSFRN YTSGPLLDRV FATYKLMHTW QTVDFVRRKH 70 80 90 100 110 120 AQFGGFSYKR MTVMEAVDML DGLVDESDPD VDFPNSFHAF QTAEGIRKAH PDKDWFHLVG 130 140 150 160 170 180 LLHDLGKVLA LAGEPQWAVV GDTFPVGCRP QASVVFRDCT FQDNPDLQDP LYSTELGMYQ 190 200 210 220 230 240 PHCGLENVLM SWGHDEYMYR MMKFNKFALP PEAFYIIRFH SFYPWHKFGD YQQLCNEQDL 250 260 270 280 AMLPWVQEFN KFDLYTKSSS LPDVAALRPY YQGLVDKYCP GILCW

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Kidney.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC151511 mRNA. Translation: AAI51512.1.
IPI	IPI00710509.
RefSeq	NP_001094535.1. NM_001101065.1.
UniGene	Bt.27866.
3D structure databases
ProteinModelPortal	A7MBE4.
SMR	A7MBE4. Positions 28-285.
ModBase	Search...
Protein-protein interaction databases
STRING	A7MBE4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	508591.
KEGG	bta:508591.
Organism-specific databases
CTD	55586.
Phylogenomic databases
eggNOG	maNOG16879.
GeneTree	ENSGT00390000016211.
HOVERGEN	HBG039556.
InParanoid	A7MBE4.
OMA	VMEAVDM.
OrthoDB	EOG454902.
Family and domain databases
InterPro	IPR007828. Inositol_oxygenase. [Graphical view]
KO	K00469.
PANTHER	PTHR12588. DUF706. 1 hit.
Pfam	PF05153. DUF706. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MIOX_BOVIN

Accession

Primary (citable) accession number: A7MBE4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	October 2, 2007
Last modified:	November 16, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program