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A7KAU2 (S47A1_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Multidrug and toxin extrusion protein 1

Short name=MATE-1
Alternative name(s):
Solute carrier family 47 member 1
Gene names
Name:SLC47A1
Synonyms:MATE1
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length568 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, procainamide. Responsible for the secretion of cationic drugs across the brush border membranes. Ref.1

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Note: Predominantly localized at the plasma membrane but also found in intracellular organelles By similarity.

Tissue specificity

Predominantly expressed in kidney and liver; restricted to the apical membrane or renal proximal tubule (RPT) cells and the canicular membrane of liver cells. Ref.1

Sequence similarities

Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. [View classification]

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 568568Multidrug and toxin extrusion protein 1
PRO_0000312848

Regions

Topological domain1 – 3636Cytoplasmic Potential
Transmembrane37 – 5721Helical; Potential
Topological domain58 – 7114Extracellular Potential
Transmembrane72 – 9221Helical; Potential
Topological domain93 – 11927Cytoplasmic Potential
Transmembrane120 – 14021Helical; Potential
Topological domain141 – 15111Extracellular Potential
Transmembrane152 – 17221Helical; Potential
Topological domain173 – 1753Cytoplasmic Potential
Transmembrane176 – 19621Helical; Potential
Topological domain197 – 21418Extracellular Potential
Transmembrane215 – 23521Helical; Potential
Topological domain236 – 25520Cytoplasmic Potential
Transmembrane256 – 27823Helical; Potential
Topological domain279 – 29416Extracellular Potential
Transmembrane295 – 31521Helical; Potential
Topological domain316 – 33520Cytoplasmic Potential
Transmembrane336 – 35621Helical; Potential
Topological domain357 – 36913Extracellular Potential
Transmembrane370 – 39021Helical; Potential
Topological domain391 – 40717Cytoplasmic Potential
Transmembrane408 – 43023Helical; Potential
Topological domain431 – 4333Extracellular Potential
Transmembrane434 – 45623Helical; Potential
Topological domain457 – 54488Cytoplasmic Potential
Transmembrane545 – 56521Helical; Potential
Topological domain566 – 5683Extracellular Potential

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Sequences

Sequence LengthMass (Da)Tools
A7KAU2 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: C8689E845DA7577A

FASTA56861,331
        10         20         30         40         50         60 
MEAPVELGPG GRQASPERRH WLRCLVLSDF REELRALLVL ACPAFLAQLM VFLISFVSSV 

        70         80         90        100        110        120 
FCGHLSKLEL NAVTLAIAVI NVMGVSVGFG LSSACDTLIS QTYGSRNLKH VGVILQRGSL 

       130        140        150        160        170        180 
ILLLCCLPCW ALFLNTQHIL LLFRQDPAVS RLTQTYVTIF IPALPATFLY TLQVKYLLNQ 

       190        200        210        220        230        240 
GIVLPQVVTG VAANLVNALA NYLFVYQLHL GVMGSALANT VAQFTLALLL FLYILRSKVY 

       250        260        270        280        290        300 
QATWGGWSLE CLQDWASFFR LAIPSMLMLC MEWWAYEIGS FLSGILGMVE LGAQSVTYEL 

       310        320        330        340        350        360 
AVIVYMIPMG LSVAVNVRVG NALGAGNIEQ AKKSSAVALL VTELIAVVFC VMLLSCKDLV 

       370        380        390        400        410        420 
GYIFTSDRDI IALVAQVTPI YAVSHLFESL AGTSGGILRG SGNQKFGAIV NAIGYYVVGL 

       430        440        450        460        470        480 
PIGIALMFAA KLGVIGLWLG IVVCAVSQAV CFLGFIARLN WTKACQQARV HANLTVNTAS 

       490        500        510        520        530        540 
NGNSAVLPDQ PHPVGPDSHG GIVLRDADRK EGAELNEQVH PELPLPVRPE DSAHLSGKQL 

       550        560 
ALRRGLLLLG VILVLLAGIL VKVYVRTQ 

« Hide

References

[1]"Molecular identification and functional characterization of rabbit MATE1 and MATE2-K."
Zhang X., Cherrington N.J., Wright S.H.
Am. J. Physiol. 293:F360-F370(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, BIOPHYSICOCHEMICAL PROPERTIES, FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EF120627 mRNA. Translation: ABO33757.1.
RefSeqNP_001103289.1. NM_001109819.1.
UniGeneOcu.7287.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000008643.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100125995.

Phylogenomic databases

eggNOGCOG0534.
HOGENOMHOG000060313.
HOVERGENHBG056043.

Family and domain databases

InterProIPR002528. MATE.
[Graphical view]
PfamPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsTIGR00797. matE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameS47A1_RABIT
AccessionPrimary (citable) accession number: A7KAU2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: September 11, 2007
Last modified: February 19, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families