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Protein

Sterol 3-beta-glucosyltransferase

Gene

ATG26

Organism
Pichia angusta (Yeast) (Hansenula polymorpha)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probable sterol 3-beta-glucosyltransferase that mediates autophagic degradation of peroxisomes (pexophagy) (PubMed:17204848). Also required for cytoplasm to vacuole transport (Cvt) and autophagic degradation of mitochondria (mitophagy) and nuclei (nucleophagy) (By similarity).By similarity1 Publication

Catalytic activityi

UDP-glucose + a sterol = UDP + a sterol 3-beta-D-glucoside.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processAutophagy, Lipid biosynthesis, Lipid metabolism, Protein transport, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism, Transport

Protein family/group databases

CAZyiGT1 Glycosyltransferase Family 1

Names & Taxonomyi

Protein namesi
Recommended name:
Sterol 3-beta-glucosyltransferaseCurated (EC:2.4.1.173Curated)
Alternative name(s):
Autophagy-related protein 26By similarity
Gene namesi
Name:ATG26By similarity
OrganismiPichia angusta (Yeast) (Hansenula polymorpha)
Taxonomic identifieri870730 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesPichiaceaeOgataea

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003180471 – 1241Sterol 3-beta-glucosyltransferaseAdd BLAST1241

Structurei

3D structure databases

ProteinModelPortaliA7KAK6
SMRiA7KAK6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini220 – 267GRAM 1Sequence analysisAdd BLAST48
Domaini271 – 373PHPROSITE-ProRule annotationAdd BLAST103
Domaini609 – 675GRAM 2Sequence analysisAdd BLAST67

Domaini

The GRAM and PH domains are required for the localization of ATG26 to the preautophagosomal structure (PAS) and are involved in autophagy (By similarity).By similarity

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family.Curated

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR004276 GlycoTrans_28_N
IPR004182 GRAM
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR002213 UDP_glucos_trans
PfamiView protein in Pfam
PF03033 Glyco_transf_28, 1 hit
PF02893 GRAM, 1 hit
PF00169 PH, 1 hit
PF00201 UDPGT, 1 hit
SMARTiView protein in SMART
SM00568 GRAM, 2 hits
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

A7KAK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGIESTEEP CDSMTESQSL SPLEPEERQT RKDSGLQSQS LTKRHFAFSP
60 70 80 90 100
HRLITSISRH TSPHKPRPKS ESRVPVPKLH SLPPQRLASP ERDKPSIEGI
110 120 130 140 150
SKSFVSFLTA ASVYAGFQDL EGEDQQVSPD DVSAGESEDQ QADESSDEQE
160 170 180 190 200
DDDQDDRTFY ATDPSPTELT INENTPLPEP EPPRRTLRKA RSRFEFSVVK
210 220 230 240 250
RLSENENDQL AQKRAIALSN KLKRTFDISD TDVFISDYPC WLMGDVLLQG
260 270 280 290 300
HLYITKHHIL FFAFLPKKQG SISKSGALTT KSYPSLREHR KWAVLRNNTF
310 320 330 340 350
SVYSNSTDLY FPLLVIDLRT ALRAEILQSS STKQNPSKPV WIRIITESRT
360 370 380 390 400
HWFLADNLAS ARSWVSSLKK HIFASRNKGD QVAIKIPLQN VVDLELTSVI
410 420 430 440 450
GVTKNLRIKV IESADTFAID DYFLMFFSRG EKAVEDIKKV IHDAGMEISE
460 470 480 490 500
GTSTESEDEQ GVDNNLLKSK IELLKKSPSM VQTSSKSNVP VIRMDEPADD
510 520 530 540 550
FSQEQESAES SKPVSDDEIV SADDNQELEE KQPQDNLANA EKENHDKVSR
560 570 580 590 600
ANSRRTWSTR SLVQGLTAIT QGWMSPSPMA HFDEKYAVLR GEEDSYFVKD
610 620 630 640 650
AEQRKAATER FRKHFSLTDG EKLIATYHAY LVKGIPAYGK IYLGSNEMCF
660 670 680 690 700
RSTLPGTGTI MILPFSDIEN VNKEKGFRFG YSGLVVVIHG HEELFFEFAS
710 720 730 740 750
DQARDDCEFM LLKQMDMFKK GSTDSSPPNA SEGSSDESCN LAESNTSLAS
760 770 780 790 800
ARLRMFENRI HDAIGLDVPI IIEEHPLTKT KVRPLKSYRF TLLTIGSRGD
810 820 830 840 850
VQPYIALGKA LMKEGHQVRI VTHAEFEPWI KKHGIRFASI AGDPSELMAL
860 870 880 890 900
MVTHPTINYN FIKEAKSKFR SWIDDLLVTS WKACQDTDIL IESPSSICGI
910 920 930 940 950
HIAEKLQIPY FRAFTMPWTR TRAYPHAFMV PDQKLGGAYN YMTHVAFENG
960 970 980 990 1000
YWRGTAHQVN KWRVETLGLP KTSLAEMKQN NVPFLYNVSP TVFPPSVDFA
1010 1020 1030 1040 1050
EWVKVTGYWF LDESETYQPP EVLTKFIEQA RKDGKKVVYI GFGSIVVSKP
1060 1070 1080 1090 1100
SELTQAVVDA VLEADVRCIL NKGWSDRLGT KTEIEVVLPP EIYNAGSVPH
1110 1120 1130 1140 1150
DWLFPQIDAA VHHGGSGTTG ASLRFGVPTI IKPFFGDQKF YAGRVEDLGC
1160 1170 1180 1190 1200
GVSLKDLNYK SLARALKEVT TNTRIIEKAK LVGARIRSET GVQTAIETIY
1210 1220 1230 1240
NEMEYARSLS ISKVKQVSVV KSDEEFDDDK DEEVEGSWLL V
Length:1,241
Mass (Da):139,706
Last modified:September 11, 2007 - v1
Checksum:iDD2EF8120266BE7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF107728 Genomic DNA Translation: ABO31066.1

Similar proteinsi

Entry informationi

Entry nameiATG26_PICAN
AccessioniPrimary (citable) accession number: A7KAK6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 11, 2007
Last modified: April 25, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

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