Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Squalene epoxidase

Gene

sqle

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-SSC-191273. Cholesterol biosynthesis.
R-SSC-2426168. Activation of gene expression by SREBF (SREBP).

Names & Taxonomyi

Protein namesi
Submitted name:
Squalene epoxidaseImported
Gene namesi
Name:sqleImported
Synonyms:SQLEImported
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 4

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 42HelicalSequence analysisAdd BLAST23
Transmembranei63 – 81HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5436.

Expressioni

Gene expression databases

BgeeiENSSSCG00000005970.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000006378.

Structurei

3D structure databases

ProteinModelPortaliA7L861.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini277 – 548SEInterPro annotationAdd BLAST272

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1298. Eukaryota.
COG0654. LUCA.
GeneTreeiENSGT00390000011759.
HOGENOMiHOG000174713.
HOVERGENiHBG005603.
KOiK00511.
OMAiFRKEYLP.
OrthoDBiEOG091G03XY.
TreeFamiTF331056.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiView protein in InterPro
IPR023753. FAD/NAD-binding_dom.
IPR013698. Squalene_epoxidase.
PfamiView protein in Pfam
PF08491. SE. 1 hit.
SUPFAMiSSF51905. SSF51905. 2 hits.

Sequencei

Sequence statusi: Complete.

A7L861-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWTFLGIATF TYFYKKCGDF VSLANKELLL GVLVFLSLGL VLSYRCRYRN
60 70 80 90 100
GALLGRQQSG SQFAVFSDIL SALPLIGFFW AKSPTGSEKK EQLGSRRGKK
110 120 130 140 150
GSNISETTLV GAAASPLISS QNDPEIIIVG SGVLGSALAA VLSRDGRKVT
160 170 180 190 200
VIERDLKEPD RILGEYLQPG GCHVLKDLGL EDTMEGIDAQ VVDGYIIHDQ
210 220 230 240 250
ESKSEVQIPF PLSENNHVQS GRAFRHGRFI MGLRKAAMAE PNAKFIEGTV
260 270 280 290 300
LQLLEEEDVV LGVQYRDKET GDIKELHAPL TIVADGLFSK FRKNLISNKV
310 320 330 340 350
SVSSHFVGFL MENAPQFKAN HAELVLANPS PVLIYQISPS ETRVLVDIRG
360 370 380 390 400
EMPRNLREYM IENIYPQLPD HLKEPFLEAS QNSHLRSMPA SFLPSSPVNK
410 420 430 440 450
RGVLLLGDAH NMRHPLTGGG MTVAFNDIKL WRKLLKGIPD LYDDAAILQA
460 470 480 490 500
KKSFYWTRKM SHSFVVNVLA QALYELFSAT DDSLYQLRKA CFFYFKLGGE
510 520 530 540 550
CISGPVALIS VLSPNPLVLI GHFFAVAVYA TYFCFKSEPW ITKPRAIFSS
560 570
GAVLYRACSV LFPLIYSEIK YLVH
Length:574
Mass (Da):63,755
Last modified:September 11, 2007 - v1
Checksum:iE6DB88308F69593C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU407238 Genomic DNA. No translation available.
CU633319 Genomic DNA. No translation available.
EF683117 mRNA. Translation: ABS57428.1.
AB530156 mRNA. Translation: BAI48103.1.
RefSeqiNP_001094496.1. NM_001101026.1.
UniGeneiSsc.81599.

Genome annotation databases

EnsembliENSSSCT00000006553; ENSSSCP00000006378; ENSSSCG00000005970.
GeneIDi100113409.
KEGGissc:100113409.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU407238 Genomic DNA. No translation available.
CU633319 Genomic DNA. No translation available.
EF683117 mRNA. Translation: ABS57428.1.
AB530156 mRNA. Translation: BAI48103.1.
RefSeqiNP_001094496.1. NM_001101026.1.
UniGeneiSsc.81599.

3D structure databases

ProteinModelPortaliA7L861.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000006378.

Chemistry databases

ChEMBLiCHEMBL5436.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000006553; ENSSSCP00000006378; ENSSSCG00000005970.
GeneIDi100113409.
KEGGissc:100113409.

Organism-specific databases

CTDi6713.

Phylogenomic databases

eggNOGiKOG1298. Eukaryota.
COG0654. LUCA.
GeneTreeiENSGT00390000011759.
HOGENOMiHOG000174713.
HOVERGENiHBG005603.
KOiK00511.
OMAiFRKEYLP.
OrthoDBiEOG091G03XY.
TreeFamiTF331056.

Enzyme and pathway databases

ReactomeiR-SSC-191273. Cholesterol biosynthesis.
R-SSC-2426168. Activation of gene expression by SREBF (SREBP).

Gene expression databases

BgeeiENSSSCG00000005970.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiView protein in InterPro
IPR023753. FAD/NAD-binding_dom.
IPR013698. Squalene_epoxidase.
PfamiView protein in Pfam
PF08491. SE. 1 hit.
SUPFAMiSSF51905. SSF51905. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiA7L861_PIG
AccessioniPrimary (citable) accession number: A7L861
Entry historyiIntegrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: April 12, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.