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A7LCX1

- A7LCX1_PIG

UniProt

A7LCX1 - A7LCX1_PIG

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Protein
Submitted name: Melanoma differentiation associated protein-5
Gene
MDA5
Organism
Sus scrofa (Pig)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. DNA binding Source: InterPro
  3. helicase activity Source: InterPro

GO - Biological processi

  1. regulation of apoptotic process Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Melanoma differentiation associated protein-5Imported
Gene namesi
Name:MDA5Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000016846.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4I1SX-ray2.29A666-808[»]
ProteinModelPortaliA7LCX1.
SMRiA7LCX1. Positions 291-489.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1111.
HOGENOMiHOG000230992.
HOVERGENiHBG106019.
KOiK12647.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR021673. RIG-I_C-RD.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF11648. RIG-I_C-RD. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7LCX1-1 [UniParc]FASTAAdd to Basket

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MSSDGYSADQ NFCYLISCFR ARVKRYIQVE PVLDYLTFLP AEVKEQIQRA     50
VATTGNINAA ELLLNTLEKG VWPPGWTRMF VQALRETGNS LAARYVNPDL 100
TDLPSPSFES SHDECLQLLN LLQPTVVDKL LVTDVLDKCV EEQLLTGEDR 150
NRVSAAENDG NESGVRELLK RIVQKENWFS TFLTVLRQTG NDALARELTG 200
TDCCESNAES DDLLGENGPE VQEPLLLATD QPSLDVSDIE KSSLESSFAD 250
SSVVSESDTS LAEGSVSCLD ESLGHNSNMG SDSGTMGSDS DEETVAQRAS 300
PEPELHLRPY QLEVAQPALE GKNIIICLPT GSGKTRVAVY IAKDHLDKKK 350
EASEPGKVIV LVNKVPLVEQ LFRKEFEPFL KKWYRVTRLS GDTQLKITFP 400
EVVKSCDVII STAQILENSL LNSEEGEDPG VQLSDFSLII IDECHHTNKE 450
AVYNNIMRRY LKQKLKNNKL KKEEKPVIPL PQILGLTASP GVGGAKKQAK 500
AEEHILKICA NLDAFTIKTV KKNINQLKDQ IKEPCKKFVI ADDTREDLFK 550
DRLLEIMTNI QTFCQISPMS DFGTQPYEQW LIQMEKKAAR DGNRKDRVCA 600
EHLKKYNEAL QINDTIRRID AYNHLKTFYN DEKEKKFEVL EDDSDDNGDD 650
SDNDEDENDE KKPSKLDESD IFLMTLFLRN KKILKKLAEN PEYENEKLTK 700
LRNTIMEHFT RTEESARGII FTKTRQSAYA LSQWITDNKK FAEVGVKAHH 750
LIGAGHSSEF KPMTQNEQRE VISKFRTGKI NLLIATTVAE EGLDIKECNI 800
VIRYGLVTNE IAMVQARGRA RADESTYVLV AQSGSGVIER ETVNDFREKM 850
MYKAIDRVQN MKPEEYAHKI LELQMQSIME KKMKIKRSIA KQCKDNPSLI 900
SFLCKNCSVL ACSGEDIHII EKMHHVNMTP EFKNLYIVRG NKALQTKFAD 950
YQTNGEIICK KCGQAWGTMM VHKGLDLPCL KIKNYVVAFK NNLFKKQYKK 1000
WVELPITFPD LNYSEYCLSS DED 1023
Length:1,023
Mass (Da):115,917
Last modified:September 11, 2007 - v1
Checksum:iC92B17D46B267222
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU006039 mRNA. Translation: ABS29718.1.
RefSeqiNP_001093664.1. NM_001100194.1.
UniGeneiSsc.19139.

Genome annotation databases

GeneIDi100101927.
KEGGissc:100101927.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU006039 mRNA. Translation: ABS29718.1 .
RefSeqi NP_001093664.1. NM_001100194.1.
UniGenei Ssc.19139.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4I1S X-ray 2.29 A 666-808 [» ]
ProteinModelPortali A7LCX1.
SMRi A7LCX1. Positions 291-489.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000016846.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100101927.
KEGGi ssc:100101927.

Organism-specific databases

CTDi 64135.

Phylogenomic databases

eggNOGi COG1111.
HOGENOMi HOG000230992.
HOVERGENi HBG106019.
KOi K12647.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR001315. CARD.
IPR011029. DEATH-like_dom.
IPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR021673. RIG-I_C-RD.
[Graphical view ]
Pfami PF00619. CARD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF11648. RIG-I_C-RD. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
SSF52540. SSF52540. 3 hits.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification and characterization of swine MDA-5."
    Wang D., Xiao S.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling."
    Motz C., Schuhmann K.M., Kirchhofer A., Moldt M., Witte G., Conzelmann K.K., Hopfner K.P.
    Science 339:690-693(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.29 ANGSTROMS) OF 666-808.

Entry informationi

Entry nameiA7LCX1_PIG
AccessioniPrimary (citable) accession number: A7LCX1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: June 11, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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