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A7KAU3

- S47A2_RABIT

UniProt

A7KAU3 - S47A2_RABIT

Protein

Multidrug and toxin extrusion protein 2

Gene

SLC47A2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes.1 Publication

    pH dependencei

    Optimum pH is 6.0.1 Publication

    GO - Molecular functioni

    1. antiporter activity Source: InterPro
    2. drug transmembrane transporter activity Source: InterPro

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Multidrug and toxin extrusion protein 2
    Short name:
    MATE-2
    Alternative name(s):
    Solute carrier family 47 member 2
    Gene namesi
    Name:SLC47A2
    Synonyms:MATE2
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    Membrane Curated; Multi-pass membrane protein Curated. Apical cell membrane Curated; Multi-pass membrane protein Curated
    Note: Predominantly found in the apical membrane of RPT cells.

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 601601Multidrug and toxin extrusion protein 2PRO_0000311954Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed in renal cortical tissues.1 Publication

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6262CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini84 – 9512ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini117 – 14529CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini167 – 18216ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini204 – 2129CytoplasmicSequence Analysis
    Topological domaini234 – 2418ExtracellularSequence Analysis
    Topological domaini263 – 28119CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini302 – 32019ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini342 – 36120CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini383 – 40220ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini424 – 43714CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini459 – 4591ExtracellularSequence Analysis
    Topological domaini481 – 57797CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini599 – 6013ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei63 – 8321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei96 – 11621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei146 – 16621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei183 – 20321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei213 – 23321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei242 – 26221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei282 – 30120HelicalSequence AnalysisAdd
    BLAST
    Transmembranei321 – 34121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei362 – 38221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei403 – 42321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei438 – 45821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei460 – 48021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei578 – 59821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi495 – 51016Gln-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0534.
    HOVERGENiHBG056043.

    Family and domain databases

    InterProiIPR002528. MATE.
    [Graphical view]
    PfamiPF01554. MatE. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00797. matE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7KAU3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNTAFAGFDE NRAGRRAPGC TGRPAFGLGM DSQQDVVNLD QGGCCPALRK    50
    LLPRGFWDEA RALFVLSGPL FLFQVLNFLT YVVGTVFCGH LGKVELASVT 100
    LGVAFVNVCG VSVGAGLSSA CDTLMSQSFG SPNKKHVGVI LQRGSLILLL 150
    CCLPCWALFL NTQHILLLFR QDPAVSRLTQ DYAMIFIPGL PAIFLYSLLA 200
    KYLQNQGIVW PQVLSGVVGN CVNGVANYAL VSVLNLGVRG SAYANTISQF 250
    VQAAFLFLHI VLKKLHLETW EGWSSQCLRD WGPFLSLAIP SMLMMCVEWW 300
    AYEIGSFLMG LLGVVDLSGQ AIIYEVATVV YMIPMGLGMA VCVRVGTALG 350
    AADTLQAKRS AVSGLLCTAG TSLVVGTLLG LLNSQLGYIF TSDEEVIALV 400
    NQVLPIYIVF QLVEAVCCVF GGVLRGTGKQ AFGAIVNAIM YYIVGLPLGI 450
    VLTFVVGMRI MGLWLGMLTC IFLAAVTFVV YAVQLDWKLA AEEAQKHAGL 500
    QQQQQQQQQQ GAECTAPSPG PDKAVVSSVA TGCNPGIALT MYSRPGCHVD 550
    FYGRPEAAPA PAAPASRLSV RQLLFRRGAA LAASVAVLMA GLLVRVLTTG 600
    Y 601
    Length:601
    Mass (Da):64,175
    Last modified:September 11, 2007 - v1
    Checksum:i571A84BF28E95F02
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF121852 mRNA. Translation: ABP96920.1.
    RefSeqiNP_001103290.2. NM_001109820.2.
    UniGeneiOcu.7286.

    Genome annotation databases

    GeneIDi100125996.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF121852 mRNA. Translation: ABP96920.1 .
    RefSeqi NP_001103290.2. NM_001109820.2.
    UniGenei Ocu.7286.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100125996.

    Organism-specific databases

    CTDi 146802.

    Phylogenomic databases

    eggNOGi COG0534.
    HOVERGENi HBG056043.

    Family and domain databases

    InterProi IPR002528. MATE.
    [Graphical view ]
    Pfami PF01554. MatE. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00797. matE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular identification and functional characterization of rabbit MATE1 and MATE2-K."
      Zhang X., Cherrington N.J., Wright S.H.
      Am. J. Physiol. 293:F360-F370(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, BIOPHYSICOCHEMICAL PROPERTIES, FUNCTION.

    Entry informationi

    Entry nameiS47A2_RABIT
    AccessioniPrimary (citable) accession number: A7KAU3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-30 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3