Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitogen-activated protein kinase kinase kinase 13

Gene

MAP3K13

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by autophosphorylation and homodimerization.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei195 – 1951ATPPROSITE-ProRule annotation
Active sitei279 – 2791Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi174 – 1829ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase 13 (EC:2.7.11.25)
Gene namesi
Name:MAP3K13
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 966966Mitogen-activated protein kinase kinase kinase 13PRO_0000366128Add
BLAST

Post-translational modificationi

Autophosphorylated on serine and threonine residues.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA7MBB4.

Interactioni

Subunit structurei

Homodimer; forms dimers through the leucine-zipper motif. Interacts with the C-terminus of MAPK8IP1 through the kinase catalytic domain. Binds PRDX3. Associates with the IKK complex through the kinase domain (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022739.

Structurei

3D structure databases

ProteinModelPortaliA7MBB4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini168 – 409242Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni433 – 45422Leucine-zipper 1Add
BLAST
Regioni486 – 50722Leucine-zipper 2Add
BLAST
Regioni815 – 82814AcidicBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili457 – 49640Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi576 – 5827Poly-Ser
Compositional biasi817 – 8226Poly-Glu

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG4721. Eukaryota.
ENOG410YKX2. LUCA.
HOGENOMiHOG000113435.
HOVERGENiHBG052383.
InParanoidiA7MBB4.
KOiK04422.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR017419. MAP3K12_MAP3K13.
IPR027258. MAPKKK13.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR23257:SF336. PTHR23257:SF336. 2 hits.
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF038165. MAPKKK12_MAPKKK13. 1 hit.
PIRSF500742. MAPKKK13. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7MBB4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANPQEHLSC SSSPRLPLSE NKTFNGLQDD LAPMGSHASP KLLKDQQEKG
60 70 80 90 100
MVQTELAEGT NSPITTTVLT SISEDSRDQF ENSVLQLREQ DESEMAMSHG
110 120 130 140 150
NSNTVDGEGT SGTEDIKIQF SRSGSGSGGF LEGLFGCLRP VWNIIGKAYS
160 170 180 190 200
TDYKLQQQDT WEVPFEEISE LQWLGSGAQG AVFLGKFRAE EVAIKKVREQ
210 220 230 240 250
NETDIKHLRK LKHPNIIAFK GVCTQAPCYC IIMEYCAHGQ LYEVLRAGRK
260 270 280 290 300
ITPRLLVDWS TGIASGMNYL HLHKIIHRDL KSPNVLVTHT DAVKISDFGT
310 320 330 340 350
SKELSDKSTK MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE
360 370 380 390 400
IPYKDVDSSA IIWGVGSNSL HLPVPSTCPD GFKILMKQTW QSKTRNRPSF
410 420 430 440 450
RQTLMHLDIA SADVLATPQE TYFKSQAEWR EEVKKHFEKI KSEGTCIHRL
460 470 480 490 500
DEELIRRRRE ELRHALDIRE HYERKLERAN NLYMELSAIM LQLEMREKEL
510 520 530 540 550
IKREQAVEKK YPGTYKRHPV RPIIHPNAME KLMKRKGMPH RPGMQAKRPD
560 570 580 590 600
LLRSEGIPSV EVAPTASPLS GSPKLSSSSS KSRYRSKPRH RRGNSRGSHG
610 620 630 640 650
DFAAILKNQP AQEDSPHPTS LHQAEPQYPS SQHHNLLQQQ YQQPPPAMSQ
660 670 680 690 700
SHHPRLNMHG QDIATCPNNL RYFGPAAALR SPLSNHSQRQ MPGSSPDLIS
710 720 730 740 750
TAMAADCWRS SEPDKGQAGP WGCCQADPYD PCLQCRPEQH GSLDVPSAKP
760 770 780 790 800
VGRSPSLFKP PAHNPLLENA QGSEKMEENE FSGYRSASSL GASHHITPPV
810 820 830 840 850
LPRKTRPLQK SGDDSSEEEE GEVDSEVEFP RRQRPHRCIS SCQSYSTFSS
860 870 880 890 900
ENFSVSDGEE GNTSDHSNSP DELADKLEDH LAEKLDDLLS QTPEIPIEIS
910 920 930 940 950
SHSDGLSDKE CAVRRVKTQM SLGKLCAEER GYENPMQFEE SDCDSSDGEC
960
SDATVRTNKH YSSATW
Length:966
Mass (Da):108,152
Last modified:October 2, 2007 - v1
Checksum:i4D632EAC6AF13FF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151464 mRNA. Translation: AAI51465.1.
RefSeqiNP_001095323.1. NM_001101853.2.
UniGeneiBt.78411.

Genome annotation databases

GeneIDi505369.
KEGGibta:505369.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151464 mRNA. Translation: AAI51465.1.
RefSeqiNP_001095323.1. NM_001101853.2.
UniGeneiBt.78411.

3D structure databases

ProteinModelPortaliA7MBB4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022739.

Proteomic databases

PaxDbiA7MBB4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi505369.
KEGGibta:505369.

Organism-specific databases

CTDi9175.

Phylogenomic databases

eggNOGiKOG4721. Eukaryota.
ENOG410YKX2. LUCA.
HOGENOMiHOG000113435.
HOVERGENiHBG052383.
InParanoidiA7MBB4.
KOiK04422.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR017419. MAP3K12_MAP3K13.
IPR027258. MAPKKK13.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR23257:SF336. PTHR23257:SF336. 2 hits.
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF038165. MAPKKK12_MAPKKK13. 1 hit.
PIRSF500742. MAPKKK13. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiM3K13_BOVIN
AccessioniPrimary (citable) accession number: A7MBB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: October 2, 2007
Last modified: June 8, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.