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Protein

Phosphate acetyltransferase

Gene

VEA_002967

Organism
Vibrio sp. (strain Ex25)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in acetate metabolism.UniRule annotation

Catalytic activityi

Acetyl-CoA + phosphate = CoA + acetyl phosphate.UniRule annotation

Pathway: acetyl-CoA biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA), Acetate kinase (ackA)
  2. Phosphate acetyltransferase (VEA_002967)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotationSAAS annotation, Transferase

Enzyme and pathway databases

BioCyciVSP150340:GJJG-1460-MONOMER.
UniPathwayiUPA00340; UER00459.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate acetyltransferaseUniRule annotation (EC:2.3.1.8UniRule annotation)
Alternative name(s):
PhosphotransacetylaseUniRule annotation
Gene namesi
Ordered Locus Names:VEA_002967Imported
ORF Names:VEx25_B0012Imported
OrganismiVibrio sp. (strain Ex25)Imported
Taxonomic identifieri150340 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000002571 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA7K4K1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site.UniRule annotation

Sequence similaritiesi

In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.UniRule annotation
In the N-terminal section; belongs to the CobB/CobQ family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0280.
HOGENOMiHOG000053797.
KOiK13788.
OMAiKPIAQPH.
OrthoDBiEOG6BKJ5W.

Family and domain databases

Gene3Di3.40.1390.20. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR010766. DRTGG.
IPR016475. P-Actrans_bac.
IPR027417. P-loop_NTPase.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
IPR028979. Ser_kin/Pase_Hpr_N_like.
[Graphical view]
PfamiPF07085. DRTGG. 1 hit.
PF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFiPIRSF006107. PhpActrans_proteobac. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF75138. SSF75138. 1 hit.
TIGRFAMsiTIGR00651. pta. 1 hit.

Sequencei

Sequence statusi: Complete.

A7K4K1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRTIMLIPT SAGVGLTSVS MGVLRAMERK GVKVSFYKPI CQPRSGGDQP
60 70 80 90 100
DLTSTIVGHN SDMKIGEPMA MSVAESLIGN DNMDELLETV VERYNQINKD
110 120 130 140 150
ADVTLIEGLV PTRKHPFANQ VNAEIAATLG AEIVLVATPG TDNPAQLKER
160 170 180 190 200
IEVACSNFGG TKNKNISGVI INKLNAPVDE AGRTRPDLSE IFDDADSAKQ
210 220 230 240 250
NELKVMEIFN TSPIRVLGCV PWSIDLIATR AIDMAKHLKA DIINEGDINT
260 270 280 290 300
RRIKSITFCA RSLPNMIEHF KPGSLLVTSA DRPDVIVAAS LAAMNGVDIG
310 320 330 340 350
AVLLTGGYDI PREIEGLCKP AFDTGLPIFK AQGNTWQTSL NLQSFSIEVP
360 370 380 390 400
ADDKERIEFI NEHVAGHIDG NWIESMTEGT QKSRRLSPPA FRYQLTELAR
410 420 430 440 450
KAGKRIVLPE GDEPRTVKAA AICAERGIAD CVLLGNPDEI RRVAAQQGVE
460 470 480 490 500
LGTGVTIIDA DAVRENYVAR LVELRGAKGM TEVVAREKLQ DSVFLGTMML
510 520 530 540 550
ENDEVDGLVS GAVHTTANTI VPPFQIIKTA PNASIVSSVF FMLLPDQVLV
560 570 580 590 600
YGDCAINPDP TAEQLAEIAI QSADSAAAFG IDPRVAMISY STGESGKGAD
610 620 630 640 650
VDKVREATRI AKEKRPDLVI DGPLQYDAAI MENVAASKAP NSPVAGKATV
660 670 680 690 700
FVFPDLNTGN TTYKAVQRSA DLVSIGPMLQ GMRKPVNDLS RGALVDDIVY
710
TIALTAIQAD QEAK
Length:714
Mass (Da):76,698
Last modified:September 11, 2007 - v1
Checksum:i0922E8741F6E9EF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001805 Genomic DNA. Translation: ACY51129.1.
DS267835 Genomic DNA. Translation: EDN56472.1.
RefSeqiWP_005396636.1. NZ_DS267835.1.
YP_003285594.1. NC_013456.1.

Genome annotation databases

EnsemblBacteriaiACY51129; ACY51129; VEA_002967.
EDN56472; EDN56472; VEx25_B0012.
KEGGivex:VEA_002967.
PATRICi28403836. VBIVibSp2903_3315.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001805 Genomic DNA. Translation: ACY51129.1.
DS267835 Genomic DNA. Translation: EDN56472.1.
RefSeqiWP_005396636.1. NZ_DS267835.1.
YP_003285594.1. NC_013456.1.

3D structure databases

ProteinModelPortaliA7K4K1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACY51129; ACY51129; VEA_002967.
EDN56472; EDN56472; VEx25_B0012.
KEGGivex:VEA_002967.
PATRICi28403836. VBIVibSp2903_3315.

Phylogenomic databases

eggNOGiCOG0280.
HOGENOMiHOG000053797.
KOiK13788.
OMAiKPIAQPH.
OrthoDBiEOG6BKJ5W.

Enzyme and pathway databases

UniPathwayiUPA00340; UER00459.
BioCyciVSP150340:GJJG-1460-MONOMER.

Family and domain databases

Gene3Di3.40.1390.20. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR010766. DRTGG.
IPR016475. P-Actrans_bac.
IPR027417. P-loop_NTPase.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
IPR028979. Ser_kin/Pase_Hpr_N_like.
[Graphical view]
PfamiPF07085. DRTGG. 1 hit.
PF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFiPIRSF006107. PhpActrans_proteobac. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF75138. SSF75138. 1 hit.
TIGRFAMsiTIGR00651. pta. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Heidelberg J., Sebastian Y.
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Ex25Imported.
  2. "Sequence of the deep-sea isolate Vibrio sp. strain Ex25."
    Munk A.C., Tapia R., Green L., Rogers Y., Detter J.C., Bruce D., Brettin T.S., Colwell R., Huq A., Grim C.J., Hasan N.A., Vonstein V., Bartels D.
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ex25Imported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: EX25Imported.

Entry informationi

Entry nameiA7K4K1_VIBSE
AccessioniPrimary (citable) accession number: A7K4K1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: June 24, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.