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Protein

Acyl-CoA synthetase short-chain family member 3, mitochondrial

Gene

ACSS3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Activates acetate so that it can be used for lipid synthesis or for energy generation.By similarity

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei538 – 5381ATPBy similarity
Binding sitei553 – 5531ATPBy similarity
Binding sitei564 – 5641ATPBy similarity
Binding sitei623 – 6231Coenzyme ABy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi424 – 4263ATPBy similarity
Nucleotide bindingi445 – 4506ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA synthetase short-chain family member 3, mitochondrial (EC:6.2.1.1)
Gene namesi
Name:ACSS3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2929MitochondrionSequence analysisAdd
BLAST
Chaini30 – 686657Acyl-CoA synthetase short-chain family member 3, mitochondrialPRO_0000320623Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei517 – 5171N6-succinyllysineBy similarity
Modified residuei523 – 5231N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiA7MB45.
PRIDEiA7MB45.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024880.

Structurei

3D structure databases

ProteinModelPortaliA7MB45.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni226 – 2294Coenzyme A bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1175. Eukaryota.
COG0365. LUCA.
HOGENOMiHOG000229981.
HOVERGENiHBG014401.
InParanoidiA7MB45.
KOiK01908.

Family and domain databases

InterProiIPR032387. ACAS_N.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF16177. ACAS_N. 1 hit.
PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7MB45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPSWLQCRK VTGAGGLGGS LPASSPARGA GPARRAYVAP GPRGALGGRG
60 70 80 90 100
CRALSSGGGE YKTHFAASVT DPERFWGKAA EQISWYKPWT KTLENRHSPS
110 120 130 140 150
TSWFVEGMLN ICYNAIDRHI ENGKGDKIAI IYDSPVTNTK ATITYKEVLE
160 170 180 190 200
QVSKLAGVLV KHGVKKGDTV VIYMPMIPQA MYAMLACARI GAIHSLIFGG
210 220 230 240 250
FASKELSTRI DHAKPKLVIT ASFGIEPGRK VEYVPLVEEA LRIGQHKPDK
260 270 280 290 300
VLIYNRPHTD MVPLAPGYYL DWDEELSKAQ SHDCVPVLSE HPLYILYTSG
310 320 330 340 350
TTGLPKGVVR PTGGYAVMLN WSMSSIYGLK PGEVWWAASD LGWVVGHSYI
360 370 380 390 400
CYGPLLHGNT TVLYEGKPVG TPDAGAYFRV LAEHGVAALF TAPTAIRAIR
410 420 430 440 450
QQDPGAALGK QYSLTRFKTL FVAGERCDVE TLEWSKKVFR VPVLDHWWQT
460 470 480 490 500
ETGSPITASC IGLGNSKTPP PGQAGKSVPG YNVMILDDNM QKLKARCLGN
510 520 530 540 550
IVVKLPLPPG AFSGLWKNQE AFKHLYFEKF PGYYDTMDAG YMDEEGYVYV
560 570 580 590 600
MSRVDDVINV AGHRISAGAL EESILSLGIV ADCAVVGKED SLKGHIPLAL
610 620 630 640 650
CVLKKDINTT EEHVLEEIVK HVRQTIGPVA AFRKAVFVKQ LPKTRSGKIP
660 670 680
RSTLSALVNG KPYKVSPTIE DPGIFEHIEA MLKQAS
Length:686
Mass (Da):74,805
Last modified:October 2, 2007 - v1
Checksum:i0EE74B4DD3E71FE0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151332 mRNA. Translation: AAI51333.1.
RefSeqiNP_001095607.1. NM_001102137.2.
UniGeneiBt.104098.

Genome annotation databases

GeneIDi531552.
KEGGibta:531552.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151332 mRNA. Translation: AAI51333.1.
RefSeqiNP_001095607.1. NM_001102137.2.
UniGeneiBt.104098.

3D structure databases

ProteinModelPortaliA7MB45.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024880.

Proteomic databases

PaxDbiA7MB45.
PRIDEiA7MB45.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi531552.
KEGGibta:531552.

Organism-specific databases

CTDi79611.

Phylogenomic databases

eggNOGiKOG1175. Eukaryota.
COG0365. LUCA.
HOGENOMiHOG000229981.
HOVERGENiHBG014401.
InParanoidiA7MB45.
KOiK01908.

Family and domain databases

InterProiIPR032387. ACAS_N.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF16177. ACAS_N. 1 hit.
PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACSS3_BOVIN
AccessioniPrimary (citable) accession number: A7MB45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 2, 2007
Last modified: July 6, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.