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A7KAU2

- S47A1_RABIT

UniProt

A7KAU2 - S47A1_RABIT

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Protein
Multidrug and toxin extrusion protein 1
Gene
SLC47A1, MATE1
Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, procainamide. Responsible for the secretion of cationic drugs across the brush border membranes.1 Publication

GO - Molecular functioni

  1. antiporter activity Source: InterPro
  2. drug transmembrane transporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug and toxin extrusion protein 1
Short name:
MATE-1
Alternative name(s):
Solute carrier family 47 member 1
Gene namesi
Name:SLC47A1
Synonyms:MATE1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

Cell membrane; Multi-pass membrane protein By similarity
Note: Predominantly localized at the plasma membrane but also found in intracellular organelles By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei37 – 5721Helical; Reviewed prediction
Add
BLAST
Topological domaini58 – 7114Extracellular Reviewed prediction
Add
BLAST
Transmembranei72 – 9221Helical; Reviewed prediction
Add
BLAST
Topological domaini93 – 11927Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei120 – 14021Helical; Reviewed prediction
Add
BLAST
Topological domaini141 – 15111Extracellular Reviewed prediction
Add
BLAST
Transmembranei152 – 17221Helical; Reviewed prediction
Add
BLAST
Topological domaini173 – 1753Cytoplasmic Reviewed prediction
Transmembranei176 – 19621Helical; Reviewed prediction
Add
BLAST
Topological domaini197 – 21418Extracellular Reviewed prediction
Add
BLAST
Transmembranei215 – 23521Helical; Reviewed prediction
Add
BLAST
Topological domaini236 – 25520Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei256 – 27823Helical; Reviewed prediction
Add
BLAST
Topological domaini279 – 29416Extracellular Reviewed prediction
Add
BLAST
Transmembranei295 – 31521Helical; Reviewed prediction
Add
BLAST
Topological domaini316 – 33520Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei336 – 35621Helical; Reviewed prediction
Add
BLAST
Topological domaini357 – 36913Extracellular Reviewed prediction
Add
BLAST
Transmembranei370 – 39021Helical; Reviewed prediction
Add
BLAST
Topological domaini391 – 40717Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei408 – 43023Helical; Reviewed prediction
Add
BLAST
Topological domaini431 – 4333Extracellular Reviewed prediction
Transmembranei434 – 45623Helical; Reviewed prediction
Add
BLAST
Topological domaini457 – 54488Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei545 – 56521Helical; Reviewed prediction
Add
BLAST
Topological domaini566 – 5683Extracellular Reviewed prediction

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568Multidrug and toxin extrusion protein 1
PRO_0000312848Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity

Keywords - PTMi

Acetylation

Expressioni

Tissue specificityi

Predominantly expressed in kidney and liver; restricted to the apical membrane or renal proximal tubule (RPT) cells and the canicular membrane of liver cells.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000008643.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0534.
HOGENOMiHOG000060313.
HOVERGENiHBG056043.

Family and domain databases

InterProiIPR002528. MATE.
[Graphical view]
PfamiPF01554. MatE. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00797. matE. 1 hit.

Sequencei

Sequence statusi: Complete.

A7KAU2-1 [UniParc]FASTAAdd to Basket

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MEAPVELGPG GRQASPERRH WLRCLVLSDF REELRALLVL ACPAFLAQLM    50
VFLISFVSSV FCGHLSKLEL NAVTLAIAVI NVMGVSVGFG LSSACDTLIS 100
QTYGSRNLKH VGVILQRGSL ILLLCCLPCW ALFLNTQHIL LLFRQDPAVS 150
RLTQTYVTIF IPALPATFLY TLQVKYLLNQ GIVLPQVVTG VAANLVNALA 200
NYLFVYQLHL GVMGSALANT VAQFTLALLL FLYILRSKVY QATWGGWSLE 250
CLQDWASFFR LAIPSMLMLC MEWWAYEIGS FLSGILGMVE LGAQSVTYEL 300
AVIVYMIPMG LSVAVNVRVG NALGAGNIEQ AKKSSAVALL VTELIAVVFC 350
VMLLSCKDLV GYIFTSDRDI IALVAQVTPI YAVSHLFESL AGTSGGILRG 400
SGNQKFGAIV NAIGYYVVGL PIGIALMFAA KLGVIGLWLG IVVCAVSQAV 450
CFLGFIARLN WTKACQQARV HANLTVNTAS NGNSAVLPDQ PHPVGPDSHG 500
GIVLRDADRK EGAELNEQVH PELPLPVRPE DSAHLSGKQL ALRRGLLLLG 550
VILVLLAGIL VKVYVRTQ 568
Length:568
Mass (Da):61,331
Last modified:September 11, 2007 - v1
Checksum:iC8689E845DA7577A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF120627 mRNA. Translation: ABO33757.1.
RefSeqiNP_001103289.1. NM_001109819.1.
UniGeneiOcu.7287.

Genome annotation databases

GeneIDi100125995.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF120627 mRNA. Translation: ABO33757.1 .
RefSeqi NP_001103289.1. NM_001109819.1.
UniGenei Ocu.7287.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000008643.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100125995.

Phylogenomic databases

eggNOGi COG0534.
HOGENOMi HOG000060313.
HOVERGENi HBG056043.

Family and domain databases

InterProi IPR002528. MATE.
[Graphical view ]
Pfami PF01554. MatE. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00797. matE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular identification and functional characterization of rabbit MATE1 and MATE2-K."
    Zhang X., Cherrington N.J., Wright S.H.
    Am. J. Physiol. 293:F360-F370(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, BIOPHYSICOCHEMICAL PROPERTIES, FUNCTION.

Entry informationi

Entry nameiS47A1_RABIT
AccessioniPrimary (citable) accession number: A7KAU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: September 11, 2007
Last modified: February 19, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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