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A7LCX1

- A7LCX1_PIG

UniProt

A7LCX1 - A7LCX1_PIG

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Protein
Submitted name:

Melanoma differentiation associated protein-5

Gene

MDA5

Organism
Sus scrofa (Pig)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. DNA binding Source: InterPro
  3. hydrolase activity, acting on acid anhydrides Source: InterPro

GO - Biological processi

  1. regulation of apoptotic process Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Melanoma differentiation associated protein-5Imported
Gene namesi
Name:MDA5Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000016846.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4I1SX-ray2.29A666-808[»]
ProteinModelPortaliA7LCX1.
SMRiA7LCX1. Positions 291-489.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1111.
HOGENOMiHOG000230992.
HOVERGENiHBG106019.
KOiK12647.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR021673. RIG-I_C-RD.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF11648. RIG-I_C-RD. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7LCX1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSDGYSADQ NFCYLISCFR ARVKRYIQVE PVLDYLTFLP AEVKEQIQRA
60 70 80 90 100
VATTGNINAA ELLLNTLEKG VWPPGWTRMF VQALRETGNS LAARYVNPDL
110 120 130 140 150
TDLPSPSFES SHDECLQLLN LLQPTVVDKL LVTDVLDKCV EEQLLTGEDR
160 170 180 190 200
NRVSAAENDG NESGVRELLK RIVQKENWFS TFLTVLRQTG NDALARELTG
210 220 230 240 250
TDCCESNAES DDLLGENGPE VQEPLLLATD QPSLDVSDIE KSSLESSFAD
260 270 280 290 300
SSVVSESDTS LAEGSVSCLD ESLGHNSNMG SDSGTMGSDS DEETVAQRAS
310 320 330 340 350
PEPELHLRPY QLEVAQPALE GKNIIICLPT GSGKTRVAVY IAKDHLDKKK
360 370 380 390 400
EASEPGKVIV LVNKVPLVEQ LFRKEFEPFL KKWYRVTRLS GDTQLKITFP
410 420 430 440 450
EVVKSCDVII STAQILENSL LNSEEGEDPG VQLSDFSLII IDECHHTNKE
460 470 480 490 500
AVYNNIMRRY LKQKLKNNKL KKEEKPVIPL PQILGLTASP GVGGAKKQAK
510 520 530 540 550
AEEHILKICA NLDAFTIKTV KKNINQLKDQ IKEPCKKFVI ADDTREDLFK
560 570 580 590 600
DRLLEIMTNI QTFCQISPMS DFGTQPYEQW LIQMEKKAAR DGNRKDRVCA
610 620 630 640 650
EHLKKYNEAL QINDTIRRID AYNHLKTFYN DEKEKKFEVL EDDSDDNGDD
660 670 680 690 700
SDNDEDENDE KKPSKLDESD IFLMTLFLRN KKILKKLAEN PEYENEKLTK
710 720 730 740 750
LRNTIMEHFT RTEESARGII FTKTRQSAYA LSQWITDNKK FAEVGVKAHH
760 770 780 790 800
LIGAGHSSEF KPMTQNEQRE VISKFRTGKI NLLIATTVAE EGLDIKECNI
810 820 830 840 850
VIRYGLVTNE IAMVQARGRA RADESTYVLV AQSGSGVIER ETVNDFREKM
860 870 880 890 900
MYKAIDRVQN MKPEEYAHKI LELQMQSIME KKMKIKRSIA KQCKDNPSLI
910 920 930 940 950
SFLCKNCSVL ACSGEDIHII EKMHHVNMTP EFKNLYIVRG NKALQTKFAD
960 970 980 990 1000
YQTNGEIICK KCGQAWGTMM VHKGLDLPCL KIKNYVVAFK NNLFKKQYKK
1010 1020
WVELPITFPD LNYSEYCLSS DED
Length:1,023
Mass (Da):115,917
Last modified:September 11, 2007 - v1
Checksum:iC92B17D46B267222
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU006039 mRNA. Translation: ABS29718.1.
RefSeqiNP_001093664.1. NM_001100194.1.
UniGeneiSsc.19139.

Genome annotation databases

GeneIDi100101927.
KEGGissc:100101927.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU006039 mRNA. Translation: ABS29718.1 .
RefSeqi NP_001093664.1. NM_001100194.1.
UniGenei Ssc.19139.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4I1S X-ray 2.29 A 666-808 [» ]
ProteinModelPortali A7LCX1.
SMRi A7LCX1. Positions 291-489.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000016846.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100101927.
KEGGi ssc:100101927.

Organism-specific databases

CTDi 64135.

Phylogenomic databases

eggNOGi COG1111.
HOGENOMi HOG000230992.
HOVERGENi HBG106019.
KOi K12647.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR021673. RIG-I_C-RD.
[Graphical view ]
Pfami PF00619. CARD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF11648. RIG-I_C-RD. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification and characterization of swine MDA-5."
    Wang D., Xiao S.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling."
    Motz C., Schuhmann K.M., Kirchhofer A., Moldt M., Witte G., Conzelmann K.K., Hopfner K.P.
    Science 339:690-693(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.29 ANGSTROMS) OF 666-808.

Entry informationi

Entry nameiA7LCX1_PIG
AccessioniPrimary (citable) accession number: A7LCX1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3