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Protein

Calcium-transporting ATPase type 2C member 2

Gene

Atp2c2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.By similarity

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi330Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi331Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi333Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi335Calcium 2By similarity1
Active sitei3774-aspartylphosphate intermediateBy similarity1
Metal bindingi672MagnesiumBy similarity1
Metal bindingi676MagnesiumBy similarity1
Metal bindingi766Calcium 2By similarity1
Metal bindingi770Calcium 2By similarity1

GO - Molecular functioni

GO - Biological processi

  • cellular calcium ion homeostasis Source: GO_Central
  • mammary gland epithelium development Source: MGI
  • positive regulation of calcium ion import Source: MGI
  • protein targeting to plasma membrane Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Calcium, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPase type 2C member 2 (EC:3.6.3.8)
Short name:
ATPase 2C2
Alternative name(s):
Secretory pathway Ca(2+)-ATPase 2
Gene namesi
Name:Atp2c2
Synonyms:Kiaa0703, Spca2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1916297. Atp2c2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 104CytoplasmicSequence analysisAdd BLAST104
Transmembranei105 – 125Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini126 – 127ExtracellularSequence analysis2
Transmembranei128 – 148Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini149 – 229CytoplasmicSequence analysisAdd BLAST81
Transmembranei230 – 250Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini251 – 291ExtracellularSequence analysisAdd BLAST41
Transmembranei292 – 312Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini313 – 329CytoplasmicSequence analysisAdd BLAST17
Transmembranei330 – 350Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini351 – 748ExtracellularSequence analysisAdd BLAST398
Transmembranei749 – 769Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini770 – 802CytoplasmicSequence analysisAdd BLAST33
Transmembranei803 – 823Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini824 – 835ExtracellularSequence analysisAdd BLAST12
Transmembranei836 – 853Helical; Name=8Sequence analysisAdd BLAST18
Topological domaini854 – 872CytoplasmicSequence analysisAdd BLAST19
Transmembranei873 – 893Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini894 – 903ExtracellularSequence analysis10
Transmembranei904 – 924Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini925 – 944CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

  • cytoplasmic side of plasma membrane Source: MGI
  • cytoplasmic vesicle Source: MGI
  • Golgi membrane Source: GO_Central
  • integral component of plasma membrane Source: GO_Central
  • perinuclear region of cytoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003561561 – 944Calcium-transporting ATPase type 2C member 2Add BLAST944

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei262PhosphothreonineBy similarity1
Modified residuei266PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA7L9Z8.
PeptideAtlasiA7L9Z8.
PRIDEiA7L9Z8.

PTM databases

PhosphoSitePlusiA7L9Z8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034112.
GenevisibleiA7L9Z8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092794.

Structurei

3D structure databases

ProteinModelPortaliA7L9Z8.
SMRiA7L9Z8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi112 – 117Poly-Leu6

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0202. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00850000132256.
HOGENOMiHOG000265621.
HOVERGENiHBG106478.
InParanoidiA7L9Z8.
KOiK01537.
OMAiWKEIPDG.
OrthoDBiEOG091G0NXU.
PhylomeDBiA7L9Z8.
TreeFamiTF354251.

