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A7KAU2

- S47A1_RABIT

UniProt

A7KAU2 - S47A1_RABIT

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Protein

Multidrug and toxin extrusion protein 1

Gene

SLC47A1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, procainamide. Responsible for the secretion of cationic drugs across the brush border membranes.1 Publication

GO - Molecular functioni

  1. antiporter activity Source: InterPro
  2. drug transmembrane transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug and toxin extrusion protein 1
Short name:
MATE-1
Alternative name(s):
Solute carrier family 47 member 1
Gene namesi
Name:SLC47A1
Synonyms:MATE1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity
Note: Predominantly localized at the plasma membrane but also found in intracellular organelles.By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568Multidrug and toxin extrusion protein 1PRO_0000312848Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Expressioni

Tissue specificityi

Predominantly expressed in kidney and liver; restricted to the apical membrane or renal proximal tubule (RPT) cells and the canicular membrane of liver cells.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000008643.

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini58 – 7114ExtracellularSequence AnalysisAdd
BLAST
Topological domaini93 – 11927CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini141 – 15111ExtracellularSequence AnalysisAdd
BLAST
Topological domaini173 – 1753CytoplasmicSequence Analysis
Topological domaini197 – 21418ExtracellularSequence AnalysisAdd
BLAST
Topological domaini236 – 25520CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini279 – 29416ExtracellularSequence AnalysisAdd
BLAST
Topological domaini316 – 33520CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini357 – 36913ExtracellularSequence AnalysisAdd
BLAST
Topological domaini391 – 40717CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini431 – 4333ExtracellularSequence Analysis
Topological domaini457 – 54488CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini566 – 5683ExtracellularSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei37 – 5721HelicalSequence AnalysisAdd
BLAST
Transmembranei72 – 9221HelicalSequence AnalysisAdd
BLAST
Transmembranei120 – 14021HelicalSequence AnalysisAdd
BLAST
Transmembranei152 – 17221HelicalSequence AnalysisAdd
BLAST
Transmembranei176 – 19621HelicalSequence AnalysisAdd
BLAST
Transmembranei215 – 23521HelicalSequence AnalysisAdd
BLAST
Transmembranei256 – 27823HelicalSequence AnalysisAdd
BLAST
Transmembranei295 – 31521HelicalSequence AnalysisAdd
BLAST
Transmembranei336 – 35621HelicalSequence AnalysisAdd
BLAST
Transmembranei370 – 39021HelicalSequence AnalysisAdd
BLAST
Transmembranei408 – 43023HelicalSequence AnalysisAdd
BLAST
Transmembranei434 – 45623HelicalSequence AnalysisAdd
BLAST
Transmembranei545 – 56521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0534.
HOGENOMiHOG000060313.
HOVERGENiHBG056043.
InParanoidiA7KAU2.

Family and domain databases

InterProiIPR002528. MATE.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00797. matE. 1 hit.

Sequencei

Sequence statusi: Complete.

A7KAU2 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEAPVELGPG GRQASPERRH WLRCLVLSDF REELRALLVL ACPAFLAQLM
60 70 80 90 100
VFLISFVSSV FCGHLSKLEL NAVTLAIAVI NVMGVSVGFG LSSACDTLIS
110 120 130 140 150
QTYGSRNLKH VGVILQRGSL ILLLCCLPCW ALFLNTQHIL LLFRQDPAVS
160 170 180 190 200
RLTQTYVTIF IPALPATFLY TLQVKYLLNQ GIVLPQVVTG VAANLVNALA
210 220 230 240 250
NYLFVYQLHL GVMGSALANT VAQFTLALLL FLYILRSKVY QATWGGWSLE
260 270 280 290 300
CLQDWASFFR LAIPSMLMLC MEWWAYEIGS FLSGILGMVE LGAQSVTYEL
310 320 330 340 350
AVIVYMIPMG LSVAVNVRVG NALGAGNIEQ AKKSSAVALL VTELIAVVFC
360 370 380 390 400
VMLLSCKDLV GYIFTSDRDI IALVAQVTPI YAVSHLFESL AGTSGGILRG
410 420 430 440 450
SGNQKFGAIV NAIGYYVVGL PIGIALMFAA KLGVIGLWLG IVVCAVSQAV
460 470 480 490 500
CFLGFIARLN WTKACQQARV HANLTVNTAS NGNSAVLPDQ PHPVGPDSHG
510 520 530 540 550
GIVLRDADRK EGAELNEQVH PELPLPVRPE DSAHLSGKQL ALRRGLLLLG
560
VILVLLAGIL VKVYVRTQ
Length:568
Mass (Da):61,331
Last modified:September 11, 2007 - v1
Checksum:iC8689E845DA7577A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF120627 mRNA. Translation: ABO33757.1.
RefSeqiNP_001103289.1. NM_001109819.1.
UniGeneiOcu.7287.

Genome annotation databases

GeneIDi100125995.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF120627 mRNA. Translation: ABO33757.1 .
RefSeqi NP_001103289.1. NM_001109819.1.
UniGenei Ocu.7287.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000008643.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100125995.

Phylogenomic databases

eggNOGi COG0534.
HOGENOMi HOG000060313.
HOVERGENi HBG056043.
InParanoidi A7KAU2.

Family and domain databases

InterProi IPR002528. MATE.
[Graphical view ]
Pfami PF01554. MatE. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00797. matE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular identification and functional characterization of rabbit MATE1 and MATE2-K."
    Zhang X., Cherrington N.J., Wright S.H.
    Am. J. Physiol. 293:F360-F370(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, BIOPHYSICOCHEMICAL PROPERTIES, FUNCTION.

Entry informationi

Entry nameiS47A1_RABIT
AccessioniPrimary (citable) accession number: A7KAU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: September 11, 2007
Last modified: October 29, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3