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A7MB73 (GT253_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable inactive glycosyltransferase 25 family member 3
Alternative name(s):
Cerebral endothelial cell adhesion molecule
Gene names
Name:CERCAM
Synonyms:CEECAM1, GLT25D3
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length595 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Has apparently no beta-galactosyltransferase activity By similarity.

Subcellular location

Endoplasmic reticulum lumen Potential.

Sequence similarities

Belongs to the glycosyltransferase 25 family.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentEndoplasmic reticulum
   DomainSignal
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: UniProtKB-KW

lipopolysaccharide biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 595571Probable inactive glycosyltransferase 25 family member 3
PRO_0000309543

Regions

Motif592 – 5954Prevents secretion from ER Potential

Amino acid modifications

Glycosylation751N-linked (GlcNAc...) Potential
Glycosylation1531N-linked (GlcNAc...) Potential
Glycosylation2371N-linked (GlcNAc...) Potential
Glycosylation3601N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
A7MB73 [UniParc].

Last modified October 2, 2007. Version 1.
Checksum: B95DF9D68F1C9460

FASTA59567,466
        10         20         30         40         50         60 
MRAAPAAPLL QLLLLLGPRP EAAGVAEPPL PTVVLAILAR NAEHSLPHYL GALERLDYPR 

        70         80         90        100        110        120 
ARLALWCATD HNVDNTTAML REWLAAVGDN YAAVVWRPEG EPRSYPDEEG PKHWTKERHQ 

       130        140        150        160        170        180 
FLMELKQEAL TFARDWGADY ILFADTDNIL TNNQTLRLLI EPGLPVVAPM LDSQTYYSNF 

       190        200        210        220        230        240 
WCGITPQGYY RRTADYFPTK NRQRRGCFRV PMVHSTFLVS LRAEGTGQLA FYPPHPNYTW 

       250        260        270        280        290        300 
PFDDIIVFAY ACQAAGVAVH VCNEQRYGYL NVPVKSHQGL EDERVNFIHL ILEALVDGPP 

       310        320        330        340        350        360 
MWASAHVSRP PKRPSKMGFD EVFVISLARR PDRRERMLTS LWEMEISGRV VDAVDGRMLN 

       370        380        390        400        410        420 
SSVMRTLGVD LLPGYQDPYS GRTLTKGEVG CFLSHYSIWE EVVTRGLAQV VVFEDDVRFE 

       430        440        450        460        470        480 
SNFKGRLEQL MEEVEAEKLP WDLIYLGRKQ VNPEEEAVVE GLPHLVAAGY SYWTLAYVLS 

       490        500        510        520        530        540 
LAGARKLLAS QPLRRMLPVD EFLPIMFDQH PNEQYKAHFW PRDLQAFSAR PLLAAPTHYA 

       550        560        570        580        590 
GDSEWLSDTE TSSPWDDDSG RLISWTGSYK TLRGPRLDLA GGSGHSLRPH PRDEL 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Fetal muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC151373 mRNA. Translation: AAI51374.1.
RefSeqNP_001095505.1. NM_001102035.1.
UniGeneBt.76302.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000004595.

Protein family/group databases

CAZyGT25. Glycosyltransferase Family 25.

Proteomic databases

PRIDEA7MB73.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID516122.
KEGGbta:516122.

Organism-specific databases

CTD51148.

Phylogenomic databases

eggNOGCOG3306.
HOGENOMHOG000007198.
HOVERGENHBG058097.
InParanoidA7MB73.

Family and domain databases

InterProIPR002654. Glyco_trans_25.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamPF01755. Glyco_transf_25. 1 hit.
[Graphical view]
SUPFAMSSF53448. SSF53448. 1 hit.
PROSITEPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20872142.

Entry information

Entry nameGT253_BOVIN
AccessionPrimary (citable) accession number: A7MB73
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 2, 2007
Last modified: June 11, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families