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A7KAU3 (S47A2_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Multidrug and toxin extrusion protein 2

Short name=MATE-2
Alternative name(s):
Solute carrier family 47 member 2
Gene names
Name:SLC47A2
Synonyms:MATE2
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length601 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes. Ref.1

Subcellular location

Membrane; Multi-pass membrane protein Potential. Apical cell membrane; Multi-pass membrane protein Potential. Note: Predominantly found in the apical membrane of RPT cells.

Tissue specificity

Expressed in renal cortical tissues. Ref.1

Sequence similarities

Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. [View classification]

Caution

It is uncertain whether Met-1 or Met-30 is the initiator.

Biophysicochemical properties

pH dependence:

Optimum pH is 6.0. Ref.1

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 601601Multidrug and toxin extrusion protein 2
PRO_0000311954

Regions

Topological domain1 – 6262Cytoplasmic Potential
Transmembrane63 – 8321Helical; Potential
Topological domain84 – 9512Extracellular Potential
Transmembrane96 – 11621Helical; Potential
Topological domain117 – 14529Cytoplasmic Potential
Transmembrane146 – 16621Helical; Potential
Topological domain167 – 18216Extracellular Potential
Transmembrane183 – 20321Helical; Potential
Topological domain204 – 2129Cytoplasmic Potential
Transmembrane213 – 23321Helical; Potential
Topological domain234 – 2418Extracellular Potential
Transmembrane242 – 26221Helical; Potential
Topological domain263 – 28119Cytoplasmic Potential
Transmembrane282 – 30120Helical; Potential
Topological domain302 – 32019Extracellular Potential
Transmembrane321 – 34121Helical; Potential
Topological domain342 – 36120Cytoplasmic Potential
Transmembrane362 – 38221Helical; Potential
Topological domain383 – 40220Extracellular Potential
Transmembrane403 – 42321Helical; Potential
Topological domain424 – 43714Cytoplasmic Potential
Transmembrane438 – 45821Helical; Potential
Topological domain4591Extracellular Potential
Transmembrane460 – 48021Helical; Potential
Topological domain481 – 57797Cytoplasmic Potential
Transmembrane578 – 59821Helical; Potential
Topological domain599 – 6013Extracellular Potential
Compositional bias495 – 51016Gln-rich

Sequences

Sequence LengthMass (Da)Tools
A7KAU3 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: 571A84BF28E95F02

FASTA60164,175
        10         20         30         40         50         60 
MNTAFAGFDE NRAGRRAPGC TGRPAFGLGM DSQQDVVNLD QGGCCPALRK LLPRGFWDEA 

        70         80         90        100        110        120 
RALFVLSGPL FLFQVLNFLT YVVGTVFCGH LGKVELASVT LGVAFVNVCG VSVGAGLSSA 

       130        140        150        160        170        180 
CDTLMSQSFG SPNKKHVGVI LQRGSLILLL CCLPCWALFL NTQHILLLFR QDPAVSRLTQ 

       190        200        210        220        230        240 
DYAMIFIPGL PAIFLYSLLA KYLQNQGIVW PQVLSGVVGN CVNGVANYAL VSVLNLGVRG 

       250        260        270        280        290        300 
SAYANTISQF VQAAFLFLHI VLKKLHLETW EGWSSQCLRD WGPFLSLAIP SMLMMCVEWW 

       310        320        330        340        350        360 
AYEIGSFLMG LLGVVDLSGQ AIIYEVATVV YMIPMGLGMA VCVRVGTALG AADTLQAKRS 

       370        380        390        400        410        420 
AVSGLLCTAG TSLVVGTLLG LLNSQLGYIF TSDEEVIALV NQVLPIYIVF QLVEAVCCVF 

       430        440        450        460        470        480 
GGVLRGTGKQ AFGAIVNAIM YYIVGLPLGI VLTFVVGMRI MGLWLGMLTC IFLAAVTFVV 

       490        500        510        520        530        540 
YAVQLDWKLA AEEAQKHAGL QQQQQQQQQQ GAECTAPSPG PDKAVVSSVA TGCNPGIALT 

       550        560        570        580        590        600 
MYSRPGCHVD FYGRPEAAPA PAAPASRLSV RQLLFRRGAA LAASVAVLMA GLLVRVLTTG 


Y 

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References

[1]"Molecular identification and functional characterization of rabbit MATE1 and MATE2-K."
Zhang X., Cherrington N.J., Wright S.H.
Am. J. Physiol. 293:F360-F370(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, BIOPHYSICOCHEMICAL PROPERTIES, FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EF121852 mRNA. Translation: ABP96920.1.
RefSeqNP_001103290.2. NM_001109820.2.
UniGeneOcu.7286.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100125996.

Phylogenomic databases

eggNOGCOG0534.
HOVERGENHBG056043.

Family and domain databases

InterProIPR002528. MATE.
[Graphical view]
PfamPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsTIGR00797. matE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameS47A2_RABIT
AccessionPrimary (citable) accession number: A7KAU3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: September 11, 2007
Last modified: February 19, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families