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Protein

Actin-related protein 2

Gene

ACTR2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi160 – 162ATP3
Nucleotide bindingi214 – 218ATP5
Nucleotide bindingi305 – 310ATP6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding, ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2
Alternative name(s):
Actin-like protein 2
Gene namesi
Name:ACTR2
Synonyms:ARP2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity
  • Cell projection By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003272461 – 394Actin-related protein 2Add BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei299N6-acetyllysineBy similarity1
Modified residuei322N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiA7MB62.
PeptideAtlasiA7MB62.
PRIDEiA7MB62.

Interactioni

Subunit structurei

Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

Binary interactionsi

WithEntry#Exp.IntActNotes
WASLQ951072EBI-6162748,EBI-6162776

Protein-protein interaction databases

BioGridi195053. 1 interactor.
DIPiDIP-29789N.
IntActiA7MB62. 2 interactors.
STRINGi9913.ENSBTAP00000012872.

Structurei

Secondary structure

1394
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi10 – 13Combined sources4
Beta strandi15 – 21Combined sources7
Beta strandi29 – 33Combined sources5
Beta strandi36 – 40Combined sources5
Helixi59 – 63Combined sources5
Helixi65 – 67Combined sources3
Beta strandi68 – 71Combined sources4
Beta strandi73 – 75Combined sources3
Helixi84 – 93Combined sources10
Turni95 – 98Combined sources4
Helixi102 – 104Combined sources3
Beta strandi109 – 111Combined sources3
Turni117 – 119Combined sources3
Beta strandi134 – 140Combined sources7
Helixi141 – 147Combined sources7
Turni148 – 150Combined sources3
Beta strandi156 – 159Combined sources4
Beta strandi164 – 167Combined sources4
Beta strandi171 – 174Combined sources4
Turni176 – 178Combined sources3
Beta strandi180 – 183Combined sources4
Helixi186 – 199Combined sources14
Turni206 – 209Combined sources4
Helixi210 – 220Combined sources11
Helixi227 – 236Combined sources10
Beta strandi238 – 240Combined sources3
Beta strandi242 – 245Combined sources4
Beta strandi251 – 254Combined sources4
Helixi257 – 260Combined sources4
Helixi262 – 265Combined sources4
Helixi268 – 271Combined sources4
Helixi278 – 288Combined sources11
Turni291 – 293Combined sources3
Helixi294 – 298Combined sources5
Beta strandi302 – 305Combined sources4
Helixi306 – 308Combined sources3
Helixi313 – 328Combined sources16
Turni329 – 332Combined sources4
Helixi336 – 339Combined sources4
Helixi350 – 352Combined sources3
Helixi353 – 361Combined sources9
Turni365 – 367Combined sources3
Beta strandi369 – 374Combined sources6
Helixi375 – 379Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K8KX-ray2.00B1-394[»]
1TYQX-ray2.55B1-394[»]
1U2VX-ray2.55B1-394[»]
2P9IX-ray2.46B1-394[»]
2P9KX-ray2.59B1-394[»]
2P9LX-ray2.65B1-394[»]
2P9NX-ray2.85B1-394[»]
2P9PX-ray2.90B1-394[»]
2P9SX-ray2.68B1-394[»]
2P9UX-ray2.75B1-394[»]
3DXKX-ray2.70B1-394[»]
3DXMX-ray2.85B1-394[»]
3RSEX-ray2.65B1-394[»]
3UKRX-ray2.48B1-394[»]
3UKUX-ray2.75B1-394[»]
3ULEX-ray2.50B1-394[»]
4JD2X-ray3.08B1-394[»]
4XEIX-ray3.87B1-394[»]
4XF2X-ray5.00B/U1-394[»]
ProteinModelPortaliA7MB62.
SMRiA7MB62.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA7MB62.

