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Protein

Rho GTPase-activating protein 32

Gene

ARHGAP32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity).By similarity7 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-194840. Rho GTPase cycle.
SignaLinkiA7KAX9.
SIGNORiA7KAX9.

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 32
Alternative name(s):
Brain-specific Rho GTPase-activating protein
GAB-associated Cdc42/Rac GTPase-activating protein
GC-GAP
GTPase regulator interacting with TrkA
Rho-type GTPase-activating protein 32
Rho/Cdc42/Rac GTPase-activating protein RICS
RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling
p200RhoGAP
p250GAP
Gene namesi
Name:ARHGAP32
Synonyms:GRIT, KIAA0712, RICS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:17399. ARHGAP32.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi173Y → A: Loss of binding to phospholipids. Cytoplasmic localization. 1 Publication1
Mutagenesisi407R → A: Mild effect on GAP activity and neurite-promotion upon nerve growth factor stimulation. 5 Publications1
Mutagenesisi407R → I: Loss of GAP activity. 5 Publications1
Mutagenesisi407R → M: Loss of GAP activity. In isoform 1, no inhibitory effect on neurite extension. 5 Publications1
Mutagenesisi447K → A: Loss of GAP activity. 1 Publication1

Organism-specific databases

DisGeNETi9743.
OpenTargetsiENSG00000134909.
PharmGKBiPA165543138.

Polymorphism and mutation databases

BioMutaiARHGAP32.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003452031 – 2087Rho GTPase-activating protein 32Add BLAST2087

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei706PhosphoserineCombined sources1
Modified residuei709PhosphoserineBy similarity1
Modified residuei732PhosphoserineBy similarity1
Modified residuei738PhosphoserineBy similarity1
Modified residuei852PhosphoserineBy similarity1
Modified residuei856PhosphoserineBy similarity1
Modified residuei892PhosphoserineCombined sources1
Modified residuei952PhosphoserineCombined sources1
Modified residuei1203PhosphoserineCombined sources1
Modified residuei1523Asymmetric dimethylarginineBy similarity1
Modified residuei1533Asymmetric dimethylarginineBy similarity1
Modified residuei1585PhosphoserineBy similarity1
Modified residuei2037Omega-N-methylarginineBy similarity1

Post-translational modificationi

Isoform 2 is phosphorylated on multiple tyrosine residues by FYN. Phosphorylated tyrosine residues undergo dephosphorylation after stimulation of NMDA receptors (By similarity). Phosphorylated in vitro by CaMK2 in the presence of calmodulin and calcium; which inhibits GAP activity (By similarity).By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

MaxQBiA7KAX9.
PaxDbiA7KAX9.
PRIDEiA7KAX9.

PTM databases

iPTMnetiA7KAX9.
PhosphoSitePlusiA7KAX9.

Expressioni

Tissue specificityi

Isoform 1 and isoform 2 are highly expressed in brain and testis. Isoform 1 is also expressed in other tissues such as lung, liver and spleen.1 Publication

Gene expression databases

BgeeiENSG00000134909.
ExpressionAtlasiA7KAX9. baseline and differential.
GenevisibleiA7KAX9. HS.

Organism-specific databases

HPAiHPA038382.
HPA038389.
HPA061505.

Interactioni

Subunit structurei

Interacts with NTRK1 (via cytoplasmic domain); the interaction is independent of the phosphorylation state of NTRK1. Interacts with SHC3 (via SH2 domain). Interacts with RASA1 (via SH3 domain); the interaction is necessary for the Ras activation and cell transforming activities of ARHGAP32 (By similarity). Interacts with GAB1 and GAB2. Interacts with CRK and CRKL. Found in a complex with CRKL and BCAR1; upon EGF stimulation BCAR1 may be replaced by EGFR. Interacts with NCK1 (via SH3 domain); NCK1 recruits phosphorylated BCAR1 to the complex. Isoform 2 interacts with FYN; the interaction appears to be dependent on tyrosine phosphorylation of ARHGAP32. Interacts with EGFR; the interaction requires EGF stimulation and is increased by SHC3. Interacts with CDC42; the interaction requires constitutively active CDC42. Interacts with CTNNB1, DLG4, CDH2 and GRIN2B (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ABI2Q9NYB93EBI-308663,EBI-743598
AESQ081173EBI-308663,EBI-717810
DZIP3Q86Y133EBI-308663,EBI-948630
FYNP062414EBI-308663,EBI-515315
LZTS2Q9BRK43EBI-308663,EBI-741037
MDFIQ997503EBI-308663,EBI-724076
NCK2O436393EBI-308663,EBI-713635

Protein-protein interaction databases

BioGridi115091. 41 interactors.
IntActiA7KAX9. 23 interactors.
MINTiMINT-268455.
STRINGi9606.ENSP00000310561.

