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A7MB73

- GT253_BOVIN

UniProt

A7MB73 - GT253_BOVIN

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Protein

Probable inactive glycosyltransferase 25 family member 3

Gene

CERCAM

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Has apparently no beta-galactosyltransferase activity By similarity.By similarity

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. lipopolysaccharide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Protein family/group databases

CAZyiGT25. Glycosyltransferase Family 25.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable inactive glycosyltransferase 25 family member 3
Alternative name(s):
Cerebral endothelial cell adhesion molecule
Gene namesi
Name:CERCAM
Synonyms:CEECAM1, GLT25D3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 595571Probable inactive glycosyltransferase 25 family member 3PRO_0000309543Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi237 – 2371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi360 – 3601N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiA7MB73.

Expressioni

Gene expression databases

ExpressionAtlasiA7MB73. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004595.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi592 – 5954Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the glycosyltransferase 25 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3306.
HOGENOMiHOG000007198.
HOVERGENiHBG058097.
InParanoidiA7MB73.

Family and domain databases

InterProiIPR002654. Glyco_trans_25.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF01755. Glyco_transf_25. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7MB73-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRAAPAAPLL QLLLLLGPRP EAAGVAEPPL PTVVLAILAR NAEHSLPHYL
60 70 80 90 100
GALERLDYPR ARLALWCATD HNVDNTTAML REWLAAVGDN YAAVVWRPEG
110 120 130 140 150
EPRSYPDEEG PKHWTKERHQ FLMELKQEAL TFARDWGADY ILFADTDNIL
160 170 180 190 200
TNNQTLRLLI EPGLPVVAPM LDSQTYYSNF WCGITPQGYY RRTADYFPTK
210 220 230 240 250
NRQRRGCFRV PMVHSTFLVS LRAEGTGQLA FYPPHPNYTW PFDDIIVFAY
260 270 280 290 300
ACQAAGVAVH VCNEQRYGYL NVPVKSHQGL EDERVNFIHL ILEALVDGPP
310 320 330 340 350
MWASAHVSRP PKRPSKMGFD EVFVISLARR PDRRERMLTS LWEMEISGRV
360 370 380 390 400
VDAVDGRMLN SSVMRTLGVD LLPGYQDPYS GRTLTKGEVG CFLSHYSIWE
410 420 430 440 450
EVVTRGLAQV VVFEDDVRFE SNFKGRLEQL MEEVEAEKLP WDLIYLGRKQ
460 470 480 490 500
VNPEEEAVVE GLPHLVAAGY SYWTLAYVLS LAGARKLLAS QPLRRMLPVD
510 520 530 540 550
EFLPIMFDQH PNEQYKAHFW PRDLQAFSAR PLLAAPTHYA GDSEWLSDTE
560 570 580 590
TSSPWDDDSG RLISWTGSYK TLRGPRLDLA GGSGHSLRPH PRDEL
Length:595
Mass (Da):67,466
Last modified:October 2, 2007 - v1
Checksum:iB95DF9D68F1C9460
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC151373 mRNA. Translation: AAI51374.1.
RefSeqiNP_001095505.1. NM_001102035.1.
UniGeneiBt.76302.

Genome annotation databases

GeneIDi516122.
KEGGibta:516122.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC151373 mRNA. Translation: AAI51374.1 .
RefSeqi NP_001095505.1. NM_001102035.1.
UniGenei Bt.76302.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000004595.

Protein family/group databases

CAZyi GT25. Glycosyltransferase Family 25.

Proteomic databases

PRIDEi A7MB73.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 516122.
KEGGi bta:516122.

Organism-specific databases

CTDi 51148.

Phylogenomic databases

eggNOGi COG3306.
HOGENOMi HOG000007198.
HOVERGENi HBG058097.
InParanoidi A7MB73.

Miscellaneous databases

NextBioi 20872142.

Gene expression databases

ExpressionAtlasi A7MB73. baseline.

Family and domain databases

InterProi IPR002654. Glyco_trans_25.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF01755. Glyco_transf_25. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal muscle.

Entry informationi

Entry nameiGT253_BOVIN
AccessioniPrimary (citable) accession number: A7MB73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 2, 2007
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3