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A7KAU2

- S47A1_RABIT

UniProt

A7KAU2 - S47A1_RABIT

Protein

Multidrug and toxin extrusion protein 1

Gene

SLC47A1

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, procainamide. Responsible for the secretion of cationic drugs across the brush border membranes.1 Publication

    GO - Molecular functioni

    1. antiporter activity Source: InterPro
    2. drug transmembrane transporter activity Source: InterPro

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Multidrug and toxin extrusion protein 1
    Short name:
    MATE-1
    Alternative name(s):
    Solute carrier family 47 member 1
    Gene namesi
    Name:SLC47A1
    Synonyms:MATE1
    OrganismiOryctolagus cuniculus (Rabbit)
    Taxonomic identifieri9986 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
    ProteomesiUP000001811: Unplaced

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity
    Note: Predominantly localized at the plasma membrane but also found in intracellular organelles.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 568568Multidrug and toxin extrusion protein 1PRO_0000312848Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Expressioni

    Tissue specificityi

    Predominantly expressed in kidney and liver; restricted to the apical membrane or renal proximal tubule (RPT) cells and the canicular membrane of liver cells.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi9986.ENSOCUP00000008643.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3636CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini58 – 7114ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini93 – 11927CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini141 – 15111ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini173 – 1753CytoplasmicSequence Analysis
    Topological domaini197 – 21418ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini236 – 25520CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini279 – 29416ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini316 – 33520CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini357 – 36913ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini391 – 40717CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini431 – 4333ExtracellularSequence Analysis
    Topological domaini457 – 54488CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini566 – 5683ExtracellularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei37 – 5721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei72 – 9221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei120 – 14021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei152 – 17221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei176 – 19621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei215 – 23521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei256 – 27823HelicalSequence AnalysisAdd
    BLAST
    Transmembranei295 – 31521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei336 – 35621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei370 – 39021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei408 – 43023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei434 – 45623HelicalSequence AnalysisAdd
    BLAST
    Transmembranei545 – 56521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0534.
    HOGENOMiHOG000060313.
    HOVERGENiHBG056043.

    Family and domain databases

    InterProiIPR002528. MATE.
    [Graphical view]
    PfamiPF01554. MatE. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00797. matE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A7KAU2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEAPVELGPG GRQASPERRH WLRCLVLSDF REELRALLVL ACPAFLAQLM    50
    VFLISFVSSV FCGHLSKLEL NAVTLAIAVI NVMGVSVGFG LSSACDTLIS 100
    QTYGSRNLKH VGVILQRGSL ILLLCCLPCW ALFLNTQHIL LLFRQDPAVS 150
    RLTQTYVTIF IPALPATFLY TLQVKYLLNQ GIVLPQVVTG VAANLVNALA 200
    NYLFVYQLHL GVMGSALANT VAQFTLALLL FLYILRSKVY QATWGGWSLE 250
    CLQDWASFFR LAIPSMLMLC MEWWAYEIGS FLSGILGMVE LGAQSVTYEL 300
    AVIVYMIPMG LSVAVNVRVG NALGAGNIEQ AKKSSAVALL VTELIAVVFC 350
    VMLLSCKDLV GYIFTSDRDI IALVAQVTPI YAVSHLFESL AGTSGGILRG 400
    SGNQKFGAIV NAIGYYVVGL PIGIALMFAA KLGVIGLWLG IVVCAVSQAV 450
    CFLGFIARLN WTKACQQARV HANLTVNTAS NGNSAVLPDQ PHPVGPDSHG 500
    GIVLRDADRK EGAELNEQVH PELPLPVRPE DSAHLSGKQL ALRRGLLLLG 550
    VILVLLAGIL VKVYVRTQ 568
    Length:568
    Mass (Da):61,331
    Last modified:September 11, 2007 - v1
    Checksum:iC8689E845DA7577A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF120627 mRNA. Translation: ABO33757.1.
    RefSeqiNP_001103289.1. NM_001109819.1.
    UniGeneiOcu.7287.

    Genome annotation databases

    GeneIDi100125995.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF120627 mRNA. Translation: ABO33757.1 .
    RefSeqi NP_001103289.1. NM_001109819.1.
    UniGenei Ocu.7287.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9986.ENSOCUP00000008643.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100125995.

    Phylogenomic databases

    eggNOGi COG0534.
    HOGENOMi HOG000060313.
    HOVERGENi HBG056043.

    Family and domain databases

    InterProi IPR002528. MATE.
    [Graphical view ]
    Pfami PF01554. MatE. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00797. matE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular identification and functional characterization of rabbit MATE1 and MATE2-K."
      Zhang X., Cherrington N.J., Wright S.H.
      Am. J. Physiol. 293:F360-F370(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, BIOPHYSICOCHEMICAL PROPERTIES, FUNCTION.

    Entry informationi

    Entry nameiS47A1_RABIT
    AccessioniPrimary (citable) accession number: A7KAU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3