A7LCX1 (A7LCX1_PIG) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Melanoma differentiation associated protein-5 EMBL ABS29718.1

Gene names

Name:

MDA5 EMBL ABS29718.1

Organism

Sus scrofa (Pig) EMBL ABS29718.1

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	1023 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Technical term	3D-structure PDB 4I1S
Gene Ontology (GO)
Biological_process	regulation of apoptotic process Inferred from electronic annotation. Source: InterPro
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: InterPro helicase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A7LCX1 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: C92B17D46B267222	FASTA	1,023	115,917
	10 20 30 40 50 60 MSSDGYSADQ NFCYLISCFR ARVKRYIQVE PVLDYLTFLP AEVKEQIQRA VATTGNINAA 70 80 90 100 110 120 ELLLNTLEKG VWPPGWTRMF VQALRETGNS LAARYVNPDL TDLPSPSFES SHDECLQLLN 130 140 150 160 170 180 LLQPTVVDKL LVTDVLDKCV EEQLLTGEDR NRVSAAENDG NESGVRELLK RIVQKENWFS 190 200 210 220 230 240 TFLTVLRQTG NDALARELTG TDCCESNAES DDLLGENGPE VQEPLLLATD QPSLDVSDIE 250 260 270 280 290 300 KSSLESSFAD SSVVSESDTS LAEGSVSCLD ESLGHNSNMG SDSGTMGSDS DEETVAQRAS 310 320 330 340 350 360 PEPELHLRPY QLEVAQPALE GKNIIICLPT GSGKTRVAVY IAKDHLDKKK EASEPGKVIV 370 380 390 400 410 420 LVNKVPLVEQ LFRKEFEPFL KKWYRVTRLS GDTQLKITFP EVVKSCDVII STAQILENSL 430 440 450 460 470 480 LNSEEGEDPG VQLSDFSLII IDECHHTNKE AVYNNIMRRY LKQKLKNNKL KKEEKPVIPL 490 500 510 520 530 540 PQILGLTASP GVGGAKKQAK AEEHILKICA NLDAFTIKTV KKNINQLKDQ IKEPCKKFVI 550 560 570 580 590 600 ADDTREDLFK DRLLEIMTNI QTFCQISPMS DFGTQPYEQW LIQMEKKAAR DGNRKDRVCA 610 620 630 640 650 660 EHLKKYNEAL QINDTIRRID AYNHLKTFYN DEKEKKFEVL EDDSDDNGDD SDNDEDENDE 670 680 690 700 710 720 KKPSKLDESD IFLMTLFLRN KKILKKLAEN PEYENEKLTK LRNTIMEHFT RTEESARGII 730 740 750 760 770 780 FTKTRQSAYA LSQWITDNKK FAEVGVKAHH LIGAGHSSEF KPMTQNEQRE VISKFRTGKI 790 800 810 820 830 840 NLLIATTVAE EGLDIKECNI VIRYGLVTNE IAMVQARGRA RADESTYVLV AQSGSGVIER 850 860 870 880 890 900 ETVNDFREKM MYKAIDRVQN MKPEEYAHKI LELQMQSIME KKMKIKRSIA KQCKDNPSLI 910 920 930 940 950 960 SFLCKNCSVL ACSGEDIHII EKMHHVNMTP EFKNLYIVRG NKALQTKFAD YQTNGEIICK 970 980 990 1000 1010 1020 KCGQAWGTMM VHKGLDLPCL KIKNYVVAFK NNLFKKQYKK WVELPITFPD LNYSEYCLSS DED

References

[1]	"Identification and characterization of swine MDA-5." Wang D., Xiao S. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling." Motz C., Schuhmann K.M., Kirchhofer A., Moldt M., Witte G., Conzelmann K.K., Hopfner K.P. Science 339:690-693(2013) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.29 ANGSTROMS) OF 546-808.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

EU006039 mRNA. Translation: ABS29718.1.

RefSeq

NP_001093664.1. NM_001100194.1.

UniGene

Ssc.19139.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4I1S	X-ray	2.29	A	546-808	[»]

ProteinModelPortal

A7LCX1.

SMR

A7LCX1. Positions 291-489.

ModBase

Search...

Protein-protein interaction databases

STRING

9823.ENSSSCP00000016846.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

100101927.

KEGG

ssc:100101927.

Organism-specific databases

CTD

64135.

Phylogenomic databases

eggNOG

COG1111.

HOGENOM

HOG000230992.

HOVERGEN

HBG106019.

KO

K12647.

Family and domain databases

Gene3D

1.10.533.10. 1 hit.

InterPro

IPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR021673. RIG-I_C-RD.
[Graphical view]

Pfam

PF00619. CARD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF11648. RIG-I_C-RD. 1 hit.
[Graphical view]

SMART

SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]

PROSITE

PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

A7LCX1_PIG

Accession

Primary (citable) accession number: A7LCX1

Entry history

Integrated into UniProtKB/TrEMBL:	September 11, 2007
Last sequence update:	September 11, 2007
Last modified:	May 1, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)