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A7L9Z8

- AT2C2_MOUSE

UniProt

A7L9Z8 - AT2C2_MOUSE

Protein

Calcium-transporting ATPase type 2C member 2

Gene

Atp2c2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.By similarity

    Catalytic activityi

    ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi330 – 3301Calcium 2; via carbonyl oxygenBy similarity
    Metal bindingi331 – 3311Calcium 2; via carbonyl oxygenBy similarity
    Metal bindingi333 – 3331Calcium 2; via carbonyl oxygenBy similarity
    Metal bindingi335 – 3351Calcium 2By similarity
    Active sitei377 – 37714-aspartylphosphate intermediateBy similarity
    Metal bindingi672 – 6721MagnesiumBy similarity
    Metal bindingi676 – 6761MagnesiumBy similarity
    Metal bindingi766 – 7661Calcium 2By similarity
    Metal bindingi770 – 7701Calcium 2By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. calcium-transporting ATPase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    ATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcium-transporting ATPase type 2C member 2 (EC:3.6.3.8)
    Short name:
    ATPase 2C2
    Alternative name(s):
    Secretory pathway Ca(2+)-ATPase 2
    Gene namesi
    Name:Atp2c2
    Synonyms:Kiaa0703, Spca2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1916297. Atp2c2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 944944Calcium-transporting ATPase type 2C member 2PRO_0000356156Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei262 – 2621PhosphothreonineBy similarity
    Modified residuei266 – 2661PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiA7L9Z8.
    PRIDEiA7L9Z8.

    PTM databases

    PhosphoSiteiA7L9Z8.

    Expressioni

    Gene expression databases

    ArrayExpressiA7L9Z8.
    BgeeiA7L9Z8.
    GenevestigatoriA7L9Z8.

    Structurei

    3D structure databases

    ProteinModelPortaliA7L9Z8.
    SMRiA7L9Z8. Positions 59-926.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 104104CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini126 – 1272ExtracellularSequence Analysis
    Topological domaini149 – 22981CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini251 – 29141ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini313 – 32917CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini351 – 748398ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini770 – 80233CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini824 – 83512ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini854 – 87219CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini894 – 90310ExtracellularSequence Analysis
    Topological domaini925 – 94420CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei105 – 12521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei128 – 14821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei230 – 25021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei292 – 31221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei330 – 35021Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei749 – 76921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei803 – 82321Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei836 – 85318Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei873 – 89321Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei904 – 92421Helical; Name=10Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi112 – 1176Poly-Leu

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0474.
    GeneTreeiENSGT00560000076887.
    HOGENOMiHOG000265621.
    HOVERGENiHBG106478.
    InParanoidiQ5DU19.
    KOiK01537.
    OMAiRNRTFLY.
    OrthoDBiEOG7F7W81.
    PhylomeDBiA7L9Z8.
    TreeFamiTF354251.

    Family and domain databases

    Gene3Di1.20.1110.10. 3 hits.
    InterProiIPR006413. ATPase_P-typ_Ca-transp_PMR1.
    IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PfamiPF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    PR00120. HATPASE.
    SMARTiSM00831. Cation_ATPase_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 2 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsiTIGR01522. ATPase-IIA2_Ca. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7L9Z8-1 [UniParc]FASTAAdd to Basket

