Calcium-transporting ATPase type 2C member 2

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A7L9Z8 (AT2C2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 46. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Calcium-transporting ATPase type 2C member 2
Short name=ATPase 2C2
EC=3.6.3.8

Alternative name(s):
Secretory pathway Ca(2+)-ATPase 2

Gene names

Name:	Atp2c2
Synonyms:	Kiaa0703, Spca2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	944 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium By similarity.
Catalytic activity	ATP + H₂O + Ca²⁺(Side 1) = ADP + phosphate + Ca²⁺(Side 2).
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. [View classification]

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Calcium Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calcium-transporting ATPase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 944

944

Calcium-transporting ATPase type 2C member 2

PRO_0000356156

Regions

Topological domain

1 – 104

104

Cytoplasmic Potential

Transmembrane

105 – 125

Helical; Name=1; Potential

Topological domain

126 – 127

Extracellular Potential

Transmembrane

128 – 148

Helical; Name=2; Potential

Topological domain

149 – 229

Cytoplasmic Potential

Transmembrane

230 – 250

Helical; Name=3; Potential

Topological domain

251 – 291

Extracellular Potential

Transmembrane

292 – 312

Helical; Name=4; Potential

Topological domain

313 – 329

Cytoplasmic Potential

Transmembrane

330 – 350

Helical; Name=5; Potential

Topological domain

351 – 748

398

Extracellular Potential

Transmembrane

749 – 769

Helical; Name=6; Potential

Topological domain

770 – 802

Cytoplasmic Potential

Transmembrane

803 – 823

Helical; Name=7; Potential

Topological domain

824 – 835

Extracellular Potential

Transmembrane

836 – 853

Helical; Name=8; Potential

Topological domain

854 – 872

Cytoplasmic Potential

Transmembrane

873 – 893

Helical; Name=9; Potential

Topological domain

894 – 903

Extracellular Potential

Transmembrane

904 – 924

Helical; Name=10; Potential

Topological domain

925 – 944

Cytoplasmic Potential

Compositional bias

112 – 117

Poly-Leu

Sites

Active site

377

4-aspartylphosphate intermediate By similarity

Metal binding

330

Calcium 2; via carbonyl oxygen By similarity

Metal binding

331

Calcium 2; via carbonyl oxygen By similarity

Metal binding

333

Calcium 2; via carbonyl oxygen By similarity

Metal binding

335

Calcium 2 By similarity

Metal binding

672

Magnesium By similarity

Metal binding

676

Magnesium By similarity

Metal binding

766

Calcium 2 By similarity

Metal binding

770

Calcium 2 By similarity

Amino acid modifications

Modified residue

262

Phosphothreonine By similarity

Modified residue

266

Phosphoserine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

A7L9Z8 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: B585BFFB96AAA375
Show »

FASTA

944

102,528

        10         20         30         40         50         60 
MGRRLKFLQK LAFLGQNHRY KALERDEVET LIDEQCELKA IEREKTVAAL PPGEACKCSR 

        70         80         90        100        110        120 
EELARAFHVD LDSGLSEFAV AQRRLVHGWN EFVTDNAEPV WKKYLDQFRN PLILLLLGSS 

       130        140        150        160        170        180 
VVSVLTKEYE DAVSIALAVL IVVTVGFIQE YRSEKSLEEL TKLVPPECNC LRDGKLRHML 

       190        200        210        220        230        240 
ARDLVPGDIV SLSMGDRIPA DIRLTEVTDL LVDESSFTGE VEPCGKTDSP LADGGDLSTL 

       250        260        270        280        290        300 
SNVVFMGTLV QCGKGQGVVI GTGEQSQFGE VFKMMRAEET PKTPLQKSMD KLGKQLTIFS 

       310        320        330        340        350        360 
FGIIGLLMLV GWVQGKPFLS MFTVGVSLAV AAIPEGLPIV VMVTLVLGVL RMAKKRVIVK 

       370        380        390        400        410        420 
KLPIVETLGC CNVICSDKTG TLTANEMTAT QLVTSDGFHA EVSGVGYSGE GTVCLLPSKE 

       430        440        450        460        470        480 
VIKGFDNVSV GKLVEAGCVA NNAVIRKNAV MGQPTEGALV VLAMKMNLGS IKDSYVRKKE 

