Reviewed, UniProtKB/Swiss-Prot A7KAL2 (ATG1_PENCW)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase ATG1
    EC=2.7.11.1
Alternative name(s):
    Autophagy-related protein 1

Gene names

Name:	atg1
ORF Names:	Pc18g03490

Organism

Penicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum) [Complete proteome]

Taxonomic identifier

500485 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Penicillium › Penicillium chrysogenum complex

Protein attributes

Sequence length	960 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Serine/threonine protein kinase probably involved in the cytoplasm to vacuole transport (Cvt) and in autophagy, where it may be required for the formation of autophagosomes By similarity. Ref.1
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 960	960	Serine/threonine-protein kinase ATG1		PRO_0000317795
Regions
	Domain	22 – 327	306	Protein kinase
	Nucleotide binding	28 – 36	9	ATP By similarity
Sites
	Active site	165	1	Proton acceptor By similarity
	Binding site	51	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A7KAL2-1 [UniParc]. Last modified September 11, 2007. Version 1. Checksum: D54DFC78DA5C4B30	FASTA	960	104,745
	10 20 30 40 50 60 MASQHSRRSR EAPRPEMSIG RYTRLDEIGR GSFATVYQGV HTKSKTYVAI KSVNLSKLNK 70 80 90 100 110 120 KLKENLSSEI DILKGLHHPH IVALIDCHES TSHIHLVMEY CALGDLSLFI KRRDTLGSHK 130 140 150 160 170 180 YTRDMIAKYP NPPGGSLNEV VTRHFLKQLS SALKFLRDRN LIHRDIKPQN LLLCPSPSSY 190 200 210 220 230 240 RSGHAQVMPY KGSDDSYEPT TGLESLPMLK IADFGFARSL PATSLAETLC GSPLYMAPEI 250 260 270 280 290 300 LRYEKYDAKA DLWSVGTVLY EMVVGRPPFR ATNHVELLRK IEKGEDRIRF PEDNPASDDI 310 320 330 340 350 360 KKLIRGLLKR NPVERLNFPE FFSNNVINDP IPGLLADDAP GPPQSPRPRQ LVGKAEESPY 370 380 390 400 410 420 DTGPEDKLAY PPGQRPVTTH PKSGTPPTAT DMRRMGSADR PAPAISKEQQ PGGTPPQRPG 430 440 450 460 470 480 PVSLATAPGR QELIDRNATT AAMDRQRHRN TYAGAPKASD STIRAQEARD RAAQEVAFER 490 500 510 520 530 540 DYVVVEKRAV EVNAFADELA HSPRLQGGLS RPGQTGAGSR RTTTQGLPTV SPSSPHANAA 550 560 570 580 590 600 KAMQVVSGRA RADSTHQRQH SYERRYGQSP TSATSAISKA LNMASGRLFG MGFSPPLAIT 610 620 630 640 650 660 KGGRSPPLAY NPFPAYPPVH ASLLITGDGS KPNATGDEDC KAVQEIEECA TRSDVVFGFA 670 680 690 700 710 720 EVKYKQLIPL APSASTDPSA RPMDTNVEPD SADSDDGLTV DAIVTLSEEA LVLYVKALSL 730 740 750 760 770 780 LAKSMDIAGA WWSRKNREEV YGESPTKDSM SAVAGTRINY VVQWVRSRFN EVIEKAEFVR 790 800 810 820 830 840 LKLIEGQRRL PPDHPSHPDN HSISSTAGSS STADVVVSPG VTAERLMYDR ALEMSRAAAI 850 860 870 880 890 900 NELTGEDLAN CEITYVTAIR MLEAVLEDDG MRSMPGSNIE RQSSSQGGEK VVLDELQVED 910 920 930 940 950 960 RQVVVKLVSS MRGRLASVRK KVAVLAKRSS APTPTAGSAG KTPTSNISPV TYATGVTPPR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"ATG genes involved in non-selective autophagy are conserved from yeast to man, but the selective Cvt and pexophagy pathways also require organism-specific genes." Meijer W.H., van der Klei I.J., Veenhuis M., Kiel J.A.K.W. Autophagy 3:106-116(2007) [PubMed: 17204848] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
[2]	"Genome sequencing and analysis of the filamentous fungus Penicillium chrysogenum." van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M., Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M., Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F., Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A. , van der Klei I.J., van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R., Bovenberg R.A.L. Nat. Biotechnol. 26:1161-1168(2008) [PubMed: 18820685] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	EF107734 Genomic DNA. Translation: ABO31072.1. AM920433 Genomic DNA. Translation: CAP94573.1.
RefSeq	XP_002562187.1.
3D structure databases
SMR	A7KAL2. Positions 16-323.
ModBase	Search...
Genome annotation databases
GeneID	8305112.
GenomeReviews	Gene locus atg1 in contig AM920433_GR.
KEGG	pcs:Pc18g03490.
Phylogenomic databases
OrthoDB	EOG98D2C4.
Enzyme and pathway databases
BRENDA	2.7.11.1. 285.
Family and domain databases
InterPro	IPR020636. Ca/CaM-dep_prot_kinase-like. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. IPR020656. Ser/Thr_prot_kinase_ATG1. IPR002290. Ser/Thr_prot_kinase_dom. [Graphical view]
PANTHER	PTHR22982. Ca/CaM-dep_prot_kinase-like. 1 hit. PTHR22982:SF39. Ser/Thr_prot_kinase_ATG1. 1 hit.
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG1_PENCW

Accession

Primary (citable) accession number: A7KAL2
Secondary accession number(s): B6HBB5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	September 11, 2007
Last modified:	January 19, 2010
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)