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A7MBE4

- MIOX_BOVIN

UniProt

A7MBE4 - MIOX_BOVIN

Protein

Inositol oxygenase

Gene

MIOX

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Myo-inositol + O2 = D-glucuronate + H2O.

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei29 – 291SubstrateBy similarity
    Metal bindingi98 – 981Iron 1By similarity
    Metal bindingi123 – 1231Iron 1By similarity
    Metal bindingi124 – 1241Iron 1By similarity
    Metal bindingi124 – 1241Iron 2By similarity
    Binding sitei127 – 1271SubstrateBy similarity
    Metal bindingi194 – 1941Iron 2By similarity
    Metal bindingi220 – 2201Iron 2By similarity
    Metal bindingi253 – 2531Iron 1By similarity

    GO - Molecular functioni

    1. ferric iron binding Source: UniProtKB
    2. inositol oxygenase activity Source: UniProtKB

    GO - Biological processi

    1. inositol catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00111; UER00527.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inositol oxygenase (EC:1.13.99.1)
    Alternative name(s):
    Myo-inositol oxygenase
    Short name:
    MI oxygenase
    Gene namesi
    Name:MIOX
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 285285Inositol oxygenasePRO_0000328412Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000003315.

    Structurei

    3D structure databases

    ProteinModelPortaliA7MBE4.
    SMRiA7MBE4. Positions 28-285.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni85 – 873Substrate bindingBy similarity
    Regioni141 – 1422Substrate bindingBy similarity
    Regioni220 – 2212Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the myo-inositol oxygenase family.Curated

    Phylogenomic databases

    eggNOGiNOG135479.
    HOGENOMiHOG000163182.
    HOVERGENiHBG039556.
    InParanoidiA7MBE4.
    KOiK00469.

    Family and domain databases

    InterProiIPR007828. Inositol_oxygenase.
    [Graphical view]
    PANTHERiPTHR12588. PTHR12588. 1 hit.
    PfamiPF05153. DUF706. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7MBE4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVAADPDPS LVSQRDMEPE AAKDKDSFRN YTSGPLLDRV FATYKLMHTW    50
    QTVDFVRRKH AQFGGFSYKR MTVMEAVDML DGLVDESDPD VDFPNSFHAF 100
    QTAEGIRKAH PDKDWFHLVG LLHDLGKVLA LAGEPQWAVV GDTFPVGCRP 150
    QASVVFRDCT FQDNPDLQDP LYSTELGMYQ PHCGLENVLM SWGHDEYMYR 200
    MMKFNKFALP PEAFYIIRFH SFYPWHKFGD YQQLCNEQDL AMLPWVQEFN 250
    KFDLYTKSSS LPDVAALRPY YQGLVDKYCP GILCW 285
    Length:285
    Mass (Da):32,973
    Last modified:October 2, 2007 - v1
    Checksum:iCC9C772AF56DD5D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC151511 mRNA. Translation: AAI51512.1.
    RefSeqiNP_001094535.1. NM_001101065.1.
    UniGeneiBt.27866.

    Genome annotation databases

    GeneIDi508591.
    KEGGibta:508591.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC151511 mRNA. Translation: AAI51512.1 .
    RefSeqi NP_001094535.1. NM_001101065.1.
    UniGenei Bt.27866.

    3D structure databases

    ProteinModelPortali A7MBE4.
    SMRi A7MBE4. Positions 28-285.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000003315.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 508591.
    KEGGi bta:508591.

    Organism-specific databases

    CTDi 55586.

    Phylogenomic databases

    eggNOGi NOG135479.
    HOGENOMi HOG000163182.
    HOVERGENi HBG039556.
    InParanoidi A7MBE4.
    KOi K00469.

    Enzyme and pathway databases

    UniPathwayi UPA00111 ; UER00527 .

    Miscellaneous databases

    NextBioi 20868588.

    Family and domain databases

    InterProi IPR007828. Inositol_oxygenase.
    [Graphical view ]
    PANTHERi PTHR12588. PTHR12588. 1 hit.
    Pfami PF05153. DUF706. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Kidney.

    Entry informationi

    Entry nameiMIOX_BOVIN
    AccessioniPrimary (citable) accession number: A7MBE4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3