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A7MB73

- GT253_BOVIN

UniProt

A7MB73 - GT253_BOVIN

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Protein
Probable inactive glycosyltransferase 25 family member 3
Gene
CERCAM, CEECAM1, GLT25D3
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Has apparently no beta-galactosyltransferase activity By similarity.

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. lipopolysaccharide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Protein family/group databases

CAZyiGT25. Glycosyltransferase Family 25.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable inactive glycosyltransferase 25 family member 3
Alternative name(s):
Cerebral endothelial cell adhesion molecule
Gene namesi
Name:CERCAM
Synonyms:CEECAM1, GLT25D3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Endoplasmic reticulum lumen Reviewed prediction

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Chaini25 – 595571Probable inactive glycosyltransferase 25 family member 3
PRO_0000309543Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi153 – 1531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi237 – 2371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi360 – 3601N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiA7MB73.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004595.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi592 – 5954Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3306.
HOGENOMiHOG000007198.
HOVERGENiHBG058097.
InParanoidiA7MB73.

Family and domain databases

InterProiIPR002654. Glyco_trans_25.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01755. Glyco_transf_25. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7MB73-1 [UniParc]FASTAAdd to Basket

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MRAAPAAPLL QLLLLLGPRP EAAGVAEPPL PTVVLAILAR NAEHSLPHYL    50
GALERLDYPR ARLALWCATD HNVDNTTAML REWLAAVGDN YAAVVWRPEG 100
EPRSYPDEEG PKHWTKERHQ FLMELKQEAL TFARDWGADY ILFADTDNIL 150
TNNQTLRLLI EPGLPVVAPM LDSQTYYSNF WCGITPQGYY RRTADYFPTK 200
NRQRRGCFRV PMVHSTFLVS LRAEGTGQLA FYPPHPNYTW PFDDIIVFAY 250
ACQAAGVAVH VCNEQRYGYL NVPVKSHQGL EDERVNFIHL ILEALVDGPP 300
MWASAHVSRP PKRPSKMGFD EVFVISLARR PDRRERMLTS LWEMEISGRV 350
VDAVDGRMLN SSVMRTLGVD LLPGYQDPYS GRTLTKGEVG CFLSHYSIWE 400
EVVTRGLAQV VVFEDDVRFE SNFKGRLEQL MEEVEAEKLP WDLIYLGRKQ 450
VNPEEEAVVE GLPHLVAAGY SYWTLAYVLS LAGARKLLAS QPLRRMLPVD 500
EFLPIMFDQH PNEQYKAHFW PRDLQAFSAR PLLAAPTHYA GDSEWLSDTE 550
TSSPWDDDSG RLISWTGSYK TLRGPRLDLA GGSGHSLRPH PRDEL 595
Length:595
Mass (Da):67,466
Last modified:October 2, 2007 - v1
Checksum:iB95DF9D68F1C9460
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC151373 mRNA. Translation: AAI51374.1.
RefSeqiNP_001095505.1. NM_001102035.1.
UniGeneiBt.76302.

Genome annotation databases

GeneIDi516122.
KEGGibta:516122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC151373 mRNA. Translation: AAI51374.1 .
RefSeqi NP_001095505.1. NM_001102035.1.
UniGenei Bt.76302.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000004595.

Protein family/group databases

CAZyi GT25. Glycosyltransferase Family 25.

Proteomic databases

PRIDEi A7MB73.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 516122.
KEGGi bta:516122.

Organism-specific databases

CTDi 51148.

Phylogenomic databases

eggNOGi COG3306.
HOGENOMi HOG000007198.
HOVERGENi HBG058097.
InParanoidi A7MB73.

Miscellaneous databases

NextBioi 20872142.

Family and domain databases

InterProi IPR002654. Glyco_trans_25.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF01755. Glyco_transf_25. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal muscle.

Entry informationi

Entry nameiGT253_BOVIN
AccessioniPrimary (citable) accession number: A7MB73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 2, 2007
Last modified: June 11, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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