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A7LCX1

- A7LCX1_PIG

UniProt

A7LCX1 - A7LCX1_PIG

Protein
Submitted name:

Melanoma differentiation associated protein-5

Gene

MDA5

Organism
Sus scrofa (Pig)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. DNA binding Source: InterPro
    3. helicase activity Source: InterPro

    GO - Biological processi

    1. regulation of apoptotic process Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Melanoma differentiation associated protein-5Imported
    Gene namesi
    Name:MDA5Imported
    OrganismiSus scrofa (Pig)Imported
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    Interactioni

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000016846.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4I1SX-ray2.29A666-808[»]
    ProteinModelPortaliA7LCX1.
    SMRiA7LCX1. Positions 291-489.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG1111.
    HOGENOMiHOG000230992.
    HOVERGENiHBG106019.
    KOiK12647.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProiIPR001315. CARD.
    IPR011029. DEATH-like_dom.
    IPR006935. Helicase/UvrB_dom.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR021673. RIG-I_C-RD.
    [Graphical view]
    PfamiPF00619. CARD. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF04851. ResIII. 1 hit.
    PF11648. RIG-I_C-RD. 1 hit.
    [Graphical view]
    SMARTiSM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    SSF52540. SSF52540. 3 hits.
    PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7LCX1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSDGYSADQ NFCYLISCFR ARVKRYIQVE PVLDYLTFLP AEVKEQIQRA     50
    VATTGNINAA ELLLNTLEKG VWPPGWTRMF VQALRETGNS LAARYVNPDL 100
    TDLPSPSFES SHDECLQLLN LLQPTVVDKL LVTDVLDKCV EEQLLTGEDR 150
    NRVSAAENDG NESGVRELLK RIVQKENWFS TFLTVLRQTG NDALARELTG 200
    TDCCESNAES DDLLGENGPE VQEPLLLATD QPSLDVSDIE KSSLESSFAD 250
    SSVVSESDTS LAEGSVSCLD ESLGHNSNMG SDSGTMGSDS DEETVAQRAS 300
    PEPELHLRPY QLEVAQPALE GKNIIICLPT GSGKTRVAVY IAKDHLDKKK 350
    EASEPGKVIV LVNKVPLVEQ LFRKEFEPFL KKWYRVTRLS GDTQLKITFP 400
    EVVKSCDVII STAQILENSL LNSEEGEDPG VQLSDFSLII IDECHHTNKE 450
    AVYNNIMRRY LKQKLKNNKL KKEEKPVIPL PQILGLTASP GVGGAKKQAK 500
    AEEHILKICA NLDAFTIKTV KKNINQLKDQ IKEPCKKFVI ADDTREDLFK 550
    DRLLEIMTNI QTFCQISPMS DFGTQPYEQW LIQMEKKAAR DGNRKDRVCA 600
    EHLKKYNEAL QINDTIRRID AYNHLKTFYN DEKEKKFEVL EDDSDDNGDD 650
    SDNDEDENDE KKPSKLDESD IFLMTLFLRN KKILKKLAEN PEYENEKLTK 700
    LRNTIMEHFT RTEESARGII FTKTRQSAYA LSQWITDNKK FAEVGVKAHH 750
    LIGAGHSSEF KPMTQNEQRE VISKFRTGKI NLLIATTVAE EGLDIKECNI 800
    VIRYGLVTNE IAMVQARGRA RADESTYVLV AQSGSGVIER ETVNDFREKM 850
    MYKAIDRVQN MKPEEYAHKI LELQMQSIME KKMKIKRSIA KQCKDNPSLI 900
    SFLCKNCSVL ACSGEDIHII EKMHHVNMTP EFKNLYIVRG NKALQTKFAD 950
    YQTNGEIICK KCGQAWGTMM VHKGLDLPCL KIKNYVVAFK NNLFKKQYKK 1000
    WVELPITFPD LNYSEYCLSS DED 1023
    Length:1,023
    Mass (Da):115,917
    Last modified:September 11, 2007 - v1
    Checksum:iC92B17D46B267222
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU006039 mRNA. Translation: ABS29718.1.
    RefSeqiNP_001093664.1. NM_001100194.1.
    UniGeneiSsc.19139.

    Genome annotation databases

    GeneIDi100101927.
    KEGGissc:100101927.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU006039 mRNA. Translation: ABS29718.1 .
    RefSeqi NP_001093664.1. NM_001100194.1.
    UniGenei Ssc.19139.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4I1S X-ray 2.29 A 666-808 [» ]
    ProteinModelPortali A7LCX1.
    SMRi A7LCX1. Positions 291-489.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000016846.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100101927.
    KEGGi ssc:100101927.

    Organism-specific databases

    CTDi 64135.

    Phylogenomic databases

    eggNOGi COG1111.
    HOGENOMi HOG000230992.
    HOVERGENi HBG106019.
    KOi K12647.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProi IPR001315. CARD.
    IPR011029. DEATH-like_dom.
    IPR006935. Helicase/UvrB_dom.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR021673. RIG-I_C-RD.
    [Graphical view ]
    Pfami PF00619. CARD. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF04851. ResIII. 1 hit.
    PF11648. RIG-I_C-RD. 1 hit.
    [Graphical view ]
    SMARTi SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    SSF52540. SSF52540. 3 hits.
    PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of swine MDA-5."
      Wang D., Xiao S.
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling."
      Motz C., Schuhmann K.M., Kirchhofer A., Moldt M., Witte G., Conzelmann K.K., Hopfner K.P.
      Science 339:690-693(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.29 ANGSTROMS) OF 666-808.

    Entry informationi

    Entry nameiA7LCX1_PIG
    AccessioniPrimary (citable) accession number: A7LCX1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 11, 2007
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3