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A7JQU5 (A7JQU5_PASHA) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
EC=2.5.1.18 EMBL EDN73431.1
Gene names
ORF Names:MHA_0454 EMBL EDN73431.1
OrganismMannheimia haemolytica PHL213 EMBL EDN73431.1
Taxonomic identifier272629 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeMannheimia

Protein attributes

Sequence length209 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the GST superfamily. RuleBase RU003494

Ontologies

Keywords
   LigandChloride PDB 4IQ1 PDB 4IW9
   Molecular functionTransferase EMBL EDN73431.1
   Technical term3D-structure PDB 4IQ1 PDB 4IW9
Gene Ontology (GO)
   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region64 – 652Chloride 1 binding PDB 4IQ1
Region65 – 662Glutathione binding
Region102 – 1043Glutathione binding
Region104 – 1074Acetate binding

Sites

Binding site101Glutathione
Binding site361Glutathione
Binding site401Glutathione
Binding site531Glutathione; via amide nitrogen and carbonyl oxygen
Binding site651Chloride 2
Binding site961Chloride 1 PDB 4IQ1

Sequences

Sequence LengthMass (Da)Tools
A7JQU5 [UniParc].

Last modified September 11, 2007. Version 1.
Checksum: A5FC09FBA2115ACA

FASTA20923,645
        10         20         30         40         50         60 
MKLYGLTGAC SFVPHVALEW VKLRANQDYA FQAVSREFIK SAEYLALNPR GNVPLLVDGD 

        70         80         90        100        110        120 
LALTQNQAIV HYLDELYPEA KLFGSKTARD KAKAARWLAF FNSDVHKSFV PLFRLPSYAE 

       130        140        150        160        170        180 
GNETLTKTIR QQSAEQILEQ LAFANAHLEN HIFFGEEISV ADAYLYIMLN WCRLLGLDFS 

       190        200 
HLSQLSAFMQ RVEADQGVDN VREQEGLKG 

« Hide

References

[1]"The genome sequence of Mannheimia haemolytica A1: insights into virulence, natural competence, and Pasteurellaceae phylogeny."
Gioia J., Qin X., Jiang H., Clinkenbeard K., Lo R., Liu Y., Fox G.E., Yerrapragada S., McLeod M.P., McNeill T.Z., Hemphill L., Sodergren E., Wang Q., Muzny D.M., Homsi F.J., Weinstock G.M., Highlander S.K.
J. Bacteriol. 188:7257-7266(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: PHL213 EMBL EDN73431.1.
[2]Giola J., Qin X., Jiang H., Clinkenbeard K., Lo R., Liu Y., Fox G.E., Yerrapragada S., McLeod M.P., McNeill T.Z., Hemphill L., Sodergren E., Wang Q., Muzney D.M., Homsi F.J., Weinstock G.M., Highlander S.K.
Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: PHL213 EMBL EDN73431.1.
[3]"Crystal structure of probable glutathione s-transferase MHA_0454 (TARGET EFI-507015) FROM Mannheimia haemolytica, Substrate-free."
Enzyme Function Initiative (EFI)
Patskovsky Y., Toro R., Bhosle R., Hillerich B., Seidel R.D., Washington E., Scott Glenn A., Chowdhury S., Evans B., Hammonds J., Zencheck W.D., Imker H.J., AL Obaidi N.F., Stead M., Love J., Gerlt J.A., Armstrong R.N., Almo S.C.
Submitted (JAN-2013) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) IN COMPLEX WITH CHLORIDE.
[4]"Crystal Structure of Probable Glutathione S-Transferase Mha_0454 (Target Efi-507015) from Mannheimia Haemolytica."
Enzyme Function Initiative (EFI)
Patskovsky Y., Toro R., Bhosle R., Hillerich B., Seidel R.D., Washington E., Scott Glenn A., Chowdhury S., Evans B., Hammonds J., Zencheck W.D., Imker H.J., Al Obaidi N., Stead M., Love J., Gerlt J.A., Armstrong R.N., Almo S.C.
Submitted (JAN-2013) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.76 ANGSTROMS) IN COMPLEX WITH ACETATE; CHLORIDE AND GLUTATHIONE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DS264611 Genomic DNA. Translation: EDN73431.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4IQ1X-ray1.85A/B/C1-209[»]
4IW9X-ray1.76A/B/C1-209[»]
ProteinModelPortalA7JQU5.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEDN73431; EDN73431; MHA_0454.
PATRIC28796897. VBIManHae426_0408.

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA7JQU5_PASHA
AccessionPrimary (citable) accession number: A7JQU5
Entry history
Integrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: April 16, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)