A7KJJ7 (KA261_MESMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Potassium channel blocker alpha-KTx 26.1 Alternative name(s): Neurotoxin BmK86
Organism	Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)
Taxonomic identifier	34649 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Mesobuthus

Protein attributes

Sequence length	57 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Recombinant toxin that reversibly inhibits the potassium current of mKv1.3/KCNA3 channel stably expressed in COS7 cells (IC50 is 150 nM). Does not inhibit large conductance calcium-activated potassium channels (BK). Ref.1
Subcellular location	Secreted By similarity.
Tissue specificity	Expressed by the venom gland. Ref.1
Sequence similarities	Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 26 subfamily.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Ion channel impairing toxin Neurotoxin Potassium channel inhibitor Toxin
PTM	Disulfide bond
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	potassium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 57	35	Potassium channel blocker alpha-KTx 26.1		PRO_0000403831
Amino acid modifications
	Disulfide bond	30 ↔ 48		By similarity
	Disulfide bond	34 ↔ 53		By similarity
	Disulfide bond	38 ↔ 55		By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7KJJ7 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: 78DCE0B71784A712	FASTA	57	6,469
	10 20 30 40 50 MSRLFVFILI ALFLSAIIDV MSNFKVEGAC SKPCRKYCID KGARNGKCIN GRCHCYY

References

[1]

"Cloning and characterization of BmK86, a novel K(+)-channel blocker from scorpion venom." Mao X., Cao Z.-J., Yin S.-J., Ma Y., Wu Y.-L., Li W.-X. Biochem. Biophys. Res. Commun. 360:728-734(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY. Tissue: Venom gland.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EF457939 mRNA. Translation: ABR14604.1.
3D structure databases
ProteinModelPortal	A7KJJ7.
SMR	A7KJJ7. Positions 22-56.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.30.30.10. 1 hit.
InterPro	IPR003614. Scorpion_toxin-like. IPR001947. Scorpion_toxinS_K_inh. [Graphical view]
Pfam	PF00451. Toxin_2. 1 hit. [Graphical view]
SUPFAM	SSF57095. SSF57095. 1 hit.
PROSITE	PS01138. SCORP_SHORT_TOXIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KA261_MESMA

Accession

Primary (citable) accession number: A7KJJ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2011
Last sequence update:	September 11, 2007
Last modified:	May 1, 2013
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program