ID   A7LPD8_CAEEL            Unreviewed;       957 AA.
AC   A7LPD8;
DT   11-SEP-2007, integrated into UniProtKB/TrEMBL.
DT   11-SEP-2007, sequence version 1.
DT   27-MAR-2024, entry version 119.
DE   SubName: Full=UBP-type domain-containing protein {ECO:0000313|EMBL:CCD71106.1};
GN   Name=hda-6 {ECO:0000313|EMBL:CCD71106.1,
GN   ECO:0000313|WormBase:F41H10.6c};
GN   ORFNames=CELE_F41H10.6 {ECO:0000313|EMBL:CCD71106.1}, F41H10.6
GN   {ECO:0000313|WormBase:F41H10.6c};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD71106.1, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CCD71106.1, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD71106.1,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-
CC         [histone]; Xref=Rhea:RHEA:58196, Rhea:RHEA-COMP:9845, Rhea:RHEA-
CC         COMP:11338, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089,
CC         ChEBI:CHEBI:61930; EC=3.5.1.98;
CC         Evidence={ECO:0000256|ARBA:ARBA00001028};
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DR   EMBL; BX284604; CCD71106.1; -; Genomic_DNA.
DR   RefSeq; NP_001122780.1; NM_001129308.2.
DR   AlphaFoldDB; A7LPD8; -.
DR   SMR; A7LPD8; -.
DR   PeptideAtlas; A7LPD8; -.
DR   EnsemblMetazoa; F41H10.6c.1; F41H10.6c.1; WBGene00018319.
DR   GeneID; 177316; -.
DR   UCSC; F41H10.6c; c. elegans.
DR   AGR; WB:WBGene00018319; -.
DR   WormBase; F41H10.6c; CE41132; WBGene00018319; hda-6.
DR   HOGENOM; CLU_007727_2_1_1; -.
DR   OMA; MCHLEEL; -.
DR   OrthoDB; 124800at2759; -.
DR   PhylomeDB; A7LPD8; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00018319; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR   ExpressionAtlas; A7LPD8; baseline and differential.
DR   GO; GO:0033558; F:protein lysine deacetylase activity; ISS:WormBase.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.40.800.20; Histone deacetylase domain; 2.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR001607; Znf_UBP.
DR   PANTHER; PTHR10625:SF31; HISTONE DEACETYLASE 6; 1.
DR   PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR   Pfam; PF00850; Hist_deacetyl; 2.
DR   Pfam; PF02148; zf-UBP; 1.
DR   PRINTS; PR01270; HDASUPER.
DR   SMART; SM00290; ZnF_UBP; 1.
DR   SUPFAM; SSF52768; Arginase/deacetylase; 2.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50271; ZF_UBP; 1.
PE   1: Evidence at protein level;
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00502};
KW   Proteomics identification {ECO:0007829|EPD:A7LPD8,
KW   ECO:0007829|PeptideAtlas:A7LPD8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00502};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00502}.
FT   DOMAIN          855..953
FT                   /note="UBP-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50271"
FT   REGION          817..842
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        819..840
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   957 AA;  107024 MW;  C2D025AFB4920FD2 CRC64;
     MLFEDRQKNR STGPTLIGFN QTQNEHENTV CPTHPESSDR ILKIKEALTK TKILEKCTVL
     TNFLEIDDAD LEVTHDKSMV KDLMESEKKT QEDINSQCEK YDSVFMTEFQ NSMKVAKDGV
     ACVRDLTNRI MANEASNGFA VVRPPGHHAD SVSPCGFCLF NNVAQAAEEA FFSGAERILI
     VDLDVHHGHG TQRIFYDDKR VLYFSIHRHE HGLFWPHLPE SDFDHIGSGK GLGYNANLAL
     NETGCTDSDY LSIIFHVLLP LATQFDPHFV IISAGFDALL GDPLGGMCLT PDGYSHILYH
     LKSLAQGRML VVLEGGYNHQ ISAVAVQRCV RVLLGYAPFS IELNEAPKES TVDSCVSLVS
     VLRHHWNCFD YFPSRTSLRL AQWPIVNTKV IYNYDPTTRR ADTGEIIQDE LASTEFTASD
     VIPTENMETL IYFNEGDDAH FDLEEDNHPE KPARTRRILK TLRESGVLEK CVDRNCERIA
     TNEEIRLVHT KKMLEHLRTT ETMKDEELME EAEKEFNSIY LTRDTLKVAR KAVGAVLQSV
     DEIFEKDAGQ RNALVIVRPP GHHASASKSS GFCIFNNVAV AAKYAQRRHK AKRVLILDWD
     VHHGNGTQEI FYEDSNVMYM SIHRHDKGNF YPIGEPKDYS DVGEGAGEGM SVNVPFSGVQ
     MGDNEYQMAF QRVIMPIAYQ FNPDLVLISA GFDAAVDDPL GEYKVTPETF ALMTYQLSSL
     AGGRIITVLE GGYNLTSISN SAQAVCEVLQ NRSMLRRLRE EKEQFATKPQ KIESSCIKTI
     REVCAVQQKY WSILKGFQVT PSNYGLDIDD EAYDDDSIDM ADQSSSSGSS SSSTRPSHNL
     EIMDSGPAHA VVPLATCPHL KEVKPLPPAK INARTACSEC QIGAEVWTCL TCYKYNCGRF
     VNEHAMMHHL SSSHPMALSM ADLSVWCYPC DSYVHNPALI GAKSAAHESK FGETMPS
//