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Protein

Protein ATP1B4

Gene

ATP1B4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-BTA-2173796. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ATP1B4
Alternative name(s):
X,K-ATPase subunit beta-m
X/potassium-transporting ATPase subunit beta-m
Gene namesi
Name:ATP1B4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome X

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 108NuclearSequence analysisAdd BLAST108
Transmembranei109 – 129Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini130 – 355Perinuclear spaceSequence analysisAdd BLAST226

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003939631 – 355Protein ATP1B4Add BLAST355

Proteomic databases

PaxDbiA7MB71.
PRIDEiA7MB71.

Expressioni

Gene expression databases

BgeeiENSBTAG00000008920.

Interactioni

Subunit structurei

Associates with a SMAD7-transcriptional complex. Interacts with SNW1 and TOR1AIP1. Does not associate with known Na,K-ATPase alpha-subunits (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011741.

Structurei

3D structure databases

ProteinModelPortaliA7MB71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi35 – 69Glu-richAdd BLAST35

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
GeneTreeiENSGT00550000074530.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiA7MB71.
KOiK01540.
OMAiPTGNAWW.
OrthoDBiEOG091G0DJ4.
TreeFamiTF314618.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7MB71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRQLRSRRA PALPYGYRYR LDDQDEVNQN YLADEEEEAE EEARVMVVPD
60 70 80 90 100
LEEEEEEEEE KEEEEKEEED SHSQETDSAW WRKLQIVNEY LWDPEKRTSL
110 120 130 140 150
ARTGQSWSLI LVIYFFFYAS LAAVITLCMY TLFLTISPYM PTFTERVKPP
160 170 180 190 200
GVMIRPFAHS LNFNFNVSEP DTWQHYVISL NGFLQGYNDS LQEEMNVDCP
210 220 230 240 250
PGQYFIQDGD EDEDKKACQF KRSFLKNCSG LEDPTFGYST GQPCILLKMN
260 270 280 290 300
RIVGFRPERG DPVKVSCKVQ RGDENDIRSI NYYPESASFD LRYYPYYGKL
310 320 330 340 350
THVNYTSPLV AMHFTDVVKN QAVPVQCQLK GKGIINDVIN DRFVGRVIFT

LNIET
Length:355
Mass (Da):41,473
Last modified:October 2, 2007 - v1
Checksum:iDC6A9541CBAD915B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151371 mRNA. Translation: AAI51372.1.
RefSeqiNP_001095389.1. NM_001101919.1.
UniGeneiBt.26179.

Genome annotation databases

EnsembliENSBTAT00000011740; ENSBTAP00000011741; ENSBTAG00000008920.
GeneIDi510026.
KEGGibta:510026.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151371 mRNA. Translation: AAI51372.1.
RefSeqiNP_001095389.1. NM_001101919.1.
UniGeneiBt.26179.

3D structure databases

ProteinModelPortaliA7MB71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011741.

Proteomic databases

PaxDbiA7MB71.
PRIDEiA7MB71.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000011740; ENSBTAP00000011741; ENSBTAG00000008920.
GeneIDi510026.
KEGGibta:510026.

Organism-specific databases

CTDi23439.

Phylogenomic databases

eggNOGiKOG3927. Eukaryota.
ENOG411150A. LUCA.
GeneTreeiENSGT00550000074530.
HOGENOMiHOG000039248.
HOVERGENiHBG050603.
InParanoidiA7MB71.
KOiK01540.
OMAiPTGNAWW.
OrthoDBiEOG091G0DJ4.
TreeFamiTF314618.

Enzyme and pathway databases

ReactomeiR-BTA-2173796. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.

Gene expression databases

BgeeiENSBTAG00000008920.

Family and domain databases

InterProiIPR000402. Na/K_ATPase_sub_beta.
[Graphical view]
PANTHERiPTHR11523. PTHR11523. 1 hit.
PfamiPF00287. Na_K-ATPase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITEiPS00390. ATPASE_NA_K_BETA_1. 1 hit.
PS00391. ATPASE_NA_K_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT1B4_BOVIN
AccessioniPrimary (citable) accession number: A7MB71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: October 2, 2007
Last modified: October 5, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.