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A7KAU3

- S47A2_RABIT

UniProt

A7KAU3 - S47A2_RABIT

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Protein
Multidrug and toxin extrusion protein 2
Gene
SLC47A2, MATE2
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, and ganciclovir. Responsible for the secretion of cationic drugs across the brush border membranes.1 Publication

pH dependencei

Optimum pH is 6.0.1 Publication

GO - Molecular functioni

  1. antiporter activity Source: InterPro
  2. drug transmembrane transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug and toxin extrusion protein 2
Short name:
MATE-2
Alternative name(s):
Solute carrier family 47 member 2
Gene namesi
Name:SLC47A2
Synonyms:MATE2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

Membrane; Multi-pass membrane protein Reviewed prediction. Apical cell membrane; Multi-pass membrane protein Reviewed prediction
Note: Predominantly found in the apical membrane of RPT cells.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6262Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei63 – 8321Helical; Reviewed prediction
Add
BLAST
Topological domaini84 – 9512Extracellular Reviewed prediction
Add
BLAST
Transmembranei96 – 11621Helical; Reviewed prediction
Add
BLAST
Topological domaini117 – 14529Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei146 – 16621Helical; Reviewed prediction
Add
BLAST
Topological domaini167 – 18216Extracellular Reviewed prediction
Add
BLAST
Transmembranei183 – 20321Helical; Reviewed prediction
Add
BLAST
Topological domaini204 – 2129Cytoplasmic Reviewed prediction
Transmembranei213 – 23321Helical; Reviewed prediction
Add
BLAST
Topological domaini234 – 2418Extracellular Reviewed prediction
Transmembranei242 – 26221Helical; Reviewed prediction
Add
BLAST
Topological domaini263 – 28119Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei282 – 30120Helical; Reviewed prediction
Add
BLAST
Topological domaini302 – 32019Extracellular Reviewed prediction
Add
BLAST
Transmembranei321 – 34121Helical; Reviewed prediction
Add
BLAST
Topological domaini342 – 36120Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei362 – 38221Helical; Reviewed prediction
Add
BLAST
Topological domaini383 – 40220Extracellular Reviewed prediction
Add
BLAST
Transmembranei403 – 42321Helical; Reviewed prediction
Add
BLAST
Topological domaini424 – 43714Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei438 – 45821Helical; Reviewed prediction
Add
BLAST
Topological domaini459 – 4591Extracellular Reviewed prediction
Transmembranei460 – 48021Helical; Reviewed prediction
Add
BLAST
Topological domaini481 – 57797Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei578 – 59821Helical; Reviewed prediction
Add
BLAST
Topological domaini599 – 6013Extracellular Reviewed prediction

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 601601Multidrug and toxin extrusion protein 2
PRO_0000311954Add
BLAST

Expressioni

Tissue specificityi

Expressed in renal cortical tissues.1 Publication

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi495 – 51016Gln-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0534.
HOVERGENiHBG056043.

Family and domain databases

InterProiIPR002528. MATE.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00797. matE. 1 hit.

Sequencei

Sequence statusi: Complete.

A7KAU3-1 [UniParc]FASTAAdd to Basket

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MNTAFAGFDE NRAGRRAPGC TGRPAFGLGM DSQQDVVNLD QGGCCPALRK    50
LLPRGFWDEA RALFVLSGPL FLFQVLNFLT YVVGTVFCGH LGKVELASVT 100
LGVAFVNVCG VSVGAGLSSA CDTLMSQSFG SPNKKHVGVI LQRGSLILLL 150
CCLPCWALFL NTQHILLLFR QDPAVSRLTQ DYAMIFIPGL PAIFLYSLLA 200
KYLQNQGIVW PQVLSGVVGN CVNGVANYAL VSVLNLGVRG SAYANTISQF 250
VQAAFLFLHI VLKKLHLETW EGWSSQCLRD WGPFLSLAIP SMLMMCVEWW 300
AYEIGSFLMG LLGVVDLSGQ AIIYEVATVV YMIPMGLGMA VCVRVGTALG 350
AADTLQAKRS AVSGLLCTAG TSLVVGTLLG LLNSQLGYIF TSDEEVIALV 400
NQVLPIYIVF QLVEAVCCVF GGVLRGTGKQ AFGAIVNAIM YYIVGLPLGI 450
VLTFVVGMRI MGLWLGMLTC IFLAAVTFVV YAVQLDWKLA AEEAQKHAGL 500
QQQQQQQQQQ GAECTAPSPG PDKAVVSSVA TGCNPGIALT MYSRPGCHVD 550
FYGRPEAAPA PAAPASRLSV RQLLFRRGAA LAASVAVLMA GLLVRVLTTG 600
Y 601
Length:601
Mass (Da):64,175
Last modified:September 11, 2007 - v1
Checksum:i571A84BF28E95F02
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF121852 mRNA. Translation: ABP96920.1.
RefSeqiNP_001103290.2. NM_001109820.2.
UniGeneiOcu.7286.

Genome annotation databases

GeneIDi100125996.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF121852 mRNA. Translation: ABP96920.1 .
RefSeqi NP_001103290.2. NM_001109820.2.
UniGenei Ocu.7286.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100125996.

Phylogenomic databases

eggNOGi COG0534.
HOVERGENi HBG056043.

Family and domain databases

InterProi IPR002528. MATE.
[Graphical view ]
Pfami PF01554. MatE. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00797. matE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular identification and functional characterization of rabbit MATE1 and MATE2-K."
    Zhang X., Cherrington N.J., Wright S.H.
    Am. J. Physiol. 293:F360-F370(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, BIOPHYSICOCHEMICAL PROPERTIES, FUNCTION.

Entry informationi

Entry nameiS47A2_RABIT
AccessioniPrimary (citable) accession number: A7KAU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: September 11, 2007
Last modified: February 19, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-30 is the initiator.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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