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A7MB78

- GYS1_BOVIN

UniProt

A7MB78 - GYS1_BOVIN

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Protein

Glycogen [starch] synthase, muscle

Gene

GYS1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.By similarity

Catalytic activityi

UDP-alpha-D-glucose + ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1).

Enzyme regulationi

Allosteric activation by glucose-6-phosphate. Phosphorylation reduces the activity towards UDP-glucose. When in the non-phosphorylated state, glycogen synthase does not require glucose-6-phosphate as an allosteric activator; when phosphorylated it does (By similarity).By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391UDP-glucoseBy similarity

GO - Molecular functioni

  1. glycogen (starch) synthase activity Source: UniProtKB
  2. glycogen synthase activity, transferring glucose-1-phosphate Source: Ensembl

GO - Biological processi

  1. glycogen biosynthetic process Source: UniProtKB
  2. heart development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Glycogen biosynthesis

Enzyme and pathway databases

ReactomeiREACT_213093. Glycogen synthesis.
REACT_219973. Myoclonic epilepsy of Lafora.
UniPathwayiUPA00164.

Protein family/group databases

CAZyiGT3. Glycosyltransferase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycogen [starch] synthase, muscle (EC:2.4.1.11)
Gene namesi
Name:GYS1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 18

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. inclusion body Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 736735Glycogen [starch] synthase, musclePRO_0000358311Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei8 – 81Phosphoserine; by AMPK and PKABy similarity
Modified residuei11 – 111PhosphoserineBy similarity
Modified residuei641 – 6411Phosphoserine; by DYRK2, GSK3-alpha, GSK3-beta and PASKBy similarity
Modified residuei645 – 6451Phosphoserine; by GSK3-alpha and GSK3-betaBy similarity
Modified residuei649 – 6491Phosphoserine; by GSK3-alpha and GSK3-betaBy similarity
Modified residuei653 – 6531Phosphoserine; by GSK3-alpha and GSK3-betaBy similarity
Modified residuei657 – 6571Phosphoserine; by CK2By similarity
Modified residuei698 – 6981PhosphoserineBy similarity
Modified residuei726 – 7261PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation at Ser-8 by AMPK inactivates the enzyme activity. Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B. Phosphorylated at Ser-641 by PASK, leading to inactivation; phosphorylation by PASK is inhibited by glycogen. Phosphorylated at Ser-641 by DYRK2, leading to inactivation. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiA7MB78.

Interactioni

Subunit structurei

Interacts with GYG1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007423.

Structurei

3D structure databases

ProteinModelPortaliA7MB78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 3 family.Curated

Phylogenomic databases

eggNOGiCOG0438.
GeneTreeiENSGT00390000018612.
HOGENOMiHOG000160890.
HOVERGENiHBG001960.
InParanoidiA7MB78.
KOiK00693.
OMAiFAMKRHG.
OrthoDBiEOG741Z1N.
TreeFamiTF300306.

Family and domain databases

InterProiIPR008631. Glycogen_synth.
[Graphical view]
PANTHERiPTHR10176. PTHR10176. 1 hit.
PfamiPF05693. Glycogen_syn. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7MB78 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLNRTLSMS SLPGLEDWED EFDLENTVLF EVAWEVANKV GGIYTVLQTK
60 70 80 90 100
AKVTGDEWGD NYYLVGPYTE QGVRTQVELL EPPTPALKRT LDSMNSKGCK
110 120 130 140 150
VYFGRWLIEG GPLVVLLDVG ASAWALERWK GELWDTCNIG VPWYDREAND
160 170 180 190 200
AVLFGFLTTW FLGEFLAQSE EKPHVVAHFH EWLAGVGLCL CRARRLPVAT
210 220 230 240 250
IFTTHATLLG RYLCAGAVDF YNNLENFNVD KEAGERQIYH RYCMERAAAH
260 270 280 290 300
CAHVFTTVSQ ITAIEAQHLL KRKPDIVTPN GLNVKKFSAM HEFQNLHAQS
310 320 330 340 350
KARIQEFVRG HFYGHLDFNL DKTLYFFIAG RYEFSNKGAD VFLEALARLN
360 370 380 390 400
YLLRVNGSEQ TVVAFFIMPA RTNNFNVETL KGQAVRKQLW DTANTVKEKF
410 420 430 440 450
GRKLYESLLV GSLPDMNKML DKEDFTMMKR AIFATQRQSF PPVCTHNMLD
460 470 480 490 500
DSSDPILTTI RRIGLFNSSA DRVKVIFHPE FLSSTSPLLP VDYEEFVRGC
510 520 530 540 550
HLGVFPSYYE PWGYTPAECT VMGIPSVSTN LSGFGCFMEE HIADPSAYGI
560 570 580 590 600
YILDRRFRSL DDSCSQLTSF LYSFCQQSRR QRIIQRNRTE RLSDLLDWKY
610 620 630 640 650
LGRYYMSARH MALAKAFPEY FTYEPHEADA TQGYRYPRPA SVPPSPSLSR
660 670 680 690 700
HSSPHQSEDE EEPRDLPPDE DDERYDEDEE AAKDRRNIRA PEWPRRASCT
710 720 730
SSTGSKRGSV DTAPSSSVST PSEPLSPASS LGEERN
Length:736
Mass (Da):83,814
Last modified:October 2, 2007 - v1
Checksum:i22300D8723EF94BD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC151381 mRNA. Translation: AAI51382.1.
RefSeqiNP_001094769.1. NM_001101299.1.
UniGeneiBt.102939.

Genome annotation databases

EnsembliENSBTAT00000007423; ENSBTAP00000007423; ENSBTAG00000039958.
GeneIDi786335.
KEGGibta:786335.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC151381 mRNA. Translation: AAI51382.1 .
RefSeqi NP_001094769.1. NM_001101299.1.
UniGenei Bt.102939.

3D structure databases

ProteinModelPortali A7MB78.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000007423.

Protein family/group databases

CAZyi GT3. Glycosyltransferase Family 3.

Proteomic databases

PRIDEi A7MB78.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000007423 ; ENSBTAP00000007423 ; ENSBTAG00000039958 .
GeneIDi 786335.
KEGGi bta:786335.

Organism-specific databases

CTDi 2997.

Phylogenomic databases

eggNOGi COG0438.
GeneTreei ENSGT00390000018612.
HOGENOMi HOG000160890.
HOVERGENi HBG001960.
InParanoidi A7MB78.
KOi K00693.
OMAi FAMKRHG.
OrthoDBi EOG741Z1N.
TreeFami TF300306.

Enzyme and pathway databases

UniPathwayi UPA00164 .
Reactomei REACT_213093. Glycogen synthesis.
REACT_219973. Myoclonic epilepsy of Lafora.

Miscellaneous databases

NextBioi 20927821.

Family and domain databases

InterProi IPR008631. Glycogen_synth.
[Graphical view ]
PANTHERi PTHR10176. PTHR10176. 1 hit.
Pfami PF05693. Glycogen_syn. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal muscle.

Entry informationi

Entry nameiGYS1_BOVIN
AccessioniPrimary (citable) accession number: A7MB78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: October 2, 2007
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3