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Protein

Calcium-transporting ATPase type 2C member 2

Gene

Atp2c2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.By similarity

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi330Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi331Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi333Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi335Calcium 2By similarity1
Active sitei3774-aspartylphosphate intermediateBy similarity1
Metal bindingi672MagnesiumBy similarity1
Metal bindingi676MagnesiumBy similarity1
Metal bindingi766Calcium 2By similarity1
Metal bindingi770Calcium 2By similarity1

GO - Molecular functioni

GO - Biological processi

  • mammary gland epithelium development Source: MGI
  • positive regulation of calcium ion import Source: MGI
  • protein targeting to plasma membrane Source: MGI

Keywordsi

Molecular functionHydrolase
Biological processCalcium transport, Ion transport, Transport
LigandATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPase type 2C member 2 (EC:3.6.3.8)
Short name:
ATPase 2C2
Alternative name(s):
Secretory pathway Ca(2+)-ATPase 2
Gene namesi
Name:Atp2c2
Synonyms:Kiaa0703, Spca2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1916297. Atp2c2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 104CytoplasmicSequence analysisAdd BLAST104
Transmembranei105 – 125Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini126 – 127ExtracellularSequence analysis2
Transmembranei128 – 148Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini149 – 229CytoplasmicSequence analysisAdd BLAST81
Transmembranei230 – 250Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini251 – 291ExtracellularSequence analysisAdd BLAST41
Transmembranei292 – 312Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini313 – 329CytoplasmicSequence analysisAdd BLAST17
Transmembranei330 – 350Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini351 – 748ExtracellularSequence analysisAdd BLAST398
Transmembranei749 – 769Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini770 – 802CytoplasmicSequence analysisAdd BLAST33
Transmembranei803 – 823Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini824 – 835ExtracellularSequence analysisAdd BLAST12
Transmembranei836 – 853Helical; Name=8Sequence analysisAdd BLAST18
Topological domaini854 – 872CytoplasmicSequence analysisAdd BLAST19
Transmembranei873 – 893Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini894 – 903ExtracellularSequence analysis10
Transmembranei904 – 924Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini925 – 944CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

  • cytoplasmic side of plasma membrane Source: MGI
  • cytoplasmic vesicle Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • perinuclear region of cytoplasm Source: MGI

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003561561 – 944Calcium-transporting ATPase type 2C member 2Add BLAST944

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei262PhosphothreonineBy similarity1
Modified residuei266PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiA7L9Z8.
PaxDbiA7L9Z8.
PeptideAtlasiA7L9Z8.
PRIDEiA7L9Z8.

PTM databases

PhosphoSitePlusiA7L9Z8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034112.
ExpressionAtlasiA7L9Z8. baseline and differential.
GenevisibleiA7L9Z8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092794.

Structurei

3D structure databases

ProteinModelPortaliA7L9Z8.
SMRiA7L9Z8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi112 – 117Poly-Leu6

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0202. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00890000139334.
HOGENOMiHOG000265621.
HOVERGENiHBG106478.
InParanoidiA7L9Z8.
KOiK01537.
OMAiPPECNCL.
OrthoDBiEOG091G0NXU.
PhylomeDBiA7L9Z8.
TreeFamiTF354251.

Family and domain databases

Gene3Di3.40.1110.10. 1 hit.
InterProiView protein in InterPro
IPR030334. ATP2C2.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006413. P-type_ATPase_IIA_PMR1.
IPR001757. P_typ_ATPase.
PANTHERiPTHR42861:SF5. PTHR42861:SF5. 1 hit.
PfamiView protein in Pfam
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PRINTSiPR00120. HATPASE.
SMARTiView protein in SMART
SM00831. Cation_ATPase_N. 1 hit.
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81653. SSF81653. 1 hit.
SSF81660. SSF81660. 1 hit.
SSF81665. SSF81665. 3 hits.
TIGRFAMsiTIGR01522. ATPase-IIA2_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.

Sequencei

Sequence statusi: Complete.

A7L9Z8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRRLKFLQK LAFLGQNHRY KALERDEVET LIDEQCELKA IEREKTVAAL
60 70 80 90 100
PPGEACKCSR EELARAFHVD LDSGLSEFAV AQRRLVHGWN EFVTDNAEPV
110 120 130 140 150
WKKYLDQFRN PLILLLLGSS VVSVLTKEYE DAVSIALAVL IVVTVGFIQE
160 170 180 190 200
YRSEKSLEEL TKLVPPECNC LRDGKLRHML ARDLVPGDIV SLSMGDRIPA
210 220 230 240 250
DIRLTEVTDL LVDESSFTGE VEPCGKTDSP LADGGDLSTL SNVVFMGTLV
260 270 280 290 300
QCGKGQGVVI GTGEQSQFGE VFKMMRAEET PKTPLQKSMD KLGKQLTIFS
310 320 330 340 350
FGIIGLLMLV GWVQGKPFLS MFTVGVSLAV AAIPEGLPIV VMVTLVLGVL
360 370 380 390 400
RMAKKRVIVK KLPIVETLGC CNVICSDKTG TLTANEMTAT QLVTSDGFHA
410 420 430 440 450
EVSGVGYSGE GTVCLLPSKE VIKGFDNVSV GKLVEAGCVA NNAVIRKNAV
460 470 480 490 500
MGQPTEGALV VLAMKMNLGS IKDSYVRKKE IPFSSEQKWM AVRCGPKSED
510 520 530 540 550
GEDIYFMKGA FEEVIHHCSM YNNGGIPLPL TPQQKSYCQQ EEKKMGSLGL
560 570 580 590 600
RVLALASGPE LGRLTFLGLV GIIDPPRAGV KEAVQVLSES GVSVKMVTGD
610 620 630 640 650
ALETALAIGR TIGLCNEKLK AMSGEEVEGT EQGALAARVR QVSVFFRTSP
660 670 680 690 700
KHKVKIIKAL QESGAIVAMT GDGVNDSVAL KSADIGIAMG QTGTDVSKEA
710 720 730 740 750
ANMILVDDDF SAIMSAVEEG KGIFYNIKNF VRFQLSTSIA ALSLITLSTV
760 770 780 790 800
CNLPSPLNAM QILWVNIIMD GPPAQSLGVE PVDRDALRRP PRSVGDTILN
810 820 830 840 850
RALILRVLMS AAVIIGGTLF IFWREIPANG TSTPRTTTMA FTCFVFFDLF
860 870 880 890 900
NALSCRSQTK LIFEIGFFRN RMFLYSVLGS LLGQLAVIYA PPLQKVFQTE
910 920 930 940
NLSALDLLLL TGLASSVFIL SELLKLWEKF LSRARPTQML PEAV
Length:944
Mass (Da):102,528
Last modified:September 11, 2007 - v1
Checksum:iB585BFFB96AAA375
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF688288 mRNA. Translation: ABS18966.1.
AK220351 mRNA. Translation: BAD90414.1.
CCDSiCCDS52684.1.
RefSeqiNP_081198.1. NM_026922.1.
UniGeneiMm.46251.

Genome annotation databases

EnsembliENSMUST00000095171; ENSMUSP00000092794; ENSMUSG00000034112.
GeneIDi69047.
KEGGimmu:69047.
UCSCiuc009nqg.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiAT2C2_MOUSE
AccessioniPrimary (citable) accession number: A7L9Z8
Secondary accession number(s): Q5DU19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: September 11, 2007
Last modified: August 30, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families