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A7MB78

- GYS1_BOVIN

UniProt

A7MB78 - GYS1_BOVIN

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Protein
Glycogen [starch] synthase, muscle
Gene
GYS1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan By similarity.

Catalytic activityi

UDP-glucose ((1->4)-alpha-D-glucosyl)(n) = UDP + ((1->4)-alpha-D-glucosyl)(n+1).

Enzyme regulationi

Allosteric activation by glucose-6-phosphate. Phosphorylation reduces the activity towards UDP-glucose. When in the non-phosphorylated state, glycogen synthase does not require glucose-6-phosphate as an allosteric activator; when phosphorylated it does By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391UDP-glucose By similarity

GO - Molecular functioni

  1. glycogen (starch) synthase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. glycogen biosynthetic process Source: UniProtKB
  2. heart development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Glycogen biosynthesis

Enzyme and pathway databases

ReactomeiREACT_213093. Glycogen synthesis.
REACT_219973. Myoclonic epilepsy of Lafora.
UniPathwayiUPA00164.

Protein family/group databases

CAZyiGT3. Glycosyltransferase Family 3.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycogen [starch] synthase, muscle (EC:2.4.1.11)
Gene namesi
Name:GYS1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 18

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. inclusion body Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 736735Glycogen [starch] synthase, muscle
PRO_0000358311Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei8 – 81Phosphoserine; by AMPK and PKA By similarity
Modified residuei11 – 111Phosphoserine By similarity
Modified residuei641 – 6411Phosphoserine; by DYRK2, GSK3-alpha, GSK3-beta and PASK By similarity
Modified residuei645 – 6451Phosphoserine; by GSK3-alpha and GSK3-beta By similarity
Modified residuei649 – 6491Phosphoserine; by GSK3-alpha and GSK3-beta By similarity
Modified residuei653 – 6531Phosphoserine; by GSK3-alpha and GSK3-beta By similarity
Modified residuei657 – 6571Phosphoserine; by CK2 By similarity
Modified residuei698 – 6981Phosphoserine By similarity
Modified residuei726 – 7261Phosphoserine By similarity

Post-translational modificationi

Phosphorylation at Ser-8 by AMPK inactivates the enzyme activity. Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B. Phosphorylated at Ser-641 by PASK, leading to inactivation; phosphorylation by PASK is inhibited by glycogen. Phosphorylated at Ser-641 by DYRK2, leading to inactivation. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiA7MB78.

Interactioni

Subunit structurei

Interacts with GYG1 By similarity.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007423.

Structurei

3D structure databases

ProteinModelPortaliA7MB78.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0438.
GeneTreeiENSGT00390000018612.
HOGENOMiHOG000160890.
HOVERGENiHBG001960.
InParanoidiA7MB78.
KOiK00693.
OMAiFAMKRHG.
OrthoDBiEOG741Z1N.
TreeFamiTF300306.

Family and domain databases

InterProiIPR008631. Glycogen_synth.
[Graphical view]
PANTHERiPTHR10176. PTHR10176. 1 hit.
PfamiPF05693. Glycogen_syn. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7MB78-1 [UniParc]FASTAAdd to Basket

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MPLNRTLSMS SLPGLEDWED EFDLENTVLF EVAWEVANKV GGIYTVLQTK    50
AKVTGDEWGD NYYLVGPYTE QGVRTQVELL EPPTPALKRT LDSMNSKGCK 100
VYFGRWLIEG GPLVVLLDVG ASAWALERWK GELWDTCNIG VPWYDREAND 150
AVLFGFLTTW FLGEFLAQSE EKPHVVAHFH EWLAGVGLCL CRARRLPVAT 200
IFTTHATLLG RYLCAGAVDF YNNLENFNVD KEAGERQIYH RYCMERAAAH 250
CAHVFTTVSQ ITAIEAQHLL KRKPDIVTPN GLNVKKFSAM HEFQNLHAQS 300
KARIQEFVRG HFYGHLDFNL DKTLYFFIAG RYEFSNKGAD VFLEALARLN 350
YLLRVNGSEQ TVVAFFIMPA RTNNFNVETL KGQAVRKQLW DTANTVKEKF 400
GRKLYESLLV GSLPDMNKML DKEDFTMMKR AIFATQRQSF PPVCTHNMLD 450
DSSDPILTTI RRIGLFNSSA DRVKVIFHPE FLSSTSPLLP VDYEEFVRGC 500
HLGVFPSYYE PWGYTPAECT VMGIPSVSTN LSGFGCFMEE HIADPSAYGI 550
YILDRRFRSL DDSCSQLTSF LYSFCQQSRR QRIIQRNRTE RLSDLLDWKY 600
LGRYYMSARH MALAKAFPEY FTYEPHEADA TQGYRYPRPA SVPPSPSLSR 650
HSSPHQSEDE EEPRDLPPDE DDERYDEDEE AAKDRRNIRA PEWPRRASCT 700
SSTGSKRGSV DTAPSSSVST PSEPLSPASS LGEERN 736
Length:736
Mass (Da):83,814
Last modified:October 2, 2007 - v1
Checksum:i22300D8723EF94BD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC151381 mRNA. Translation: AAI51382.1.
RefSeqiNP_001094769.1. NM_001101299.1.
UniGeneiBt.102939.

Genome annotation databases

EnsembliENSBTAT00000007423; ENSBTAP00000007423; ENSBTAG00000039958.
GeneIDi786335.
KEGGibta:786335.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC151381 mRNA. Translation: AAI51382.1 .
RefSeqi NP_001094769.1. NM_001101299.1.
UniGenei Bt.102939.

3D structure databases

ProteinModelPortali A7MB78.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000007423.

Protein family/group databases

CAZyi GT3. Glycosyltransferase Family 3.

Proteomic databases

PRIDEi A7MB78.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000007423 ; ENSBTAP00000007423 ; ENSBTAG00000039958 .
GeneIDi 786335.
KEGGi bta:786335.

Organism-specific databases

CTDi 2997.

Phylogenomic databases

eggNOGi COG0438.
GeneTreei ENSGT00390000018612.
HOGENOMi HOG000160890.
HOVERGENi HBG001960.
InParanoidi A7MB78.
KOi K00693.
OMAi FAMKRHG.
OrthoDBi EOG741Z1N.
TreeFami TF300306.

Enzyme and pathway databases

UniPathwayi UPA00164 .
Reactomei REACT_213093. Glycogen synthesis.
REACT_219973. Myoclonic epilepsy of Lafora.

Miscellaneous databases

NextBioi 20927821.

Family and domain databases

InterProi IPR008631. Glycogen_synth.
[Graphical view ]
PANTHERi PTHR10176. PTHR10176. 1 hit.
Pfami PF05693. Glycogen_syn. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal muscle.

Entry informationi

Entry nameiGYS1_BOVIN
AccessioniPrimary (citable) accession number: A7MB78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: October 2, 2007
Last modified: September 3, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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