       490        500        510        520        530        540 
IPFSSEQKWM AVRCGPKSED GEDIYFMKGA FEEVIHHCSM YNNGGIPLPL TPQQKSYCQQ 

       550        560        570        580        590        600 
EEKKMGSLGL RVLALASGPE LGRLTFLGLV GIIDPPRAGV KEAVQVLSES GVSVKMVTGD 

       610        620        630        640        650        660 
ALETALAIGR TIGLCNEKLK AMSGEEVEGT EQGALAARVR QVSVFFRTSP KHKVKIIKAL 

       670        680        690        700        710        720 
QESGAIVAMT GDGVNDSVAL KSADIGIAMG QTGTDVSKEA ANMILVDDDF SAIMSAVEEG 

       730        740        750        760        770        780 
KGIFYNIKNF VRFQLSTSIA ALSLITLSTV CNLPSPLNAM QILWVNIIMD GPPAQSLGVE 

       790        800        810        820        830        840 
PVDRDALRRP PRSVGDTILN RALILRVLMS AAVIIGGTLF IFWREIPANG TSTPRTTTMA 

       850        860        870        880        890        900 
FTCFVFFDLF NALSCRSQTK LIFEIGFFRN RMFLYSVLGS LLGQLAVIYA PPLQKVFQTE 

       910        920        930        940 
NLSALDLLLL TGLASSVFIL SELLKLWEKF LSRARPTQML PEAV

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"SPCA2 of Mus musculus." Sepulveda M.R., Vanoevelen J., Raeymaekers L., Wuytack F. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Swiss.
[2]	"Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H. Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 88-897. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EF688288 mRNA. Translation: ABS18966.1. AK220351 mRNA. Translation: BAD90414.1.
IPI	IPI00849112.
RefSeq	NP_081198.1. NM_026922.1.
UniGene	Mm.46251.
3D structure databases
ProteinModelPortal	A7L9Z8.
SMR	A7L9Z8. Positions 59-926.
ModBase	Search...
PTM databases
PhosphoSite	A7L9Z8.
Proteomic databases
PaxDb	A7L9Z8.
PRIDE	A7L9Z8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000095171; ENSMUSP00000092794; ENSMUSG00000034112.
GeneID	69047.
KEGG	mmu:69047.
UCSC	uc009nqg.1. mouse.
Organism-specific databases
CTD	9914.
MGI	MGI:1916297. Atp2c2.
Rouge	Search...
Phylogenomic databases
eggNOG	COG0474.
GeneTree	ENSGT00560000076887.
HOGENOM	HOG000265621.
HOVERGEN	HBG106478.
InParanoid	Q5DU19.
KO	K01537.
OMA	PPECNCL.
OrthoDB	EOG4THVSC.
Gene expression databases
ArrayExpress	A7L9Z8.
Bgee	A7L9Z8.
Genevestigator	A7L9Z8.
Family and domain databases
Gene3D	1.20.1110.10. 3 hits.
InterPro	IPR006413. ATPase_P-typ_Ca-transp_PMR1. IPR006068. ATPase_P-typ_cation-transptr_C. IPR004014. ATPase_P-typ_cation-transptr_N. IPR023299. ATPase_P-typ_cyto_domN. IPR018303. ATPase_P-typ_P_site. IPR023298. ATPase_P-typ_TM_dom. IPR008250. ATPase_P-typ_transduc_dom_A. IPR001757. Cation_transp_P_typ_ATPase. IPR023214. HAD-like_dom. [Graphical view]
PANTHER	PTHR24093. PTHR24093. 1 hit.
Pfam	PF00689. Cation_ATPase_C. 1 hit. PF00690. Cation_ATPase_N. 1 hit. PF00122. E1-E2_ATPase. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00120. HATPASE.
SMART	SM00831. Cation_ATPase_N. 1 hit. [Graphical view]
SUPFAM	SSF81660. ATPase_cation_domN. 1 hit. SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01522. ATPase-IIA2_Ca. 1 hit. TIGR01494. ATPase_P-type. 2 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	328462.
SOURCE	Search...

Entry information

Entry name

AT2C2_MOUSE

Accession

Primary (citable) accession number: A7L9Z8
Secondary accession number(s): Q5DU19

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 16, 2008
Last sequence update:	September 11, 2007
Last modified:	May 1, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents