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A7JQU5

- A7JQU5_PASHA

UniProt

A7JQU5 - A7JQU5_PASHA

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Protein
Submitted name: Glutathione transferase
Gene
MHA_0454
Organism
Mannheimia haemolytica PHL213
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei10 – 101GlutathioneImported
Binding sitei36 – 361GlutathioneImported
Binding sitei40 – 401GlutathioneImported
Binding sitei53 – 531Glutathione; via amide nitrogen and carbonyl oxygenImported
Binding sitei65 – 651Chloride 2

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    TransferaseImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Glutathione transferaseImported (EC:2.5.1.18Imported)
    Gene namesi
    ORF Names:MHA_0454Imported
    OrganismiMannheimia haemolytica PHL213Imported
    Taxonomic identifieri272629 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeMannheimia

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4IQ1X-ray1.85A/B/C1-209[»]
    4IW9X-ray1.76A/B/C1-209[»]
    ProteinModelPortaliA7JQU5.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni65 – 662Glutathione bindingImported
    Regioni102 – 1043Glutathione bindingImported
    Regioni104 – 1074Acetate binding

    Sequence similaritiesi

    Belongs to the GST superfamily.UniRule annotation

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00043. GST_C. 1 hit.
    PF13417. GST_N_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A7JQU5-1 [UniParc]FASTAAdd to Basket

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    MKLYGLTGAC SFVPHVALEW VKLRANQDYA FQAVSREFIK SAEYLALNPR    50
    GNVPLLVDGD LALTQNQAIV HYLDELYPEA KLFGSKTARD KAKAARWLAF 100
    FNSDVHKSFV PLFRLPSYAE GNETLTKTIR QQSAEQILEQ LAFANAHLEN 150
    HIFFGEEISV ADAYLYIMLN WCRLLGLDFS HLSQLSAFMQ RVEADQGVDN 200
    VREQEGLKG 209
    Length:209
    Mass (Da):23,645
    Last modified:September 11, 2007 - v1
    Checksum:iA5FC09FBA2115ACA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS264611 Genomic DNA. Translation: EDN73431.1.

    Genome annotation databases

    EnsemblBacteriaiEDN73431; EDN73431; MHA_0454.
    PATRICi28796897. VBIManHae426_0408.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS264611 Genomic DNA. Translation: EDN73431.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4IQ1 X-ray 1.85 A/B/C 1-209 [» ]
    4IW9 X-ray 1.76 A/B/C 1-209 [» ]
    ProteinModelPortali A7JQU5.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai EDN73431 ; EDN73431 ; MHA_0454 .
    PATRICi 28796897. VBIManHae426_0408.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR004046. GST_C.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00043. GST_C. 1 hit.
    PF13417. GST_N_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Mannheimia haemolytica A1: insights into virulence, natural competence, and Pasteurellaceae phylogeny."
      Gioia J., Qin X., Jiang H., Clinkenbeard K., Lo R., Liu Y., Fox G.E., Yerrapragada S., McLeod M.P., McNeill T.Z., Hemphill L., Sodergren E., Wang Q., Muzny D.M., Homsi F.J., Weinstock G.M., Highlander S.K.
      J. Bacteriol. 188:7257-7266(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: PHL213Imported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: PHL213Imported.
    3. "Crystal structure of probable glutathione s-transferase MHA_0454 (TARGET EFI-507015) FROM Mannheimia haemolytica, Substrate-free."
      Enzyme Function Initiative (EFI)
      Patskovsky Y., Toro R., Bhosle R., Hillerich B., Seidel R.D., Washington E., Scott Glenn A., Chowdhury S., Evans B., Hammonds J., Zencheck W.D., Imker H.J., AL Obaidi N.F., Stead M., Love J., Gerlt J.A., Armstrong R.N., Almo S.C.
      Submitted (JAN-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
    4. "Crystal Structure of Probable Glutathione S-Transferase Mha_0454 (Target Efi-507015) from Mannheimia Haemolytica."
      Enzyme Function Initiative (EFI)
      Patskovsky Y., Toro R., Bhosle R., Hillerich B., Seidel R.D., Washington E., Scott Glenn A., Chowdhury S., Evans B., Hammonds J., Zencheck W.D., Imker H.J., Al Obaidi N., Stead M., Love J., Gerlt J.A., Armstrong R.N., Almo S.C.
      Submitted (JAN-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.76 ANGSTROMS) IN COMPLEX WITH GLUTATHIONE.

    Entry informationi

    Entry nameiA7JQU5_PASHA
    AccessioniPrimary (citable) accession number: A7JQU5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 11, 2007
    Last sequence update: September 11, 2007
    Last modified: September 3, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3

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