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A7MB78

- GYS1_BOVIN

UniProt

A7MB78 - GYS1_BOVIN

Protein

Glycogen [starch] synthase, muscle

Gene

GYS1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.By similarity

    Catalytic activityi

    UDP-alpha-D-glucose + ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1).

    Enzyme regulationi

    Allosteric activation by glucose-6-phosphate. Phosphorylation reduces the activity towards UDP-glucose. When in the non-phosphorylated state, glycogen synthase does not require glucose-6-phosphate as an allosteric activator; when phosphorylated it does By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei39 – 391UDP-glucoseBy similarity

    GO - Molecular functioni

    1. glycogen (starch) synthase activity Source: UniProtKB

    GO - Biological processi

    1. glycogen biosynthetic process Source: UniProtKB
    2. heart development Source: Ensembl

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Glycogen biosynthesis

    Enzyme and pathway databases

    ReactomeiREACT_213093. Glycogen synthesis.
    REACT_219973. Myoclonic epilepsy of Lafora.
    UniPathwayiUPA00164.

    Protein family/group databases

    CAZyiGT3. Glycosyltransferase Family 3.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycogen [starch] synthase, muscle (EC:2.4.1.11)
    Gene namesi
    Name:GYS1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 18

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. inclusion body Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 736735Glycogen [starch] synthase, musclePRO_0000358311Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei8 – 81Phosphoserine; by AMPK and PKABy similarity
    Modified residuei11 – 111PhosphoserineBy similarity
    Modified residuei641 – 6411Phosphoserine; by DYRK2, GSK3-alpha, GSK3-beta and PASKBy similarity
    Modified residuei645 – 6451Phosphoserine; by GSK3-alpha and GSK3-betaBy similarity
    Modified residuei649 – 6491Phosphoserine; by GSK3-alpha and GSK3-betaBy similarity
    Modified residuei653 – 6531Phosphoserine; by GSK3-alpha and GSK3-betaBy similarity
    Modified residuei657 – 6571Phosphoserine; by CK2By similarity
    Modified residuei698 – 6981PhosphoserineBy similarity
    Modified residuei726 – 7261PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylation at Ser-8 by AMPK inactivates the enzyme activity. Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B. Phosphorylated at Ser-641 by PASK, leading to inactivation; phosphorylation by PASK is inhibited by glycogen. Phosphorylated at Ser-641 by DYRK2, leading to inactivation. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiA7MB78.

    Interactioni

    Subunit structurei

    Interacts with GYG1.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000007423.

    Structurei

    3D structure databases

    ProteinModelPortaliA7MB78.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 3 family.Curated

    Phylogenomic databases

    eggNOGiCOG0438.
    GeneTreeiENSGT00390000018612.
    HOGENOMiHOG000160890.
    HOVERGENiHBG001960.
    InParanoidiA7MB78.
    KOiK00693.
    OMAiFAMKRHG.
    OrthoDBiEOG741Z1N.
    TreeFamiTF300306.

    Family and domain databases

    InterProiIPR008631. Glycogen_synth.
    [Graphical view]
    PANTHERiPTHR10176. PTHR10176. 1 hit.
    PfamiPF05693. Glycogen_syn. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A7MB78-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLNRTLSMS SLPGLEDWED EFDLENTVLF EVAWEVANKV GGIYTVLQTK    50
    AKVTGDEWGD NYYLVGPYTE QGVRTQVELL EPPTPALKRT LDSMNSKGCK 100
    VYFGRWLIEG GPLVVLLDVG ASAWALERWK GELWDTCNIG VPWYDREAND 150
    AVLFGFLTTW FLGEFLAQSE EKPHVVAHFH EWLAGVGLCL CRARRLPVAT 200
    IFTTHATLLG RYLCAGAVDF YNNLENFNVD KEAGERQIYH RYCMERAAAH 250
    CAHVFTTVSQ ITAIEAQHLL KRKPDIVTPN GLNVKKFSAM HEFQNLHAQS 300
    KARIQEFVRG HFYGHLDFNL DKTLYFFIAG RYEFSNKGAD VFLEALARLN 350
    YLLRVNGSEQ TVVAFFIMPA RTNNFNVETL KGQAVRKQLW DTANTVKEKF 400
    GRKLYESLLV GSLPDMNKML DKEDFTMMKR AIFATQRQSF PPVCTHNMLD 450
    DSSDPILTTI RRIGLFNSSA DRVKVIFHPE FLSSTSPLLP VDYEEFVRGC 500
    HLGVFPSYYE PWGYTPAECT VMGIPSVSTN LSGFGCFMEE HIADPSAYGI 550
    YILDRRFRSL DDSCSQLTSF LYSFCQQSRR QRIIQRNRTE RLSDLLDWKY 600
    LGRYYMSARH MALAKAFPEY FTYEPHEADA TQGYRYPRPA SVPPSPSLSR 650
    HSSPHQSEDE EEPRDLPPDE DDERYDEDEE AAKDRRNIRA PEWPRRASCT 700
    SSTGSKRGSV DTAPSSSVST PSEPLSPASS LGEERN 736
    Length:736
    Mass (Da):83,814
    Last modified:October 2, 2007 - v1
    Checksum:i22300D8723EF94BD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC151381 mRNA. Translation: AAI51382.1.
    RefSeqiNP_001094769.1. NM_001101299.1.
    UniGeneiBt.102939.

    Genome annotation databases

    EnsembliENSBTAT00000007423; ENSBTAP00000007423; ENSBTAG00000039958.
    GeneIDi786335.
    KEGGibta:786335.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC151381 mRNA. Translation: AAI51382.1 .
    RefSeqi NP_001094769.1. NM_001101299.1.
    UniGenei Bt.102939.

    3D structure databases

    ProteinModelPortali A7MB78.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000007423.

    Protein family/group databases

    CAZyi GT3. Glycosyltransferase Family 3.

    Proteomic databases

    PRIDEi A7MB78.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000007423 ; ENSBTAP00000007423 ; ENSBTAG00000039958 .
    GeneIDi 786335.
    KEGGi bta:786335.

    Organism-specific databases

    CTDi 2997.

    Phylogenomic databases

    eggNOGi COG0438.
    GeneTreei ENSGT00390000018612.
    HOGENOMi HOG000160890.
    HOVERGENi HBG001960.
    InParanoidi A7MB78.
    KOi K00693.
    OMAi FAMKRHG.
    OrthoDBi EOG741Z1N.
    TreeFami TF300306.

    Enzyme and pathway databases

    UniPathwayi UPA00164 .
    Reactomei REACT_213093. Glycogen synthesis.
    REACT_219973. Myoclonic epilepsy of Lafora.

    Miscellaneous databases

    NextBioi 20927821.

    Family and domain databases

    InterProi IPR008631. Glycogen_synth.
    [Graphical view ]
    PANTHERi PTHR10176. PTHR10176. 1 hit.
    Pfami PF05693. Glycogen_syn. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal muscle.

    Entry informationi

    Entry nameiGYS1_BOVIN
    AccessioniPrimary (citable) accession number: A7MB78
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 16, 2008
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3