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A7L9Z8 (AT2C2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calcium-transporting ATPase type 2C member 2

Short name=ATPase 2C2
EC=3.6.3.8
Alternative name(s):
Secretory pathway Ca(2+)-ATPase 2
Gene names
Name:Atp2c2
Synonyms:Kiaa0703, Spca2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length944 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium By similarity.

Catalytic activity

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 944944Calcium-transporting ATPase type 2C member 2
PRO_0000356156

Regions

Topological domain1 – 104104Cytoplasmic Potential
Transmembrane105 – 12521Helical; Name=1; Potential
Topological domain126 – 1272Extracellular Potential
Transmembrane128 – 14821Helical; Name=2; Potential
Topological domain149 – 22981Cytoplasmic Potential
Transmembrane230 – 25021Helical; Name=3; Potential
Topological domain251 – 29141Extracellular Potential
Transmembrane292 – 31221Helical; Name=4; Potential
Topological domain313 – 32917Cytoplasmic Potential
Transmembrane330 – 35021Helical; Name=5; Potential
Topological domain351 – 748398Extracellular Potential
Transmembrane749 – 76921Helical; Name=6; Potential
Topological domain770 – 80233Cytoplasmic Potential
Transmembrane803 – 82321Helical; Name=7; Potential
Topological domain824 – 83512Extracellular Potential
Transmembrane836 – 85318Helical; Name=8; Potential
Topological domain854 – 87219Cytoplasmic Potential
Transmembrane873 – 89321Helical; Name=9; Potential
Topological domain894 – 90310Extracellular Potential
Transmembrane904 – 92421Helical; Name=10; Potential
Topological domain925 – 94420Cytoplasmic Potential
Compositional bias112 – 1176Poly-Leu

Sites

Active site37714-aspartylphosphate intermediate By similarity
Metal binding3301Calcium 2; via carbonyl oxygen By similarity
Metal binding3311Calcium 2; via carbonyl oxygen By similarity
Metal binding3331Calcium 2; via carbonyl oxygen By similarity
Metal binding3351Calcium 2 By similarity
Metal binding6721Magnesium By similarity
Metal binding6761Magnesium By similarity
Metal binding7661Calcium 2 By similarity
Metal binding7701Calcium 2 By similarity

Amino acid modifications

Modified residue2621Phosphothreonine By similarity
Modified residue2661Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
A7L9Z8 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: B585BFFB96AAA375

FASTA944102,528
        10         20         30         40         50         60 
MGRRLKFLQK LAFLGQNHRY KALERDEVET LIDEQCELKA IEREKTVAAL PPGEACKCSR 

        70         80         90        100        110        120 
EELARAFHVD LDSGLSEFAV AQRRLVHGWN EFVTDNAEPV WKKYLDQFRN PLILLLLGSS 

       130        140        150        160        170        180 
VVSVLTKEYE DAVSIALAVL IVVTVGFIQE YRSEKSLEEL TKLVPPECNC LRDGKLRHML 

       190        200        210        220        230        240 
ARDLVPGDIV SLSMGDRIPA DIRLTEVTDL LVDESSFTGE VEPCGKTDSP LADGGDLSTL 

       250        260        270        280        290        300 
SNVVFMGTLV QCGKGQGVVI GTGEQSQFGE VFKMMRAEET PKTPLQKSMD KLGKQLTIFS 

       310        320        330        340        350        360 
FGIIGLLMLV GWVQGKPFLS MFTVGVSLAV AAIPEGLPIV VMVTLVLGVL RMAKKRVIVK 

       370        380        390        400        410        420 
KLPIVETLGC CNVICSDKTG TLTANEMTAT QLVTSDGFHA EVSGVGYSGE GTVCLLPSKE 

       430        440        450        460        470        480 
VIKGFDNVSV GKLVEAGCVA NNAVIRKNAV MGQPTEGALV VLAMKMNLGS IKDSYVRKKE 

       490        500        510        520        530        540 
IPFSSEQKWM AVRCGPKSED GEDIYFMKGA FEEVIHHCSM YNNGGIPLPL TPQQKSYCQQ 

       550        560        570        580        590        600 
EEKKMGSLGL RVLALASGPE LGRLTFLGLV GIIDPPRAGV KEAVQVLSES GVSVKMVTGD 

       610        620        630        640        650        660 
ALETALAIGR TIGLCNEKLK AMSGEEVEGT EQGALAARVR QVSVFFRTSP KHKVKIIKAL 

       670        680        690        700        710        720 
QESGAIVAMT GDGVNDSVAL KSADIGIAMG QTGTDVSKEA ANMILVDDDF SAIMSAVEEG 

       730        740        750        760        770        780 
KGIFYNIKNF VRFQLSTSIA ALSLITLSTV CNLPSPLNAM QILWVNIIMD GPPAQSLGVE 

       790        800        810        820        830        840 
PVDRDALRRP PRSVGDTILN RALILRVLMS AAVIIGGTLF IFWREIPANG TSTPRTTTMA 

       850        860        870        880        890        900 
FTCFVFFDLF NALSCRSQTK LIFEIGFFRN RMFLYSVLGS LLGQLAVIYA PPLQKVFQTE 

       910        920        930        940 
NLSALDLLLL TGLASSVFIL SELLKLWEKF LSRARPTQML PEAV 

« Hide

References

« Hide 'large scale' references
[1]"SPCA2 of Mus musculus."
Sepulveda M.R., Vanoevelen J., Raeymaekers L., Wuytack F.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Swiss.
[2]"Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 88-897.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EF688288 mRNA. Translation: ABS18966.1.
AK220351 mRNA. Translation: BAD90414.1.
RefSeqNP_081198.1. NM_026922.1.
UniGeneMm.46251.

3D structure databases

ProteinModelPortalA7L9Z8.
SMRA7L9Z8. Positions 59-926.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteA7L9Z8.

Proteomic databases

PaxDbA7L9Z8.
PRIDEA7L9Z8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000095171; ENSMUSP00000092794; ENSMUSG00000034112.
GeneID69047.
KEGGmmu:69047.
UCSCuc009nqg.1. mouse.

Organism-specific databases

CTD9914.
MGIMGI:1916297. Atp2c2.
RougeSearch...

Phylogenomic databases

eggNOGCOG0474.
GeneTreeENSGT00560000076887.
HOGENOMHOG000265621.
HOVERGENHBG106478.
InParanoidQ5DU19.
KOK01537.
OMADFSAIMN.
OrthoDBEOG7F7W81.
PhylomeDBA7L9Z8.
TreeFamTF354251.

Gene expression databases

ArrayExpressA7L9Z8.
BgeeA7L9Z8.
GenevestigatorA7L9Z8.

Family and domain databases

Gene3D1.20.1110.10. 3 hits.
InterProIPR006413. ATPase_P-typ_Ca-transp_PMR1.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
PR00120. HATPASE.
SMARTSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsTIGR01522. ATPase-IIA2_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio328462.
PROA7L9Z8.
SOURCESearch...

Entry information

Entry nameAT2C2_MOUSE
AccessionPrimary (citable) accession number: A7L9Z8
Secondary accession number(s): Q5DU19
Entry history
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: September 11, 2007
Last modified: April 16, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot