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A7MB62

- ARP2_BOVIN

UniProt

A7MB62 - ARP2_BOVIN

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Protein

Actin-related protein 2

Gene
ACTR2, ARP2
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi160 – 1623ATP
Nucleotide bindingi214 – 2185ATP
Nucleotide bindingi305 – 3106ATP

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein binding Source: IntAct
Complete GO annotation...

Keywords - Ligandi

Actin-binding, ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_196755. Regulation of actin dynamics for phagocytic cup formation.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2
Alternative name(s):
Actin-like protein 2
Gene namesi
Name:ACTR2
Synonyms:ARP2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Cytoplasmcytoskeleton By similarity. Cell projection By similarity

GO - Cellular componenti

  1. cell projection Source: UniProtKB-SubCell
  2. cytoskeleton Source: UniProtKB-SubCell
  3. cytosol Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Actin-related protein 2PRO_0000327246Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei299 – 2991N6-acetyllysine By similarity
Modified residuei322 – 3221N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiA7MB62.
PRIDEiA7MB62.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

Binary interactionsi

WithEntry#Exp.IntActNotes
WASLQ951072EBI-6162748,EBI-6162776

Protein-protein interaction databases

DIPiDIP-29789N.
IntActiA7MB62. 2 interactions.
STRINGi9913.ENSBTAP00000012872.

Structurei

Secondary structure

1
394
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi10 – 134
Beta strandi15 – 217
Beta strandi29 – 335
Beta strandi36 – 405
Helixi59 – 635
Helixi65 – 673
Beta strandi68 – 714
Beta strandi73 – 753
Helixi84 – 9310
Turni95 – 984
Helixi102 – 1043
Beta strandi109 – 1113
Turni117 – 1193
Beta strandi134 – 1407
Helixi141 – 1477
Turni148 – 1503
Beta strandi156 – 1594
Beta strandi164 – 1674
Beta strandi171 – 1744
Turni176 – 1783
Beta strandi180 – 1834
Helixi186 – 19914
Turni206 – 2094
Helixi210 – 22011
Helixi227 – 23610
Beta strandi238 – 2403
Beta strandi242 – 2454
Beta strandi251 – 2544
Helixi257 – 2604
Helixi262 – 2654
Helixi268 – 2714
Helixi278 – 28811
Turni291 – 2933
Helixi294 – 2985
Beta strandi302 – 3054
Helixi306 – 3083
Helixi313 – 32816
Turni329 – 3324
Helixi336 – 3394
Helixi350 – 3523
Helixi353 – 3619
Turni365 – 3673
Beta strandi369 – 3746
Helixi375 – 3795

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K8KX-ray2.00B1-394[»]
1TYQX-ray2.55B1-394[»]
1U2VX-ray2.55B1-394[»]
2P9IX-ray2.46B1-394[»]
2P9KX-ray2.59B1-394[»]
2P9LX-ray2.65B1-394[»]
2P9NX-ray2.85B1-394[»]
2P9PX-ray2.90B1-394[»]
2P9SX-ray2.68B1-394[»]
2P9UX-ray2.75B1-394[»]
3DXKX-ray2.70B1-394[»]
3DXMX-ray2.85B1-394[»]
3RSEX-ray2.65B1-394[»]
3UKRX-ray2.48B1-394[»]
3UKUX-ray2.75B1-394[»]
3ULEX-ray2.50B1-394[»]
4JD2X-ray3.08B1-394[»]
ProteinModelPortaliA7MB62.
SMRiA7MB62. Positions 4-388.

Miscellaneous databases

EvolutionaryTraceiA7MB62.

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family. ARP2 subfamily.

Phylogenomic databases

eggNOGiCOG5277.
HOGENOMiHOG000233340.
HOVERGENiHBG003771.
InParanoidiA7MB62.
KOiK17260.

