Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable inactive glycosyltransferase 25 family member 3

Gene

CERCAM

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Has apparently no beta-galactosyltransferase activity (By similarity).By similarity

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. lipopolysaccharide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Protein family/group databases

CAZyiGT25. Glycosyltransferase Family 25.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable inactive glycosyltransferase 25 family member 3
Alternative name(s):
Cerebral endothelial cell adhesion molecule
Gene namesi
Name:CERCAM
Synonyms:CEECAM1, GLT25D3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 595571Probable inactive glycosyltransferase 25 family member 3PRO_0000309543Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi237 – 2371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi360 – 3601N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiA7MB73.

Expressioni

Gene expression databases

ExpressionAtlasiA7MB73. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004595.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi592 – 5954Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the glycosyltransferase 25 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3306.
HOGENOMiHOG000007198.
HOVERGENiHBG058097.
InParanoidiA7MB73.

Family and domain databases

InterProiIPR002654. Glyco_trans_25.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01755. Glyco_transf_25. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7MB73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAAPAAPLL QLLLLLGPRP EAAGVAEPPL PTVVLAILAR NAEHSLPHYL
60 70 80 90 100
GALERLDYPR ARLALWCATD HNVDNTTAML REWLAAVGDN YAAVVWRPEG
110 120 130 140 150
EPRSYPDEEG PKHWTKERHQ FLMELKQEAL TFARDWGADY ILFADTDNIL
160 170 180 190 200
TNNQTLRLLI EPGLPVVAPM LDSQTYYSNF WCGITPQGYY RRTADYFPTK
210 220 230 240 250
NRQRRGCFRV PMVHSTFLVS LRAEGTGQLA FYPPHPNYTW PFDDIIVFAY
260 270 280 290 300
ACQAAGVAVH VCNEQRYGYL NVPVKSHQGL EDERVNFIHL ILEALVDGPP
310 320 330 340 350
MWASAHVSRP PKRPSKMGFD EVFVISLARR PDRRERMLTS LWEMEISGRV
360 370 380 390 400
VDAVDGRMLN SSVMRTLGVD LLPGYQDPYS GRTLTKGEVG CFLSHYSIWE
410 420 430 440 450
EVVTRGLAQV VVFEDDVRFE SNFKGRLEQL MEEVEAEKLP WDLIYLGRKQ
460 470 480 490 500
VNPEEEAVVE GLPHLVAAGY SYWTLAYVLS LAGARKLLAS QPLRRMLPVD
510 520 530 540 550
EFLPIMFDQH PNEQYKAHFW PRDLQAFSAR PLLAAPTHYA GDSEWLSDTE
560 570 580 590
TSSPWDDDSG RLISWTGSYK TLRGPRLDLA GGSGHSLRPH PRDEL
Length:595
Mass (Da):67,466
Last modified:October 2, 2007 - v1
Checksum:iB95DF9D68F1C9460
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151373 mRNA. Translation: AAI51374.1.
RefSeqiNP_001095505.1. NM_001102035.1.
UniGeneiBt.76302.

Genome annotation databases

GeneIDi516122.
KEGGibta:516122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151373 mRNA. Translation: AAI51374.1.
RefSeqiNP_001095505.1. NM_001102035.1.
UniGeneiBt.76302.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004595.

Protein family/group databases

CAZyiGT25. Glycosyltransferase Family 25.

Proteomic databases

PRIDEiA7MB73.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi516122.
KEGGibta:516122.

Organism-specific databases

CTDi51148.

Phylogenomic databases

eggNOGiCOG3306.
HOGENOMiHOG000007198.
HOVERGENiHBG058097.
InParanoidiA7MB73.

Miscellaneous databases

NextBioi20872142.

Gene expression databases

ExpressionAtlasiA7MB73. baseline.

Family and domain databases

InterProiIPR002654. Glyco_trans_25.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01755. Glyco_transf_25. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal muscle.

Entry informationi

Entry nameiGT253_BOVIN
AccessioniPrimary (citable) accession number: A7MB73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 2, 2007
Last modified: January 7, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.