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Protein

SKI family transcriptional corepressor 2

Gene

Skor2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a TGF-beta antagonist in the nervous system (By similarity). Exhibits transcriptional repressor activity.By similarity1 Publication

GO - Molecular functioni

  • chromatin binding Source: MGI
  • histone deacetylase binding Source: MGI
  • SMAD binding Source: MGI
  • transcription corepressor activity Source: UniProtKB

GO - Biological processi

  • cell development Source: MGI
  • cerebellar Purkinje cell differentiation Source: MGI
  • cerebellum morphogenesis Source: MGI
  • negative regulation of BMP signaling pathway Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • positive regulation of smoothened signaling pathway Source: MGI
  • regulation of cerebellar granule cell precursor proliferation Source: MGI
  • regulation of dendrite morphogenesis Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
SKI family transcriptional corepressor 2
Alternative name(s):
Fussel-18 homolog
LBX1 corepressor 1-like protein
Ladybird homeobox corepressor 1-like protein
Transcriptional corepressor Corl2
Gene namesi
Name:Skor2
Synonyms:Corl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:3645984. Skor2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10081008SKI family transcriptional corepressor 2PRO_0000334612Add
BLAST

Proteomic databases

PaxDbiA7M7C7.
PRIDEiA7M7C7.

PTM databases

iPTMnetiA7M7C7.
PhosphoSiteiA7M7C7.

Expressioni

Tissue specificityi

Expression is restricted to adult and embryonic central nervous system. Expressed at high levels in the developing cerebellum, ventral metencephalon and myelencephalon at E12.5 (at protein level). In the adult cerebellum, expressed specifically in Purkinje cells.1 Publication

Developmental stagei

First detected at E11 and expression continues into adulthood with higher levels in embryonic than adult brain. In developing brain, not expressed in neural progenitors during the proliferative phase but expression is detected in postmitotic neural precursors shortly after exiting the cell cycle.2 Publications

Gene expression databases

BgeeiA7M7C7.

Interactioni

Subunit structurei

Interacts with SMAD2 and SMAD3.By similarity

GO - Molecular functioni

  • histone deacetylase binding Source: MGI
  • SMAD binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000132338.

Structurei

3D structure databases

ProteinModelPortaliA7M7C7.
SMRiA7M7C7. Positions 43-131, 147-236.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi261 – 371111Ala-richAdd
BLAST
Compositional biasi285 – 2939Pro-rich
Compositional biasi464 – 705242Pro-richAdd
BLAST
Compositional biasi601 – 66565His-richAdd
BLAST
Compositional biasi723 – 76644Glu-richAdd
BLAST
Compositional biasi829 – 8357Poly-Pro

Sequence similaritiesi

Belongs to the SKI family.Curated

Phylogenomic databases

eggNOGiENOG410IEFD. Eukaryota.
ENOG410XPY0. LUCA.
GeneTreeiENSGT00530000063040.
HOVERGENiHBG107746.
InParanoidiA7M7C7.
OMAiGLCHKKE.
OrthoDBiEOG7R56SW.
PhylomeDBiA7M7C7.
TreeFamiTF324133.

Family and domain databases

Gene3Di3.10.260.20. 1 hit.
3.10.390.10. 1 hit.
InterProiIPR014890. c-SKI_SMAD4-bd_dom.
IPR009061. DNA-bd_dom_put.
IPR010919. SAND_dom-like.
IPR028376. SKI_corepress_2.
IPR003380. Transform_Ski.
IPR023216. Tscrpt_reg_SKI_SnoN.
[Graphical view]
PANTHERiPTHR10005. PTHR10005. 7 hits.
PTHR10005:SF7. PTHR10005:SF7. 7 hits.
PfamiPF08782. c-SKI_SMAD_bind. 1 hit.
PF02437. Ski_Sno. 1 hit.
[Graphical view]
SMARTiSM01046. c-SKI_SMAD_bind. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF63763. SSF63763. 1 hit.

Sequencei

Sequence statusi: Complete.

