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Protein

Transforming growth factor-beta receptor-associated protein 1

Gene

TGFBRAP1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2 (By similarity).By similarity
Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Functions predominantly in APPL1-containing endosomes and in degradative but not recycling trafficking of endocytosed cargo (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming growth factor-beta receptor-associated protein 1
Short name:
TGF-beta receptor-associated protein 1
Short name:
TRAP-1
Short name:
TRAP1
Gene namesi
Name:TGFBRAP1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

  • Cytoplasm
  • Early endosome By similarity

  • Note: Colocalizes with TGF-beta receptors in the absence of signaling.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 859859Transforming growth factor-beta receptor-associated protein 1PRO_0000345404Add
BLAST

Proteomic databases

PaxDbiA7MB11.

Interactioni

Subunit structurei

Interacts with TGFBR2 and ACVR2B; in the absence of ligand stimulation. Interacts with TGFBR1, ACVRL1, BMPR1A and ACVR1B; in the absence of ligand stimulation and to a less extent. Interacts with SMAD4; the interaction seems to be mutually exclusive with the interaction of SMAD4 and phosphorylated SMAD2. May interact with ALOX5. Interacts with RAB5C. Interacts with VPS8, VPS11 and VPS16. Component of the putative class C core vacuaole/endosome tethering (CORVET) complex; the core of which composed of the class C Vps proteins VPS11, VPS16, VPS18 and VPS33A, is associated with VPS8 and TGFBRAP1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028967.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 297274CNHPROSITE-ProRule annotationAdd
BLAST
Repeati563 – 727165CHCRAdd
BLAST

Sequence similaritiesi

Belongs to the TRAP1 family.Curated
Contains 1 CHCR (clathrin heavy-chain) repeat.PROSITE-ProRule annotation
Contains 1 CNH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2063. Eukaryota.
ENOG410XNSX. LUCA.
HOGENOMiHOG000007291.
HOVERGENiHBG108563.
InParanoidiA7MB11.
KOiK20177.

Family and domain databases

InterProiIPR000547. Clathrin_H-chain/VPS_repeat.
IPR001180. CNH_dom.
IPR019452. VPS39/TGF_beta_rcpt-assoc_1.
IPR019453. VPS39/TGF_beta_rcpt-assoc_2.
[Graphical view]
PfamiPF00637. Clathrin. 1 hit.
PF00780. CNH. 1 hit.
PF10366. Vps39_1. 1 hit.
PF10367. Vps39_2. 1 hit.
[Graphical view]
PROSITEiPS50236. CHCR. 1 hit.
PS50219. CNH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7MB11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSTKAFTLV PAIEREQLLS DRDRGLLECV ECCGRNLYVG TSDCFVYHFL
60 70 80 90 100
LEEKTLPGGS ATFTATRQLH RHLGFKKAVS ELRAASALSR LLVLCDGCIS
110 120 130 140 150
LVHMLSLEPV PSGARIKGAT AFALNENPVS GDPFCVEVCI ISVKRRTIQV
160 170 180 190 200
FLVYEDRVQI VREVSTPEQP LAVAVDGHFL CLALTTQYII LNYSTGAAQD
210 220 230 240 250
LFPFCSEERR PIVKRIGRQE FLLAGPGGLG MFATVAGISQ RAPVRWSENV
260 270 280 290 300
IGAAVCFPYV VALDDEFITV HSMLDQQQKQ TLPFKEGHIL QDFEGRVIVA
310 320 330 340 350
TSKGVYILVP LPLEKRIQDL LASHRVEEAL VLAKGARRNI PKEKFQVMYR
360 370 380 390 400
RILLQAGFIQ FAQLQFLKAK ELFRSGQLDV RELISLYPLL LPTSSSFTRS
410 420 430 440 450
HPPLHEFADL NQLTQGDQDK VAKCKRFLMS YLNEVRSTEV ANGYKEDIDT
460 470 480 490 500
ALLKLYAEAD HDSLLDLLVT ENFCLLPDSA AWLEKHKKYF ALGLLYHYNH
510 520 530 540 550
QDAAAVQLWV SIVNGDIQDS TRSDLYEYIV DFLTYSTDPD LVWRHADWVL
560 570 580 590 600
QRSQEVGVQV FTKRPLDEQQ SGFNPDDIIS CLKKYPQALV KYLEHLVTER
610 620 630 640 650
RLQKEEYHTH LAVLYLDEVL QQRPCTPDKD AEVTETQAKL RRLLQESDLY
660 670 680 690 700
RVHFLMDRTR GAGLPLESAI LHGKLEQHEE ALHILVHELA DFPAAEDYCL
710 720 730 740 750
WRSEGRDPPY RQRLFHLLLA VYLGPGPAAP ARTVAAVDLL NRHAVEFDAA
760 770 780 790 800
QVLQLLPGTW SVQLLRPFLM GAMRDSIHAR RTTQVAVGLA RSENLIYKYD
810 820 830 840 850
KMKLKGSSVR LSDEKLCQMC QNPFLEPVFV RYPNGGLVHT HCAASRHTEP

SSPSAGART
Length:859
Mass (Da):97,006
Last modified:October 2, 2007 - v1
Checksum:iF056154B83D653E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151278 mRNA. Translation: AAI51279.1.
RefSeqiNP_001095478.1. NM_001102008.1.
UniGeneiBt.5257.

Genome annotation databases

GeneIDi514660.
KEGGibta:514660.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151278 mRNA. Translation: AAI51279.1.
RefSeqiNP_001095478.1. NM_001102008.1.
UniGeneiBt.5257.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028967.

Proteomic databases

PaxDbiA7MB11.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi514660.
KEGGibta:514660.

Organism-specific databases

CTDi9392.

Phylogenomic databases

eggNOGiKOG2063. Eukaryota.
ENOG410XNSX. LUCA.
HOGENOMiHOG000007291.
HOVERGENiHBG108563.
InParanoidiA7MB11.
KOiK20177.

Family and domain databases

InterProiIPR000547. Clathrin_H-chain/VPS_repeat.
IPR001180. CNH_dom.
IPR019452. VPS39/TGF_beta_rcpt-assoc_1.
IPR019453. VPS39/TGF_beta_rcpt-assoc_2.
[Graphical view]
PfamiPF00637. Clathrin. 1 hit.
PF00780. CNH. 1 hit.
PF10366. Vps39_1. 1 hit.
PF10367. Vps39_2. 1 hit.
[Graphical view]
PROSITEiPS50236. CHCR. 1 hit.
PS50219. CNH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTGFA1_BOVIN
AccessioniPrimary (citable) accession number: A7MB11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: October 2, 2007
Last modified: July 6, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.