Reviewed, UniProtKB/Swiss-Prot A7KII6 (PB9LB_SALSA)

Names and origin

Protein names

Recommended name:
    Proteasome subunit beta type-9-B like protein
    EC=3.4.25.1
Alternative name(s):
    Low molecular mass protein 2-delta-B

Gene names

Name:	psmb9l-b
Synonyms:	lmp2-delta-b

Organism

Salmo salar (Atlantic salmon)

Taxonomic identifier

8030 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Protacanthopterygii › Salmoniformes › Salmonidae › Salmoninae › Salmo

Protein attributes

Sequence length	217 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides By similarity.
Catalytic activity	Cleavage of peptide bonds with very broad specificity.
Subunit structure	The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. This subunit is part of the immunoproteasome where it displaces the equivalent houskeeping subunit PSMB6 By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the peptidase T1B family.

Ontologies

Keywords
Biological process	Immune response
Cellular component	Cytoplasm Nucleus Proteasome
Molecular function	Hydrolase Protease Threonine protease
PTM	Zymogen
Gene Ontology (GO)
Biological process	immune response Inferred from electronic annotation. Source: UniProtKB-KW proteolysis involved in cellular protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell proteasome core complex Inferred from electronic annotation. Source: InterPro
Molecular function	threonine-type endopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – 18	18	By similarity		PRO_0000341326
	Chain	19 – 217	199	Proteasome subunit beta type-9-B like protein		PRO_0000341327
Sites
	Active site	17	1	Nucleophile By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7KII6-1 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: FA17D10CB66EBCE2	FASTA	217	23,208
	10 20 30 40 50 60 MERHFMDSQI KGVSTGTTIL AVTFNGGVII GSDSRASIGG SYVSSKTINK LIQVHDRIFC 70 80 90 100 110 120 CIAGSLADAQ AVTKAAKFQI SFHSIQMESP PLVKAAASVL KELCYNNKEE LQAGFITAGW 130 140 150 160 170 180 DRKKGPQVYT VALGGMLLSQ PFTIGGSGST YIYGYADAKY KPDMSKEECL QFATNALALA 190 200 210 MGRDNVSGGV AHLVVITEEG VEHVVIPGDK LPKFHDE

References

[1]

"Genomic organization of duplicated major histocompatibility complex class I regions in Atlantic salmon (Salmo salar)." Lukacs M.F., Harstad H., Grimholt U., Beetz-Sargent M., Cooper G.A., Reid L., Bakke H.G., Phillips R.B., Miller K.M., Davidson W.S., Koop B.F. BMC Genomics 8:251-251(2007) [PubMed: 17651474] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	EF427379 Genomic DNA. Translation: ABQ59652.1.
3D structure databases
ModBase	Search...
Protein family/group databases
MEROPS	T01.010.
Family and domain databases
InterPro	IPR000243. Pept_T1A_subB. IPR016050. Proteasome_bsu_CS. IPR001353. Proteasome_sua/b. [Graphical view]
Pfam	PF00227. Proteasome. 1 hit. [Graphical view]
PRINTS	PR00141. PROTEASOME.
PROSITE	PS00854. PROTEASOME_B. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PB9LB_SALSA

Accession

Primary (citable) accession number: A7KII6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	September 11, 2007
Last modified:	October 13, 2009
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)