Structurei

Secondary structure

12087
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi374 – 381Combined sources8
Helixi387 – 399Combined sources13
Turni403 – 407Combined sources5
Helixi412 – 423Combined sources12
Turni433 – 437Combined sources5
Helixi439 – 452Combined sources14
Turni460 – 462Combined sources3
Helixi463 – 470Combined sources8
Beta strandi472 – 474Combined sources3
Helixi475 – 486Combined sources12
Helixi491 – 508Combined sources18
Helixi511 – 514Combined sources4
Helixi518 – 529Combined sources12
Helixi553 – 561Combined sources9
Helixi563 – 566Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IUGX-ray1.77A/B367-577[»]
ProteinModelPortaliA7KAX9.
SMRiA7KAX9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA7KAX9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 245PX; atypicalAdd BLAST115
Domaini259 – 321SH3PROSITE-ProRule annotationAdd BLAST63
Domaini372 – 567Rho-GAPPROSITE-ProRule annotationAdd BLAST196

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1391 – 1711Interaction with GAB21 PublicationAdd BLAST321
Regioni1685 – 2087Interaction with FYN1 PublicationAdd BLAST403

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1031 – 1036Poly-Pro6
Compositional biasi1305 – 1310Poly-Pro6

Domaini

The N-terminal PX domain interacts specifically with phosphatidylinositides.By similarity

Sequence similaritiesi

Belongs to the PX domain-containing GAP family.Curated
Contains 1 PX (phox homology) domain.Curated
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG1449. Eukaryota.
ENOG410Y1FN. LUCA.
GeneTreeiENSGT00840000129752.
HOGENOMiHOG000090208.
HOVERGENiHBG108407.
InParanoidiA7KAX9.
KOiK20647.
OMAiYGTVQLR.
OrthoDBiEOG091G02IN.
PhylomeDBiA7KAX9.
TreeFamiTF351451.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00787. PX. 1 hit.
PF00620. RhoGAP. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A7KAX9-1) [UniParc]FASTAAdd to basket
Also known as: PX-RICS

