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A7MB46

- PCD18_BOVIN

UniProt

A7MB46 - PCD18_BOVIN

Protein

Protocadherin-18

Gene

PCDH18

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    Potential calcium-dependent cell-adhesion protein.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. brain development Source: UniProtKB
    2. homophilic cell adhesion Source: InterPro

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protocadherin-18
    Gene namesi
    Name:PCDH18
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 11341107Protocadherin-18PRO_0000352393Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi559 – 5591N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    Interacts with DAB1.By similarity

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000020655.

    Structurei

    3D structure databases

    ProteinModelPortaliA7MB46.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 699672ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini721 – 1134414CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei700 – 72021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 137110Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini138 – 246109Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini247 – 354108Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini361 – 465105Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini466 – 576111Cadherin 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini582 – 697116Cadherin 6PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni892 – 1134243Interaction with DAB1By similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi701 – 7044Poly-Ile

    Sequence similaritiesi

    Contains 6 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG319372.
    HOGENOMiHOG000220893.
    HOVERGENiHBG054878.
    InParanoidiA7MB46.
    KOiK16499.

    Family and domain databases

    Gene3Di2.60.40.60. 5 hits.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR013164. Cadherin_N.
    [Graphical view]
    PfamiPF00028. Cadherin. 5 hits.
    PF08266. Cadherin_2. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    SMARTiSM00112. CA. 6 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 5 hits.
    PROSITEiPS00232. CADHERIN_1. 5 hits.
    PS50268. CADHERIN_2. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A7MB46-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYQMNAKMHF TFVFALLVVS FNLDVLGKNL KYRIYEEQRV GSVIARLSED     50
    VADVLVKLPN PSTVRFRAMQ RGNTPLLVVN EDNGEISIGA KIDREQLCQK 100
    NLNCSIEFDV ITLPTEHLQL FHIEVEVLDI NDNSPQFSRS LIPIEISESA 150
    AVGTRIPLDS AFDPDVGENS LHTYSLSAND FFNIEVRTRT DGAKYAELIV 200
    VRELDRELKS SYELQLTASD MGVPQRSGSS ILKISISDSN DNSPAFEQQS 250
    YIIQLLENSP VGTLLLDLNA TDPDEGANGK IVYSFSSHVS PKIIETFKID 300
    SERGHLTLFK QVDYEITKSY EIDVQAQDLG PNSIPAHCKI IIKVVDVNDN 350
    KPEISINLMS PGKEEISYIF EGDPIDTFVA LVRVQDKDSG LNGEIVCKLH 400
    GHGHFKLQKT YENNYLILTN ATLDREKRSE YSLTVIAEDK GTPSLSTVKH 450
    FTVQINDIND NPPHFQRSRY EFAISENNSP GAYITTVTAT DPDLGENGQV 500
    TYTILESFIL GSSITTYDTI DPSNGAIYAL RIFDHEEVSQ ITFVVEARDG 550
    GSPKQLVSNT TVVLTIIDEN DNVPVVIGPA LRNNTAEISI PKGAESGFHV 600
    TRIRAIDRDS GVNAELSCSI VAGNEENIFV IDPRSCDIHT NVSMESVPYT 650
    EWELSVVIQD KGNPQLHTKV LLKCVIFEYA ESVTSTAMTS VSQAPLDVSM 700
    IIIISLGAIC AVLLVIMVLF ATRCNREKKD TRSYNCRVAE STYQHHPKRP 750
    SRQIHKGDIT LVPTVNGTLP IRSHHRSSPS SSPTLERGQM GSRQSHNSHQ 800
    SLNSLVTISS NHVPENFSLE LTHATPAVEV SQLLSMLHQG QYQPRPSFRG 850
    NKYSRSYRYA LQDMDKFSLK DSGRGDSEAG DSDYDLGRDS PIDRLLGEGF 900
    SDLFLTDGRI PAAMRLCTEE CRVLGHSDQC WMPPLPSPSS DYRSNMFIPG 950
    EEFPAQPQQQ HPHQSLEDDV QPVDSGEKKK SFSTFGKDSP SEEDSGDTST 1000
    SSLLSEMSSV FQRLLPASLD TYSECTEMDR SNSLERRKGP LPAKTVGYPQ 1050
    GVAAWAASTH FQNPTNNSGP PLGTHSSVQP SSKWLPAMEE IPENYEEDDF 1100
    DNVLNHLNDG KHELMDASEL VAEINKLLQD VRQS 1134
    Length:1,134
    Mass (Da):125,864
    Last modified:October 2, 2007 - v1
    Checksum:i1685D1AE8DF19817
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC151333 mRNA. Translation: AAI51334.1.
    RefSeqiNP_001095699.1. NM_001102229.2.
    UniGeneiBt.42456.

    Genome annotation databases

    GeneIDi539464.
    KEGGibta:539464.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC151333 mRNA. Translation: AAI51334.1 .
    RefSeqi NP_001095699.1. NM_001102229.2.
    UniGenei Bt.42456.

    3D structure databases

    ProteinModelPortali A7MB46.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000020655.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 539464.
    KEGGi bta:539464.

    Organism-specific databases

    CTDi 54510.

    Phylogenomic databases

    eggNOGi NOG319372.
    HOGENOMi HOG000220893.
    HOVERGENi HBG054878.
    InParanoidi A7MB46.
    KOi K16499.

    Miscellaneous databases

    NextBioi 20878004.

    Family and domain databases

    Gene3Di 2.60.40.60. 5 hits.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR013164. Cadherin_N.
    [Graphical view ]
    Pfami PF00028. Cadherin. 5 hits.
    PF08266. Cadherin_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    SMARTi SM00112. CA. 6 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 5 hits.
    PROSITEi PS00232. CADHERIN_1. 5 hits.
    PS50268. CADHERIN_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Hypothalamus.

    Entry informationi

    Entry nameiPCD18_BOVIN
    AccessioniPrimary (citable) accession number: A7MB46
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 14, 2008
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3