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A7MB46 (PCD18_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protocadherin-18
Gene names
Name:PCDH18
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length1134 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potential calcium-dependent cell-adhesion protein.

Subunit structure

Interacts with DAB1 By similarity.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Contains 6 cadherin domains.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentCell membrane
Membrane
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   LigandCalcium
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbrain development

Inferred from sequence or structural similarity. Source: UniProtKB

homophilic cell adhesion

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 11341107Protocadherin-18
PRO_0000352393

Regions

Topological domain28 – 699672Extracellular Potential
Transmembrane700 – 72021Helical; Potential
Topological domain721 – 1134414Cytoplasmic Potential
Domain28 – 137110Cadherin 1
Domain138 – 246109Cadherin 2
Domain247 – 354108Cadherin 3
Domain361 – 465105Cadherin 4
Domain466 – 576111Cadherin 5
Domain582 – 697116Cadherin 6
Region892 – 1134243Interaction with DAB1 By similarity
Compositional bias701 – 7044Poly-Ile

Amino acid modifications

Glycosylation1031N-linked (GlcNAc...) Potential
Glycosylation2691N-linked (GlcNAc...) Potential
Glycosylation5591N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
A7MB46 [UniParc].

Last modified October 2, 2007. Version 1.
Checksum: 1685D1AE8DF19817

FASTA1,134125,864
        10         20         30         40         50         60 
MYQMNAKMHF TFVFALLVVS FNLDVLGKNL KYRIYEEQRV GSVIARLSED VADVLVKLPN 

        70         80         90        100        110        120 
PSTVRFRAMQ RGNTPLLVVN EDNGEISIGA KIDREQLCQK NLNCSIEFDV ITLPTEHLQL 

       130        140        150        160        170        180 
FHIEVEVLDI NDNSPQFSRS LIPIEISESA AVGTRIPLDS AFDPDVGENS LHTYSLSAND 

       190        200        210        220        230        240 
FFNIEVRTRT DGAKYAELIV VRELDRELKS SYELQLTASD MGVPQRSGSS ILKISISDSN 

       250        260        270        280        290        300 
DNSPAFEQQS YIIQLLENSP VGTLLLDLNA TDPDEGANGK IVYSFSSHVS PKIIETFKID 

       310        320        330        340        350        360 
SERGHLTLFK QVDYEITKSY EIDVQAQDLG PNSIPAHCKI IIKVVDVNDN KPEISINLMS 

       370        380        390        400        410        420 
PGKEEISYIF EGDPIDTFVA LVRVQDKDSG LNGEIVCKLH GHGHFKLQKT YENNYLILTN 

       430        440        450        460        470        480 
ATLDREKRSE YSLTVIAEDK GTPSLSTVKH FTVQINDIND NPPHFQRSRY EFAISENNSP 

       490        500        510        520        530        540 
GAYITTVTAT DPDLGENGQV TYTILESFIL GSSITTYDTI DPSNGAIYAL RIFDHEEVSQ 

       550        560        570        580        590        600 
ITFVVEARDG GSPKQLVSNT TVVLTIIDEN DNVPVVIGPA LRNNTAEISI PKGAESGFHV 

       610        620        630        640        650        660 
TRIRAIDRDS GVNAELSCSI VAGNEENIFV IDPRSCDIHT NVSMESVPYT EWELSVVIQD 

       670        680        690        700        710        720 
KGNPQLHTKV LLKCVIFEYA ESVTSTAMTS VSQAPLDVSM IIIISLGAIC AVLLVIMVLF 

       730        740        750        760        770        780 
ATRCNREKKD TRSYNCRVAE STYQHHPKRP SRQIHKGDIT LVPTVNGTLP IRSHHRSSPS 

       790        800        810        820        830        840 
SSPTLERGQM GSRQSHNSHQ SLNSLVTISS NHVPENFSLE LTHATPAVEV SQLLSMLHQG 

       850        860        870        880        890        900 
QYQPRPSFRG NKYSRSYRYA LQDMDKFSLK DSGRGDSEAG DSDYDLGRDS PIDRLLGEGF 

       910        920        930        940        950        960 
SDLFLTDGRI PAAMRLCTEE CRVLGHSDQC WMPPLPSPSS DYRSNMFIPG EEFPAQPQQQ 

       970        980        990       1000       1010       1020 
HPHQSLEDDV QPVDSGEKKK SFSTFGKDSP SEEDSGDTST SSLLSEMSSV FQRLLPASLD 

      1030       1040       1050       1060       1070       1080 
TYSECTEMDR SNSLERRKGP LPAKTVGYPQ GVAAWAASTH FQNPTNNSGP PLGTHSSVQP 

      1090       1100       1110       1120       1130 
SSKWLPAMEE IPENYEEDDF DNVLNHLNDG KHELMDASEL VAEINKLLQD VRQS

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Hypothalamus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC151333 mRNA. Translation: AAI51334.1.
IPIIPI00687398.
RefSeqNP_001095699.1. NM_001102229.2.
UniGeneBt.42456.

3D structure databases

ProteinModelPortalA7MB46.
ModBaseSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000020655.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID539464.
KEGGbta:539464.

Organism-specific databases

CTD54510.

Phylogenomic databases

eggNOGNOG319372.
HOGENOMHOG000220893.
HOVERGENHBG054878.
InParanoidA7MB46.
KOK16499.
OrthoDBEOG4N04D5.

Family and domain databases

Gene3D2.60.40.60. 5 hits.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
SMARTSM00112. CA. 6 hits.
[Graphical view]
SUPFAMSSF49313. Cadherin. 6 hits.
PROSITEPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20878004.

Entry information

Entry namePCD18_BOVIN
AccessionPrimary (citable) accession number: A7MB46
Entry history
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: October 2, 2007
Last modified: April 3, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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