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METESESSTL GDDSVFWLES EVIIQVTDCE EEEREEKFRK MKSSVHSEED
60 70 80 90 100
DFVPELHRNV HPRERPDWEE TLSAMARGAD VPEIPGDLTL KTCGSTASMK
110 120 130 140 150
VKHVKKLPFT KGHFPKMAEC AHFHYENVEF GSIQLSLSEE QNEVMKNGCE
160 170 180 190 200
SKELVYLVQI ACQGKSWIVK RSYEDFRVLD KHLHLCIYDR RFSQLSELPR
210 220 230 240 250
SDTLKDSPES VTQMLMAYLS RLSAIAGNKI NCGPALTWME IDNKGNHLLV
260 270 280 290 300
HEESSINTPA VGAAHVIKRY TARAPDELTL EVGDIVSVID MPPKVLSTWW
310 320 330 340 350
RGKHGFQVGL FPGHCVELIN QKVPQSVTNS VPKPVSKKHG KLITFLRTFM
360 370 380 390 400
KSRPTKQKLK QRGILKERVF GCDLGEHLLN SGFEVPQVLQ SCTAFIERYG
410 420 430 440 450
IVDGIYRLSG VASNIQRLRH EFDSEHVPDL TKEPYVQDIH SVGSLCKLYF
460 470 480 490 500
RELPNPLLTY QLYEKFSDAV SAATDEERLI KIHDVIQQLP PPHYRTLEFL
510 520 530 540 550
MRHLSLLADY CSITNMHAKN LAIVWAPNLL RSKQIESACF SGTAAFMEVR
560 570 580 590 600
IQSVVVEFIL NHVDVLFSGR ISMAMQEGAA SLSRPKSLLV SSPSTKLLTL
610 620 630 640 650
EEAQARTQAQ VNSPIVTENK YIEVGEGPAA LQGKFHTIIE FPLERKRPQN
660 670 680 690 700
KMKKSPVGSW RSFFNLGKSS SVSKRKLQRN ESEPSEMKAM ALKGGRAEGT
710 720 730 740 750
LRSAKSEESL TSLHAVDGDS KLFRPRRPRS SSDALSASFN GEMLGNRCNS
760 770 780 790 800
YDNLPHDNES EEEGGLLHIP ALMSPHSAED VDLSPPDIGV ASLDFDPMSF
810 820 830 840 850
QCSPPKAESE CLESGASFLD SPGYSKDKPS ANKKDAETGS SQCQTPGSTA
860 870 880 890 900
SSEPVSPLQE KLSPFFTLDL SPTEDKSSKP SSFTEKVVYA FSPKIGRKLS
910 920 930 940 950
KSPSMSISEP ISVTLPPRVS EVIGTVSNTT AQNASSSTWD KCVEERDATN
960 970 980 990 1000
RSPTQIVKMK TNETVAQEAY ESEVQPLDQV AAEEVELPGK EDQSVSSSQS
1010 1020 1030 1040 1050
KAVASGQTQT GAVTHDPPQD SVPVSSVSLI PPPPPPKNVA RMLALALAES
1060 1070 1080 1090 1100
AQQASTQSLK RPGTSQAGYT NYGDIAVATT EDNLSSSYSA VALDKAYFQT
1110 1120 1130 1140 1150
DRPAEQFHLQ NNAPGNCDHP LPETTATGDP THSNTTESGE QHHQVDLTGN
1160 1170 1180 1190 1200
QPHQAYLSGD PEKARITSVP LDSEKSDDHV SFPEDQSGKN SMPTVSFLDQ
1210 1220 1230 1240 1250
DQSPPRFYSG DQPPSYLGAS VDKLHHPLEF ADKSPTPPNL PSDKIYPPSG
1260 1270 1280 1290 1300
SPEENTSTAT MTYMTTTPAT AQMSTKEASW DVAEQPTTAD FAAATLQRTH
1310 1320 1330 1340 1350
RTNRPLPPPP SQRSAEQPPV VGQVQAATNI GLNNSHKVQG VVPVPERPPE
1360 1370 1380 1390 1400
PRAMDDPASA FISDSGAAAA QCPMATAVQP GLPEKVRDGA RVPLLHLRAE
1410 1420 1430 1440 1450
SVPAHPCGFP APLPPTRMME SKMIAAIHSS SADATSSSNY HSFVTASSTS
1460 1470 1480 1490 1500
VDDALPLPLP VPQPKHASQK TVYSSFARPD VTTEPFGPDN CLHFNMTPNC
1510 1520 1530 1540 1550
QYRPQSVPPH HNKLEQHQVY GARSEPPASM GLRYNTYVAP GRNASGHHSK
1560 1570 1580 1590 1600
PCSRVEYVSS LSSSVRNTCY PEDIPPYPTI RRVQSLHAPP SSMIRSVPIS
1610 1620 1630 1640 1650
RTEVPPDDEP AYCPRPLYQY KPYQSSQARS DYHVTQLQPY FENGRVHYRY
1660 1670 1680 1690 1700
SPYSSSSSSY YSPDGALCDV DAYGTVQLRP LHRLPNRDFA FYNPRLQGKS
1710 1720 1730 1740 1750
LYSYAGLAPR PRANVTGYFS PNDHNVVSMP PAADVKHTYT SWDLEDMEKY
1760 1770 1780 1790 1800
RMQSIRRESR ARQKVKGPVM SQYDNMTPAV QDDLGGIYVI HLRSKSDPGK
1810 1820 1830 1840 1850
TGLLSVAEGK ESRHAAKAIS PEGEDRFYRR HPEAEMDRAH HHGGHGSTQP
1860 1870 1880 1890 1900
EKPSLPQKQS SLRSRKLPDM GCSLPEHRAH QEASHRQFCE SKNGPPYPQG
1910 1920 1930 1940 1950
AGQLDYGSKG IPDTSEPVSY HNSGVKYAAS GQESLRLNHK EVRLSKEMER
1960 1970 1980 1990 2000
PWVRQPSAPE KHSRDCYKEE EHLTQSIVPP PKPERSHSLK LHHTQNVERD
2010 2020 2030 2040 2050
PSVLYQYQPH GKRQSSVTVV SQYDNLEDYH SLPQHQRGVF GGGGMGTYVP
2060 2070 2080
PGFPHPQSRT YATALGQGAF LPAELSLQHP ETQIHAE
Length:2,087
Mass (Da):230,529
Last modified:September 11, 2007 - v1
Checksum:i075E5B4902857D06
GO
Isoform 2 (identifier: A7KAX9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-349: Missing.

Show »
Length:1,738
Mass (Da):190,970
Checksum:i49B5C6F92BDE9A27
GO
Isoform 3 (identifier: A7KAX9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-290: Missing.
     567-612: FSGRISMAMQ...AQARTQAQVN → LPHFSARTEL...LVQITVCISI
     613-2087: Missing.