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    MGRRLKFLQK LAFLGQNHRY KALERDEVET LIDEQCELKA IEREKTVAAL    50
    PPGEACKCSR EELARAFHVD LDSGLSEFAV AQRRLVHGWN EFVTDNAEPV 100
    WKKYLDQFRN PLILLLLGSS VVSVLTKEYE DAVSIALAVL IVVTVGFIQE 150
    YRSEKSLEEL TKLVPPECNC LRDGKLRHML ARDLVPGDIV SLSMGDRIPA 200
    DIRLTEVTDL LVDESSFTGE VEPCGKTDSP LADGGDLSTL SNVVFMGTLV 250
    QCGKGQGVVI GTGEQSQFGE VFKMMRAEET PKTPLQKSMD KLGKQLTIFS 300
    FGIIGLLMLV GWVQGKPFLS MFTVGVSLAV AAIPEGLPIV VMVTLVLGVL 350
    RMAKKRVIVK KLPIVETLGC CNVICSDKTG TLTANEMTAT QLVTSDGFHA 400
    EVSGVGYSGE GTVCLLPSKE VIKGFDNVSV GKLVEAGCVA NNAVIRKNAV 450
    MGQPTEGALV VLAMKMNLGS IKDSYVRKKE IPFSSEQKWM AVRCGPKSED 500
    GEDIYFMKGA FEEVIHHCSM YNNGGIPLPL TPQQKSYCQQ EEKKMGSLGL 550
    RVLALASGPE LGRLTFLGLV GIIDPPRAGV KEAVQVLSES GVSVKMVTGD 600
    ALETALAIGR TIGLCNEKLK AMSGEEVEGT EQGALAARVR QVSVFFRTSP 650
    KHKVKIIKAL QESGAIVAMT GDGVNDSVAL KSADIGIAMG QTGTDVSKEA 700
    ANMILVDDDF SAIMSAVEEG KGIFYNIKNF VRFQLSTSIA ALSLITLSTV 750
    CNLPSPLNAM QILWVNIIMD GPPAQSLGVE PVDRDALRRP PRSVGDTILN 800
    RALILRVLMS AAVIIGGTLF IFWREIPANG TSTPRTTTMA FTCFVFFDLF 850
    NALSCRSQTK LIFEIGFFRN RMFLYSVLGS LLGQLAVIYA PPLQKVFQTE 900
    NLSALDLLLL TGLASSVFIL SELLKLWEKF LSRARPTQML PEAV 944
    Length:944
    Mass (Da):102,528
    Last modified:September 11, 2007 - v1
    Checksum:iB585BFFB96AAA375
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF688288 mRNA. Translation: ABS18966.1.
    AK220351 mRNA. Translation: BAD90414.1.
    CCDSiCCDS52684.1.
    RefSeqiNP_081198.1. NM_026922.1.
    UniGeneiMm.46251.

    Genome annotation databases

    EnsembliENSMUST00000095171; ENSMUSP00000092794; ENSMUSG00000034112.
    GeneIDi69047.
    KEGGimmu:69047.
    UCSCiuc009nqg.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF688288 mRNA. Translation: ABS18966.1 .
    AK220351 mRNA. Translation: BAD90414.1 .
    CCDSi CCDS52684.1.
    RefSeqi NP_081198.1. NM_026922.1.
    UniGenei Mm.46251.

    3D structure databases

    ProteinModelPortali A7L9Z8.
    SMRi A7L9Z8. Positions 59-926.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei A7L9Z8.

    Proteomic databases

    PaxDbi A7L9Z8.
    PRIDEi A7L9Z8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000095171 ; ENSMUSP00000092794 ; ENSMUSG00000034112 .
    GeneIDi 69047.
    KEGGi mmu:69047.
    UCSCi uc009nqg.1. mouse.

    Organism-specific databases

    CTDi 9914.
    MGIi MGI:1916297. Atp2c2.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG0474.
    GeneTreei ENSGT00560000076887.
    HOGENOMi HOG000265621.
    HOVERGENi HBG106478.
    InParanoidi Q5DU19.
    KOi K01537.
    OMAi RNRTFLY.
    OrthoDBi EOG7F7W81.
    PhylomeDBi A7L9Z8.
    TreeFami TF354251.

    Miscellaneous databases

    NextBioi 328462.
    PROi A7L9Z8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi A7L9Z8.
    Bgeei A7L9Z8.
    Genevestigatori A7L9Z8.

    Family and domain databases

    Gene3Di 1.20.1110.10. 3 hits.
    InterProi IPR006413. ATPase_P-typ_Ca-transp_PMR1.
    IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    Pfami PF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    PR00120. HATPASE.
    SMARTi SM00831. Cation_ATPase_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 2 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsi TIGR01522. ATPase-IIA2_Ca. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "SPCA2 of Mus musculus."
      Sepulveda M.R., Vanoevelen J., Raeymaekers L., Wuytack F.
      Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Swiss.
    2. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 88-897.
      Tissue: Brain.

    Entry informationi

    Entry nameiAT2C2_MOUSE
    AccessioniPrimary (citable) accession number: A7L9Z8
    Secondary accession number(s): Q5DU19
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 16, 2008
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3