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Protein

Sterol 3-beta-glucosyltransferase

Gene

atg26

Organism
Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May be involved in decane metabolism and autophagy. Involved in the biosynthesis of sterol glucoside (By similarity).By similarity1 Publication

Catalytic activityi

UDP-glucose + a sterol = UDP + a sterol 3-beta-D-glucoside.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Autophagy, Lipid biosynthesis, Lipid metabolism, Protein transport, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism, Transport

Enzyme and pathway databases

BioCyciPCHR:PC12G16190-MONOMER.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
Sterol 3-beta-glucosyltransferase (EC:2.4.1.173)
Alternative name(s):
Autophagy-related protein 26
Gene namesi
Name:atg26
ORF Names:Pc12g16190
OrganismiPenicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum)
Taxonomic identifieri500485 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaePenicilliumPenicillium chrysogenum complex
Proteomesi
  • UP000000724 Componenti: Contig Pc00c12

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13741374Sterol 3-beta-glucosyltransferasePRO_0000318045Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi500485.XP_002558417.1.

Structurei

3D structure databases

ProteinModelPortaliA7KAN4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini234 – 28350GRAM 1Add
BLAST
Domaini285 – 38298PHPROSITE-ProRule annotationAdd
BLAST
Domaini704 – 77067GRAM 2Add
BLAST

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family.Curated
Contains 2 GRAM domains.Curated
Contains 1 PH domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
HOGENOMiHOG000034145.
KOiK05841.
OMAiWEATHSE.
OrthoDBiEOG092C09PF.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR004276. GlycoTrans_28_N.
IPR004182. GRAM.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF03033. Glyco_transf_28. 1 hit.
PF02893. GRAM. 2 hits.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00568. GRAM. 2 hits.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A7KAN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPLRDDAKR RADRQLSASM KPTSSNRPFS DRVPDRFKDG DDAQFDFTAP
60 70 80 90 100
PRGMGSRDGN VHYMQQSLFS MIAAVGSKSD FHARFDESSD SDGEMEEQPR
110 120 130 140 150
VEQTTGKASS RTPPVPSLDP RQPSKRSEPS KLVLEERGRR HQRACSDNKL
160 170 180 190 200
LQRLPKSDAE GGVNESSNQS DSLLKVPPLR RTRSATPRAA PVLSRMVEAQ
210 220 230 240 250
SHFDLTSATP YLPPNNPDKS MEDQPQSSAS ALSMRLMKMF EFAKPEKVLV
260 270 280 290 300
EYACSLLQSM LLQGYMYVTE GHICFYAYLP KKSNVAIKSG YLSKRGRKNP
310 320 330 340 350
KYHRYWFALK GDVLSYYADP SNLYFPSGHV DLRYGISASL TERKDGDAKD
360 370 380 390 400
FQVTTDQRTY LFRADSATSA KEWVKALQQV IFRTHNEGDS VKVSFPIANV
410 420 430 440 450
IDLEESPMAD FAETFKIRVI DSGETYAIDE YFFSFFDSGQ DAFNYIKGLV
460 470 480 490 500
NAVSTTTATK EAQDQHDIKH QPESSRTAYK RQSVSSVRVS DQRREDSPRK
510 520 530 540 550
RSSSVGNENQ GSADSFAEQG TGSSPIIQSM TDTTESASQI LHRSDVFQAP
560 570 580 590 600
TMRTLQGRSL DVGESIRRYS DDTTPSASAR LDLDAAVGSP CGTLGHNETT
610 620 630 640 650
EDARYATGQS DLMQSSRPSS VTQLNELVKA GVYPLQRAAG FAEYLKSRSK
660 670 680 690 700
QMSTLLATES MGYIEKVSGM WIGGQKHYGE REGPLLEDQN VDPEDNEGSF
710 720 730 740 750
NYGDRFRAHF ALPPTEKLQA TYYAYLHRVL PLYGKIYISQ KKLCFRSLIP
760 770 780 790 800
GTRTKMILPF KDIENVEKEK GFRFGYHGLV VIIRGHEELF FEFNASDSRD
810 820 830 840 850
DCAVTLHQNL ESVKFLVESG LLAEDERDEV EAAKAEHRML EEARLDSPEG
860 870 880 890 900
HDAPPTLTED SSEIHPFFDD PRASIINFKP PEPLRITCLT IGSRGDVQPY
910 920 930 940 950
IALCKGLLAE GHKPKIATHA EFEPWIRKHG IDFAPVDGDP AELMRICVEN
960 970 980 990 1000
GMFTYSFLRE ASLKFRGWID DLLSSAWIGC QGSDLLIESP SAMAGIHIAE
1010 1020 1030 1040 1050
ALRIPYFRGF TMPWTRTRAY PHAFAVPENR MGGAYNYITY VMFDNIFWKA
1060 1070 1080 1090 1100
IAGQVNRWRN NELGLKATTL DKMQQNKVPF LYNYSPSVVA PPLDYPDWIR
1110 1120 1130 1140 1150
ITGYWFLNEG TDWTPPTELS NFIAQARSDG KKLVYIGFGS IVVSDPSALT
1160 1170 1180 1190 1200
RTVIESVLKA DVRCILSKGW SDRLGDPAST KTEIPLPPEI LQIQSAPHDW
1210 1220 1230 1240 1250
LFSQIDAAAH HGGAGTTGAS LRAGVPTIVK PFFGDQFFFG SRVEDLGVGI
1260 1270 1280 1290 1300
CMKKLNVSVF SRALWEATHS ERMIVKARNL GIQIRNEDGV ATAIQALYRD
1310 1320 1330 1340 1350
LEYAKTLARQ KSLASSTPFS PTPTAKASPD GGDDDLDDIE EWTFVGDETG
1360 1370
FDIAKRMRER AASDADRIGS NMFQ
Length:1,374
Mass (Da):153,587
Last modified:September 11, 2007 - v1
Checksum:i1ED04830463732DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF110900 Genomic DNA. Translation: ABO31321.1.
AM920427 Genomic DNA. Translation: CAP81246.1.
RefSeqiXP_002558417.1. XM_002558371.1.

Genome annotation databases

EnsemblFungiiCAP81246; CAP81246; PCH_Pc12g16190.
GeneIDi8306628.
KEGGipcs:Pc12g16190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF110900 Genomic DNA. Translation: ABO31321.1.
AM920427 Genomic DNA. Translation: CAP81246.1.
RefSeqiXP_002558417.1. XM_002558371.1.

3D structure databases

ProteinModelPortaliA7KAN4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi500485.XP_002558417.1.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAP81246; CAP81246; PCH_Pc12g16190.
GeneIDi8306628.
KEGGipcs:Pc12g16190.

Phylogenomic databases

eggNOGiKOG1192. Eukaryota.
COG1819. LUCA.
HOGENOMiHOG000034145.
KOiK05841.
OMAiWEATHSE.
OrthoDBiEOG092C09PF.

Enzyme and pathway databases

BioCyciPCHR:PC12G16190-MONOMER.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR004276. GlycoTrans_28_N.
IPR004182. GRAM.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF03033. Glyco_transf_28. 1 hit.
PF02893. GRAM. 2 hits.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00568. GRAM. 2 hits.
SM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATG26_PENRW
AccessioniPrimary (citable) accession number: A7KAN4
Secondary accession number(s): B6GYP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 11, 2007
Last modified: September 7, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.