Family and domain databases

InterProiIPR004000. Actin-related.
IPR020902. Actin/actin-like_CS.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7MB62-1 [UniParc]FASTAAdd to Basket

« Hide

MDSQGRKVVV CDNGTGFVKC GYAGSNFPEH IFPALVGRPI IRSTTKVGNI    50
EIKDLMVGDE ASELRSMLEV NYPMENGIVR NWDDMKHLWD YTFGPEKLNI 100
DTRNCKILLT EPPMNPTKNR EKIVEVMFET YQFSGVYVAI QAVLTLYAQG 150
LLTGVVVDSG DGVTHICPVY EGFSLPHLTR RLDIAGRDIT RYLIKLLLLR 200
GYAFNHSADF ETVRMIKEKL CYVGYNIEQE QKLALETTVL VESYTLPDGR 250
IIKVGGERFE APEALFQPHL INVEGVGVAE LLFNTIQAAD IDTRSEFYKH 300
IVLSGGSTMY PGLPSRLERE LKQLYLERVL KGDVEKLSKF KIRIEDPPRR 350
KHMVFLGGAV LADIMKDKDN FWMTRQEYQE KGVRVLEKLG VTVR 394
Length:394
Mass (Da):44,761
Last modified:October 2, 2007 - v1
Checksum:i1BFA6B442ED1A797
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC151356 mRNA. Translation: AAI51357.1.
RefSeqiNP_001095683.1. NM_001102213.1.
UniGeneiBt.3684.

Genome annotation databases

GeneIDi538486.
KEGGibta:538486.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC151356 mRNA. Translation: AAI51357.1 .
RefSeqi NP_001095683.1. NM_001102213.1.
UniGenei Bt.3684.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1K8K X-ray 2.00 B 1-394 [» ]
1TYQ X-ray 2.55 B 1-394 [» ]
1U2V X-ray 2.55 B 1-394 [» ]
2P9I X-ray 2.46 B 1-394 [» ]
2P9K X-ray 2.59 B 1-394 [» ]
2P9L X-ray 2.65 B 1-394 [» ]
2P9N X-ray 2.85 B 1-394 [» ]
2P9P X-ray 2.90 B 1-394 [» ]
2P9S X-ray 2.68 B 1-394 [» ]
2P9U X-ray 2.75 B 1-394 [» ]
3DXK X-ray 2.70 B 1-394 [» ]
3DXM X-ray 2.85 B 1-394 [» ]
3RSE X-ray 2.65 B 1-394 [» ]
3UKR X-ray 2.48 B 1-394 [» ]
3UKU X-ray 2.75 B 1-394 [» ]
3ULE X-ray 2.50 B 1-394 [» ]
4JD2 X-ray 3.08 B 1-394 [» ]
ProteinModelPortali A7MB62.
SMRi A7MB62. Positions 4-388.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-29789N.
IntActi A7MB62. 2 interactions.
STRINGi 9913.ENSBTAP00000012872.

Proteomic databases

PaxDbi A7MB62.
PRIDEi A7MB62.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 538486.
KEGGi bta:538486.

Organism-specific databases

CTDi 10097.

Phylogenomic databases

eggNOGi COG5277.
HOGENOMi HOG000233340.
HOVERGENi HBG003771.
InParanoidi A7MB62.
KOi K17260.

Enzyme and pathway databases

Reactomei REACT_196755. Regulation of actin dynamics for phagocytic cup formation.

Miscellaneous databases

EvolutionaryTracei A7MB62.
NextBioi 20877389.

Family and domain databases

InterProi IPR004000. Actin-related.
IPR020902. Actin/actin-like_CS.
[Graphical view ]
PANTHERi PTHR11937. PTHR11937. 1 hit.
Pfami PF00022. Actin. 1 hit.
[Graphical view ]
PRINTSi PR00190. ACTIN.
SMARTi SM00268. ACTIN. 1 hit.
[Graphical view ]
PROSITEi PS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal skin.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF ARP2/3 COMPLEX.
  3. "Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP."
    Nolen B.J., Littlefield R.S., Pollard T.D.
    Proc. Natl. Acad. Sci. U.S.A. 101:15627-15632(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF ARP2/3 COMPLEX WITH BOUND ATP.
  4. "Insights into the influence of nucleotides on actin family proteins from seven structures of Arp2/3 complex."
    Nolen B.J., Pollard T.D.
    Mol. Cell 26:449-457(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.46 ANGSTROMS) OF ARP2/3 COMPLEX WITH BOUND ATP.

Entry informationi

Entry nameiARP2_BOVIN
AccessioniPrimary (citable) accession number: A7MB62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 2, 2007
Last modified: September 3, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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