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006413. P-type_ATPase_IIA_PMR1.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01522. ATPase-IIA2_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7L9Z8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRRLKFLQK LAFLGQNHRY KALERDEVET LIDEQCELKA IEREKTVAAL
60 70 80 90 100
PPGEACKCSR EELARAFHVD LDSGLSEFAV AQRRLVHGWN EFVTDNAEPV
110 120 130 140 150
WKKYLDQFRN PLILLLLGSS VVSVLTKEYE DAVSIALAVL IVVTVGFIQE
160 170 180 190 200
YRSEKSLEEL TKLVPPECNC LRDGKLRHML ARDLVPGDIV SLSMGDRIPA
210 220 230 240 250
DIRLTEVTDL LVDESSFTGE VEPCGKTDSP LADGGDLSTL SNVVFMGTLV
260 270 280 290 300
QCGKGQGVVI GTGEQSQFGE VFKMMRAEET PKTPLQKSMD KLGKQLTIFS
310 320 330 340 350
FGIIGLLMLV GWVQGKPFLS MFTVGVSLAV AAIPEGLPIV VMVTLVLGVL
360 370 380 390 400
RMAKKRVIVK KLPIVETLGC CNVICSDKTG TLTANEMTAT QLVTSDGFHA
410 420 430 440 450
EVSGVGYSGE GTVCLLPSKE VIKGFDNVSV GKLVEAGCVA NNAVIRKNAV
460 470 480 490 500
MGQPTEGALV VLAMKMNLGS IKDSYVRKKE IPFSSEQKWM AVRCGPKSED
510 520 530 540 550
GEDIYFMKGA FEEVIHHCSM YNNGGIPLPL TPQQKSYCQQ EEKKMGSLGL
560 570 580 590 600
RVLALASGPE LGRLTFLGLV GIIDPPRAGV KEAVQVLSES GVSVKMVTGD
610 620 630 640 650
ALETALAIGR TIGLCNEKLK AMSGEEVEGT EQGALAARVR QVSVFFRTSP
660 670 680 690 700
KHKVKIIKAL QESGAIVAMT GDGVNDSVAL KSADIGIAMG QTGTDVSKEA
710 720 730 740 750
ANMILVDDDF SAIMSAVEEG KGIFYNIKNF VRFQLSTSIA ALSLITLSTV
760 770 780 790 800
CNLPSPLNAM QILWVNIIMD GPPAQSLGVE PVDRDALRRP PRSVGDTILN
810 820 830 840 850
RALILRVLMS AAVIIGGTLF IFWREIPANG TSTPRTTTMA FTCFVFFDLF
860 870 880 890 900
NALSCRSQTK LIFEIGFFRN RMFLYSVLGS LLGQLAVIYA PPLQKVFQTE
910 920 930 940
NLSALDLLLL TGLASSVFIL SELLKLWEKF LSRARPTQML PEAV
Length:944
Mass (Da):102,528
Last modified:September 11, 2007 - v1
Checksum:iB585BFFB96AAA375
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF688288 mRNA. Translation: ABS18966.1.
AK220351 mRNA. Translation: BAD90414.1.
CCDSiCCDS52684.1.
RefSeqiNP_081198.1. NM_026922.1.
UniGeneiMm.46251.

Genome annotation databases

EnsembliENSMUST00000095171; ENSMUSP00000092794; ENSMUSG00000034112.
GeneIDi69047.
KEGGimmu:69047.
UCSCiuc009nqg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF688288 mRNA. Translation: ABS18966.1.
AK220351 mRNA. Translation: BAD90414.1.
CCDSiCCDS52684.1.
RefSeqiNP_081198.1. NM_026922.1.
UniGeneiMm.46251.

3D structure databases

ProteinModelPortaliA7L9Z8.
SMRiA7L9Z8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092794.

PTM databases

PhosphoSitePlusiA7L9Z8.

Proteomic databases

PaxDbiA7L9Z8.
PeptideAtlasiA7L9Z8.
PRIDEiA7L9Z8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095171; ENSMUSP00000092794; ENSMUSG00000034112.
GeneIDi69047.
KEGGimmu:69047.
UCSCiuc009nqg.1. mouse.

Organism-specific databases

CTDi9914.
MGIiMGI:1916297. Atp2c2.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0202. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00850000132256.
HOGENOMiHOG000265621.
HOVERGENiHBG106478.
InParanoidiA7L9Z8.
KOiK01537.
OMAiWKEIPDG.
OrthoDBiEOG091G0NXU.
PhylomeDBiA7L9Z8.
TreeFamiTF354251.

Enzyme and pathway databases

ReactomeiR-MMU-936837. Ion transport by P-type ATPases.

Miscellaneous databases

PROiA7L9Z8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034112.
GenevisibleiA7L9Z8. MM.

Family and domain databases

Gene3Di1.20.1110.10. 3 hits.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006413. P-type_ATPase_IIA_PMR1.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01522. ATPase-IIA2_Ca. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT2C2_MOUSE
AccessioniPrimary (citable) accession number: A7L9Z8
Secondary accession number(s): Q5DU19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: September 11, 2007
Last modified: November 2, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.