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Protein

Probable inactive glycosyltransferase 25 family member 3

Gene

CERCAM

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Has apparently no beta-galactosyltransferase activity (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Protein family/group databases

CAZyiGT25. Glycosyltransferase Family 25.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable inactive glycosyltransferase 25 family member 3
Alternative name(s):
Cerebral endothelial cell adhesion molecule
Gene namesi
Name:CERCAM
Synonyms:CEECAM1, GLT25D3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000030954325 – 595Probable inactive glycosyltransferase 25 family member 3Add BLAST571

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...)Sequence analysis1
Glycosylationi153N-linked (GlcNAc...)Sequence analysis1
Glycosylationi237N-linked (GlcNAc...)Sequence analysis1
Glycosylationi360N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA7MB73.
PRIDEiA7MB73.

Expressioni

Gene expression databases

BgeeiENSBTAG00000038139.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004595.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi592 – 595Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the glycosyltransferase 25 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4179. Eukaryota.
ENOG410XQQN. LUCA.
HOGENOMiHOG000007198.
HOVERGENiHBG058097.
InParanoidiA7MB73.

Family and domain databases

CDDicd06532. Glyco_transf_25. 1 hit.
InterProiIPR002654. Glyco_trans_25.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01755. Glyco_transf_25. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7MB73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAAPAAPLL QLLLLLGPRP EAAGVAEPPL PTVVLAILAR NAEHSLPHYL
60 70 80 90 100
GALERLDYPR ARLALWCATD HNVDNTTAML REWLAAVGDN YAAVVWRPEG
110 120 130 140 150
EPRSYPDEEG PKHWTKERHQ FLMELKQEAL TFARDWGADY ILFADTDNIL
160 170 180 190 200
TNNQTLRLLI EPGLPVVAPM LDSQTYYSNF WCGITPQGYY RRTADYFPTK
210 220 230 240 250
NRQRRGCFRV PMVHSTFLVS LRAEGTGQLA FYPPHPNYTW PFDDIIVFAY
260 270 280 290 300
ACQAAGVAVH VCNEQRYGYL NVPVKSHQGL EDERVNFIHL ILEALVDGPP
310 320 330 340 350
MWASAHVSRP PKRPSKMGFD EVFVISLARR PDRRERMLTS LWEMEISGRV
360 370 380 390 400
VDAVDGRMLN SSVMRTLGVD LLPGYQDPYS GRTLTKGEVG CFLSHYSIWE
410 420 430 440 450
EVVTRGLAQV VVFEDDVRFE SNFKGRLEQL MEEVEAEKLP WDLIYLGRKQ
460 470 480 490 500
VNPEEEAVVE GLPHLVAAGY SYWTLAYVLS LAGARKLLAS QPLRRMLPVD
510 520 530 540 550
EFLPIMFDQH PNEQYKAHFW PRDLQAFSAR PLLAAPTHYA GDSEWLSDTE
560 570 580 590
TSSPWDDDSG RLISWTGSYK TLRGPRLDLA GGSGHSLRPH PRDEL
Length:595
Mass (Da):67,466
Last modified:October 2, 2007 - v1
Checksum:iB95DF9D68F1C9460
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151373 mRNA. Translation: AAI51374.1.
RefSeqiNP_001095505.1. NM_001102035.1.
UniGeneiBt.76302.

Genome annotation databases

GeneIDi516122.
KEGGibta:516122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151373 mRNA. Translation: AAI51374.1.
RefSeqiNP_001095505.1. NM_001102035.1.
UniGeneiBt.76302.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004595.

Protein family/group databases

CAZyiGT25. Glycosyltransferase Family 25.

Proteomic databases

PaxDbiA7MB73.
PRIDEiA7MB73.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi516122.
KEGGibta:516122.

Organism-specific databases

CTDi51148.

Phylogenomic databases

eggNOGiKOG4179. Eukaryota.
ENOG410XQQN. LUCA.
HOGENOMiHOG000007198.
HOVERGENiHBG058097.
InParanoidiA7MB73.

Gene expression databases

BgeeiENSBTAG00000038139.

Family and domain databases

CDDicd06532. Glyco_transf_25. 1 hit.
InterProiIPR002654. Glyco_trans_25.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01755. Glyco_transf_25. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGT253_BOVIN
AccessioniPrimary (citable) accession number: A7MB73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 2, 2007
Last modified: September 7, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.