A7M7C7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSPLPGPN DILLASPSSA FQPDALSQPR PGHANLKPNQ VGQVILYGIP
60 70 80 90 100
IVSLVIDGQE RLCLAQISNT LLKNFSYNEI HNRRVALGIT CVQCTPVQLE
110 120 130 140 150
ILRRAGAMPI SSRRCGMITK REAERLCKSF LGENRPPKLP DNFAFDVSHE
160 170 180 190 200
CAWGCRGSFI PARYNSSRAK CIKCSYCNMY FSPNKFIFHS HRTPDAKYTQ
210 220 230 240 250
PDAANFNSWR RHLKLTDKSP QDELVFAWED VKAMFNGGSR KRALPQPSAH
260 270 280 290 300
PACHPLSSVK AAAVAAAAAV AGGGGLLGPH LLGAPPPPPP PPPLAELAGA
310 320 330 340 350
PHAHHKRPRF DDDDDSLQEA AVVAAASLSA AAASLSVAAA TGGAGPGAGG
360 370 380 390 400
PGGGCVAGVG VGASAGAGAA AGTKGPRSYP VIPVPSKGSF GGVLQKFPGC
410 420 430 440 450
GGLFPHPYTF PAAAAAFGLC HKKEDAGTAA EALGGAGAGS AGAAPKAGLS
460 470 480 490 500
GLFWPAGRKD AFYPPFCMFW PPRTPGGLPV PTYLQPPPQP PSALGCALGD
510 520 530 540 550
SPALLRQAFL DLAEPGGAGG SAEAAPPPGQ PPPVVANGPG SGPPATGGTG
560 570 580 590 600
ARDTLFESPP GGSGGDCSAG STPPAEQGVT SGTGSASSGA GSVGTRVPAP
610 620 630 640 650
HHPHLLEGRK AGGGSYHHSS AFRPVGGKDD AESLAKLHGA SAGTPHSAPA
660 670 680 690 700
HHHHHHHHPH HHHHHPPQPP SPLLLLQPQP DEPGSERHHP APPPPPPPPP
710 720 730 740 750
LAPQPHHRGL LSPEGTSCSY PSEDSSEDEE DEEEEQEVDV EGHKPLEGEE
760 770 780 790 800
EEDGRDPEDE EEEDEETRVL LGDSLVGGGR FLQGRGLSEK GSGRDRTTPA
810 820 830 840 850
VGAFPLALNS SRLLQEDGKL GDSGGSDLPA PPPPPLAPQK ASSSGGSRPG
860 870 880 890 900
SPVHHPSLEE EPSYKDNQKP KENNQVIIST KDDNFSDKNK GHGFFITDSD
910 920 930 940 950
SSGDFWRERS GEHTQETNSP HSLKKDVENM GKEELQKVLF EQIDLRRRLE
960 970 980 990 1000
QEFQVLKGNT SFPVFNNFQD QMKRELAYRE EMVQQLQIIP YAASLIRKEK

LGAHLSKS
Length:1,008
Mass (Da):105,616
Last modified:October 2, 2007 - v1
Checksum:i365AD6D63C0D50C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB358976 mRNA. Translation: BAF76044.1.
CCDSiCCDS50322.1.
RefSeqiNP_001103213.1. NM_001109743.1.
XP_006526499.1. XM_006526436.2.
UniGeneiMm.329543.

Genome annotation databases

EnsembliENSMUST00000166956; ENSMUSP00000132338; ENSMUSG00000091519.
GeneIDi664805.
KEGGimmu:664805.
UCSCiuc008fqq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB358976 mRNA. Translation: BAF76044.1.
CCDSiCCDS50322.1.
RefSeqiNP_001103213.1. NM_001109743.1.
XP_006526499.1. XM_006526436.2.
UniGeneiMm.329543.

3D structure databases

ProteinModelPortaliA7M7C7.
SMRiA7M7C7. Positions 43-131, 147-236.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000132338.

PTM databases

iPTMnetiA7M7C7.
PhosphoSiteiA7M7C7.

Proteomic databases

PaxDbiA7M7C7.
PRIDEiA7M7C7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000166956; ENSMUSP00000132338; ENSMUSG00000091519.
GeneIDi664805.
KEGGimmu:664805.
UCSCiuc008fqq.1. mouse.

Organism-specific databases

CTDi652991.
MGIiMGI:3645984. Skor2.

Phylogenomic databases

eggNOGiENOG410IEFD. Eukaryota.
ENOG410XPY0. LUCA.
GeneTreeiENSGT00530000063040.
HOVERGENiHBG107746.
InParanoidiA7M7C7.
OMAiGLCHKKE.
OrthoDBiEOG7R56SW.
PhylomeDBiA7M7C7.
TreeFamiTF324133.

Miscellaneous databases

PROiA7M7C7.
SOURCEiSearch...

Gene expression databases

BgeeiA7M7C7.

Family and domain databases

Gene3Di3.10.260.20. 1 hit.
3.10.390.10. 1 hit.
InterProiIPR014890. c-SKI_SMAD4-bd_dom.
IPR009061. DNA-bd_dom_put.
IPR010919. SAND_dom-like.
IPR028376. SKI_corepress_2.
IPR003380. Transform_Ski.
IPR023216. Tscrpt_reg_SKI_SnoN.
[Graphical view]
PANTHERiPTHR10005. PTHR10005. 7 hits.
PTHR10005:SF7. PTHR10005:SF7. 7 hits.
PfamiPF08782. c-SKI_SMAD_bind. 1 hit.
PF02437. Ski_Sno. 1 hit.
[Graphical view]
SMARTiSM01046. c-SKI_SMAD_bind. 1 hit.
[Graphical view]
SUPFAMiSSF46955. SSF46955. 1 hit.
SSF63763. SSF63763. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Identification of a novel transcriptional corepressor, Corl2, as a cerebellar Purkinje cell-selective marker."
    Minaki Y., Nakatani T., Mizuhara E., Inoue T., Ono Y.
    Gene Expr. Patterns 8:418-423(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Embryonic brain.
  2. "Cloning and functional characterization of a new Ski homolog, Fussel-18, specifically expressed in neuronal tissues."
    Arndt S., Poser I., Schubert T., Moser M., Bosserhoff A.-K.
    Lab. Invest. 85:1330-1341(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiSKOR2_MOUSE
AccessioniPrimary (citable) accession number: A7M7C7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 2, 2007
Last modified: June 8, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.