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Protein

Multidrug and toxin extrusion protein 2

Gene

SLC47A2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes.1 Publication

pH dependencei

Optimum pH is 6.0.1 Publication

GO - Molecular functioni

  1. antiporter activity Source: InterPro
  2. drug transmembrane transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug and toxin extrusion protein 2
Short name:
MATE-2
Alternative name(s):
Solute carrier family 47 member 2
Gene namesi
Name:SLC47A2
Synonyms:MATE2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

Membrane Curated; Multi-pass membrane protein Curated. Apical cell membrane Curated; Multi-pass membrane protein Curated
Note: Predominantly found in the apical membrane of RPT cells.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6262CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei63 – 8321HelicalSequence AnalysisAdd
BLAST
Topological domaini84 – 9512ExtracellularSequence AnalysisAdd
BLAST
Transmembranei96 – 11621HelicalSequence AnalysisAdd
BLAST
Topological domaini117 – 14529CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei146 – 16621HelicalSequence AnalysisAdd
BLAST
Topological domaini167 – 18216ExtracellularSequence AnalysisAdd
BLAST
Transmembranei183 – 20321HelicalSequence AnalysisAdd
BLAST
Topological domaini204 – 2129CytoplasmicSequence Analysis
Transmembranei213 – 23321HelicalSequence AnalysisAdd
BLAST
Topological domaini234 – 2418ExtracellularSequence Analysis
Transmembranei242 – 26221HelicalSequence AnalysisAdd
BLAST
Topological domaini263 – 28119CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei282 – 30120HelicalSequence AnalysisAdd
BLAST
Topological domaini302 – 32019ExtracellularSequence AnalysisAdd
BLAST
Transmembranei321 – 34121HelicalSequence AnalysisAdd
BLAST
Topological domaini342 – 36120CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei362 – 38221HelicalSequence AnalysisAdd
BLAST
Topological domaini383 – 40220ExtracellularSequence AnalysisAdd
BLAST
Transmembranei403 – 42321HelicalSequence AnalysisAdd
BLAST
Topological domaini424 – 43714CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei438 – 45821HelicalSequence AnalysisAdd
BLAST
Topological domaini459 – 4591ExtracellularSequence Analysis
Transmembranei460 – 48021HelicalSequence AnalysisAdd
BLAST
Topological domaini481 – 57797CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei578 – 59821HelicalSequence AnalysisAdd
BLAST
Topological domaini599 – 6013ExtracellularSequence Analysis

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 601601Multidrug and toxin extrusion protein 2PRO_0000311954Add
BLAST

Expressioni

Tissue specificityi

Expressed in renal cortical tissues.1 Publication

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi495 – 51016Gln-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0534.
HOVERGENiHBG056043.
InParanoidiA7KAU3.
KOiK03327.

Family and domain databases

InterProiIPR002528. MATE.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00797. matE. 1 hit.

Sequencei

Sequence statusi: Complete.

A7KAU3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNTAFAGFDE NRAGRRAPGC TGRPAFGLGM DSQQDVVNLD QGGCCPALRK
60 70 80 90 100
LLPRGFWDEA RALFVLSGPL FLFQVLNFLT YVVGTVFCGH LGKVELASVT
110 120 130 140 150
LGVAFVNVCG VSVGAGLSSA CDTLMSQSFG SPNKKHVGVI LQRGSLILLL
160 170 180 190 200
CCLPCWALFL NTQHILLLFR QDPAVSRLTQ DYAMIFIPGL PAIFLYSLLA
210 220 230 240 250
KYLQNQGIVW PQVLSGVVGN CVNGVANYAL VSVLNLGVRG SAYANTISQF
260 270 280 290 300
VQAAFLFLHI VLKKLHLETW EGWSSQCLRD WGPFLSLAIP SMLMMCVEWW
310 320 330 340 350
AYEIGSFLMG LLGVVDLSGQ AIIYEVATVV YMIPMGLGMA VCVRVGTALG
360 370 380 390 400
AADTLQAKRS AVSGLLCTAG TSLVVGTLLG LLNSQLGYIF TSDEEVIALV
410 420 430 440 450
NQVLPIYIVF QLVEAVCCVF GGVLRGTGKQ AFGAIVNAIM YYIVGLPLGI
460 470 480 490 500
VLTFVVGMRI MGLWLGMLTC IFLAAVTFVV YAVQLDWKLA AEEAQKHAGL
510 520 530 540 550
QQQQQQQQQQ GAECTAPSPG PDKAVVSSVA TGCNPGIALT MYSRPGCHVD
560 570 580 590 600
FYGRPEAAPA PAAPASRLSV RQLLFRRGAA LAASVAVLMA GLLVRVLTTG

Y
Length:601
Mass (Da):64,175
Last modified:September 11, 2007 - v1
Checksum:i571A84BF28E95F02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF121852 mRNA. Translation: ABP96920.1.
RefSeqiNP_001103290.2. NM_001109820.2.
UniGeneiOcu.7286.

Genome annotation databases

GeneIDi100125996.
KEGGiocu:100125996.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF121852 mRNA. Translation: ABP96920.1.
RefSeqiNP_001103290.2. NM_001109820.2.
UniGeneiOcu.7286.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100125996.
KEGGiocu:100125996.

Organism-specific databases

CTDi146802.

Phylogenomic databases

eggNOGiCOG0534.
HOVERGENiHBG056043.
InParanoidiA7KAU3.
KOiK03327.

Family and domain databases

InterProiIPR002528. MATE.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00797. matE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Molecular identification and functional characterization of rabbit MATE1 and MATE2-K."
    Zhang X., Cherrington N.J., Wright S.H.
    Am. J. Physiol. 293:F360-F370(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, BIOPHYSICOCHEMICAL PROPERTIES, FUNCTION.

Entry informationi

Entry nameiS47A2_RABIT
AccessioniPrimary (citable) accession number: A7KAU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: September 11, 2007
Last modified: February 4, 2015
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-30 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.