Show »
Length:322
Mass (Da):36,669
Checksum:iCE60526885AED792
GO

Sequence cautioni

The sequence BAA34432 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0349331 – 349Missing in isoform 2. 5 PublicationsAdd BLAST349
Alternative sequenceiVSP_0349341 – 290Missing in isoform 3. 1 PublicationAdd BLAST290
Alternative sequenceiVSP_034935567 – 612FSGRI…QAQVN → LPHFSARTELIVPFPLRLLR KQFTPPLLGPMSPLNPLVQI TVCISI in isoform 3. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_034936613 – 2087Missing in isoform 3. 1 PublicationAdd BLAST1475

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB079856 mRNA. Translation: BAC24802.1.
AY194287 mRNA. Translation: AAO43677.1.
AB088416 mRNA. Translation: BAM34446.1.
EF127492 mRNA. Translation: ABO33171.1.
AB018255 mRNA. Translation: BAA34432.2. Different initiation.
CH471065 Genomic DNA. Translation: EAW67740.1.
BC000277 mRNA. Translation: AAH00277.2.
BC104898 mRNA. Translation: AAI04899.1.
BC113429 mRNA. Translation: AAI13430.1.
CCDSiCCDS31718.1. [A7KAX9-2]
CCDS44769.1. [A7KAX9-1]
RefSeqiNP_001136157.1. NM_001142685.1. [A7KAX9-1]
NP_055530.2. NM_014715.3. [A7KAX9-2]
UniGeneiHs.440379.

Genome annotation databases

EnsembliENST00000310343; ENSP00000310561; ENSG00000134909. [A7KAX9-1]
ENST00000392657; ENSP00000376425; ENSG00000134909. [A7KAX9-2]
ENST00000527272; ENSP00000432862; ENSG00000134909. [A7KAX9-2]
GeneIDi9743.
KEGGihsa:9743.
UCSCiuc001qez.4. human. [A7KAX9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB079856 mRNA. Translation: BAC24802.1.
AY194287 mRNA. Translation: AAO43677.1.
AB088416 mRNA. Translation: BAM34446.1.
EF127492 mRNA. Translation: ABO33171.1.
AB018255 mRNA. Translation: BAA34432.2. Different initiation.
CH471065 Genomic DNA. Translation: EAW67740.1.
BC000277 mRNA. Translation: AAH00277.2.
BC104898 mRNA. Translation: AAI04899.1.
BC113429 mRNA. Translation: AAI13430.1.
CCDSiCCDS31718.1. [A7KAX9-2]
CCDS44769.1. [A7KAX9-1]
RefSeqiNP_001136157.1. NM_001142685.1. [A7KAX9-1]
NP_055530.2. NM_014715.3. [A7KAX9-2]
UniGeneiHs.440379.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IUGX-ray1.77A/B367-577[»]
ProteinModelPortaliA7KAX9.
SMRiA7KAX9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115091. 41 interactors.
IntActiA7KAX9. 23 interactors.
MINTiMINT-268455.
STRINGi9606.ENSP00000310561.

PTM databases

iPTMnetiA7KAX9.
PhosphoSitePlusiA7KAX9.

Polymorphism and mutation databases

BioMutaiARHGAP32.

Proteomic databases

MaxQBiA7KAX9.
PaxDbiA7KAX9.
PRIDEiA7KAX9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310343; ENSP00000310561; ENSG00000134909. [A7KAX9-1]
ENST00000392657; ENSP00000376425; ENSG00000134909. [A7KAX9-2]
ENST00000527272; ENSP00000432862; ENSG00000134909. [A7KAX9-2]
GeneIDi9743.
KEGGihsa:9743.
UCSCiuc001qez.4. human. [A7KAX9-1]

Organism-specific databases

CTDi9743.
DisGeNETi9743.
GeneCardsiARHGAP32.
H-InvDBHIX0010264.
HGNCiHGNC:17399. ARHGAP32.
HPAiHPA038382.
HPA038389.
HPA061505.
MIMi608541. gene.
neXtProtiNX_A7KAX9.
OpenTargetsiENSG00000134909.
PharmGKBiPA165543138.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1449. Eukaryota.
ENOG410Y1FN. LUCA.
GeneTreeiENSGT00840000129752.
HOGENOMiHOG000090208.
HOVERGENiHBG108407.
InParanoidiA7KAX9.
KOiK20647.
OMAiYGTVQLR.
OrthoDBiEOG091G02IN.
PhylomeDBiA7KAX9.
TreeFamiTF351451.

Enzyme and pathway databases

ReactomeiR-HSA-194840. Rho GTPase cycle.
SignaLinkiA7KAX9.
SIGNORiA7KAX9.

Miscellaneous databases

ChiTaRSiARHGAP32. human.
EvolutionaryTraceiA7KAX9.
GeneWikiiRICS_(gene).
GenomeRNAii9743.
PROiA7KAX9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134909.
ExpressionAtlasiA7KAX9. baseline and differential.
GenevisibleiA7KAX9. HS.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00787. PX. 1 hit.
PF00620. RhoGAP. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRHG32_HUMAN
AccessioniPrimary (citable) accession number: A7KAX9
Secondary accession number(s): I7H0B0
, O94820, Q86YL6, Q8IUG4, Q9BWG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: September 11, 2007
Last modified: November 30, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.