Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein RRP5 homolog

Gene

PDCD11

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

rRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Protein RRP5 homolog
Alternative name(s):
Programmed cell death protein 11
Gene namesi
Name:PDCD11
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003641992 – 1874Protein RRP5 homologAdd BLAST1873

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei7PhosphoserineBy similarity1
Modified residuei438PhosphoserineBy similarity1
Cross-linki1028Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei1362PhosphoserineBy similarity1
Modified residuei1479PhosphoserineBy similarity1
Modified residuei1496PhosphoserineBy similarity1
Modified residuei1501PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiA7MB10.
PRIDEiA7MB10.

Interactioni

Subunit structurei

Interacts with NF-kappa-B p50/NFKB1 and NF-kappa-B p65/RELA.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012818.

Structurei

3D structure databases

ProteinModelPortaliA7MB10.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 171S1 motif 1PROSITE-ProRule annotationAdd BLAST89
Domaini187 – 258S1 motif 2PROSITE-ProRule annotationAdd BLAST72
Domaini281 – 346S1 motif 3PROSITE-ProRule annotationAdd BLAST66
Domaini365 – 436S1 motif 4PROSITE-ProRule annotationAdd BLAST72
Domaini453 – 522S1 motif 5PROSITE-ProRule annotationAdd BLAST70
Domaini542 – 611S1 motif 6PROSITE-ProRule annotationAdd BLAST70
Domaini634 – 705S1 motif 7PROSITE-ProRule annotationAdd BLAST72
Domaini727 – 796S1 motif 8PROSITE-ProRule annotationAdd BLAST70
Domaini844 – 909S1 motif 9PROSITE-ProRule annotationAdd BLAST66
Domaini1034 – 1107S1 motif 10PROSITE-ProRule annotationAdd BLAST74
Domaini1148 – 1222S1 motif 11PROSITE-ProRule annotationAdd BLAST75
Domaini1230 – 1298S1 motif 12PROSITE-ProRule annotationAdd BLAST69
Domaini1324 – 1396S1 motif 13PROSITE-ProRule annotationAdd BLAST73
Repeati1602 – 1634HAT 1Add BLAST33
Repeati1708 – 1740HAT 2Add BLAST33
Repeati1778 – 1810HAT 3Add BLAST33
Repeati1812 – 1847HAT 4Add BLAST36