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family. ARP2 subfamily.Curated

Phylogenomic databases

eggNOGiKOG0677. Eukaryota.
COG5277. LUCA.
HOGENOMiHOG000233340.
HOVERGENiHBG003771.
InParanoidiA7MB62.
KOiK17260.

Family and domain databases

InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR027306. Arp2.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF149. PTHR11937:SF149. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7MB62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSQGRKVVV CDNGTGFVKC GYAGSNFPEH IFPALVGRPI IRSTTKVGNI
60 70 80 90 100
EIKDLMVGDE ASELRSMLEV NYPMENGIVR NWDDMKHLWD YTFGPEKLNI
110 120 130 140 150
DTRNCKILLT EPPMNPTKNR EKIVEVMFET YQFSGVYVAI QAVLTLYAQG
160 170 180 190 200
LLTGVVVDSG DGVTHICPVY EGFSLPHLTR RLDIAGRDIT RYLIKLLLLR
210 220 230 240 250
GYAFNHSADF ETVRMIKEKL CYVGYNIEQE QKLALETTVL VESYTLPDGR
260 270 280 290 300
IIKVGGERFE APEALFQPHL INVEGVGVAE LLFNTIQAAD IDTRSEFYKH
310 320 330 340 350
IVLSGGSTMY PGLPSRLERE LKQLYLERVL KGDVEKLSKF KIRIEDPPRR
360 370 380 390
KHMVFLGGAV LADIMKDKDN FWMTRQEYQE KGVRVLEKLG VTVR
Length:394
Mass (Da):44,761
Last modified:October 2, 2007 - v1
Checksum:i1BFA6B442ED1A797
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151356 mRNA. Translation: AAI51357.1.
RefSeqiNP_001095683.1. NM_001102213.1.
UniGeneiBt.3684.

Genome annotation databases

GeneIDi538486.
KEGGibta:538486.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151356 mRNA. Translation: AAI51357.1.
RefSeqiNP_001095683.1. NM_001102213.1.
UniGeneiBt.3684.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K8KX-ray2.00B1-394[»]
1TYQX-ray2.55B1-394[»]
1U2VX-ray2.55B1-394[»]
2P9IX-ray2.46B1-394[»]
2P9KX-ray2.59B1-394[»]
2P9LX-ray2.65B1-394[»]
2P9NX-ray2.85B1-394[»]
2P9PX-ray2.90B1-394[»]
2P9SX-ray2.68B1-394[»]
2P9UX-ray2.75B1-394[»]
3DXKX-ray2.70B1-394[»]
3DXMX-ray2.85B1-394[»]
3RSEX-ray2.65B1-394[»]
3UKRX-ray2.48B1-394[»]
3UKUX-ray2.75B1-394[»]
3ULEX-ray2.50B1-394[»]
4JD2X-ray3.08B1-394[»]
4XEIX-ray3.87B1-394[»]
4XF2X-ray5.00B/U1-394[»]
ProteinModelPortaliA7MB62.
SMRiA7MB62.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi195053. 1 interactor.
DIPiDIP-29789N.
IntActiA7MB62. 2 interactors.
STRINGi9913.ENSBTAP00000012872.

Proteomic databases

PaxDbiA7MB62.
PeptideAtlasiA7MB62.
PRIDEiA7MB62.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi538486.
KEGGibta:538486.

Organism-specific databases

CTDi10097.

Phylogenomic databases

eggNOGiKOG0677. Eukaryota.
COG5277. LUCA.
HOGENOMiHOG000233340.
HOVERGENiHBG003771.
InParanoidiA7MB62.
KOiK17260.

Miscellaneous databases

EvolutionaryTraceiA7MB62.
PROiA7MB62.

Family and domain databases

InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR027306. Arp2.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF149. PTHR11937:SF149. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
PROSITEiPS01132. ACTINS_ACT_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARP2_BOVIN
AccessioniPrimary (citable) accession number: A7MB62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 2, 2007
Last modified: November 2, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.