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Protein

Protocadherin-18

Gene

PCDH18

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. brain development Source: UniProtKB
  2. homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protocadherin-18
Gene namesi
Name:PCDH18
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 699672ExtracellularSequence AnalysisAdd
BLAST
Transmembranei700 – 72021HelicalSequence AnalysisAdd
BLAST
Topological domaini721 – 1134414CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 11341107Protocadherin-18PRO_0000352393Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi559 – 5591N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

Interacts with DAB1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020655.

Structurei

3D structure databases

ProteinModelPortaliA7MB46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 137110Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini138 – 246109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini247 – 354108Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini361 – 465105Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini466 – 576111Cadherin 5PROSITE-ProRule annotationAdd
BLAST
Domaini582 – 697116Cadherin 6PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni892 – 1134243Interaction with DAB1By similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi701 – 7044Poly-Ile

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG319372.
HOGENOMiHOG000220893.
HOVERGENiHBG054878.
InParanoidiA7MB46.
KOiK16499.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7MB46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYQMNAKMHF TFVFALLVVS FNLDVLGKNL KYRIYEEQRV GSVIARLSED
60 70 80 90 100
VADVLVKLPN PSTVRFRAMQ RGNTPLLVVN EDNGEISIGA KIDREQLCQK
110 120 130 140 150
NLNCSIEFDV ITLPTEHLQL FHIEVEVLDI NDNSPQFSRS LIPIEISESA
160 170 180 190 200
AVGTRIPLDS AFDPDVGENS LHTYSLSAND FFNIEVRTRT DGAKYAELIV
210 220 230 240 250
VRELDRELKS SYELQLTASD MGVPQRSGSS ILKISISDSN DNSPAFEQQS
260 270 280 290 300
YIIQLLENSP VGTLLLDLNA TDPDEGANGK IVYSFSSHVS PKIIETFKID
310 320 330 340 350
SERGHLTLFK QVDYEITKSY EIDVQAQDLG PNSIPAHCKI IIKVVDVNDN
360 370 380 390 400
KPEISINLMS PGKEEISYIF EGDPIDTFVA LVRVQDKDSG LNGEIVCKLH
410 420 430 440 450
GHGHFKLQKT YENNYLILTN ATLDREKRSE YSLTVIAEDK GTPSLSTVKH
460 470 480 490 500
FTVQINDIND NPPHFQRSRY EFAISENNSP GAYITTVTAT DPDLGENGQV
510 520 530 540 550
TYTILESFIL GSSITTYDTI DPSNGAIYAL RIFDHEEVSQ ITFVVEARDG
560 570 580 590 600
GSPKQLVSNT TVVLTIIDEN DNVPVVIGPA LRNNTAEISI PKGAESGFHV
610 620 630 640 650
TRIRAIDRDS GVNAELSCSI VAGNEENIFV IDPRSCDIHT NVSMESVPYT
660 670 680 690 700
EWELSVVIQD KGNPQLHTKV LLKCVIFEYA ESVTSTAMTS VSQAPLDVSM
710 720 730 740 750
IIIISLGAIC AVLLVIMVLF ATRCNREKKD TRSYNCRVAE STYQHHPKRP
760 770 780 790 800
SRQIHKGDIT LVPTVNGTLP IRSHHRSSPS SSPTLERGQM GSRQSHNSHQ
810 820 830 840 850
SLNSLVTISS NHVPENFSLE LTHATPAVEV SQLLSMLHQG QYQPRPSFRG
860 870 880 890 900
NKYSRSYRYA LQDMDKFSLK DSGRGDSEAG DSDYDLGRDS PIDRLLGEGF
910 920 930 940 950
SDLFLTDGRI PAAMRLCTEE CRVLGHSDQC WMPPLPSPSS DYRSNMFIPG
960 970 980 990 1000
EEFPAQPQQQ HPHQSLEDDV QPVDSGEKKK SFSTFGKDSP SEEDSGDTST
1010 1020 1030 1040 1050
SSLLSEMSSV FQRLLPASLD TYSECTEMDR SNSLERRKGP LPAKTVGYPQ
1060 1070 1080 1090 1100
GVAAWAASTH FQNPTNNSGP PLGTHSSVQP SSKWLPAMEE IPENYEEDDF
1110 1120 1130
DNVLNHLNDG KHELMDASEL VAEINKLLQD VRQS
Length:1,134
Mass (Da):125,864
Last modified:October 2, 2007 - v1
Checksum:i1685D1AE8DF19817
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151333 mRNA. Translation: AAI51334.1.
RefSeqiNP_001095699.1. NM_001102229.2.
UniGeneiBt.42456.

Genome annotation databases

GeneIDi539464.
KEGGibta:539464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151333 mRNA. Translation: AAI51334.1.
RefSeqiNP_001095699.1. NM_001102229.2.
UniGeneiBt.42456.

3D structure databases

ProteinModelPortaliA7MB46.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020655.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi539464.
KEGGibta:539464.

Organism-specific databases

CTDi54510.

Phylogenomic databases

eggNOGiNOG319372.
HOGENOMiHOG000220893.
HOVERGENiHBG054878.
InParanoidiA7MB46.
KOiK16499.

Miscellaneous databases

NextBioi20878004.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiPCD18_BOVIN
AccessioniPrimary (citable) accession number: A7MB46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: October 2, 2007
Last modified: January 7, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.