Sequence similaritiesi

Contains 4 HAT repeats.Curated
Contains 13 S1 motif domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1070. Eukaryota.
COG0539. LUCA.
HOGENOMiHOG000088607.
HOVERGENiHBG108419.
InParanoidiA7MB10.
KOiK14792.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR003107. HAT.
IPR012340. NA-bd_OB-fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
IPR008847. Suf.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF00575. S1. 5 hits.
PF05843. Suf. 1 hit.
[Graphical view]
SMARTiSM00386. HAT. 7 hits.
SM00316. S1. 13 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF50249. SSF50249. 10 hits.
PROSITEiPS50126. S1. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A7MB10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAMEESFPR GGTRKTHKSE KAFQQSVEQD NLFDISTEEE STKRKKIQKG
60 70 80 90 100
PAKTKKLKVE TRQSSKFVRE KFEILNVESL CEGMRILGCV KEVNELELAI
110 120 130 140 150
SLPNGLQGYV QVTEICDAYT EKLNEQVAQE EPLQDLVGLP ELFSPGMLVR
160 170 180 190 200
CVVSSLDTTK GSKKNVMLSL NPKNVNRVLS AETLKPGMLL TGTVSSLEDH
210 220 230 240 250
GYLVDIGVSG ARAFLPLQKA QEYIRQKNKG AKLKVGQYLN CLIEEVKGSR
260 270 280 290 300
GVVTLSIGHS EVSAAIATEE QSWTLNSLLP GLVVKAQVQK VTPLGLTLKF
310 320 330 340 350
LSFFSGLVDF MHLDPKKAGT YFSNQQVRAC VLCVHPRTRA VRLSLRPVFL
360 370 380 390 400
QPGRPLTRLL CQQLGAVLDD VPVQGFFGSA GATFKLKDGT LAYARRNHLS
410 420 430 440 450
NSKKTFKPEA FKPGNTHKCR IIDYSQMDEL ALLSLRTSII EAQFLWYHDI
460 470 480 490 500
KPGALVKGKV LTIKPHGMVV KMGKQIRGLV PTMHLADILI KNPEKKYHVG
510 520 530 540 550
DEVKCRVLLC DPKAKKLMMT LKKTLVESKL PAITCYDDAK PGLQTHGFIL
560 570 580 590 600
RVKDYGCIVK FYNDVQGLVP RHELSAEYVP DPESVFYTGQ VVKVVVLNCE
610 620 630 640 650
PSKERMLLSF RLLSDPKQEG EGQSQKKKKA VSAGQLADVK VLEKTKDGLK
660 670 680 690 700
VAVLPHNIPG FLPTAHLSDH VTNGPLLYHW LQTGDTLHRV LCLSVSEERV
710 720 730 740 750
LLCRKPALVS AVEGGQNPKS FSEIHPGMLL IGFVKNIKDY GVFVQFPSGL
760 770 780 790 800
SGLAPKAILS DKFVTSTSDH FVEGQTVVAK VTNVDEEKQR MLLSLRLSDC
810 820 830 840 850
TLGDLATTSL LLLSQCLEER QGVRSLMSNR DSVLIQTLAE MTPGMALDLE
860 870 880 890 900
VQEVLEDGSV LFSEGPVPGL VLRASKYHRA GQELEPGQKK KAVILNVDML
910 920 930 940 950
KLEVHVSLCH DLVNRKAKKL KKGSDLQAIV QHLEESFAVA SLVETGHLAA
960 970 980 990 1000
FSLTSHLNDT FRFDSEKLQV GQGVSLTLQT TEPGVTGLLL AIEGPAAKRT
1010 1020 1030 1040 1050
MRQTRKDSET VDEDEEVDPA LVVGTVKKHT LSIGDVVTGT VKSIKPTHVV
1060 1070 1080 1090 1100
VTLEDGIIGC IHASHILDDV PVGTSPTAKL KVGKKVTARV IGGRDMKTFK
1110 1120 1130 1140 1150
FLPISHPRFI RTIPELSVRP SELKEDGHTT LNTHSVSPLE KIKQYQPGQT
1160 1170 1180 1190 1200
VTCFLKKYNM VKKWLEVEIA PDIRGRIPLL LTSLSFKVLK HPDKKFQIGQ
1210 1220 1230 1240 1250
ALKATVVGPA ESSKAFLCLS LIGPHKLKKG EVAMGRVVKV TPKEGLTVSF
1260 1270 1280 1290 1300
PFGRVGRVSM FHVSDSYSET HLEDFVPQQV VRCYVLSAAT PVLTLSLRSS
1310 1320 1330 1340 1350
RTNPETKSKI TDPEINSIED LEEGQLLRGF VKSVQPSGVL VGLGPSVTGL
1360 1370 1380 1390 1400
ARHPHVSQHN QSKNAPYDRH LPEGKLLTAK VLRLNHQESL VELSLLPDAT
1410 1420 1430 1440 1450
GKQDVLSAPL GQPPPKQEGR ETEAVERNHE GKAKEKKKQK QKEKRTGKGQ
1460 1470 1480 1490 1500
EGAQPPSKDK KEPQKPQAKK LGKRPHPESS SEQEIGNKKQ KKAALSEEDD
1510 1520 1530 1540 1550
SGVEVYYREG EEAEEMSMLP KEKLTRPAEA PRLQLSSGFV WDVGLDTLTP
1560 1570 1580 1590 1600
ALPPHGDSSD SEEDEKPEQA TQKKKSKKER ELEKQKAEKE LSRIEEALMD
1610 1620 1630 1640 1650
PGRQPESAED FDRLVLSSPS SSLLWLQYMA FHLQATEIEK ARAVAERALK
1660 1670 1680 1690 1700
TISFREEQEK LNVWVALLNL ENMYGSQESL TKVFERAVQY NEPLKVFLHL
1710 1720 1730 1740 1750
ADIYTKSEKF QEAGELYNRM LKRFRQEKAV WVKYGAFLLR RGKAEASHRV
1760 1770 1780 1790 1800
MQRALECLPK KEHVDVIAKF AQLEFQLGDA ERARAIFEST LSIYPKRTDV
1810 1820 1830 1840 1850
WSVYIDMIIK HGSQKEARAI FERVIHLSLA PKRMKFFFKR YLDYEKQHGS
1860 1870
EKDVQAVKAK ALEYVEAKSS MMDD
Length:1,874
Mass (Da):208,543
Last modified:October 2, 2007 - v1
Checksum:iD5A3A28DC4BE595E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151277 mRNA. Translation: AAI51278.1.
RefSeqiNP_001095573.1. NM_001102103.2.
UniGeneiBt.23141.

Genome annotation databases

GeneIDi526867.
KEGGibta:526867.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151277 mRNA. Translation: AAI51278.1.
RefSeqiNP_001095573.1. NM_001102103.2.
UniGeneiBt.23141.

3D structure databases

ProteinModelPortaliA7MB10.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012818.

Proteomic databases

PaxDbiA7MB10.
PRIDEiA7MB10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi526867.
KEGGibta:526867.

Organism-specific databases

CTDi22984.

Phylogenomic databases

eggNOGiKOG1070. Eukaryota.
COG0539. LUCA.
HOGENOMiHOG000088607.
HOVERGENiHBG108419.
InParanoidiA7MB10.
KOiK14792.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR003107. HAT.
IPR012340. NA-bd_OB-fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
IPR008847. Suf.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF00575. S1. 5 hits.
PF05843. Suf. 1 hit.
[Graphical view]
SMARTiSM00386. HAT. 7 hits.
SM00316. S1. 13 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
SSF50249. SSF50249. 10 hits.
PROSITEiPS50126. S1. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRRP5_BOVIN
AccessioniPrimary (citable) accession number: A7MB10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: October 2, 2007
Last modified: October 5, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.