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Protein

Multidrug and toxin extrusion protein 2

Gene

SLC47A2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes.1 Publication

pH dependencei

Optimum pH is 6.0.1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug and toxin extrusion protein 2
Short name:
MATE-2
Alternative name(s):
Solute carrier family 47 member 2
Gene namesi
Name:SLC47A2
Synonyms:MATE2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 62CytoplasmicSequence analysisAdd BLAST62
Transmembranei63 – 83HelicalSequence analysisAdd BLAST21
Topological domaini84 – 95ExtracellularSequence analysisAdd BLAST12
Transmembranei96 – 116HelicalSequence analysisAdd BLAST21
Topological domaini117 – 145CytoplasmicSequence analysisAdd BLAST29
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Topological domaini167 – 182ExtracellularSequence analysisAdd BLAST16
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Topological domaini204 – 212CytoplasmicSequence analysis9
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Topological domaini234 – 241ExtracellularSequence analysis8
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Topological domaini263 – 281CytoplasmicSequence analysisAdd BLAST19
Transmembranei282 – 301HelicalSequence analysisAdd BLAST20
Topological domaini302 – 320ExtracellularSequence analysisAdd BLAST19
Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
Topological domaini342 – 361CytoplasmicSequence analysisAdd BLAST20
Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
Topological domaini383 – 402ExtracellularSequence analysisAdd BLAST20
Transmembranei403 – 423HelicalSequence analysisAdd BLAST21
Topological domaini424 – 437CytoplasmicSequence analysisAdd BLAST14
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459ExtracellularSequence analysis1
Transmembranei460 – 480HelicalSequence analysisAdd BLAST21
Topological domaini481 – 577CytoplasmicSequence analysisAdd BLAST97
Transmembranei578 – 598HelicalSequence analysisAdd BLAST21
Topological domaini599 – 601ExtracellularSequence analysis3

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003119541 – 601Multidrug and toxin extrusion protein 2Add BLAST601

Expressioni

Tissue specificityi

Expressed in renal cortical tissues.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000010244.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi495 – 510Gln-richAdd BLAST16

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1347. Eukaryota.
COG0534. LUCA.
HOVERGENiHBG056043.
InParanoidiA7KAU3.
KOiK03327.

Family and domain databases

InterProiIPR002528. MATE_fam.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00797. matE. 1 hit.

Sequencei

Sequence statusi: Complete.

A7KAU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTAFAGFDE NRAGRRAPGC TGRPAFGLGM DSQQDVVNLD QGGCCPALRK
60 70 80 90 100
LLPRGFWDEA RALFVLSGPL FLFQVLNFLT YVVGTVFCGH LGKVELASVT
110 120 130 140 150
LGVAFVNVCG VSVGAGLSSA CDTLMSQSFG SPNKKHVGVI LQRGSLILLL
160 170 180 190 200
CCLPCWALFL NTQHILLLFR QDPAVSRLTQ DYAMIFIPGL PAIFLYSLLA
210 220 230 240 250
KYLQNQGIVW PQVLSGVVGN CVNGVANYAL VSVLNLGVRG SAYANTISQF
260 270 280 290 300
VQAAFLFLHI VLKKLHLETW EGWSSQCLRD WGPFLSLAIP SMLMMCVEWW
310 320 330 340 350
AYEIGSFLMG LLGVVDLSGQ AIIYEVATVV YMIPMGLGMA VCVRVGTALG
360 370 380 390 400
AADTLQAKRS AVSGLLCTAG TSLVVGTLLG LLNSQLGYIF TSDEEVIALV
410 420 430 440 450
NQVLPIYIVF QLVEAVCCVF GGVLRGTGKQ AFGAIVNAIM YYIVGLPLGI
460 470 480 490 500
VLTFVVGMRI MGLWLGMLTC IFLAAVTFVV YAVQLDWKLA AEEAQKHAGL
510 520 530 540 550
QQQQQQQQQQ GAECTAPSPG PDKAVVSSVA TGCNPGIALT MYSRPGCHVD
560 570 580 590 600
FYGRPEAAPA PAAPASRLSV RQLLFRRGAA LAASVAVLMA GLLVRVLTTG

Y
Length:601
Mass (Da):64,175
Last modified:September 11, 2007 - v1
Checksum:i571A84BF28E95F02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF121852 mRNA. Translation: ABP96920.1.
RefSeqiNP_001103290.2. NM_001109820.2.
UniGeneiOcu.7286.

Genome annotation databases

GeneIDi100125996.
KEGGiocu:100125996.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF121852 mRNA. Translation: ABP96920.1.
RefSeqiNP_001103290.2. NM_001109820.2.
UniGeneiOcu.7286.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000010244.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100125996.
KEGGiocu:100125996.

Organism-specific databases

CTDi146802.

Phylogenomic databases

eggNOGiKOG1347. Eukaryota.
COG0534. LUCA.
HOVERGENiHBG056043.
InParanoidiA7KAU3.
KOiK03327.

Family and domain databases

InterProiIPR002528. MATE_fam.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00797. matE. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS47A2_RABIT
AccessioniPrimary (citable) accession number: A7KAU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: September 11, 2007
Last modified: November 11, 2015
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-30 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.