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Protein

Probable inactive glycosyltransferase 25 family member 3

Gene

CERCAM

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Has apparently no beta-galactosyltransferase activity (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCell adhesion

Protein family/group databases

CAZyiGT25. Glycosyltransferase Family 25.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable inactive glycosyltransferase 25 family member 3
Alternative name(s):
Cerebral endothelial cell adhesion molecule
Gene namesi
Name:CERCAM
Synonyms:CEECAM1, GLT25D3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000030954325 – 595Probable inactive glycosyltransferase 25 family member 3Add BLAST571

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi237N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi360N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA7MB73.
PRIDEiA7MB73.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004595.

Structurei

3D structure databases

SMRiA7MB73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi592 – 595Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the glycosyltransferase 25 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4179. Eukaryota.
ENOG410XQQN. LUCA.
HOGENOMiHOG000007198.
HOVERGENiHBG058097.
InParanoidiA7MB73.

Family and domain databases

CDDicd06532. Glyco_transf_25. 1 hit.
Gene3Di3.90.550.10. 1 hit.
InterProiView protein in InterPro
IPR002654. Glyco_trans_25.
IPR029044. Nucleotide-diphossugar_trans.
PfamiView protein in Pfam
PF01755. Glyco_transf_25. 1 hit.
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiView protein in PROSITE
PS00014. ER_TARGET. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7MB73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAAPAAPLL QLLLLLGPRP EAAGVAEPPL PTVVLAILAR NAEHSLPHYL
60 70 80 90 100
GALERLDYPR ARLALWCATD HNVDNTTAML REWLAAVGDN YAAVVWRPEG
110 120 130 140 150
EPRSYPDEEG PKHWTKERHQ FLMELKQEAL TFARDWGADY ILFADTDNIL
160 170 180 190 200
TNNQTLRLLI EPGLPVVAPM LDSQTYYSNF WCGITPQGYY RRTADYFPTK
210 220 230 240 250
NRQRRGCFRV PMVHSTFLVS LRAEGTGQLA FYPPHPNYTW PFDDIIVFAY
260 270 280 290 300
ACQAAGVAVH VCNEQRYGYL NVPVKSHQGL EDERVNFIHL ILEALVDGPP
310 320 330 340 350
MWASAHVSRP PKRPSKMGFD EVFVISLARR PDRRERMLTS LWEMEISGRV
360 370 380 390 400
VDAVDGRMLN SSVMRTLGVD LLPGYQDPYS GRTLTKGEVG CFLSHYSIWE
410 420 430 440 450
EVVTRGLAQV VVFEDDVRFE SNFKGRLEQL MEEVEAEKLP WDLIYLGRKQ
460 470 480 490 500
VNPEEEAVVE GLPHLVAAGY SYWTLAYVLS LAGARKLLAS QPLRRMLPVD
510 520 530 540 550
EFLPIMFDQH PNEQYKAHFW PRDLQAFSAR PLLAAPTHYA GDSEWLSDTE
560 570 580 590
TSSPWDDDSG RLISWTGSYK TLRGPRLDLA GGSGHSLRPH PRDEL
Length:595
Mass (Da):67,466
Last modified:October 2, 2007 - v1
Checksum:iB95DF9D68F1C9460
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151373 mRNA. Translation: AAI51374.1.
RefSeqiNP_001095505.1. NM_001102035.1.
UniGeneiBt.76302.

Genome annotation databases

GeneIDi516122.
KEGGibta:516122.

Similar proteinsi

Entry informationi

Entry nameiGT253_BOVIN
AccessioniPrimary (citable) accession number: A7MB73
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 2, 2007
Last modified: August 30, 2017
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families