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Protein

Glycogen [starch] synthase, muscle

Gene

GYS1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.By similarity

Catalytic activityi

UDP-alpha-D-glucose + ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1).

Enzyme regulationi

Allosteric activation by glucose-6-phosphate. Phosphorylation reduces the activity towards UDP-glucose. When in the non-phosphorylated state, glycogen synthase does not require glucose-6-phosphate as an allosteric activator; when phosphorylated it does (By similarity).By similarity

Pathwayi: glycogen biosynthesis

This protein is involved in the pathway glycogen biosynthesis, which is part of Glycan biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycogen biosynthesis and in Glycan biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39UDP-glucoseBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processGlycogen biosynthesis

Enzyme and pathway databases

ReactomeiR-BTA-3322077. Glycogen synthesis.
UniPathwayiUPA00164.

Protein family/group databases

CAZyiGT3. Glycosyltransferase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycogen [starch] synthase, muscle (EC:2.4.1.11)
Gene namesi
Name:GYS1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003583111 – 736Glycogen [starch] synthase, muscleAdd BLAST736

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8Phosphoserine; by AMPK and PKABy similarity1
Modified residuei11PhosphoserineBy similarity1
Modified residuei412PhosphoserineBy similarity1
Modified residuei641Phosphoserine; by DYRK2, GSK3-alpha, GSK3-beta and PASKBy similarity1
Modified residuei645Phosphoserine; by GSK3-alpha and GSK3-betaBy similarity1
Modified residuei649Phosphoserine; by GSK3-alpha and GSK3-betaBy similarity1
Modified residuei652PhosphoserineBy similarity1
Modified residuei653Phosphoserine; by GSK3-alpha and GSK3-betaBy similarity1
Modified residuei657Phosphoserine; by CK2By similarity1
Modified residuei698PhosphoserineBy similarity1
Modified residuei700PhosphothreonineBy similarity1
Modified residuei709PhosphoserineBy similarity1
Modified residuei720PhosphothreonineBy similarity1
Modified residuei726PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation at Ser-8 by AMPK inactivates the enzyme activity. Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B. Phosphorylated at Ser-641 by PASK, leading to inactivation; phosphorylation by PASK is inhibited by glycogen. Phosphorylated at Ser-641 by DYRK2, leading to inactivation. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA7MB78.
PRIDEiA7MB78.

Expressioni

Gene expression databases

BgeeiENSBTAG00000039958.

Interactioni

Subunit structurei

Interacts with GYG1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007423.

Structurei

3D structure databases

ProteinModelPortaliA7MB78.
SMRiA7MB78.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 3 family.Curated

Phylogenomic databases

eggNOGiKOG3742. Eukaryota.
COG0438. LUCA.
GeneTreeiENSGT00390000018612.
HOGENOMiHOG000160890.
HOVERGENiHBG001960.
InParanoidiA7MB78.
KOiK00693.
OMAiKVYFGRW.
OrthoDBiEOG091G0304.
TreeFamiTF300306.

Family and domain databases

CDDicd03793. GT1_Glycogen_synthase_GSY2_lik. 1 hit.
InterProiView protein in InterPro
IPR008631. Glycogen_synth.
PANTHERiPTHR10176. PTHR10176. 1 hit.
PfamiView protein in Pfam
PF05693. Glycogen_syn. 1 hit.

Sequencei

Sequence statusi: Complete.

A7MB78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLNRTLSMS SLPGLEDWED EFDLENTVLF EVAWEVANKV GGIYTVLQTK
60 70 80 90 100
AKVTGDEWGD NYYLVGPYTE QGVRTQVELL EPPTPALKRT LDSMNSKGCK
110 120 130 140 150
VYFGRWLIEG GPLVVLLDVG ASAWALERWK GELWDTCNIG VPWYDREAND
160 170 180 190 200
AVLFGFLTTW FLGEFLAQSE EKPHVVAHFH EWLAGVGLCL CRARRLPVAT
210 220 230 240 250
IFTTHATLLG RYLCAGAVDF YNNLENFNVD KEAGERQIYH RYCMERAAAH
260 270 280 290 300
CAHVFTTVSQ ITAIEAQHLL KRKPDIVTPN GLNVKKFSAM HEFQNLHAQS
310 320 330 340 350
KARIQEFVRG HFYGHLDFNL DKTLYFFIAG RYEFSNKGAD VFLEALARLN
360 370 380 390 400
YLLRVNGSEQ TVVAFFIMPA RTNNFNVETL KGQAVRKQLW DTANTVKEKF
410 420 430 440 450
GRKLYESLLV GSLPDMNKML DKEDFTMMKR AIFATQRQSF PPVCTHNMLD
460 470 480 490 500
DSSDPILTTI RRIGLFNSSA DRVKVIFHPE FLSSTSPLLP VDYEEFVRGC
510 520 530 540 550
HLGVFPSYYE PWGYTPAECT VMGIPSVSTN LSGFGCFMEE HIADPSAYGI
560 570 580 590 600
YILDRRFRSL DDSCSQLTSF LYSFCQQSRR QRIIQRNRTE RLSDLLDWKY
610 620 630 640 650
LGRYYMSARH MALAKAFPEY FTYEPHEADA TQGYRYPRPA SVPPSPSLSR
660 670 680 690 700
HSSPHQSEDE EEPRDLPPDE DDERYDEDEE AAKDRRNIRA PEWPRRASCT
710 720 730
SSTGSKRGSV DTAPSSSVST PSEPLSPASS LGEERN
Length:736
Mass (Da):83,814
Last modified:October 2, 2007 - v1
Checksum:i22300D8723EF94BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151381 mRNA. Translation: AAI51382.1.
RefSeqiNP_001094769.1. NM_001101299.1.
UniGeneiBt.102939.
Bt.37378.

Genome annotation databases

EnsembliENSBTAT00000007423; ENSBTAP00000007423; ENSBTAG00000039958.
GeneIDi786335.
KEGGibta:786335.

Similar proteinsi

Entry informationi

Entry nameiGYS1_BOVIN
AccessioniPrimary (citable) accession number: A7MB78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: October 2, 2007
Last modified: August 30, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families