Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

N-acetylglucosamine-6-phosphate deacetylase

Gene

AMDHD2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.By similarity

Catalytic activityi

N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 1 divalent metal cation per subunit.By similarity

Pathwayi: N-acetylneuraminate degradation

This protein is involved in the pathway N-acetylneuraminate degradation, which is part of Amino-sugar metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway N-acetylneuraminate degradation and in Amino-sugar metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi143Divalent metal cationBy similarity1
Metal bindingi211Divalent metal cation; via tele nitrogenBy similarity1
Metal bindingi232Divalent metal cation; via tele nitrogenBy similarity1
Binding sitei243SubstrateBy similarity1
Active sitei294Proton donor/acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-446210. Synthesis of UDP-N-acetyl-glucosamine.
UniPathwayiUPA00629.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylglucosamine-6-phosphate deacetylaseBy similarity (EC:3.5.1.25By similarity)
Short name:
GlcNAc 6-P deacetylaseBy similarity
Alternative name(s):
Amidohydrolase domain-containing protein 2By similarity
Gene namesi
Name:AMDHD2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003157751 – 409N-acetylglucosamine-6-phosphate deacetylaseAdd BLAST409

Proteomic databases

PaxDbiA7MBC0.
PRIDEiA7MBC0.

Expressioni

Gene expression databases

BgeeiENSBTAG00000001022.
ExpressionAtlasiA7MBC0. differential.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001355.

Structurei

3D structure databases

ProteinModelPortaliA7MBC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni154 – 155Substrate bindingBy similarity2
Regioni235 – 236Substrate bindingBy similarity2
Regioni269 – 272Substrate bindingBy similarity4
Regioni328 – 330Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the NagA family.Curated

Phylogenomic databases

eggNOGiKOG3892. Eukaryota.
COG1820. LUCA.
GeneTreeiENSGT00390000012605.
HOGENOMiHOG000275010.
HOVERGENiHBG108170.
InParanoidiA7MBC0.
KOiK01443.
OMAiGRHIFYG.
OrthoDBiEOG091G08JG.
TreeFamiTF315036.

Family and domain databases

CDDicd00854. NagA. 1 hit.
Gene3Di2.30.40.10. 2 hits.
InterProiIPR006680. Amidohydro-rel.
IPR003764. GlcNAc_6-P_deAcase.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
PIRSFiPIRSF038994. NagA. 1 hit.
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR00221. nagA. 1 hit.

Sequencei

Sequence statusi: Complete.

A7MBC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGGQGAARA PVIQFTNCRI LRGGALLRED LWVRGGRILD PEKLFFEERR
60 70 80 90 100
VADEQRDCGG CILAPGFIDV QINGGFGVDF SQASEDVGSG VALVARRILS
110 120 130 140 150
HGVTSFCPTL VTSPLEVYHK VLPQIPVKSG GPHGAGVLGV HLEGPFISRE
160 170 180 190 200
KRGAHPEAHL RSFEADAFQD VLATYGGLDN VRIVTLAPEL GHSQEVIRAL
210 220 230 240 250
TALGICVSLG HSVADLGTAE EAVQSGATFI THLFNAMLPF HHRDPGIVGL
260 270 280 290 300
LTSDRLPAGR HIFYGMIADG IHTNPAALRI AHRAHPKGLV LVTDAVPALG
310 320 330 340 350
LGNGRHTLGQ QEVEVDGLTA YVAGTNTLSG SIAPMDTCVR HFLQATGCSV
360 370 380 390 400
ESALEAASLH PAQLLGLEKR KGTLDFGADA DFVVLDDSLH VRATYISGEL

VWQVEEARP
Length:409
Mass (Da):43,496
Last modified:October 2, 2007 - v1
Checksum:iF0B34ACF01011397
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151478 mRNA. Translation: AAI51479.1.
RefSeqiNP_001094574.1. NM_001101104.2.
UniGeneiBt.31831.

Genome annotation databases

EnsembliENSBTAT00000001355; ENSBTAP00000001355; ENSBTAG00000001022.
GeneIDi521401.
KEGGibta:521401.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151478 mRNA. Translation: AAI51479.1.
RefSeqiNP_001094574.1. NM_001101104.2.
UniGeneiBt.31831.

3D structure databases

ProteinModelPortaliA7MBC0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000001355.

Proteomic databases

PaxDbiA7MBC0.
PRIDEiA7MBC0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000001355; ENSBTAP00000001355; ENSBTAG00000001022.
GeneIDi521401.
KEGGibta:521401.

Organism-specific databases

CTDi51005.

Phylogenomic databases

eggNOGiKOG3892. Eukaryota.
COG1820. LUCA.
GeneTreeiENSGT00390000012605.
HOGENOMiHOG000275010.
HOVERGENiHBG108170.
InParanoidiA7MBC0.
KOiK01443.
OMAiGRHIFYG.
OrthoDBiEOG091G08JG.
TreeFamiTF315036.

Enzyme and pathway databases

UniPathwayiUPA00629.
ReactomeiR-BTA-446210. Synthesis of UDP-N-acetyl-glucosamine.

Gene expression databases

BgeeiENSBTAG00000001022.
ExpressionAtlasiA7MBC0. differential.

Family and domain databases

CDDicd00854. NagA. 1 hit.
Gene3Di2.30.40.10. 2 hits.
InterProiIPR006680. Amidohydro-rel.
IPR003764. GlcNAc_6-P_deAcase.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
[Graphical view]
PfamiPF01979. Amidohydro_1. 1 hit.
[Graphical view]
PIRSFiPIRSF038994. NagA. 1 hit.
SUPFAMiSSF51338. SSF51338. 2 hits.
SSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR00221. nagA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNAGA_BOVIN
AccessioniPrimary (citable) accession number: A7MBC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 2, 2007
Last modified: November 30, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.